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  1. Book ; Online ; E-Book: Molecular pathology in cancer research

    Lakhani, Sunil R. / Fox, Stephen B.

    2016  

    Author's details Sunil R. Lakhani, Stephen B. Fox editors
    Keywords Neoplasms / genetics ; Pathology, Molecular ; Proteomics ; Research
    Language English
    Size 1 Online-Ressource (viii, 369 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019390865
    ISBN 978-1-4939-6643-1 ; 9781493966417 ; 1-4939-6643-X ; 1493966413
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: WHO classification of tumours of the breast

    Lakhani, Sunil R.

    [... reflects the views of a working group that convened for a consensus and editorial meeting at the International Agency for Research on Cancer (IARC), Lyon, September 1 - 3, 2011]

    (World Health Organization classification of tumours ; 4)

    2012  

    Title variant Classification of tumours of the breast
    Institution Weltgesundheitsorganisation
    Author's details ed. by Sunil R. Lakhani
    Series title World Health Organization classification of tumours ; 4
    Collection
    Language English
    Size 240 S. : zahlr. Ill, graph. Darst.
    Edition 4. ed.
    Publisher Internat. Agency for Research on Cancer
    Publishing place Lyon
    Publishing country France
    Document type Book
    HBZ-ID HT017355203
    ISBN 978-92-832-2433-4 ; 92-832-2433-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 3581 order for loan Magazin

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  3. Book: Basic pathology

    Lakhani, Sunil R. / Dilly, Susan A. / Finlayson, Caroline J.

    an introduction to the mechanisms of disease

    2009  

    Author's details Sunil R. Lakhani ; Susan A. Dilly ; Caroline J. Finlayson
    Keywords Pathology
    Language English
    Size IX, 329 S. : zahlr. Ill.
    Edition 4. ed.
    Publisher Hodder Arnold
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT015829419
    ISBN 0-340-95003-X ; 978-0-340-95003-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 299 order for loan Magazin

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  4. Article ; Online: Lobular carcinoma in situ: diagnostic criteria and molecular correlates.

    Sokolova, Anna / Lakhani, Sunil R

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2020  Volume 34, Issue Suppl 1, Page(s) 8–14

    Abstract: Lobular neoplasia (LN) is an atypical proliferation of small, dyscohesive epithelial cells within the terminal duct lobular unit (TDLU), with or without pagetoid extension and encompasses both lobular carcinoma in situ (LCIS) and atypical lobular ... ...

    Abstract Lobular neoplasia (LN) is an atypical proliferation of small, dyscohesive epithelial cells within the terminal duct lobular unit (TDLU), with or without pagetoid extension and encompasses both lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH). LN is a non-obligate precursor of invasive breast carcinoma and the diagnosis of LN confers an increased risk of invasive carcinoma development, compared to the general population. Diagnostic challenges arise in the accurate classification of LCIS into classic, pleomorphic and florid subtypes, in distinguishing between LCIS and ductal carcinoma in situ (DCIS) and in the appropriate use and interpretation of E-cadherin immunohistochemistry. Due to the paucity of robust data on the natural history of LCIS, and hence its clinical significance, the management is often pragmatic rather than entirely evidence-based and requires a multidisciplinary approach. In this review, we discuss the clinicopathologic and molecular features of LCIS and address the key challenges that arise in the diagnosis and management of LCIS.
    MeSH term(s) Biopsy, Large-Core Needle ; Breast Carcinoma In Situ/diagnosis ; Breast Carcinoma In Situ/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Cadherins/analysis ; Carcinoma, Intraductal, Noninfiltrating/diagnosis ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Mammary Glands, Human/pathology ; Precancerous Conditions/pathology
    Chemical Substances Cadherins
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1038/s41379-020-00689-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: NDRG1 in Cancer: A Suppressor, Promoter, or Both?

    Joshi, Vaibhavi / Lakhani, Sunil R / McCart Reed, Amy E

    Cancers

    2022  Volume 14, Issue 23

    Abstract: N-myc downregulated gene-1 (NDRG1) has been variably reported as a metastasis suppressor, a biomarker of poor outcome, and a facilitator of disease progression in a range of different cancers. NDRG1 is poorly understood in cancer due to its context- ... ...

    Abstract N-myc downregulated gene-1 (NDRG1) has been variably reported as a metastasis suppressor, a biomarker of poor outcome, and a facilitator of disease progression in a range of different cancers. NDRG1 is poorly understood in cancer due to its context-dependent and pleiotropic functions. Within breast cancer, NDRG1 is reported to be either a facilitator of, or an inhibitor of tumour progression and metastasis. The wide array of roles played by NDRG1 are dependent on post-translational modifications and subcellular localization, as well as the cellular context, for example, cancer type. We present an update on NDRG1, and its association with hallmarks of cancer such as hypoxia, its interaction with oncogenic proteins such as p53 as well its role in oncogenic and metastasis pathways in breast and other cancers. We further comment on its functional implications as a metastasis suppressor and promoter, its clinical relevance, and discuss its therapeutic targetability in different cancers.
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The increasing importance of pathology in modern clinical trial conduct: OlympiA as a case in point.

    Kalinowski, Lauren / Viale, Giuseppe / Domchek, Susan / Tutt, Andrew / Lucas, Peter C / Lakhani, Sunil R

    Pathology

    2022  Volume 54, Issue 5, Page(s) 511–516

    MeSH term(s) Clinical Trials as Topic ; Humans ; Pathology
    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type Editorial
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2022.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Book: Biopsy pathology of the breast

    Sloane, John P. / Trott, Peter A. / Lakhani, Sunil R.

    (Biopsy pathology series ; 24)

    2001  

    Author's details J. P. Sloane. With a contribution by P. A. Trott and ed. by S. R. Lakhani
    Series title Biopsy pathology series ; 24
    Collection
    Keywords Breast Diseases / pathology ; Breast Neoplams / pathology ; Mamma ; Biopsie
    Subject Brust ; Busen ; Weibliche Brust
    Language English
    Size IX, 309 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Arnold
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013043216
    ISBN 0-340-75876-7 ; 978-0-340-75876-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 2757 order for loan Magazin

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  8. Article ; Online: Survey of recurrent diagnostic challenges in breast phyllodes tumours.

    Tan, Benjamin Yongcheng / Fox, Stephen B / Lakhani, Sunil R / Tan, Puay Hoon

    Histopathology

    2022  Volume 82, Issue 1, Page(s) 95–105

    Abstract: Background: Breast phyllodes tumours (PTs) are graded as benign, borderline, or malignant by analysis of multiple histological features. PT grading is often inconsistent, likely due to variation in the weighting of grading criteria by pathologists.: ... ...

    Abstract Background: Breast phyllodes tumours (PTs) are graded as benign, borderline, or malignant by analysis of multiple histological features. PT grading is often inconsistent, likely due to variation in the weighting of grading criteria by pathologists.
    Design: The hierarchy of use of diagnostic criteria was identified using a 20-question survey.
    Results: In all, 213 pathologists from 29 countries responded. 54% reported 10-50 PT cases per year. Criteria considered key to PT diagnosis were: increased stromal cellularity (84.3%), stromal overgrowth (76.6%), increased stromal mitoses (67.8%), stromal atypia (61.5%), stromal fronding (59.0%), periductal stromal condensation (58.0%), irregular tumour borders (46.3%), and/or lesional heterogeneity (33.7%). The importance of grading parameters were: mitotic activity (55.5%), stromal overgrowth (54.0%), stromal atypia (51.9%), increased stromal cellularity (41.7%), and nature of the tumour border (38.9%). 49% would diagnose malignant PT without a full array of adverse features. 89% used the term "cellular fibroepithelial lesion (FEL)" for difficult cases; 45% would diagnose an FEL with stromal fronding (but lacking other PT features) as fibroadenoma (FA), 35% FEL, and 17% PT. 59% deemed clinico-radiological findings diagnostically significant; 68% considered age (≥40 years) important in determining if an FEL was a FA or PT. In FELs from young patients, increased stromal cellularity (83%), fronding (52%), and mitoses (41%) were more common. 34% regarded differentiating cellular FA from PT as a specific challenge; 54% had issues assigning a borderline PT grade.
    Conclusion: Criteria for grading PT lie on a spectrum, leading to interpretive variability. The survey highlights the criteria most used by pathologists, which do not completely align with WHO recommendations.
    MeSH term(s) Humans ; Adult ; Female ; Phyllodes Tumor/diagnosis ; Breast Neoplasms/diagnosis
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1328: Show issues Location:
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  9. Article ; Online: Pitfalls and controversies in pathology impacting breast cancer management.

    Kim, Woo Gyeong / Cummings, Margaret C / Lakhani, Sunil R

    Expert review of anticancer therapy

    2020  Volume 20, Issue 3, Page(s) 205–219

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mass Screening/methods ; Neoadjuvant Therapy ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2020.1738222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5907: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: An Update on the Molecular Pathology of Metaplastic Breast Cancer.

    McCart Reed, Amy E / Kalaw, Emarene M / Lakhani, Sunil R

    Breast cancer (Dove Medical Press)

    2021  Volume 13, Page(s) 161–170

    Abstract: Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even ... ...

    Abstract Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.
    Language English
    Publishing date 2021-02-26
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S296784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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