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Article ; Online: Author Correction: A comparative study of auto-contouring softwares in delineation of organs at risk in lung cancer and rectal cancer.

Chen, Weijun / Wang, Cheng / Zhan, Wenming / Jia, Yongshi / Ruan, Fangfang / Qiu, Lingyun / Yang, Shuangyan / Li, Yucheng

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3569

Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54103-y
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Article ; Online: Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse.

Yang, Shijing / Li, Yaoxing / Zheng, Xiaoman / Zheng, Xirui / Lin, Yongshi / Guo, Shining / Liu, Cui

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155415

Abstract: Background: Chichoric acid (CA) is a major active ingredient found in chicory and Echinacea. As a derivative of caffeic acid, it has various pharmacological effects.: Purpose: Due to the unclear etiology and disease mechanisms, effective treatment ... ...

Abstract	Background: Chichoric acid (CA) is a major active ingredient found in chicory and Echinacea. As a derivative of caffeic acid, it has various pharmacological effects. Purpose: Due to the unclear etiology and disease mechanisms, effective treatment methods for ulcerative colitis (UC) are currently lacking. The study investigated the therapeutic effects of the folate-chicory acid liposome on both LPS-induced macrophage inflammation models and dextran sulfate sodium (DSS)-induced mouse UC models. Methods: Folate-chicory acid liposome was prepared using the double emulsion ultrasonic method with the aim of targeting folate receptors specifically expressed on macrophages. The study investigated the therapeutic effects of the folate-chicory acid liposome on both LPS-induced macrophage inflammation models and DSS -induced mouse UC models. Furthermore, the effects of the liposomes on macrophage polarization and their underlying mechanisms in UC were explored. Results: The average particle size of folate-chicory acid liposome was 120.4 ± 0.46 nm, with an encapsulation efficiency of 77.32 ± 3.19 %. The folate-chicory acid liposome could alleviate macrophage apoptosis induced by LPS, decrease the expression of inflammatory factors in macrophages, enhance the expression of anti-inflammatory factors, inhibit macrophage polarization towards the M1 phenotype, and mitigate cellular inflammation in vetro. In vivo test, folate-chicory acid liposome could attenuate clinical symptoms, increased colon length, reduced DAI scores, CMDI scores, and alleviated the severity of colonic histopathological damage in UC mice. Furthermore, it inhibited the polarization of macrophages towards the M1 phenotype in the colon and downregulated the TLR4/NF-κB signaling pathway, thereby ameliorating UC in mice. Conclusion: Folate-chicory acid liposome exhibited a uniform particle size distribution and high encapsulation efficiency. It effectively treated UC mice by inhibiting the polarization of macrophages towards the M1 phenotype in the colon and downregulating the TLR4/NF-κB signaling pathway.
MeSH term(s)	Animals ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/chemically induced ; Liposomes ; Folic Acid/pharmacology ; Folic Acid/chemistry ; Folic Acid/analogs & derivatives ; Toll-Like Receptor 4/metabolism ; Mice ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Macrophages/drug effects ; Caffeic Acids/pharmacology ; Caffeic Acids/chemistry ; Lipopolysaccharides ; Male ; RAW 264.7 Cells ; Disease Models, Animal ; Dextran Sulfate ; Succinates/pharmacology ; Succinates/chemistry ; Mice, Inbred C57BL ; Apoptosis/drug effects ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Liposomes ; Folic Acid (935E97BOY8) ; Toll-Like Receptor 4 ; NF-kappa B ; chicoric acid (S4YY3V8YHD) ; Caffeic Acids ; Lipopolysaccharides ; Tlr4 protein, mouse ; Dextran Sulfate (9042-14-2) ; Succinates ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155415
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Article ; Online: Carboxymethyl cellulose-based multifunctional film integrated with polyphenol-rich extract and carbon dots from coffee husk waste for active food packaging applications.

Yang, Junxian / Li, Yongshi / Liu, Bingzhen / Wang, Kun / Li, Hui / Peng, Lincai

Food chemistry

2024 Volume 448, Page(s) 139143

Abstract: Sustainable carboxymethyl cellulose (CMC)-based active composite films were developed through the addition of polyphenol-rich extract from coffee husk (CHE) and carbon dots (CDs) prepared using the biowaste residue of CHE extraction. The influences of ... ...

Abstract	Sustainable carboxymethyl cellulose (CMC)-based active composite films were developed through the addition of polyphenol-rich extract from coffee husk (CHE) and carbon dots (CDs) prepared using the biowaste residue of CHE extraction. The influences of various CDs contents on the physicochemical and functional characteristics of composite films have been researched. The 6% (w/w) CHE and 3% (w/w) CDs were uniformly dispersed within the CMC matrix to produce a homogenous film with enhanced mechanical properties. The CMC/CHE/CDs3% film exhibited outstanding UV-light blocking, improved water and gas barriers, potent antioxidant activity with above 95% DPPH and ABTS scavenging rates, and effective antibacterial capabilities against L. monocytogenes and E. coli. The food packaging experiment demonstrated that this active composite film slowed the rotting of fresh-cut apples and extended their shelf-life to 7 days at 4 °C storage. Therefore, the obtained multifunctional film showed promise as an environmentally friendly food packaging material.
MeSH term(s)	Food Packaging/instrumentation ; Polyphenols/chemistry ; Carboxymethylcellulose Sodium/chemistry ; Plant Extracts/chemistry ; Carbon/chemistry ; Waste Products/analysis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Listeria monocytogenes/drug effects ; Antioxidants/chemistry ; Coffee/chemistry ; Coffea/chemistry ; Quantum Dots/chemistry ; Malus/chemistry
Chemical Substances	Polyphenols ; Carboxymethylcellulose Sodium (K679OBS311) ; Plant Extracts ; Carbon (7440-44-0) ; Waste Products ; Anti-Bacterial Agents ; Antioxidants ; Coffee
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article ; Evaluation Study
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139143
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Article ; Online: The top 100 most cited articles in anaphylaxis: a bibliometric analysis.

Song, Yu / Zhang, Lishan / Yang, Yongshi / Sun, Jinlyu

Clinical and experimental medicine

2022 Volume 23, Issue 5, Page(s) 1783–1799

Abstract: Bibliometric analysis is helpful to determine the most influential studies in a specific field. A large number of publications in anaphylaxis have been published. However, no bibliometric analysis of anaphylaxis was conducted based on our known. The aim ... ...

Abstract	Bibliometric analysis is helpful to determine the most influential studies in a specific field. A large number of publications in anaphylaxis have been published. However, no bibliometric analysis of anaphylaxis was conducted based on our known. The aim of this study is to identify the top 100 most cited articles in anaphylaxis and analyze their bibliometric characteristics. We searched in the Web of Science core database on November 20, 2021. Articles were listed in descending order by their total citations. Hence the top 100 most cited articles in anaphylaxis were identified and analyzed. Bibliometric indicators included: year of publication, total number of citations and average citations per year (ACY), journal of publication and impact factor (IF), countries, institutes, and authors, which were analyzed by Biblioshiny. Co-occurrence was used to visualize the classification and hotspots. The top 100 most cited articles were published between 1991 and 2017. The largest number of articles was published in a single interval in 2006-2008. Total citations of the 100 articles were between 155 and 1241 and were positively correlated with the number of articles published in each 3-year interval. The top100 articles were published in 34 different journals. The Journal of Allergy and Clinical Immunology published the most (n = 41). The corresponding authors of the top100 articles were from 13 different countries, mostly in North America and Europe. Statistical analysis revealed a positive correlation between total number of citations and ACY (r = 0.670, p < 0.01) and between total number of citations and IF (r = 0.219, p < 0.05), whereas a negative correlation between ACY and length of time since publication (r = - 0.697, p < 0.01). The research focuses were classified into three clusters: (1) the epidemiology and management. (2) the risk factor and treatment. (3) the assessment and diagnosis. COVID-19 vaccines, drug allergy and management were the recent major topics. This bibliometric analysis reveals the progress and hotspots of research in anaphylaxis, which may lay a foundation for further research.
MeSH term(s)	Humans ; Anaphylaxis/epidemiology ; COVID-19 Vaccines ; COVID-19 ; Bibliometrics ; Research Design
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-09-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-022-00890-5
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Zs.A 5481: Show issues

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Article ; Online: Comparison of the therapeutic effects of medication therapy, specific immunotherapy and anti-IgE (Omalizumab) in patients with hay fever.

Tang, Rui / Lyu, Xiaohong / Hou, Yibo / Yang, Yongshi / Fu, Guodong / Zhu, Liping / Xue, Lu / Li, Hong / Wang, Ruiqi

Frontiers in immunology

2024 Volume 15, Page(s) 1363034

Abstract: Background: Hay fever, characterized by seasonal allergic reactions, poses a significant health challenge. Existing therapies encompass standard drug regimens, biological agents, and specific immunotherapy. This study aims to assess and compare the ... ...

Abstract	Background: Hay fever, characterized by seasonal allergic reactions, poses a significant health challenge. Existing therapies encompass standard drug regimens, biological agents, and specific immunotherapy. This study aims to assess and compare the effectiveness of anti-IgE (omalizumab), medication therapy, and subcutaneous immunotherapy (SCIT) for hay fever. Methods: Conducted as a retrospective cohort study, this research involved 98 outpatient hay fever patients who underwent routine medication, omalizumab treatment, or SCIT before the onset of the spring pollen season. A follow-up was performed one month after the start of the pollen season. The comprehensive symptoms and drug scores were used to evaluate patients with different intervention methods, facilitating a comparative analysis of therapeutic outcomes. Results: Compared with before treatment, the symptoms of patients treated with the three methods were all significantly relieved, and the medication score were significantly reduced. Patients treated with omalizumab demonstrated higher symptoms and medication scores than SCIT group before treatment, but similar scores after treatment, which were both lower than medicine treatment group. After treatment with omalizumab or SCIT, patients in both groups had significantly lower medication scores than the medication group and were close to no longer using medication for symptom relief. The mountain juniper-sIgE was significantly higher after treatment than before treatment in both medicine treatment group and omalizumab treatment group. Conclusion: Omalizumab and SCIT offer superior effects than medication therapy in hay fever patients.
MeSH term(s)	Humans ; Omalizumab/therapeutic use ; Rhinitis, Allergic, Seasonal/drug therapy ; Retrospective Studies ; Immunosuppressive Agents/therapeutic use ; Immunotherapy ; Antibodies, Anti-Idiotypic
Chemical Substances	Omalizumab (2P471X1Z11) ; anti-IgE antibodies ; Immunosuppressive Agents ; Antibodies, Anti-Idiotypic
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1363034
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Article: Diagnosis and treatment of postoperative bleeding in patients after gastrectomy: a retrospective case series study.

Shen, Yongshi / Xiao, Min / Weng, Jinsen / Yang, Liuxin / Feng, Ye / Ye, Yong / Zheng, Peng

Journal of gastrointestinal oncology

2023 Volume 14, Issue 1, Page(s) 110–118

Abstract: Background: There are significant differences in terms of the pathophysiology and clinical manifestations between intra- and extra-luminal bleeding, and it is also difficult to determine the reasonable management of the bleeding. This study is to ... ...

Abstract	Background: There are significant differences in terms of the pathophysiology and clinical manifestations between intra- and extra-luminal bleeding, and it is also difficult to determine the reasonable management of the bleeding. This study is to analyze the clinical characteristics of postoperative bleeding in gastric cancer, and to explore the management of postoperative intra-intestinal and extra-intestinal bleeding. Methods: We collected the clinical data of 2,978 patients with gastric cancer from the Department of Surgery, Fujian Cancer Hospital, from May 2014 to September 2019. A total gastrectomy or a distal or proximal subtotal gastrectomy with regional lymph node dissection (D1+ or D2) was included. The clinic data and management of both early (postoperative days ≤6 d) and delayed (postoperative days ≥7 d) post-operative hemorrhage were explored. This retrospective study is to compare the clinical characteristics and treatment of intra-intestinal and extra-intestinal hemorrhage. Results: The incidence of postoperative bleeding in gastric cancer was 2.85% (n=85), and the bleeding-related mortality was 4.7% (4/85). There were 67 men and 18 women, and four patients died, with a bleeding-related mortality rate of 4.7%. There were 46 cases of intra-intestinal hemorrhage and 39 cases of extra-intestinal hemorrhage. The reoperation rate in the extraneous bleeding group was higher than that in the intra-intestinal bleeding group (66.67% Conclusions: A greater number of gastric cancer patients with intra-intestinal hemorrhage are treated conservatively, while more patients with extra-intestinal hemorrhage are treated by reoperation. External bleeding is more likely to occur in the delayed period of bleeding. TAE is a safe and effective means of hemostasis if the hemodynamics is stable.
Language	English
Publishing date	2023-02-20
Publishing country	China
Document type	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-22-1203
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Article ; Online: Knockdown of circ_CLIP2 regulates the proliferation, metastasis and apoptosis of glioma cells through miR-641/EPHA3/STAT3 axis.

Li, Huibing / Jin, Xin / Lai, Mingyao / Li, Yongshi / Li, Ruixing / Yang, Huihui / Yang, Baoying

Journal of neurogenetics

2023 Volume 37, Issue 3, Page(s) 93–102

Abstract: A great amount of reaches have confirmed that circular RNAs (circRNAs) are novel regulators in glioma progression. Here, our work aimed to probe the specific role of circ_CLIP2 in glioma. The mRNA and protein expressions were analyzed by qRT-PCR and ... ...

Abstract	A great amount of reaches have confirmed that circular RNAs (circRNAs) are novel regulators in glioma progression. Here, our work aimed to probe the specific role of circ_CLIP2 in glioma. The mRNA and protein expressions were analyzed by qRT-PCR and western blot, respectively. Cell viability, migration, invasion and apoptosis were examined by MTT assay, tranwell and flow cytometry assays, respectively. Moreover, the binding relationships between circ_CLIP2, microRNA (miR)-641 and erythropoietin-producing human hepatocellular (Eph)A3 were verified by dual luciferase reporter gene assay and/or RIP assay. The following data showed that circ_CLIP2 and EPHA3 were markedly increased in glioma tissues and cells, while miR-647 was downregulated. Gain- and loss-of-function experiments discovered that circ_CLIP2 knockdown remarkably inhibited cell proliferation, migration and invasion and promoted cell apoptosis of glioma cells, while these effects of circ_CLIP2 knockdown were abolished by miR-641 inhibition. Circ_CLIP2 was proved as a sponge of miR-641 to competitively upregulate EPHA3 expression. In addition, EPHA3 overexpression could abolish the inhibitory effects of miR-641 overexpression on the malignant behaviors of glioma cells by activating the signal transducer and activator of transcription 3 (STAT3). These findings elucidated that circ_CLIP2 knockdown suppressed glioma development by regulation of the miR-641/EP HA3/STAT3 axis, which provided a novel mechanism for understanding the pathogenesis of glioma.
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	605543-6
ISSN	1563-5260 ; 0167-7063
ISSN (online)	1563-5260
ISSN	0167-7063
DOI	10.1080/01677063.2023.2199067
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Article ; Online: Crosslinked fish scale gelatin/alginate dialdehyde functional films incorporated with carbon dots derived from pomelo peel waste for active food packaging.

Li, Yongshi / Yang, Junxian / Sun, Linping / Liu, Bingzhen / Li, Hui / Peng, Lincai

International journal of biological macromolecules

2023 Volume 253, Issue Pt 6, Page(s) 127290

Abstract: A multifunctional and environmentally friendly composite film was developed by incorporating pomelo peel-derived carbon dots (PCDs) into a fish scale gelatin (FSG)/alginate dialdehyde (ADA) biopolymer matrix. ADA was used to reinforce the ... ...

Abstract	A multifunctional and environmentally friendly composite film was developed by incorporating pomelo peel-derived carbon dots (PCDs) into a fish scale gelatin (FSG)/alginate dialdehyde (ADA) biopolymer matrix. ADA was used to reinforce the physicomechanical properties of the FSG film via Schiff base crosslinking. PCDs with strong antioxidant and antimicrobial activities were synthesized via a hydrothermal method. The effect of various PCDs content on the surface morphological, physicochemical, and functional characteristics of the composite films was investigated. The results showed that the introduction of PCDs into the FSG/ADA matrix effectively reinforced the mechanical performance, enhanced the water vapor and water resistance, increased UV-light blocking, conferred fluorescence properties, and improved the thermal properties of the composite films. Under 3 wt% PCDs content, the FSG/ADA/PCDs-3 % composite film not only presented significant antioxidant capacity with a radical scavenging rate of 91.71 % for DPPH and approximately 100 % for ABTS, but also exhibited excellent antimicrobial ability against bacteria and fungi. Results of a preservation experiment showed that the prepared FSG/ADA/PCDs-3 % film preserved the physiological qualities of strawberries post-harvest and extended their shelf-life to 7 days at room temperature. Overall, the fabricated FSG/ADA/PCDs composite films are promising for use in eco-friendly active food packaging.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Food Packaging ; Gelatin ; Fruit ; Alginates ; Carbon ; Fishes ; Anti-Infective Agents/pharmacology
Chemical Substances	Antioxidants ; Gelatin (9000-70-8) ; Alginates ; Carbon (7440-44-0) ; Anti-Infective Agents
Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127290
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Article: [Relationship between trace elements in synovial fluid and cartilage and severity of knee osteoarthritis].

Li, Yongshi / Chen, Hong / Mou, Ping / Sun, Bangjie / Zeng, Yi / Yang, Jing

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

2023 Volume 37, Issue 5, Page(s) 584–588

Abstract: Objective: To investigate the relationship between trace elements in synovial fluid and cartilage and severity of knee osteoarthritis (KOA).: Methods: Patients with KOA who underwent knee arthrocentesis or total knee arthroplasty (TKA) were recruited ...

Abstract	Objective: To investigate the relationship between trace elements in synovial fluid and cartilage and severity of knee osteoarthritis (KOA). Methods: Patients with KOA who underwent knee arthrocentesis or total knee arthroplasty (TKA) were recruited based on inclusion criteria between June 2021 and December 2021. Synovial fluid samples were obtained during knee arthrocentesis and TKA, and participants were divided into the mild group (grading Ⅰ/Ⅱ) and the severe group (grading Ⅲ/Ⅳ) according to the Kellgren-Lawrence grading (K-L grading). Cartilage samples with different degrees of wear were collected during the TKA from the same patient and were divided into mild wear (0-1 point) and severe wear (2-4 points) groups based on the Pelletier score. The contents of copper (Cu), zinc (Zn), and manganese (Mn) in synovial fluid and cartilage were evaluated by inductively coupled plasma mass spectrometry, and the differences between groups were compared. Results: A total of 33 synovial fluid samples were collected, including 19 specimens from 14 patients who underwent knee arthrocentesis of mild group, with 5 bilateral sides knee arthrocentesis in them, and 14 specimens from 14 TKA patients of severe group. The patients were significantly younger in the mild group than in the severe group ( Conclusion: The Cu content increases with the severity of cartilage wear in patients with KOA.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Osteoarthritis, Knee/surgery ; Synovial Fluid ; Trace Elements ; Knee Joint/surgery ; Cartilage, Articular ; Zinc
Chemical Substances	Trace Elements ; Zinc (J41CSQ7QDS)
Language	Chinese
Publishing date	2023-05-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1420212-8
ISSN	1002-1892
ISSN	1002-1892
DOI	10.7507/1002-1892.202302008
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Article ; Online: Confining Nano-Fe

Xiong, Zhu / Huang, Yongshi / Huang, Zehui / Shi, Yiwen / Qu, Fangshu / Zhang, Gaosheng / Yang, Jingxin / Zhao, Shuaifei

ACS applied materials & interfaces

2022 Volume 14, Issue 22, Page(s) 26044–26056

Abstract: Membrane surface fouling is often reversible as it can be mitigated by enhancing the crossflow shear force. However, membrane internal fouling is often irreversible and thus more challenging. In this study, we developed a new superhydrophilic poly( ... ...

Abstract	Membrane surface fouling is often reversible as it can be mitigated by enhancing the crossflow shear force. However, membrane internal fouling is often irreversible and thus more challenging. In this study, we developed a new superhydrophilic poly(vinylidene fluoride) (P-PVDF) membrane confined with nano-Fe
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c04685
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