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  1. Article ; Online: The Dual Role of CCR5 in the Course of Influenza Infection: Exploring Treatment Opportunities.

    Ferrero, Maximiliano Ruben / Tavares, Luciana Pádua / Garcia, Cristiana Couto

    Frontiers in immunology

    2022  Volume 12, Page(s) 826621

    Abstract: Influenza is one of the most relevant respiratory viruses to human health causing annual epidemics, and recurrent pandemics. Influenza disease is principally associated with inappropriate activation of the immune response. Chemokine receptor 5 (CCR5) and ...

    Abstract Influenza is one of the most relevant respiratory viruses to human health causing annual epidemics, and recurrent pandemics. Influenza disease is principally associated with inappropriate activation of the immune response. Chemokine receptor 5 (CCR5) and its cognate chemokines CCL3, CCL4 and CCL5 are rapidly induced upon influenza infection, contributing to leukocyte recruitment into the airways and a consequent effective antiviral response. Here we discuss the existing evidence for CCR5 role in the host immune responses to influenza virus. Complete absence of CCR5 in mice revealed the receptor's role in coping with influenza
    MeSH term(s) Animals ; Biomarkers ; Disease Susceptibility ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Influenza A virus/immunology ; Influenza, Human/immunology ; Influenza, Human/metabolism ; Influenza, Human/therapy ; Influenza, Human/virology ; Mutation ; Phenotype ; Receptors, CCR5/genetics ; Receptors, CCR5/metabolism ; Severity of Illness Index
    Chemical Substances Biomarkers ; Receptors, CCR5
    Language English
    Publishing date 2022-01-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.826621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of SARS-CoV-2 and additional respiratory pathogens cases under the investigation of COVID-19 initial phase in a Brazilian reference laboratory.

    Matos, Aline da Rocha / Motta, Fernando Couto / Caetano, Braulia Costa / Ogrzewalska, Maria / Garcia, Cristiana Couto / Lopes, Jonathan Christian Oliveira / Miranda, Milene / Livorati, Miriam Teresinha Furlam Prando / Abreu, André / Brown, David / Siqueira, Marilda Mendonça

    Memorias do Instituto Oswaldo Cruz

    2020  Volume 115, Page(s) e200232

    Abstract: Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase ... ...

    Abstract Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase of the outbreak in Brazil, from late February to late March. From 707 samples analysed, 29 (4.1%) were SARS-CoV-2 positive. Fever and cough were their most prevalent symptoms. Co-detection of rhinovirus was observed in 2 (6.9%) cases. Additional pathogens were identified in 66.1% of the SARS-CoV-2 negative cases, mainly rhinovirus and influenza A(H1N1)pdm09. Thus, we emphasise the importance of differential diagnosis in COVID-19 suspected cases.
    MeSH term(s) Betacoronavirus/isolation & purification ; Brazil/epidemiology ; COVID-19 ; China ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Diagnosis, Differential ; Humans ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Rhinovirus/isolation & purification ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 953293-6
    ISSN 1678-8060 ; 0074-0276
    ISSN (online) 1678-8060
    ISSN 0074-0276
    DOI 10.1590/0074-02760200232
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  3. Article ; Online: Morphology and morphogenesis of SARS-CoV-2 in Vero-E6 cells.

    Barreto-Vieira, Debora Ferreira / da Silva, Marcos Alexandre Nunes / Garcia, Cristiana Couto / Miranda, Milene Dias / Matos, Aline da Rocha / Caetano, Braulia Costa / Resende, Paola Cristina / Motta, Fernando Couto / Siqueira, Marilda Mendonça / Girard-Dias, Wendell / Archanjo, Bráulio Soares / Barth, Ortrud Monika

    Memorias do Instituto Oswaldo Cruz

    2021  Volume 116, Page(s) e200443

    Abstract: Background: The coronaviruses (CoVs) called the attention of the world for causing outbreaks of severe acute respiratory syndrome (SARS-CoV), in Asia in 2002-03, and respiratory disease in the Middle East (MERS-CoV), in 2012. In December 2019, yet again ...

    Abstract Background: The coronaviruses (CoVs) called the attention of the world for causing outbreaks of severe acute respiratory syndrome (SARS-CoV), in Asia in 2002-03, and respiratory disease in the Middle East (MERS-CoV), in 2012. In December 2019, yet again a new coronavirus (SARS-CoV-2) first identified in Wuhan, China, was associated with a severe respiratory infection, known today as COVID-19. This new virus quickly spread throughout China and 30 additional countries. As result, the World Health Organization (WHO) elevated the status of the COVID-19 outbreak from emergency of international concern to pandemic on March 11, 2020. The impact of COVID-19 on public health and economy fueled a worldwide race to approve therapeutic and prophylactic agents, but so far, there are no specific antiviral drugs or vaccines available. In current scenario, the development of in vitro systems for viral mass production and for testing antiviral and vaccine candidates proves to be an urgent matter.
    Objective: The objective of this paper is study the biology of SARS-CoV-2 in Vero-E6 cells at the ultrastructural level.
    Methods: In this study, we documented, by transmission electron microscopy and real-time reverse transcription polymerase chain reaction (RT-PCR), the infection of Vero-E6 cells with SARS-CoV-2 samples isolated from Brazilian patients.
    Findings: The infected cells presented cytopathic effects and SARS-CoV-2 particles were observed attached to the cell surface and inside cytoplasmic vesicles. The entry of the virus into cells occurred through the endocytic pathway or by fusion of the viral envelope with the cell membrane. Assembled nucleocapsids were verified inside rough endoplasmic reticulum cisterns (RER). Viral maturation seemed to occur by budding of viral particles from the RER into smooth membrane vesicles.
    Main conclusions: Therefore, the susceptibility of Vero-E6 cells to SARS-CoV-2 infection and the viral pathway inside the cells were demonstrated by ultrastructural analysis.
    MeSH term(s) Animals ; Chlorocebus aethiops ; Cytopathogenic Effect, Viral ; Cytoplasmic Vesicles/virology ; Endocytosis ; Endoplasmic Reticulum/virology ; Humans ; Microscopy, Electron, Transmission ; Nucleocapsid ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/physiology ; Vero Cells/virology ; Virus Internalization
    Language English
    Publishing date 2021-02-08
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 953293-6
    ISSN 1678-8060 ; 0074-0276
    ISSN (online) 1678-8060
    ISSN 0074-0276
    DOI 10.1590/0074-02760200443
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.33: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Identification of SARS-CoV-2 and additional respiratory pathogens cases under the investigation of COVID-19 initial phase in a Brazilian reference laboratory

    Aline da Rocha Matos / Fernando Couto Motta / Braulia Costa Caetano / Maria Ogrzewalska / Cristiana Couto Garcia / Jonathan Christian Oliveira Lopes / Milene Miranda / Miriam Teresinha Furlam Prando Livorati / André Abreu / David Brown / Marilda Mendonça Siqueira

    Memórias do Instituto Oswaldo Cruz., Vol

    2020  Volume 115

    Abstract: Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase ... ...

    Abstract Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase of the outbreak in Brazil, from late February to late March. From 707 samples analysed, 29 (4.1%) were SARS-CoV-2 positive. Fever and cough were their most prevalent symptoms. Co-detection of rhinovirus was observed in 2 (6.9%) cases. Additional pathogens were identified in 66.1% of the SARS-CoV-2 negative cases, mainly rhinovirus and influenza A(H1N1)pdm09. Thus, we emphasise the importance of differential diagnosis in COVID-19 suspected cases.
    Keywords SARS-CoV-2 ; COVID-19 ; surveillance ; laboratory ; Arctic medicine. Tropical medicine ; RC955-962 ; Microbiology ; QR1-502
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Instituto Oswaldo Cruz, Ministério da Saúde
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Identification of SARS-CoV-2 and additional respiratory pathogens cases under the investigation of COVID-19 initial phase in a Brazilian reference laboratory

    Matos, Aline da Rocha / Motta, Fernando Couto / Caetano, Braulia Costa / Ogrzewalska, Maria / Garcia, Cristiana Couto / Lopes, Jonathan Christian Oliveira / Miranda, Milene / Livorati, Miriam Teresinha Furlam Prando / Abreu, André / Brown, David / Siqueira, Marilda Mendonça

    Memórias do Instituto Oswaldo Cruz v.115 2020

    2020  

    Abstract: Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase ... ...

    Abstract Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase of the outbreak in Brazil, from late February to late March. From 707 samples analysed, 29 (4.1%) were SARS-CoV-2 positive. Fever and cough were their most prevalent symptoms. Co-detection of rhinovirus was observed in 2 (6.9%) cases. Additional pathogens were identified in 66.1% of the SARS-CoV-2 negative cases, mainly rhinovirus and influenza A(H1N1)pdm09. Thus, we emphasise the importance of differential diagnosis in COVID-19 suspected cases.
    Keywords SARS-CoV-2 ; COVID-19 ; surveillance ; laboratory ; covid19
    Language English
    Publishing date 2020-01-01
    Publisher Instituto Oswaldo Cruz, Ministério da Saúde
    Publishing country br
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus.

    Aikawa, Nadia Emi / Borba, Eduardo Ferreira / Balbi, Verena Andrade / Sallum, Adriana Maluf Elias / Buscatti, Izabel Mantovani / Campos, Lucia Maria Arruda / Kozu, Kátia Tomie / Garcia, Cristiana Couto / Capão, Artur Silva Vidal / de Proença, Adriana Coracini Tonacio / Leon, Elaine Pires / da Silva Duarte, Alberto José / Lopes, Marta Heloisa / Silva, Clovis Artur / Bonfá, Eloisa

    Advances in rheumatology (London, England)

    2023  Volume 63, Issue 1, Page(s) 55

    Abstract: Introduction: Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1. Data assessing immunogenicity and safety of this virus component in juvenile ... ...

    Abstract Introduction: Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1. Data assessing immunogenicity and safety of this virus component in juvenile systemic lupus erythematosus (JSLE) is lacking in the literature.
    Objective: To evaluate short-term immunogenicity and safety of influenza A/Singapore (H3N2) vaccine in JSLE.
    Methods: 24 consecutive JSLE patients and 29 healthy controls (HC) were vaccinated with influenza A/Singapore/INFIMH-16-0019/2016(H3N2)-like virus. Influenza A (H3N2) seroprotection (SP), seroconversion (SC), geometric mean titers (GMT), factor increase in GMT (FI-GMT) titers were assessed before and 4 weeks post-vaccination. Disease activity, therapies and adverse events (AE) were also evaluated.
    Results: JSLE patients and controls were comparable in current age [14.5 (10.1-18.3) vs. 14 (9-18.4) years, p = 0.448] and female sex [21 (87.5%) vs. 19 (65.5%), p = 0.108]. Before vaccination, JSLE and HC had comparable SP rates [22 (91.7%) vs. 25 (86.2%), p = 0.678] and GMT titers [102.3 (95% CI 75.0-139.4) vs. 109.6 (95% CI 68.2-176.2), p = 0.231]. At D30, JSLE and HC had similar immune response, since no differences were observed in SP [24 (100%) vs. 28 (96.6%), p = 1.000)], SC [4 (16.7%) vs. 9 (31.0%), p = 0.338), GMT [162.3 (132.9-198.3) vs. 208.1 (150.5-287.8), p = 0.143] and factor increase in GMT [1.6 (1.2-2.1) vs. 1.9 (1.4-2.5), p = 0.574]. SLEDAI-2K scores [2 (0-17) vs. 2 (0-17), p = 0.765] and therapies remained stable throughout the study. Further analysis of possible factors influencing vaccine immune response among JSLE patients demonstrated similar GMT between patients with SLEDAI < 4 compared to SLEDAI ≥ 4 (p = 0.713), as well as between patients with and without current use of prednisone (p = 0.420), azathioprine (p = 1.0), mycophenolate mofetil (p = 0.185), and methotrexate (p = 0.095). No serious AE were reported in both groups and most of them were asymptomatic (58.3% vs. 44.8%, p = 0.958). Local and systemic AE were alike in both groups (p > 0.05).
    Conclusion: This is the first study that identified adequate immune protection against H3N2-influenza strain with additional vaccine-induced increment of immune response and an adequate safety profile in JSLE. ( www.
    Clinicaltrials: gov , NCT03540823).
    MeSH term(s) Female ; Humans ; Antibodies, Viral ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Influenza Vaccines/adverse effects ; Influenza, Human/prevention & control ; Influenza, Human/epidemiology ; Lupus Erythematosus, Systemic/epidemiology ; Male ; Child ; Adolescent
    Chemical Substances Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2523-3106
    ISSN (online) 2523-3106
    DOI 10.1186/s42358-023-00339-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Identification of SARS-CoV-2 and additional respiratory pathogens cases under the investigation of COVID-19 initial phase in a Brazilian reference laboratory

    Matos, Aline da Rocha / Motta, Fernando Couto / Caetano, Braulia Costa / Ogrzewalska, Maria / Garcia, Cristiana Couto / Lopes, Jonathan Christian Oliveira / Miranda, Milene / Livorati, Miriam Teresinha Furlam Prando / Abreu, André / Brown, David / Siqueira, Marilda Mendonça

    Mem Inst Oswaldo Cruz

    Abstract: Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase ... ...

    Abstract Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase of the outbreak in Brazil, from late February to late March. From 707 samples analysed, 29 (4.1%) were SARS-CoV-2 positive. Fever and cough were their most prevalent symptoms. Co-detection of rhinovirus was observed in 2 (6.9%) cases. Additional pathogens were identified in 66.1% of the SARS-CoV-2 negative cases, mainly rhinovirus and influenza A(H1N1)pdm09. Thus, we emphasise the importance of differential diagnosis in COVID-19 suspected cases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #788945
    Database COVID19

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  8. Article ; Online: Rhythmic profile of memory T and B-cells along childhood and adolescence.

    Brito-de-Sousa, Joaquim Pedro / Lima-Silva, Maria Luiza / Costa-Rocha, Ismael Artur da / Júnior, Luiz Roberto Alves de Oliveira / Campi-Azevedo, Ana Carolina / Peruhype-Magalhães, Vanessa / Quetz, Josiane da Silva / Coelho-Dos-Reis, Jordana Grazziela Alves / Costa-Pereira, Christiane / Garcia, Cristiana Couto / Antonelli, Lis Ribeiro do Vale / Fonseca, Cristina Toscano / Lemos, Jandira Aparecida Campos / Mambrini, Juliana Vaz de Melo / Souza-Fagundes, Elaine Maria / Teixeira-Carvalho, Andréa / Faria, Ana Maria de Caetano / Gomes, Angelica Oliveira / Torres, Karen Cecília de Lima /
    Martins-Filho, Olindo Assis

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20978

    Abstract: Immunobiography describes the life-long effects of exogenous or endogenous stimuli on remodeling of immune cell biology, including the development of memory T and B-cells. The present study aimed at investigating the rhythms of changes in phenotypic ... ...

    Abstract Immunobiography describes the life-long effects of exogenous or endogenous stimuli on remodeling of immune cell biology, including the development of memory T and B-cells. The present study aimed at investigating the rhythms of changes in phenotypic features of memory T and B-cells along childhood and adolescence. A descriptive-observational investigation was conducted including 812 healthy volunteers, clustered into six consecutive age groups (9
    MeSH term(s) Male ; Female ; Humans ; Adolescent ; Child ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; B-Lymphocytes ; Immunophenotyping ; Flow Cytometry ; Immunologic Memory ; T-Lymphocyte Subsets
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48115-3
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  9. Article ; Online: CCR5 Antagonist Maraviroc Inhibits Acute Exacerbation of Lung Inflammation Triggered by Influenza Virus in Cigarette Smoke-Exposed Mice

    Maximiliano Ruben Ferrero / Cristiana Couto Garcia / Marcella Dutra de Almeida / Jullian Torres Braz da Silva / Daniella Bianchi Reis Insuela / Tatiana Paula Teixeira Ferreira / Diego de Sá Coutinho / Carolina Trindade de Azevedo / Patrícia Machado Rodrigues e Silva / Marco Aurélio Martins

    Pharmaceuticals, Vol 14, Iss 620, p

    2021  Volume 620

    Abstract: Influenza A virus (IAV) infection is a common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Since macrophage inflammatory protein 1 α, a chemokine that acts through CC-chemokine receptor (CCR)-5, appears elevated in COPD ...

    Abstract Influenza A virus (IAV) infection is a common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Since macrophage inflammatory protein 1 α, a chemokine that acts through CC-chemokine receptor (CCR)-5, appears elevated in COPD patients’ airways, we evaluated whether CCR5 antagonist Maraviroc could inhibit the exacerbated lung inflammatory response noted after IAV H1N1 infection in mice exposed to cigarette smoke (Cs). C57BL/6 mice, subjected or not to Cs inhalation for 11 days, were infected with H1N1 at day 7. Maraviroc (10 mg/kg) or dexamethasone (1 mg/kg) were given in a therapeutic schedule, followed by the analyses of lung function, survival rate, and inflammatory changes. As compared to mice subjected to Cs or H1N1 alone, the insult combination significantly worsened airway obstruction, neutrophil infiltration in the airways, and the survival rate. All changes were sensitive to Maraviroc but not dexamethasone. Maraviroc also reduced the accumulation of neutrophils and macrophages as well as CXCL1 production in the lung tissue, and serum levels of IL-6, whereas comparable viral titers in the lungs were noted in all infected groups. Collectively, these findings suggest that Maraviroc oral treatment could be an effective therapy for controlling acute exacerbations of respiratory diseases such as COPD.
    Keywords chemokine receptor ; chronic obstructive pulmonary disease ; Influenza A (H1N1) ; Maraviroc ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  10. Article ; Online: Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil.

    de Sá, Nathalia Beatriz Ramos / Neira-Goulart, Milena / Ribeiro-Alves, Marcelo / Perazzo, Hugo / Geraldo, Kim Mattos / Ribeiro, Maria Pia Diniz / Cardoso, Sandra Wagner / Grinsztejn, Beatriz / Veloso, Valdiléa G / Capão, Artur / Siqueira, Marilda Mendonça / de Lima Bezerra, Ohanna Cavalcanti / Garcia, Cristiana Couto / Gomes, Larissa Rodrigues / da Silva Cazote, Andressa / de Almeida, Dalziza Victalina / Giacoia-Gripp, Carmem Beatriz Wagner / Côrtes, Fernanda Heloise / Morgado, Mariza Gonçalves

    BioMed research international

    2022  Volume 2022, Page(s) 9082455

    Abstract: COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe symptoms and death. The mechanisms underlying its clinical evolution are still unclear. Upon SARS-CoV-2 infection, host factors, such as the ... ...

    Abstract COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe symptoms and death. The mechanisms underlying its clinical evolution are still unclear. Upon SARS-CoV-2 infection, host factors, such as the inflammasome system, are activated by the presence of the virus inside host cells. The search for COVID-19 risk factors is of relevance for clinical management. In this study, we investigated the impact of inflammasome single-nucleotide polymorphisms (SNPs) in SARS-CoV-2-infected individuals with distinct severity profiles at clinical presentation. Patients were divided into two groups according to disease severity at clinical presentation based on the WHO Clinical Progression Scale. Group 1 included patients with mild/moderate disease (WHO < 6;
    MeSH term(s) Apoptosis Regulatory Proteins/genetics ; Brazil/epidemiology ; CARD Signaling Adaptor Proteins/genetics ; COVID-19/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Inflammasomes/genetics ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neoplasm Proteins/genetics ; Pandemics ; Polymorphism, Single Nucleotide/genetics ; SARS-CoV-2
    Chemical Substances Apoptosis Regulatory Proteins ; CARD Signaling Adaptor Proteins ; CARD8 protein, human ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Neoplasm Proteins
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/9082455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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