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  1. Article ; Online: Response letter to the editor.

    Chew, Claire Alexandra Zhen / Koh, Zong Jie / Zhang, John / Syn, Nicholas / Kim, Guowei / So, Jimmy Bok Yan / Shabbir, Asim

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2021  Volume 17, Issue 5, Page(s) 1033–1034

    MeSH term(s) Bariatric Surgery ; Bariatrics ; Humans
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2021.01.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6572: Show issues Location:
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  2. Article ; Online: Revisional Bariatric Surgery: Focus on Quality of Life.

    Chew, Claire Alexandra Zhen / Shabbir, Asim

    Journal of obesity & metabolic syndrome

    2017  Volume 26, Issue 2, Page(s) 97–101

    Abstract: Bariatric surgery is considered to be the most effective treatment for morbid obesity. At present, revisional surgery is considered in patients who experience complications, or in whom the intended weight loss is not achieved. However, as there is no ... ...

    Abstract Bariatric surgery is considered to be the most effective treatment for morbid obesity. At present, revisional surgery is considered in patients who experience complications, or in whom the intended weight loss is not achieved. However, as there is no consensus on what constitutes failure of primary surgery, there are no guidelines on who should receive revisional surgery. Physical parameters alone may be insufficient and quality of life has emerged as an alternative to provide a holistic appraisal of the outcome of primary surgery and the need for further revisional surgery in bariatric patients. Quality of life surveys such as short form health survey (SF-36) or Moorehead-Ardelt II (MA-II) assess the patients' perception of their weight and can also be used to assess the impact of post-operative complications such as gastro-esophageal reflux disease or dysphagia. However, unrealistic expectations of weight loss have been shown to be prevalent in bariatric patients and patients who seek revisional surgery on the basis of disappointment with the primary outcome are unlikely to be satisfied with the revisional outcome. Indications for re-operative surgery must be tailored to improve the quality and longevity of each individual patient's life. Long term studies are required to investigate and validate quality of life as an indication for revisional surgery.
    Language English
    Publishing date 2017-06-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3021984-X
    ISSN 2508-7576 ; 2508-6235
    ISSN (online) 2508-7576
    ISSN 2508-6235
    DOI 10.7570/jomes.2017.26.2.97
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metabolic outcomes after revisional bariatric surgery: a systematic review and meta-analysis.

    Koh, Zong Jie / Chew, Claire Alexandra Zhen / Zhang, John J Y / Syn, Nicholas / Kim, Guowei / Yan So, Jimmy Bok / Shabbir, Asim

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2020  Volume 16, Issue 10, Page(s) 1442–1454

    Abstract: Background: It has been well-established that primary bariatric surgery is effective in inducing improvement of diabetes and other associated co-morbidities in patients with obesity. Evidence demonstrating the influence of revisional bariatric surgery ... ...

    Abstract Background: It has been well-established that primary bariatric surgery is effective in inducing improvement of diabetes and other associated co-morbidities in patients with obesity. Evidence demonstrating the influence of revisional bariatric surgery on this trajectory, however, is lacking.
    Objectives: We performed a systematic review and meta-analysis to examine the impact of revisional bariatric surgery on obesity-related metabolic outcomes.
    Setting: University Hospital, Singapore METHODS: We examined outcomes of remission and improvement of diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea. Revisional surgeries included sleeve gastrectomy, Roux-en-Y gastric bypass, pouch revision, duodenal switch, and minigastric bypass.
    Results: Our search identified 33 relevant studies including a total of 1593 patients. Meta-analysis of proportions demonstrated a 92% improvement in diabetes with 50% achieving remission after revisional bariatric surgery. Of patients, 81% achieved improvement of hypertension with 33% achieving complete remission. In both groups, the highest proportion of improvement was observed after revisional duodenal switch. Although reported by fewer studies, a remission of hyperlipidemia was reported in 37% of patients and improvement of obstructive sleep apnea was seen in 86% of patients.
    Conclusions: Revisional bariatric surgery improves the outcomes of obesity-related co-morbidities and should be considered in patients with persistent metabolic disease after primary bariatric surgery.
    MeSH term(s) Bariatric Surgery ; Gastric Bypass ; Humans ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Reoperation ; Retrospective Studies ; Singapore ; Weight Loss
    Language English
    Publishing date 2020-06-06
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2020.05.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The diagnosis and management of H. pylori infection in Singapore.

    Chew, Claire Alexandra Zhen / Lye, Tong Fong / Ang, Daphne / Ang, Tiing Leong

    Singapore medical journal

    2017  Volume 58, Issue 5, Page(s) 234–240

    Abstract: Helicobacter pylori (H. pylori) is an infection that has a role in causing dyspepsia and complications such as peptic ulcer disease and gastric malignancies. In the primary care setting, one can adopt a stepwise approach with the 'test-and-treat' ... ...

    Abstract Helicobacter pylori (H. pylori) is an infection that has a role in causing dyspepsia and complications such as peptic ulcer disease and gastric malignancies. In the primary care setting, one can adopt a stepwise approach with the 'test-and-treat' strategy to manage H. pylori-associated dyspepsia in young patients without alarm symptoms. Empiric first-line therapies should be for a two-week duration; options include clarithromycin-containing triple therapy alone or with the addition of bismuth, concomitant therapy and bismuth quadruple therapy. Post-treatment carbon urea breath test must be performed at least four weeks after the end of treatment to confirm the cure. Options for empiric second-line treatment include bismuth quadruple therapy and levofloxacin-containing triple therapy. Patients with persistent or alarm symptoms should be referred for further evaluation. Patients with persistent infection should be referred for gastroscopy so that gastric biopsies can be obtained for H. pylori culture and antibiotic susceptibility testing.
    MeSH term(s) Antacids/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bismuth/therapeutic use ; Breath Tests ; Clarithromycin/therapeutic use ; Drug Therapy, Combination ; Dyspepsia/drug therapy ; Dyspepsia/microbiology ; Gastroscopy ; Helicobacter Infections/complications ; Helicobacter Infections/diagnosis ; Helicobacter pylori/isolation & purification ; Humans ; Levofloxacin/therapeutic use ; Singapore
    Chemical Substances Antacids ; Anti-Bacterial Agents ; Levofloxacin (6GNT3Y5LMF) ; Clarithromycin (H1250JIK0A) ; Bismuth (U015TT5I8H)
    Language English
    Publishing date 2017
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2017037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 589: Show issues Location:
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  5. Article ; Online: Blunt traumatic aortic injury of right aortic arch in a patient with an aberrant left subclavian artery.

    Yeo, Daryl Li-Tian / Haider, Sajjad / Zhen, Claire Alexandra Chew

    The Yale journal of biology and medicine

    2015  Volume 88, Issue 1, Page(s) 93–97

    Abstract: Right-sided aortic arch (RAA) is a rare congenital developmental variant present in about 0.1 percent of the population. This anatomical anomaly is commonly associated with congenital heart disease and complications from compression of mediastinal ... ...

    Abstract Right-sided aortic arch (RAA) is a rare congenital developmental variant present in about 0.1 percent of the population. This anatomical anomaly is commonly associated with congenital heart disease and complications from compression of mediastinal structures. However, it is unknown if patients are at a higher risk of blunt thoracic aortic injury (BTAI). We report a case of a 20-year-old man admitted to the hospital after being hit by an automobile. Computed tomographic scan revealed an RAA with an aberrant left subclavian artery originating from a Kommerell's diverticulum. A pseudo-aneurysm was also seen along the aortic arch. A diagnosis of blunt traumatic aortic injury was made. The patient was successfully treated with a 26mm Vascutek hybrid stentgraft using the frozen elephant trunk technique. A literature review of the pathophysiology of BTAI was performed to investigate if patients with right-sided aortic arch are at a higher risk of suffering from BTAI. Results from the review suggest that although theoretically there may be a higher risk of BTAI in RAA patients, the rarity of this condition has prevented large studies to be conducted. Previously reported cases of BTAI in RAA have highlighted the possibility that the aortic isthmus may be anatomically weak and therefore prone to injury. We have explored this possibility by reviewing current literature of the embryological origins of the aortic arch and descending aorta.
    MeSH term(s) Accidents, Traffic ; Aneurysm/diagnostic imaging ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/injuries ; Aorta, Thoracic/pathology ; Aorta, Thoracic/surgery ; Cardiovascular Abnormalities/diagnostic imaging ; Deglutition Disorders/diagnostic imaging ; Humans ; Male ; Postoperative Care ; Subclavian Artery/abnormalities ; Subclavian Artery/diagnostic imaging ; Tomography, X-Ray Computed ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/diagnostic imaging ; Wounds, Nonpenetrating/surgery ; Young Adult
    Language English
    Publishing date 2015-03-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Early weight loss after laparoscopic sleeve gastrectomy predicts midterm weight loss in morbidly obese Asians.

    Chew, Claire Alexandra Zhen / Tan, Ian Jse-Wei / Ng, Hannah Jia Hui / Lomanto, Davide / So, Jimmy / Shabbir, Asim

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2017  Volume 13, Issue 12, Page(s) 1966–1972

    Abstract: Background: Laparoscopic sleeve gastrectomy (SG) is a popular bariatric procedure in morbidly obese Asians.: Objectives: To investigate the effect of initial weight loss on midterm weight maintenance and remission of co-morbidities after laparoscopic ...

    Abstract Background: Laparoscopic sleeve gastrectomy (SG) is a popular bariatric procedure in morbidly obese Asians.
    Objectives: To investigate the effect of initial weight loss on midterm weight maintenance and remission of co-morbidities after laparoscopic SG in morbidly obese Asians.
    Setting: University Hospital, Singapore.
    Methods: Data of patients who underwent laparoscopic SG were analyzed. Change in body mass index (BMI), percentage of total weight loss (%WL), and of excess weight loss (%EWL) was calculated and remission of obesity-related co-morbidities was examined. Linear regression analysis was performed to determine the effect of initial weight loss on successful weight maintenance. Receiver operative characteristic curve analysis was used to define optimal cutoff values.
    Results: Two hundred and seventy-two patients were included in this study. Mean preoperative weight and BMI were 115.4±25.5 kg and 42.5±8.0 kg/m
    Conclusion: Early weight loss at 3 months predicts weight maintenance up to 3 years and remission of co-morbidities at 1 year after laparoscopic SG in Asians.
    MeSH term(s) Adolescent ; Adult ; Aged ; Asian Continental Ancestry Group ; Female ; Gastrectomy ; Humans ; Laparoscopy ; Male ; Middle Aged ; Obesity, Morbid/ethnology ; Obesity, Morbid/surgery ; Retrospective Studies ; Sensitivity and Specificity ; Singapore ; Time Factors ; Treatment Outcome ; Weight Loss ; Young Adult
    Language English
    Publishing date 2017-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2017.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6572: Show issues Location:
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