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Article ; Online: m

Alvizi, Lucas / Brito, Luciano Abreu / Kobayashi, Gerson Shigeru / Bischain, Bárbara / da Silva, Camila Bassi Fernandes / Ramos, Sofia Ligia Guimaraes / Wang, Jaqueline / Passos-Bueno, Maria Rita

Epigenetics

2022 Volume 17, Issue 13, Page(s) 2278–2295

Abstract: Non-syndromic cleft lip with or without cleft palate (NSCLP), the most common human craniofacial malformation, is a complex disorder given its genetic heterogeneity and multifactorial component revealed by genetic, epidemiological, and epigenetic ... ...

Abstract	Non-syndromic cleft lip with or without cleft palate (NSCLP), the most common human craniofacial malformation, is a complex disorder given its genetic heterogeneity and multifactorial component revealed by genetic, epidemiological, and epigenetic findings. Epigenetic variations associated with NSCLP have been identified; however, functional investigation has been limited. Here, we combined a reanalysis of NSCLP methylome data with genetic analysis and used both
MeSH term(s)	Animals ; Humans ; Cleft Lip/genetics ; Cleft Palate/genetics ; Zebrafish/genetics ; Genetic Predisposition to Disease ; DNA Methylation ; Hypoxia/genetics ; Polymorphism, Single Nucleotide ; MicroRNAs/genetics
Chemical Substances	MIRN152 microRNA, human ; MicroRNAs
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.1080/15592294.2022.2115606
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Article ; Online: M. bovis

Schwarz, Marcos Gustavo Araujo / Luzes, Bianca Gallart Cinelli / Correa, Paloma Rezende / da Silva-Gonçalves, Antônio José / Machado, Lucas de Almeida / Guimarães, Ana Carolina Ramos / Mendonça-Lima, Leila

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 658888

Abstract: Tuberculosis still remains a concerning health problem worldwide. Its etiologic agent, ...

Abstract	Tuberculosis still remains a concerning health problem worldwide. Its etiologic agent,
MeSH term(s)	BCG Vaccine ; Brazil ; Flavins ; Mycobacterium bovis ; Mycobacterium tuberculosis
Chemical Substances	BCG Vaccine ; Flavins
Language	English
Publishing date	2021-03-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.658888
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Article ; Online: The Xpert® MTB/RIF cycle threshold value predicts M. tuberculosis transmission to close contacts in a Brazilian prospective multicenter cohort.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: Background: The Xpert® MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form of cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as a potential ... ...

Abstract	Background: The Xpert® MTB/RIF rapid molecular test provides a quantitative measure of Mycobacterium tuberculosis (Mtb) DNA in the form of cycle threshold (Ct) values. This information can be translated into mycobacterial load and used as a potential risk measure of bacterial spread for tuberculosis cases, which can impact infection control. However, the role of Ct values in assessing Mtb transmission to close contacts has not yet been demonstrated. Methods: A prospective study was performed to investigate the association between Xpert® MTB/RIF Ct values and Mtb transmission to close contacts of patients with culture-confirmed pulmonary TB in a multi-center Brazilian cohort. We evaluated clinical and laboratory data, such as age, sex, race, smoking habits, drug use, alcohol use, chest radiograph, Xpert® MTB/RIF results among pulmonary tuberculosis cases, and QuantiFERON(QFT)-Plus results at baseline and after six months for close contacts who had a negative result at baseline. Results: A total of 1,055 close contacts of 382 pulmonary tuberculosis cases were included in the study. The median Ct values from pulmonary tuberculosis cases of QFT-Plus positive (at baseline or six months) close contacts were lower compared with those who were QFT-Plus negative. An adjusted logistic regression demonstrated that reduced Ct values from the index cases were independently associated with QFT-Plus conversion from negative to positive (OR: 1.61, 95% CI: 1.12-2.32) after adjusting for clinical characteristics. Conclusion: Close contacts of pulmonary TB index cases exhibiting low Xpert MTB/RIF Ct values displayed higher rates of TB infection, reflecting Mtb transmission.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad794
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Incidence and Levels of Aflatoxin M

Silva, Isabela Maria de Moura / da Cruz, Adriano Gomes / Ali, Sher / Freire, Lucas Gabriel Dionisio / Fonseca, Luzianna Macedo / Rosim, Roice Eliana / Corassin, Carlos Humberto / Oliveira, Rodrigo Barbosa Acioli de / Oliveira, Carlos Augusto Fernandes de

Toxins

2023 Volume 15, Issue 3

Abstract: ... affinity to caseins. The consumption of cheese contaminated with high levels of aflatoxin M ...

Abstract	Cheese is one of the most susceptible dairy foods to accumulating aflatoxins due to their high affinity to caseins. The consumption of cheese contaminated with high levels of aflatoxin M
MeSH term(s)	Humans ; Animals ; Aflatoxin M1/analysis ; Cheese/analysis ; Brazil ; Incidence ; Milk/chemistry ; Food Contamination/analysis
Chemical Substances	Aflatoxin M1 (6795-23-9)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins15030182
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Article ; Online: Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells.

Hyroššová, Petra / Aragó, Marc / Muñoz-Pinedo, Cristina / Viñals, Francesc / García-Rovés, Pablo M / Escolano, Carmen / Méndez-Lucas, Andrés / Perales, Jose C

Cell death & disease

2022 Volume 13, Issue 8, Page(s) 730

Abstract: ... stimulated entosis. Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is upregulated by glucose ... deprivation, thereby enhancing cell survival. Therefore, we presumed that PEPCK-M could play a role ... in this process by offsetting key metabolites into glycosyl moieties using alternative substrates. PEPCK-M ...

Abstract	On glucose restriction, epithelial cells can undergo entosis, a cell-in-cell cannibalistic process, to allow considerable withstanding to this metabolic stress. Thus, we hypothesized that reduced protein glycosylation might participate in the activation of this cell survival pathway. Glucose deprivation promoted entosis in an MCF7 breast carcinoma model, as evaluated by direct inspection under the microscope, or revealed by a shift to apoptosis + necrosis in cells undergoing entosis treated with a Rho-GTPase kinase inhibitor (ROCKi). In this context, curbing protein glycosylation defects with N-acetyl-glucosamine partially rescued entosis, whereas limiting glycosylation in the presence of glucose with tunicamycin or NGI-1, but not with other unrelated ER-stress inducers such as thapsigargin or amino-acid limitation, stimulated entosis. Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is upregulated by glucose deprivation, thereby enhancing cell survival. Therefore, we presumed that PEPCK-M could play a role in this process by offsetting key metabolites into glycosyl moieties using alternative substrates. PEPCK-M inhibition using iPEPCK-2 promoted entosis in the absence of glucose, whereas its overexpression inhibited entosis. PEPCK-M inhibition had a direct role on total protein glycosylation as determined by Concanavalin A binding, and the specific ratio of fully glycosylated LAMP1 or E-cadherin. The content of metabolites, and the fluxes from
MeSH term(s)	Breast Neoplasms ; Entosis ; Female ; Glucose/metabolism ; Glycosylation ; Humans ; Phosphoenolpyruvate Carboxykinase (ATP)/metabolism
Chemical Substances	PCK2 protein, human (EC 4.1.1.49) ; Phosphoenolpyruvate Carboxykinase (ATP) (EC 4.1.1.49) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-05177-x
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Book ; Online: M\=aori algorithmic sovereignty

Brown, Paul T. / Wilson, Daniel / West, Kiri / Escott, Kirita-Rose / Basabas, Kiya / Ritchie, Ben / Lucas, Danielle / Taia, Ivy / Kusabs, Natalie / Keegan, Te Taka

idea, principles, and use

2023

Abstract: Due to the emergence of data-driven technologies in Aotearoa New Zealand that use M\=aori data ... M\=aori data sovereignty principles are well-known and are used by researchers and ... government agencies to guide the culturally appropriate use of M\=aori data. Extending these principles to fit ...

Abstract	Due to the emergence of data-driven technologies in Aotearoa New Zealand that use M\=aori data, there is a need for values-based frameworks to guide thinking around balancing the tension between the opportunities these create, and the inherent risks that these technologies can impose. Algorithms can be framed as a particular use of data, therefore data frameworks that currently exist can be extended to include algorithms. M\=aori data sovereignty principles are well-known and are used by researchers and government agencies to guide the culturally appropriate use of M\=aori data. Extending these principles to fit the context of algorithms, and re-working the underlying sub-principles to address issues related to responsible algorithms from a M\=aori perspective leads to the M\=aori algorithmic sovereignty principles. We define this idea, present the updated principles and subprinciples, and highlight how these can be used to decolonise algorithms currently in use, and argue that these ideas could potentially be used to developed Indigenised algorithms.
Keywords	Computer Science - Computers and Society
Subject code	006
Publishing date	2023-11-26
Publishing country	us
Document type	Book ; Online
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Article ; Online: Polluted wetlands contain multidrug-resistance plasmids encoding CTX-M-type extended-spectrum β-lactamases.

Botts, Ryan T / Page, Dawne M / Bravo, Joseph A / Brown, Madelaine L / Castilleja, Claudia C / Guzman, Victoria L / Hall, Samantha / Henderson, Jacob D / Kenney, Shelby M / Lensink, Mariele E / Paternoster, Megan V / Pyle, Sarah L / Ustick, Lucas / Walters-Laird, Chara J / Top, Eva M / Cummings, David E

Plasmid

2023 Volume 126, Page(s) 102682

Abstract: While most detailed analyses of antibiotic resistance plasmids focus on those found in clinical isolates, less is known about the vast environmental reservoir of mobile genetic elements and the resistance and virulence factors they encode. We selectively ...

Abstract	While most detailed analyses of antibiotic resistance plasmids focus on those found in clinical isolates, less is known about the vast environmental reservoir of mobile genetic elements and the resistance and virulence factors they encode. We selectively isolated three strains of cefotaxime-resistant Escherichia coli from a wastewater-impacted coastal wetland. The cefotaxime-resistant phenotype was transmissible to a lab strain of E. coli after one hour, with frequencies as high as 10
MeSH term(s)	Humans ; Plasmids/genetics ; Escherichia coli/genetics ; Wetlands ; Anti-Bacterial Agents/pharmacology ; Cefotaxime/pharmacology ; Virulence Factors ; beta-Lactamases/genetics ; Escherichia coli Infections ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Cefotaxime (N2GI8B1GK7) ; Virulence Factors ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	282384-6
ISSN	1095-9890 ; 0147-619X
ISSN (online)	1095-9890
ISSN	0147-619X
DOI	10.1016/j.plasmid.2023.102682
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Zs.A 1736: Show issues

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Book ; Online: Sliced-Wasserstein on Symmetric Positive Definite Matrices for M/EEG Signals

Bonet, Clément / Malézieux, Benoît / Rakotomamonjy, Alain / Drumetz, Lucas / Moreau, Thomas / Kowalski, Matthieu / Courty, Nicolas

2023

Abstract: ... to deal with distributions of covariance matrices and demonstrate its computational efficiency on M/EEG ...

Abstract	When dealing with electro or magnetoencephalography records, many supervised prediction tasks are solved by working with covariance matrices to summarize the signals. Learning with these matrices requires using Riemanian geometry to account for their structure. In this paper, we propose a new method to deal with distributions of covariance matrices and demonstrate its computational efficiency on M/EEG multivariate time series. More specifically, we define a Sliced-Wasserstein distance between measures of symmetric positive definite matrices that comes with strong theoretical guarantees. Then, we take advantage of its properties and kernel methods to apply this distance to brain-age prediction from MEG data and compare it to state-of-the-art algorithms based on Riemannian geometry. Finally, we show that it is an efficient surrogate to the Wasserstein distance in domain adaptation for Brain Computer Interface applications. Comment: Published as a conference paper at ICML2023
Keywords	Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Signal Processing ; Statistics - Machine Learning
Subject code	006
Publishing date	2023-03-10
Publishing country	us
Document type	Book ; Online
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Article ; Online: Phylogenomic Analysis of CTX-M-15-Positive

Sartori, Luciana / Sellera, Fábio P / Fuga, Bruna / Sano, Elder / Monte, Daniel F M / Cardoso, Brenda / Côrtes, Lucas de Angelis / Lincopan, Nilton

Microbial drug resistance (Larchmont, N.Y.)

2023 Volume 29, Issue 7, Page(s) 296–301

Abstract: The global dissemination of extended-spectrum-β-lactamase (ESBL)- ... ...

Abstract	The global dissemination of extended-spectrum-β-lactamase (ESBL)-producing
MeSH term(s)	Animals ; Dogs ; Humans ; Escherichia coli ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/veterinary ; Escherichia coli Infections/epidemiology ; Phylogeny ; Pets ; One Health ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; beta-Lactamases/genetics
Chemical Substances	ST 90 (81252-14-4) ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1290490-9
ISSN	1931-8448 ; 1076-6294
ISSN (online)	1931-8448
ISSN	1076-6294
DOI	10.1089/mdr.2022.0249
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Article ; Online: C. elegans srGAP is an α-catenin M domain-binding protein that strengthens cadherin-dependent adhesion during morphogenesis.

Serre, Joel M / Lucas, Bethany / Martin, Sterling C T / Heier, Jonathon A / Shao, Xiangqiang / Hardin, Jeff

Development (Cambridge, England)

2022 Volume 149, Issue 18

Abstract: ... SRGP-1 binds to the M domain of the core CCC component, HMP-1/α-catenin, via its C terminus. The SRGP-1 ... salt bridges in the M domain block this recruitment. Loss of SRGP-1 leads to an increase in mobility ...

Abstract	The cadherin-catenin complex (CCC) is central to embryonic development and tissue repair, yet how CCC binding partners function alongside core CCC components remains poorly understood. Here, we establish a previously unappreciated role for an evolutionarily conserved protein, the slit-robo GTPase-activating protein SRGP-1/srGAP, in cadherin-dependent morphogenetic processes in the Caenorhabditis elegans embryo. SRGP-1 binds to the M domain of the core CCC component, HMP-1/α-catenin, via its C terminus. The SRGP-1 C terminus is sufficient to target it to adherens junctions, but only during later embryonic morphogenesis, when junctional tension is known to increase. Surprisingly, mutations that disrupt stabilizing salt bridges in the M domain block this recruitment. Loss of SRGP-1 leads to an increase in mobility and decrease of junctional HMP-1. In sensitized genetic backgrounds with weakened adherens junctions, loss of SRGP-1 leads to late embryonic failure. Rescue of these phenotypes requires the C terminus of SRGP-1 but also other domains of the protein. Taken together, these data establish a role for an srGAP in stabilizing and organizing the CCC during epithelial morphogenesis by binding to a partially closed conformation of α-catenin at junctions.
MeSH term(s)	Animals ; Cadherins/genetics ; Cadherins/metabolism ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; GTPase-Activating Proteins/metabolism ; Morphogenesis/genetics ; alpha Catenin/genetics ; alpha Catenin/metabolism
Chemical Substances	Cadherins ; Caenorhabditis elegans Proteins ; GTPase-Activating Proteins ; alpha Catenin
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.200775
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Zs.MG 91: Show issues

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