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Book ; Conference proceedings: International Symposium on Cell Biology: From Basic Research to Clinical Applictions

Chan, Hsiao Chang

Chongqing, (China), 14 - 16 October 2004

(Cell biology international ; 28,8/9, [Suppl.])

2004

Event/congress	International Symposium on Cell Biology: From Basic Research to Clinical Applications (2004, Chongqing)
Author's details	organizing committee: Hsiao Chang Chan
Series title	Cell biology international ; 28,8/9, [Suppl.]
Collection
Language	English
Size	S30 S.
Publisher	Elsevier
Publishing place	S.l.
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT014156273
Database	Catalogue ZB MED Medicine, Health

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Zs A 1451 -28-	not available for loan	Zeitschriften-Lesesaal

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Article: Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities.

Li, Chien-Hsiu / Chang, Yu-Chan / Hsiao, Michael / Chan, Ming-Hsien

Pharmaceutics

2022 Volume 14, Issue 6

Abstract: ... of changing the accumulation of materials, it is possible to examine the results by comparing images ... at the tumor site upon ultrasonic imaging, in accordance with their modification characteristics. As a result ...

Abstract	Cancer is a disease characterized by abnormal cell growth. According to a report published by the World Health Organization (WHO), cancer is the second leading cause of death globally, responsible for an estimated 9.6 million deaths in 2018. It should be noted that ultrasound is already widely used as a diagnostic procedure for detecting tumorigenesis. In addition, ultrasound energy can also be utilized effectively for treating cancer. By filling the interior of lipospheres with gas molecules, these particles can serve both as contrast agents for ultrasonic imaging and as delivery systems for drugs such as microbubbles and nanobubbles. Therefore, this review aims to describe the nanoparticle-assisted drug delivery system and how it can enhance image analysis and biomedicine. The formation characteristics of nanoparticles indicate that they will accumulate at the tumor site upon ultrasonic imaging, in accordance with their modification characteristics. As a result of changing the accumulation of materials, it is possible to examine the results by comparing images of other tumor cell lines. It is also possible to investigate ultrasound images for evidence of cellular effects. In combination with a precision ultrasound imaging system, drug-carrying lipospheres can precisely track tumor tissue and deliver drugs to tumor cells to enhance the ability of this nanocomposite to treat cancer.
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14061282
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Article ; Online: Inferiorly based nasolabial flap for reconstruction of full-thickness medium-sized lower lip and commissural defects following ablative cancer surgery.

Tsai, Chien-Sheng / Chang, Chan-Chi / Hsiao, Jenn-Ren

Journal of the Chinese Medical Association : JCMA

2022 Volume 85, Issue 11, Page(s) 1083–1087

Abstract: Background: Information regarding the design and usage of inferiorly based nasolabial flap for lower lip and commissural defect reconstruction following ablative cancer surgery remains limited. This study aimed to provide our design and experiences for ... ...

Abstract	Background: Information regarding the design and usage of inferiorly based nasolabial flap for lower lip and commissural defect reconstruction following ablative cancer surgery remains limited. This study aimed to provide our design and experiences for such reconstructive purpose. Methods: Patients with lower lip or oral commissural cancer who received curative surgery involving reconstruction with inferiorly based nasolabial flap were included. The demographic data and clinical outcomes of these patients were obtained by retrospective chart review. Results: A total of eight patients were enrolled in this study. All patients received ablative surgery at the National Cheng Kung University Hospital during May 2019 to May 2021, with their surgical defects reconstructed with unilateral inferiorly based nasolabial flap successfully. Among the five patients with lower lip cancer, one had a limited area of necrosis at flap tip. Another patient had a small orocutaneous fistula that healed spontaneously. No trismus or oral incompetence was noted following recovery. For the three patients with commissural cancer, a second stage commisuroplasy was needed after primary reconstruction. One patient had limited wound dehiscence at mouth angle following surgery, resulting in mild oral incompetence. Although mild trismus was noted in these three commissural cancer patients, all patients resumed normal diet during follow-up. Conclusion: Inferiorly based nasolabial flap is an excellent local flap for lower lip reconstruction following cancer ablative surgery. It is also a viable option for reconstruction of oral commissural defects. Minimal donor side morbidity, good functional recovery, and esthetic outcomes can be achieved with meticulous flap design.
MeSH term(s)	Humans ; Retrospective Studies ; Surgical Flaps/surgery ; Lip/surgery ; Mouth Neoplasms/surgery ; Reconstructive Surgical Procedures/methods
Language	English
Publishing date	2022-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000805
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Article: Iron-Based Ceramic Composite Nanomaterials for Magnetic Fluid Hyperthermia and Drug Delivery.

Chan, Ming-Hsien / Li, Chien-Hsiu / Chang, Yu-Chan / Hsiao, Michael

Pharmaceutics

2022 Volume 14, Issue 12

Abstract: ... proportions of ceramic minerals before and after modification to enhance saturation magnetization ...

Abstract	Because of the unique physicochemical properties of magnetic iron-based nanoparticles, such as superparamagnetism, high saturation magnetization, and high effective surface area, they have been applied in biomedical fields such as diagnostic imaging, disease treatment, and biochemical separation. Iron-based nanoparticles have been used in magnetic resonance imaging (MRI) to produce clearer and more detailed images, and they have therapeutic applications in magnetic fluid hyperthermia (MFH). In recent years, researchers have used clay minerals, such as ceramic materials with iron-based nanoparticles, to construct nanocomposite materials with enhanced saturation, magnetization, and thermal effects. Owing to their unique structure and large specific surface area, iron-based nanoparticles can be homogenized by adding different proportions of ceramic minerals before and after modification to enhance saturation magnetization. In this review, we assess the potential to improve the magnetic properties of iron-based nanoparticles and in the preparation of multifunctional composite materials through their combination with ceramic materials. We demonstrate the potential of ferromagnetic enhancement and multifunctional composite materials for MRI diagnosis, drug delivery, MFH therapy, and cellular imaging applications.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14122584
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Article ; Online: Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression.

Chang, Yu-Chan / Chan, Ming-Hsien / Yang, Yi-Fang / Li, Chien-Hsiu / Hsiao, Michael

Cancer letters

2023 Volume 563, Page(s) 216179

Abstract: The glucose transporter family (GLUT) consists of fourteen members. It is responsible for glucose homeostasis and glucose transport from the extracellular space to the cell cytoplasm to further cascade catalysis. GLUT proteins are encoded by the solute ... ...

Abstract	The glucose transporter family (GLUT) consists of fourteen members. It is responsible for glucose homeostasis and glucose transport from the extracellular space to the cell cytoplasm to further cascade catalysis. GLUT proteins are encoded by the solute carrier family 2 (SLC2) genes and are members of the major facilitator superfamily of membrane transporters. Moreover, different GLUTs also have their transporter kinetics and distribution, so each GLUT member has its uniqueness and importance to play essential roles in human physiology. Evidence from many studies in the field of diabetes showed that GLUT4 travels between the plasma membrane and intracellular vesicles (GLUT4-storage vesicles, GSVs) and that the PI3K/Akt pathway regulates this activity in an insulin-dependent manner or by the AMPK pathway in response to muscle contraction. Moreover, some published results also pointed out that GLUT4 mediates insulin-dependent glucose uptake. Thus, dysfunction of GLUT4 can induce insulin resistance, metabolic reprogramming in diverse chronic diseases, inflammation, and cancer. In addition to the relationship between GLUT4 and insulin response, recent studies also referred to the potential upstream transcription factors that can bind to the promoter region of GLUT4 to regulating downstream signals. Combined all of the evidence, we conclude that GLUT4 has shown valuable unknown functions and is of clinical significance in cancers, which deserves our in-depth discussion and design compounds by structure basis to achieve therapeutic effects. Thus, we intend to write up a most updated review manuscript to include the most recent and critical research findings elucidating how and why GLUT4 plays an essential role in carcinogenesis, which may have broad interests and impacts on this field.
MeSH term(s)	Humans ; Cell Membrane/metabolism ; Glucose/metabolism ; Glucose Transport Proteins, Facilitative/metabolism ; Glycolysis ; Insulin/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Transport
Chemical Substances	Glucose (IY9XDZ35W2) ; Glucose Transport Proteins, Facilitative ; Insulin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; SLC2A4 protein, human
Language	English
Publishing date	2023-04-14
Publishing country	Ireland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2023.216179
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Zs.A 1177: Show issues

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Article ; Online: The CHST11 gene is linked to lung cancer and pulmonary fibrosis.

Li, Chien-Hsiu / Chan, Ming-Hsien / Chang, Yu-Chan / Hsiao, Michael

The journal of gene medicine

2022 Volume 24, Issue 12, Page(s) e3451

Abstract: Background: The abnormal modification of chondroitin sulfate is one of the leading causes ... a vital role in its modification, but its role in cancer is not fully understood. Therefore, understanding ...

Abstract	Background: The abnormal modification of chondroitin sulfate is one of the leading causes of disease, including cancer progression. During chondroitin sulfate biosynthesis, the CHST11 enzyme plays a vital role in its modification, but its role in cancer is not fully understood. Therefore, understanding the relationship between CHST11 and pulmonary-related diseases through clinically relevant information may be useful for diagnosis or treatment. Methods: A variety of pulmonary fibrosis clinical gene expression omnibus (GEO) datasets were used to assess the association between CHST11-related manifestations and fibrosis. Multiple lung cancer-related databases, including The Cancer Genome Atlas, GEO datasets, UCSC Xena, GEPIA2, Cbioportal and ingenuity pathway analysis were used to evaluate the clinical correlation between CHST11 and lung cancer and potential molecular mechanisms. For drug repurposing prediction, the molecules that correlated with CHST11 were subjected to the LINCS L1000 algorithm. A variety of in vitro assays were performed to evaluate the in-silico models, including RNA and protein expression, proliferation, migration and invasion. Results: Clinical analyses indicate that the levels of CHST11 are significantly elevated in cases of pulmonary-related diseases, including fibrosis and lung cancer. According to multiple lung cancer cohorts, CHST11 is the only member of the carbohydrate sulfotransferase family associated with overall survival for lung adenocarcinomas, and it is highly related to smoking-induced lung cancer patients. Based on the results of in vitro experiments, CHST11 expression contributes to tumor malignancy and promotes multiple fibrotic activators. Correlation-based ingenuity pathway analysis indicated that CHST11-related molecules contributed to pulmonary fibrosis or lung adenocarcinomas via similar upstream stimulators. Based on known molecular regulatory relationships, CHST11 has been associated with the regulation of TGF-β and INFγ as important molecules contributing to fibrosis and cancer progression. Interestingly, WordCloud analysis revealed that CHST11-related molecules are involved in regulation primarily by integrin signaling, and these relationships were consistently reflected in the analysis of cell lines and the clinical correlation. A CHST11 signature-based drug repurposing analysis demonstrated that the CHST11/integrin axis could be targeted by AG-1478 (Tyrphostin AG 1478), brefeldin A, geldanamycin and importazole. Conclusions: This study provides the first demonstration that CHST11 may be used as a biomarker for pulmonary fibrosis or lung cancer, and the levels of CHST11 were increased by TGF-β and INFγ. The molecular simulation analyses demonstrate that the CHST11/integrin axis is a potential therapeutic target for treating lung cancer.
MeSH term(s)	Humans ; Pulmonary Fibrosis/genetics ; Chondroitin Sulfates ; Lung Neoplasms/genetics ; Adenocarcinoma of Lung/genetics ; Transforming Growth Factor beta ; Integrins ; Sulfotransferases/genetics
Chemical Substances	Chondroitin Sulfates (9007-28-7) ; Transforming Growth Factor beta ; Integrins ; CHST11 protein, human (EC 2.8.2-) ; Sulfotransferases (EC 2.8.2.-)
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3451
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Zs.A 5423: Show issues

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Article ; Online: Myoelectric, Myo-Oxygenation, and Myotonometry Changes during Robot-Assisted Bilateral Arm Exercises with Varying Resistances.

Chan, Hsiao-Lung / Meng, Ling-Fu / Kao, Yung-An / Chang, Ya-Ju / Chang, Hao-Wei / Chen, Szi-Wen / Wu, Ching-Yi

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 4

Abstract: Robot-assisted bilateral arm training has demonstrated its effectiveness in improving motor function in individuals post-stroke, showing significant enhancements with increased repetitions. However, prolonged training sessions may lead to both mental and ...

Abstract	Robot-assisted bilateral arm training has demonstrated its effectiveness in improving motor function in individuals post-stroke, showing significant enhancements with increased repetitions. However, prolonged training sessions may lead to both mental and muscle fatigue. We conducted two types of robot-assisted bimanual wrist exercises on 16 healthy adults, separated by one week: long-duration, low-resistance workouts and short-duration, high-resistance exercises. Various measures, including surface electromyograms, near-infrared spectroscopy, heart rate, and the Borg Rating of Perceived Exertion scale, were employed to assess fatigue levels and the impacts of exercise intensity. High-resistance exercise resulted in a more pronounced decline in electromyogram median frequency and recruited a greater amount of hemoglobin, indicating increased muscle fatigue and a higher metabolic demand to cope with the intensified workload. Additionally, high-resistance exercise led to increased sympathetic activation and a greater sense of exertion. Conversely, engaging in low-resistance exercises proved beneficial for reducing post-exercise muscle stiffness and enhancing muscle elasticity. Choosing a low-resistance setting for robot-assisted wrist movements offers advantages by alleviating mental and physiological loads. The reduced training intensity can be further optimized by enabling extended exercise periods while maintaining an approximate dosage compared to high-resistance exercises.
MeSH term(s)	Adult ; Humans ; Arm ; Robotics ; Exercise Therapy ; Exercise/physiology ; Upper Extremity
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24041061
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Article ; Online: Fascin-1: Updated biological functions and therapeutic implications in cancer biology.

Li, Chien-Hsiu / Chan, Ming-Hsien / Liang, Shu-Mei / Chang, Yu-Chan / Hsiao, Michael

BBA advances

2022 Volume 2, Page(s) 100052

Abstract: Filopodia are cellular protrusions that respond to a variety of stimuli. Filopodia are formed when actin is bound to the protein Fascin, which may play a crucial role in cellular interactions and motility during cancer metastasis. Significantly, the ... ...

Abstract	Filopodia are cellular protrusions that respond to a variety of stimuli. Filopodia are formed when actin is bound to the protein Fascin, which may play a crucial role in cellular interactions and motility during cancer metastasis. Significantly, the noncanonical features of Fascin-1 are gradually being clarified, including the related molecular network contributing to metabolic reprogramming, chemotherapy resistance, stemness ac-tivity, and tumor microenvironment events. However, the relationship between biological characteristics and pathological features to identify effective therapeutic strategies needs to be studied further. The pur-pose of this review article is to provide a broad overview of the latest molecular networks and multiomics research regarding fascins and cancer. It also highlights their direct and indirect effects on available cancer treatments. With this multidisciplinary approach, researchers and clinicians can gain the most relevant in-formation on the function of fascins in cancer progression, which may facilitate clinical applications in the future.
Language	English
Publishing date	2022-05-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2667-1603
ISSN (online)	2667-1603
DOI	10.1016/j.bbadva.2022.100052
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Article: Postoperative 30-Day Comparative Complications of Multilevel Anterior Cervical Discectomy and Fusion and Laminoplasty for Cervical Spondylotic Myelopathy: An Evidence in Reaching Consensus.

Chan, Ryan Wing-Yuk / Chiang, Yung-Hsiao / Lin, Hsiu-Chen / Chang, Chih-Yau / Tsou, Yi-Syue

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 12

Abstract: Although a few large-scale studies have investigated multilevel anterior cervical discectomy and fusion (ACDF) and laminoplasty (LAMP) and their related complications for cervical spondylotic myelopathy (CSM), the optimal surgical intervention remains ... ...

Abstract	Although a few large-scale studies have investigated multilevel anterior cervical discectomy and fusion (ACDF) and laminoplasty (LAMP) and their related complications for cervical spondylotic myelopathy (CSM), the optimal surgical intervention remains controversial. Therefore, we compared their 30 days of postoperative complications. Through the 2010-2019 ACS NSQIP Participant Use Data Files, we estimated the risk of serious morbidity, reoperation, readmission, mortality, and other postoperative complications. Initially, propensity score matching (PSM) of the preoperative characteristics of both groups was performed for further analysis. Multivariable logistic regression analysis provided OR and 95% CI for comparative complications. After PSM, 621 pairs of cohorts were generated for both groups. Increased frequency of postoperative complications was observed in the LAMP group, especially for surgical wound infection, no matter whether superficial (ACDF/LAMP = 0%/1.13%,
Language	English
Publishing date	2023-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13122024
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Article ; Online: The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis.

Li, Chien-Hsiu / Fang, Chih-Yeu / Chan, Ming-Hsien / Chen, Chi-Long / Chang, Yu-Chan / Hsiao, Michael

Journal of cellular and molecular medicine

2023 Volume 27, Issue 5, Page(s) 672–686

Abstract: Follistatin-like (FSTL) family members are associated with cancer progression. However, differences between FSTL members with identical cancer types have not been systematically investigated. Among the most malignant tumours worldwide, colorectal cancer ( ...

Abstract	Follistatin-like (FSTL) family members are associated with cancer progression. However, differences between FSTL members with identical cancer types have not been systematically investigated. Among the most malignant tumours worldwide, colorectal cancer (CRC) has high metastatic potential and chemoresistance, which makes it challenging to treat. A systematic examination of the relationship between the expression of FSTL family members in CRC will provide valuable information for prognosis and therapeutic development. Based on large cohort survival analyses, we determined that FSTL3 was associated with a significantly worse prognosis in CRC at the RNA and protein levels. Immunohistochemistry staining of CRC specimens revealed that FSTL3 expression levels in the cytosol were significantly associated with a poor prognosis in terms of overall and disease-free survival. Molecular simulation analysis showed that FSTL3 participated in multiple cell motility signalling pathways via the TGF-β1/TWIST1 axis to control CRC metastasis. The findings provide evidence of the significance of FSTL3 in the oncogenesis and metastasis of CRC. FSTL3 may be useful as a diagnostic or prognostic biomarker, and as a potential therapeutic target.
MeSH term(s)	Humans ; Cytosol/metabolism ; Cell Transformation, Neoplastic ; Signal Transduction ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Cohort Studies ; Biomarkers, Tumor/genetics ; Follistatin-Related Proteins/genetics ; Follistatin-Related Proteins/metabolism
Chemical Substances	Biomarkers, Tumor ; Fstl3 protein, human ; Follistatin-Related Proteins
Language	English
Publishing date	2023-02-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.17690
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