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Article ; Online: Testing for Arginine Vasopressin Deficiency.

Newell-Price, John

2023 Volume 389, Issue 20, Page(s) 1920–1921

MeSH term(s)	Humans ; Arginine ; Arginine Vasopressin/deficiency ; Diabetes Insipidus, Neurogenic/diagnosis
Chemical Substances	Arginine (94ZLA3W45F) ; Arginine Vasopressin (113-79-1)
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Editorial
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMe2311293
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Book ; Conference proceedings: Updating grassland fertiliser recommendations

Newell-Price, J. P. / Lobley, Matt / Williams, J. R.

principles and practice ; paper presesented to the International Fertiliser Society at a conference in Cambridge, UK, on 10th December 2015

(Proceedings / International Fertiliser Society ; 789)

2016

Author's details	by J. P. Newell Price, M. Lobley and J. R. Williams
Series title	Proceedings / International Fertiliser Society ; 789 Proceedings / the International Fertiliser Society
Collection	Proceedings / the International Fertiliser Society
Keywords	Nitrogen fertilizers ; Grasses/Fertilizers ; Plants/Effect of nitrogen on
Subject code	633.20889
Language	English
Size	28 S. : graph. Darst., 21 cm
Publisher	Internat. Fertiliser Society
Publishing place	Colchester
Publishing country	Great Britain
Document type	Book ; Conference proceedings
Note	Includes bibliographical references
HBZ-ID	HT019213095
ISBN	978-0-85310-426-1 ; 0-85310-426-3
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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178/51	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Cushing Mortality in Remission: Not Out of the Woods.

Kelsall, Alan / Newell-Price, John

The Journal of clinical endocrinology and metabolism

2022 Volume 107, Issue 10, Page(s) e4232–e4233

MeSH term(s)	Cause of Death ; Cushing Syndrome/etiology ; Humans ; Pituitary ACTH Hypersecretion/complications
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgac341
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Article ; Online: A retrospective study on weaning glucocorticoids and recovery of the hypothalamic-pituitary-adrenal axis.

Arshad, Muhammad Fahad / Elder, Charlotte / Newell-Price, John / Ross, Richard / Debono, Miguel

The Journal of clinical endocrinology and metabolism

2024

Abstract: Context: Glucocorticoids suppress the hypothalamic-pituitary-adrenal (HPA) axis resulting in tertiary adrenal insufficiency (AI). When weaning patients off glucocorticoids there is no consensus on whether to maintain patients on prednisolone or convert ... ...

Abstract	Context: Glucocorticoids suppress the hypothalamic-pituitary-adrenal (HPA) axis resulting in tertiary adrenal insufficiency (AI). When weaning patients off glucocorticoids there is no consensus on whether to maintain patients on prednisolone or convert to hydrocortisone. Objective: Investigate HPA axis recovery in patients on long-term prednisolone and assess outcome after hydrocortisone conversion. Design: Retrospective cohort study. Setting: Outpatient endocrine steroid clinic. Patients: Patients on long-term prednisolone referred for HPA axis testing between 2015-2022. Main outcomes measured: 1) HPA axis recovery rate in patients on prednisolone demonstrated by normal ACTH stimulation test (AST).2) HPA axis recovery rate sub-analysis of dose-matched patients with confirmed tertiary AI on prednisolone or hydrocortisone. Results: 206 patients on prednisolone were tested for tertiary AI. Of these 176 remained on prednisolone while 30 were converted to hydrocortisone. The overall HPA axis recovery rate for patients on prednisolone after interval testing was 137/206 (66.5%). HPA axis recovery rate in dose-matched prednisolone and hydrocortisone conversion groups was 7/10 (70%) and 2/13 (15%) (p=0.008), respectively. There was no difference in mean (SD) age (67.1(12.2) v 63.4(11.1) years; p=0.464) and baseline cortisol (5.3(4.2) v 4.6(3.1)µg/dL; p=0.648) and median [IQR] glucocorticoids duration (1213[1114] v 2316[4808] days; p=0.693) and baseline ACTH (20.5[29.0] v 16.3[14.8]ng/L; p=0.905) between dose-matched prednisolone and hydrocortisone groups. Follow-up duration in prednisolone group was significantly lower (median [IQR] 348[975] v 667[884] days; p=0.012). Conclusions: Patients with glucocorticoid induced AI maintained on once-daily prednisolone can recover HPA axis function when weaning. There is no apparent advantage to recover HPA axis function in converting to multiple dosing hydrocortisone.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae059
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Article ; Online: MEN1 Surveillance Guidelines: Time to (Re)Think?

Newey, Paul J / Newell-Price, John

Journal of the Endocrine Society

2022 Volume 6, Issue 2, Page(s) bvac001

Abstract: Clinical practice guidelines for patients with multiple endocrine neoplasia type 1 (MEN1) recommend a variety of surveillance options. Given progress over the past decade in this area, it is timely to evaluate their ongoing utility. MEN1 is characterized ...

Abstract	Clinical practice guidelines for patients with multiple endocrine neoplasia type 1 (MEN1) recommend a variety of surveillance options. Given progress over the past decade in this area, it is timely to evaluate their ongoing utility. MEN1 is characterized by the development of synchronous or asynchronous tumors affecting a multitude of endocrine and nonendocrine tissues, resulting in premature morbidity and mortality, such that the rationale for undertaking surveillance screening in at-risk individuals appears robust. Current guidelines recommend an intensive regimen of clinical, biochemical, and radiological surveillance commencing in early childhood for those with a clinical or genetic diagnosis of MEN1, with the aim of early tumor detection and treatment. Although it is tempting to assume that such screening results in patient benefits and improved outcomes, the lack of a strong evidence base for several aspects of MEN1 care, and the potential for iatrogenic harms related to screening tests or interventions of unproven benefit, make such assumptions potentially unsound. Furthermore, the psychological as well as economic burdens of intensive screening remain largely unstudied. Although screening undoubtedly constitutes an important component of MEN1 patient care, this perspective aims to highlight some of the current uncertainties and challenges related to existing MEN1 guidelines with a particular focus on the role of screening for presymptomatic tumors. Looking forward, a screening approach that acknowledges these limitations and uncertainties and places the patient at the heart of the decision-making process is advocated.
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvac001
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Article ; Online: COVID-19 pandemic and adrenals: deep insights and implications in patients with glucocorticoid disorders.

Cozzolino, Alessia / Hasenmajer, Valeria / Newell-Price, John / Isidori, Andrea M

Endocrine

2023 Volume 82, Issue 1, Page(s) 1–14

Abstract: Purpose: Coronavirus disease-19 (COVID-19) has spread throughout the world. It was initially defined as a potentially severe syndrome affecting the respiratory tract, but it has since been shown to be a systemic disease with relevant extrapulmonary ... ...

Abstract	Purpose: Coronavirus disease-19 (COVID-19) has spread throughout the world. It was initially defined as a potentially severe syndrome affecting the respiratory tract, but it has since been shown to be a systemic disease with relevant extrapulmonary manifestations that increase mortality. The endocrine system has been found to be vulnerable to COVID-19 infection. The current review aims to evaluate the available data on the impact of COVID-19 infection and treatment, as well as COVID-19 vaccines, on adrenal gland function, particularly in patients with GC disorders. Methods: A thorough search of published peer-reviewed studies in PubMed was performed using proper keywords. Results: Adrenal viral tropism and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the adrenal glands have been demonstrated, and adrenal insufficiency (AI) is a rare, but potentially severe complication in COVID-19 disease, whose recognition can be difficult if only for the empirical treatments administered in the early stages. Glucocorticoid (GC) treatment have had a pivotal role in preventing clinical deterioration in patients with COVID-19, but long-term GC use may increase COVID-19-related mortality and the development of iatrogenic AI. Patients with GC disorders, especially AI and Cushing's syndrome, have been identified as being at high risk of COVID-19 infection and complications. Published evidence suggests that AI patient awareness and proper education may help adjust GC replacement therapy appropriately when necessary, thereby reducing COVID-19 severity. The COVID-19 pandemic has had an impact on AI management, particularly in terms of adherence to patients' care plans and self-perceived challenges. On the other hand, published evidence suggests that the clinical course of COVID-19 may be affected by the severity of hypercortisolism in patients with CS. Therefore, to ameliorate the risk profile in these patients, cortisol levels should be adequately controlled, along with careful monitoring of metabolic and cardiovascular comorbidities. To date, the COVID-19 vaccine remains the only available tool to face SARS-CoV-2, and it should not be treated differently in patients with AI and CS. Conclusion: SARS-CoV-2 infection has been linked to adrenal damage and AI is a rare complication in COVID-19 disease, requiring prompt recognition. Educational efforts and patient awareness may reduce COVID-19 severity in patients with AI. Control of cortisol levels and monitoring of complications may improve the clinical course of COVID-19 in patients with CS.
MeSH term(s)	Humans ; Glucocorticoids/adverse effects ; COVID-19/complications ; Hydrocortisone/therapeutic use ; COVID-19 Vaccines ; Pandemics ; SARS-CoV-2 ; Adrenal Insufficiency/epidemiology ; Adrenal Insufficiency/etiology ; Cushing Syndrome/drug therapy ; Adrenal Glands ; Disease Progression
Chemical Substances	Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ) ; COVID-19 Vaccines
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03411-w
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Article ; Online: Cushing's disease-from Minnie G to key issues in the early 21st century.

Kelsall, Alan / Newell-Price, John

The lancet. Diabetes & endocrinology

2019 Volume 7, Issue 12, Page(s) 959–964

Abstract: Oct 7, 2019, marks the 80th anniversary of the death of Harvey Cushing, the father of modern neurosurgery. Here we give a historical perspective from Cushing's original description of the clinical syndrome that now bears his name through to the modern ... ...

Abstract	Oct 7, 2019, marks the 80th anniversary of the death of Harvey Cushing, the father of modern neurosurgery. Here we give a historical perspective from Cushing's original description of the clinical syndrome that now bears his name through to the modern day. We highlight some of the key milestones that allowed improved understanding and management of this extraordinarily challenging condition, and identify some of the key issues that still exist in the 21st century.
MeSH term(s)	Female ; Humans ; Young Adult ; Disease Progression ; History, 20th Century ; Neurosurgery/history ; Pituitary ACTH Hypersecretion/history ; Pituitary ACTH Hypersecretion/physiopathology ; History, 21st Century
Language	English
Publishing date	2019-10-07
Publishing country	England
Document type	Historical Article ; Journal Article
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(19)30343-2
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Article ; Online: Pituitary gland: Mortality in Cushing disease.

Newell-Price, John

Nature reviews. Endocrinology

2016 Volume 12, Issue 9, Page(s) 502–503

Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/nrendo.2016.118
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Article ; Online: New Molecular Targets for Treatment of Cushing's Disease.

Foulkes, Elizabeth / Newell-Price, John

Endocrinology and metabolism clinics of North America

2018 Volume 47, Issue 2, Page(s) 367–373

Abstract: Despite the best outcomes from trans-sphenoidal surgery, approximately one-third of patients with Cushing's disease will need medical therapy. Current treatments have drawbacks and there is a clear clinical need for new therapies. Recent understanding of ...

Abstract	Despite the best outcomes from trans-sphenoidal surgery, approximately one-third of patients with Cushing's disease will need medical therapy. Current treatments have drawbacks and there is a clear clinical need for new therapies. Recent understanding of molecular pathways leading to excess ACTH secretion has identified key components that may be targeted with the aim to provide novel effective treatment for this devastating disease. These include testicular orphan nuclear receptor 4, heat shock protein 90, and epidermal growth factor receptor. Based on data from preclinical studies, clinical trials are seeking to assess whether targeting these novel pathways can translate into patient benefit.
MeSH term(s)	Endopeptidases/metabolism ; Endosomal Sorting Complexes Required for Transport/metabolism ; ErbB Receptors/metabolism ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Pituitary ACTH Hypersecretion/drug therapy ; Pituitary ACTH Hypersecretion/metabolism ; Pro-Opiomelanocortin/metabolism ; Receptors, Steroid/metabolism ; Receptors, Thyroid Hormone/metabolism ; Ubiquitin Thiolesterase/metabolism
Chemical Substances	Endosomal Sorting Complexes Required for Transport ; HSP90 Heat-Shock Proteins ; NR2C2 protein, human ; Receptors, Steroid ; Receptors, Thyroid Hormone ; Pro-Opiomelanocortin (66796-54-1) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Endopeptidases (EC 3.4.-) ; USP8 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2018-04-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2018.02.006
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Article: Adrenal incidentaloma: cardiovascular and metabolic effects of mild cortisol excess.

Kelsall, Alan / Iqbal, Ahmed / Newell-Price, John

Gland surgery

2020 Volume 9, Issue 1, Page(s) 94–104

Abstract: In the vast majority of cases adrenal incidentalomas (AI) are benign adrenocortical adenomas. They are present in up to 10% of the population over 70 years, with incidence increasing with age. Mild cortisol excess (MCE) in the context of AI is defined as ...

Abstract	In the vast majority of cases adrenal incidentalomas (AI) are benign adrenocortical adenomas. They are present in up to 10% of the population over 70 years, with incidence increasing with age. Mild cortisol excess (MCE) in the context of AI is defined as autonomous cortisol secretion (ACS) in the absence of the classical clinical features of Cushing's syndrome. MCE has been reported in up to at least one third of patients with AI. Numerous studies have shown that MCE in AI is associated with increased cardiovascular events and mortality, likely to be consequent upon both hemodynamic changes and inflammatory pathways, and a worse metabolic phenotype characterized by: pancreatic β-cell dysfunction, insulin resistance, visceral obesity and dyslipidemia. There is currently no level 3 evidence from large intervention randomized controlled trials to guide management of MCE in AI, and there is a lack of predictive tools to allow stratification to intervention of only those patients who would benefit in terms of improved metabolic and cardiovascular end-points. Here, we describe the mal-effects of cortisol on cardiovascular and metabolic tissues and discuss management strategies based on current largely observational data.
Language	English
Publishing date	2020-03-16
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs.2019.11.19
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