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Article: Fauna Associated with American Alligator (

Rainwater, Thomas R / Singh, Randeep / Tuten, Clarissa A / Given, Aaron M / Gibbons, Parker W / Song, Bo / Platt, Steven G / Wilkinson, Philip M / Bodinof Jachowski, Catherine M

Animals : an open access journal from MDPI

2024 Volume 14, Issue 4

Abstract: Crocodilians are considered to be "ecosystem engineers" because their modification of habitats provides opportunities for feeding, drinking, breeding, and other vital life activities to a wide variety of other animals. One such habitat modification is ... ...

Abstract	Crocodilians are considered to be "ecosystem engineers" because their modification of habitats provides opportunities for feeding, drinking, breeding, and other vital life activities to a wide variety of other animals. One such habitat modification is the construction of nest mounds during the breeding season by most crocodilian species, including American alligators (
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14040620
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Article ; Online: Modeling and comparing the distributions and associations of two co-occurring catshark species off South Africa.

van der Heever, G M / Yemane, D / Leslie, R W / van der Lingen, C D / Gibbons, M J

Journal of fish biology

2023 Volume 103, Issue 5, Page(s) 1095–1105

Abstract: Holohalaelurus regani and Scyliorhinus capensis are relatively small catsharks, which both occur off the continental shelf around South Africa and are often caught together as by-catch in demersal trawls. The present study used data collected during ... ...

Abstract	Holohalaelurus regani and Scyliorhinus capensis are relatively small catsharks, which both occur off the continental shelf around South Africa and are often caught together as by-catch in demersal trawls. The present study used data collected during annual demersal research surveys conducted between 2009 and 2015 and is a first attempt at modeling the potential intra- and interspecific associations, by maturity stage and depth, of H. regani and S. capensis to elucidate species-specific patterns in their distributions in South African waters. Intraspecifically, both species displayed a wide overlap in distribution between maturity stages, but only H. regani displayed marked changes in distribution with maturity stage, with mature individuals found further eastwards and occupying deeper waters than immature individuals. Interspecifically, the two catsharks displayed an inverse relationship in their distribution, with an increase in the abundance of H. regani and a decrease in the abundance of S. capensis when moving from the south coast to the west coast. Some localized patches of co-occurrence were, however, evident between species and maturity stages, especially in offshore areas. Overall, our results indicated a stronger co-occurrence of mature and immature stages within each species and a rather weak co-occurrence of maturity stages between the two species. The spatial information provided in the present study provides useful information on how sharks with similar morphologies and lifestyles may partition their habitat as a mechanism for potentially reducing competition between them.
MeSH term(s)	Humans ; Animals ; South Africa ; Ecosystem ; Sharks ; Species Specificity
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	410564-3
ISSN	1095-8649 ; 0022-1112
ISSN (online)	1095-8649
ISSN	0022-1112
DOI	10.1111/jfb.15497
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Article ; Online: Comparative Genomics Reveals a Single Nucleotide Deletion in

Gibbons, John G / D'Avino, Paolo / Zhao, Shu / Cox, Grace W / Rinker, David C / Fortwendel, Jarrod R / Latge, Jean-Paul

Frontiers in fungal biology

2022 Volume 3, Page(s) 897954

Abstract: Aspergillus ... ...

Abstract	Aspergillus fumigatus
Language	English
Publishing date	2022-06-07
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6128
ISSN (online)	2673-6128
DOI	10.3389/ffunb.2022.897954
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Article ; Online: Positive Energy Functional for Massless Scalars in Rotating Black Hole Backgrounds of Maximal Ungauged Supergravity.

Cvetič, M / Gibbons, G W / Pope, C N / Whiting, B F

Physical review letters

2020 Volume 124, Issue 23, Page(s) 231102

Abstract: We outline a proof of the stability of a massless neutral scalar field ψ in the background of a wide class of four dimensional asymptotically flat rotating and "electrically charged" solutions of supergravity, and the low energy limit of string theory, ... ...

Abstract	We outline a proof of the stability of a massless neutral scalar field ψ in the background of a wide class of four dimensional asymptotically flat rotating and "electrically charged" solutions of supergravity, and the low energy limit of string theory, known as STU metrics. Despite their complexity, we find it possible to circumvent the difficulties presented by the existence of ergo regions and the related phenomenon of superradiance in the original metrics by following a strategy due to Whiting, and passing to an auxiliary metric admitting an everywhere lightlike Killing field and constructing a scalar field ψ (related to a possible unstable mode ψ by a nonlocal transformation) which satisfies the massless wave equation with respect to the auxiliary metric. By contrast with the case for ψ, the associated energy density of ψ is not only conserved but is also non-negative.
Language	English
Publishing date	2020-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.231102
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Article ; Online: Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma.

Berlo, K / Xia, W / Zwillich, F / Gibbons, E / Gaudiuso, R / Ewusi-Annan, E / Chiklis, G R / Melikechi, N

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1614

Abstract: As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with ... ...

Abstract	As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra.
MeSH term(s)	Barium/analysis ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; Data Accuracy ; Discriminant Analysis ; False Negative Reactions ; False Positive Reactions ; Humans ; Immunity ; Lasers ; Machine Learning ; Pandemics ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Sensitivity and Specificity ; Spectrophotometry, Atomic/methods ; Zinc/analysis
Chemical Substances	Barium (24GP945V5T) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05509-z
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Article ; Online: Initial Validation of a Computerized Adaptive Test for Substance Use Disorder Identification in Adolescents.

Adams, Zachary W / Hulvershorn, Leslie A / Smoker, Michael P / Marriott, Brigid R / Aalsma, Matthew C / Gibbons, Robert D

Substance use & misuse

2024 Volume 59, Issue 6, Page(s) 867–873

Abstract: ... accuracy ranged from excellent (e.g., opioids, AUC = 0.84) to outstanding (e.g., stimulants, AUC = 0.96). K ...

Abstract	Purpose: Computerized adaptive tests (CATs) are highly efficient assessment tools that couple low patient and clinician time burden with high diagnostic accuracy. A CAT for substance use disorders (CAT-SUD-E) has been validated in adult populations but has yet to be tested in adolescents. The purpose of this study was to perform initial evaluation of the K-CAT-SUD-E (i.e., Kiddy-CAT-SUD-E) in an adolescent sample compared to a gold-standard diagnostic interview. Methods: Adolescents ( Results: Using the K-CAT-SUD-E continuous severity score and diagnoses to predict the presence of any K-SADS SUD diagnosis, the classification accuracy ranged from excellent for current SUD (AUC = 0.89, 95% CI = 0.81, 0.95) to outstanding (AUC = 0.93, 95% CI = 0.82, 0.97) for lifetime SUD. Regarding current substance-specific diagnoses, the classification accuracy was excellent for alcohol (AUC = 0.82), cannabis (AUC = 0.83) and nicotine/tobacco (AUC = 0.90). For lifetime substance-specific diagnoses, the classification accuracy ranged from excellent (e.g., opioids, AUC = 0.84) to outstanding (e.g., stimulants, AUC = 0.96). K-CAT-SUD-E median completion time was 4 min 22 s compared to 45 min for the K-SADS. Conclusions: This study provides initial support for the K-CAT-SUD-E as a feasible accurate diagnostic tool for assessing SUDs in adolescents. Future studies should further validate the K-CAT-SUD-E in a larger sample of adolescents and examine its acceptability, feasibility, and scalability in youth-serving settings.
MeSH term(s)	Adult ; Humans ; Adolescent ; Substance-Related Disorders/diagnosis ; Cannabis ; Ethanol ; Psychiatric Status Rating Scales
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2024.2305801
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Article: Laboratory performance of genome-wide cfDNA for copy number variants as compared to prenatal microarray.

Soster, Erica / Tynan, John / Gibbons, Clare / Meschino, Wendy / Wardrop, Jenna / Almasri, Eyad / Schwartz, Stuart / McLennan, Graham

Molecular cytogenetics

2023 Volume 16, Issue 1, Page(s) 10

Abstract: Background: Noninvasive prenatal testing (NIPT) allows for screening of fetal aneuploidy and copy number variants (CNVs) from cell-free DNA (cfDNA) in maternal plasma. Professional societies have not yet embraced NIPT for fetal CNVs, citing a need for ... ...

Abstract	Background: Noninvasive prenatal testing (NIPT) allows for screening of fetal aneuploidy and copy number variants (CNVs) from cell-free DNA (cfDNA) in maternal plasma. Professional societies have not yet embraced NIPT for fetal CNVs, citing a need for additional performance data. A clinically available genome-wide cfDNA test screens for fetal aneuploidy and CNVs larger than 7 megabases (Mb). Results: This study reviews 701 pregnancies with "high risk" indications for fetal aneuploidy which underwent both genome-wide cfDNA and prenatal microarray. For aneuploidies and CNVs considered 'in-scope' for the cfDNA test (CNVs ≥ 7 Mb and select microdeletions), sensitivity and specificity was 93.8% and 97.3% respectively, with positive and negative predictive values of 63.8% and 99.7% as compared to microarray. When including 'out-of-scope' CNVs on array as false negatives, the sensitivity of cfDNA falls to 48.3%. If only pathogenic out-of-scope CNVs are treated as false negatives, the sensitivity is 63.8%. Of the out-of-scope CNVs identified by array smaller than 7 Mb, 50% were classified as variants of uncertain significance (VUS), with an overall VUS rate in the study of 2.29%. Conclusions: While microarray provides the most robust assessment of fetal CNVs, this study suggests that genome-wide cfDNA can reliably screen for large CNVs in a high-risk cohort. Informed consent and adequate pretest counseling are essential to ensuring patients understand the benefits and limitations of all prenatal testing and screening options.
Language	English
Publishing date	2023-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2420849-8
ISSN	1755-8166
ISSN	1755-8166
DOI	10.1186/s13039-023-00642-4
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Article: Myeloid/Lymphoid Neoplasm with FGFR1 Rearrangement Presenting with Polycythemia Vera and T-cell Acute Lymphoblastic Leukemia.

Marinelli, Lisa M / Romain, Joshua T / Ehman, William / Ortega, Veronica / Velagaleti, Gopalrao / Gibbons, Thomas F / Nazario-Toole, Ashley / Holmes, Allen R

Cancer genetics

2023 Volume 276-277, Page(s) 43–47

Abstract: Myeloid/lymphoid neoplasm with fibroblast growth factor 1 rearrangements (MLN-FGFR1) represents a rare group of hematologic neoplasms, with approximately 100 cases reported to date. A 69-year-old woman with a history of polycythemia and leukocytosis, ... ...

Abstract	Myeloid/lymphoid neoplasm with fibroblast growth factor 1 rearrangements (MLN-FGFR1) represents a rare group of hematologic neoplasms, with approximately 100 cases reported to date. A 69-year-old woman with a history of polycythemia and leukocytosis, with negative molecular testing for JAK2, CALR, and MPL, presented with diffuse adenopathy. A lymph node (LN) biopsy revealed effacement by T-lymphoblasts, consistent with T-cell acute lymphoblastic lymphoma (T-ALL). A staging bone marrow (BM) biopsy demonstrated trilineage hyperplasia, which, taken together with the patient's elevated hemoglobin and low serum erythropoietin level, fulfilled diagnostic criteria for polycythemia vera. Karyotype and fluorescence in situ hybridization on both the BM and LN demonstrated a FGFR1 rearrangement due to t(8;13), consistent with MLN-FGFR1. Whole genome sequencing on the LN additionally identified a pathogenic frameshift mutation of ASXL1 NC_000020.11:g32434646dup NM_015338.6(ASXL1):c.1934dup p.(Gly646Trpfs) predicted to result in loss of protein function, a finding also observed in 8.1% of BM reads. Both the BM and LN harbored missense variants in HDAC4 NM_001378414.1(HDAC4):c.[2763G>A]; [2763=] p.(Met921Ile) and CHEK2 NM_007194.4(CHEK2):c.[538C>T];[538=] p.(Arg180Cys), with an unknown significance. Despite initial response to Mini-CVD + venetoclax, the patient subsequently experienced rapid clinical deterioration and death. We report the second case of MLN-FGFR1 with an ASXL1 mutation and the first case with HDAC4 and CHEK2 variants.
MeSH term(s)	Female ; Humans ; Aged ; Polycythemia Vera/genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; In Situ Hybridization, Fluorescence ; Myeloproliferative Disorders/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Receptor, Fibroblast Growth Factor, Type 1/genetics
Chemical Substances	FGFR1 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Case Reports ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2599227-2
ISSN	2210-7762
ISSN	2210-7762
DOI	10.1016/j.cancergen.2023.07.001
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Article ; Online: Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans.

Gibbons, Travis D / Cotter, James D / Ainslie, Philip N / Abraham, Wickliffe C / Mockett, Bruce G / Campbell, Holly A / Jones, Emma M W / Jenkins, Elliott J / Thomas, Kate N

The Journal of physiology

2023 Volume 601, Issue 11, Page(s) 2121–2137

Abstract: Intermittent fasting and exercise provide neuroprotection from age-related cognitive decline. A link between these two seemingly distinct stressors is their capability to steer the brain away from exclusively glucose metabolism. This cerebral substrate ... ...

Abstract	Intermittent fasting and exercise provide neuroprotection from age-related cognitive decline. A link between these two seemingly distinct stressors is their capability to steer the brain away from exclusively glucose metabolism. This cerebral substrate switch has been implicated in upregulating brain-derived neurotrophic factor (BDNF), a protein involved in neuroplasticity, learning and memory, and may underlie some of these neuroprotective effects. We examined the isolated and interactive effects of (1) 20-h fasting, (2) 90-min light exercise, and (3) high-intensity exercise on peripheral venous BDNF in 12 human volunteers. A follow-up study isolated the influence of cerebrovascular shear stress on circulating BDNF. Fasting for 20 h decreased glucose and increased ketones (P ≤ 0.0157) but had no effect on BDNF (P ≥ 0.4637). Light cycling at 25% of peak oxygen uptake (
MeSH term(s)	Humans ; Brain-Derived Neurotrophic Factor ; Neuroprotective Agents ; Follow-Up Studies ; Fasting ; Lactic Acid
Chemical Substances	Brain-Derived Neurotrophic Factor ; Neuroprotective Agents ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP283582
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Article: Interactions of ignored and attended valence in a valence-detection task with emotional words support the model of evaluative space

Gibbons, Henning / Schmuck, Jonas / Kirsten, Hannah

Language, Cognition and Neuroscience

An ERP study

2022 , Page(s) 1–21

Abstract: ... J. T., Gardner, W. L., & Berntson, G. G. (1997). Beyond bipolar conceptualizations and measures ...

Title translation	Interaktionen von ignorierter und beachteter Valenz in einer Valenzerkennungsaufgabe mit emotionalen Wörtern unterstützen das Modell des evaluativen Raums: Eine ERP-Studie. (DeepL)
Abstract	In a valence-detection task with emotional adjectives, 57 participants selectively responded to a predefined target level of valence (negative, positive, or neutral). Event-related potentials of ignored nontargets were examined for a novel type of emotion-attention interaction between a nontarget's valence and valence of the attentional set. Findings support an extension of the model of evaluative space [Cacioppo, J. T., Gardner, W. L., & Berntson, G. G. (1997). Beyond bipolar conceptualizations and measures: The case of attitudes and evaluative space. Personality and Social Psychology Review, 1(1), 3-25. https://doi.org/10.1207/s15327957pspr0101 2], proposing associations of negative and positive stimuli/attentional sets with high and low arousal, respectively. Consistently, in the neutral attentional set involving low arousal, false alarms were more frequent and an average-referenced EPN-like posterior negativity (150-250 ms) was smaller for positive than negative nontarget words. The late positive potential was reduced for positive nontargets in the negative attentional set, but not the reverse, indicating conjoint effects of a negativity bias and distractor-target distance in terms of valence. Finally, data suggest a sensitivity of mastoid-referenced lateral-posterior N170 to inhibition of task-irrelevant affect.
Keywords	Affective Valence ; Emotional States ; Emotionale Valenz ; Emotionale Zustände ; Emotionen ; Emotions ; Evoked Potentials ; Evozierte Potenziale
Language	English
Document type	Article
ZDB-ID	2753366-9
ISSN	2327-3801 ; 2327-3798
ISSN (online)	2327-3801
ISSN	2327-3798
DOI	10.1080/23273798.2022.2088817
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