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  1. Article ; Online: Evaluation of the prognostic potential of histopathological subtyping in high-grade serous ovarian carcinoma.

    Zelisse, Hein S / Hwan, Robin A / van de Vijver, Marc J / Dijk, Frederike / Mom, Constantijne H / Hooijer, Gerrit K J / van Gent, Mignon D J M / Snijders, Malou L H

    Virchows Archiv : an international journal of pathology

    2024  

    Abstract: High-grade serous ovarian carcinoma (HGSOC) can be categorized into four gene expression-based subtypes, with supposedly distinct prognoses and treatment responses. Murakami et al. translated these gene expression-based subtypes into the ... ...

    Abstract High-grade serous ovarian carcinoma (HGSOC) can be categorized into four gene expression-based subtypes, with supposedly distinct prognoses and treatment responses. Murakami et al. translated these gene expression-based subtypes into the histopathological mesenchymal, immunoreactive, solid and proliferative, and papilloglandular subtypes, showing differences in survival outcomes. Miyagawa et al. refined these criteria to improve the interobserver concordance. The current retrospective study evaluated the interobserver variability and the prognostic differences between the histopathologic subtypes using the criteria of both Murakami et al. and Miyagawa et al. in 208 HGSOC cases. The mesenchymal subtype was considered first, followed by the immunoreactive subtype. Non-conforming cases were categorized as solid and proliferative or papilloglandular. The mesenchymal subtype was identified in 122 patients (58.7%) for both criteria. Using the criteria of Murakami et al., 10 cases (4.8%) were immunoreactive, 26 (12.5%) solid and proliferative, and 50 (24%) papilloglandular, with a concordance rate of 62.5% (κ = 0.34, p < .001). Using the Miyagawa et al. criteria, 23 cases (11%) were immunoreactive, 20 (9.6%) solid and proliferative, and 43 (20.7%) papilloglandular. No survival differences were observed between the subtypes. The fair reproducibility of the histopathological subtype classification of HGSOC and the lack of survival differences among these subtypes indicate the need for further refinement of the criteria and exploration of their correlation with overall survival outcomes before clinical application.
    Language English
    Publishing date 2024-04-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-024-03807-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outcomes of patients with early stage mucinous ovarian carcinoma: a Dutch population-based cohort study comparing expansile and infiltrative subtypes.

    Algera, Marc Daniël / Van de Vijver, Koen K / van Driel, Willemien J / Slangen, Brigitte F M / Lof, Fabienne C / van der Aa, Maaike / Kruitwagen, R F P M / Lok, Christianne A R

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Abstract: Objective: This study aimed to assess the outcomes of patients with early stage mucinous ovarian carcinoma based on subtype (expansile vs infiltrative).: Methods: We retrospectively analyzed all surgically treated patients with mucinous ovarian ... ...

    Abstract Objective: This study aimed to assess the outcomes of patients with early stage mucinous ovarian carcinoma based on subtype (expansile vs infiltrative).
    Methods: We retrospectively analyzed all surgically treated patients with mucinous ovarian carcinoma in the Netherlands (2015-2020), using data from national registries. Subtypes were determined, with any ambiguities resolved by a dedicated gynecologic pathologist. Patients with International Federation of Gynecology and Obstetrics (FIGO) stage I were categorized into full staging, fertility-sparing, or partial stagings. Outcomes were overall survival and recurrence free survival, and recurrence rates.
    Results: Among 409 identified patients, 257 (63%) had expansile and 152 (37%) had infiltrative tumors. Patients with expansile tumors had FIGO stage I more frequently (n=243, 95% vs n=116, 76%, p<0.001). For FIGO stage I disease, patients with expansile and infiltrative tumors underwent similar proportions of partial (n=165, 68% vs n=78, 67%), full (n=32, 13% vs n=23, 20%), and fertility-sparing stagings (n=46, 19% vs n=15, 13%) (p=0.139). Patients with expansile FIGO stage I received less adjuvant chemotherapy (n=11, 5% vs n=24, 21%, p<0.001), exhibited better overall and recurrence free survival (p=0.006, p=0.012), and fewer recurrences (n=13, 5% vs n=16, 14%, p=0.011). Survival and recurrence rates were similar across the expansile extent of staging groups. Patients undergoing fertility-sparing staging for infiltrative tumors had more recurrences compared with full or partial stagings, while recurrence free survival was similar across these groups. Full staging correlated with better overall survival in infiltrative FIGO stage I (p=0.022).
    Conclusions: While most patients with FIGO stage I underwent partial staging, those with expansile had better outcomes than those with infiltrative tumors. Full staging was associated with improved overall survival in infiltrative, but not in expansile FIGO stage I. These results provide insight for tailored surgical approaches.
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
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  3. Article ; Online: The Information Technology (IT) Infrastructure of the Multicenter Archipelago of Ovarian Cancer Research Biobank: A Potential Blueprint for Other Biobanks.

    Zelisse, Hein S / de Ridder, Sander / van Gent, Mignon D J M / Mom, Constantijne H / Wisman, G Bea A / Roes, Eva-Maria / Reyners, Anna K L / Piek, Jurgen M / Nieuwenhuyzen-de Boer, Gatske M / Lok, Christianne A R / de Kroon, Cornelis D / Kooreman, Loes F S / Janssen, Marc-Jan / Jansen, Maurice Phm / Horlings, Hugo M / Collée, Margriet / Broeks, Annegien / Boere, Ingrid A / Bart, Joost /
    van Altena, Anne M / Heeling, Marlou / Stoter, I Matthijs / Voorham, Quirinus J / van de Vijver, Marc J / Dijk, Frederike / Belien, Jeroen A M

    Biopreservation and biobanking

    2024  

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2023.0118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Oncogene activation in breast cancer

    Vijver, Marc J. van de

    1989  

    Author's details door Marc Joan van de Vijver
    Size 121 S. : Ill., graph. Darst.
    Publisher Rodopi
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Amsterdam, Univ., Diss., 1989
    HBZ-ID HT003982137
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    92 E 354 order for loan Magazin

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  5. Article ; Online: Surgical treatment for clinical early-stage expansile and infiltrative mucinous ovarian cancer: can staging surgeries safely be omitted?

    Algera, Marc D / van Driel, Willemien J / van de Vijver, Koen K / Kruitwagen, Roy F P M / Lok, Christianne A R

    Current opinion in oncology

    2022  Volume 34, Issue 5, Page(s) 497–503

    Abstract: Purpose of review: Mucinous ovarian cancers (MOCs) are categorized into infiltrative and expansile subtypes. These subtypes have different characteristics and prognoses. Patients with clinical early-stage disease of both subtypes currently undergo ... ...

    Abstract Purpose of review: Mucinous ovarian cancers (MOCs) are categorized into infiltrative and expansile subtypes. These subtypes have different characteristics and prognoses. Patients with clinical early-stage disease of both subtypes currently undergo surgical staging (peritoneal washing, biopsies, omentectomy). Peritoneal and lymph node metastases of expansile MOC are rare, but whereas lymph node sampling (LNS) is omitted in these patients, peritoneal staging is not. Therefore, we collected all available MOC data to determine whether staging surgeries could safely be omitted in clinical early-stage expansile and infiltrative MOC.
    Recent findings: Current literature confirms that peritoneal metastases are rare in expansile MOC: more than 90% of patients have early-stage disease. Only 3.4% of the patients with clinical early-stage expansile MOC had positive peritoneal washings at surgical staging. Patients with infiltrative MOC were diagnosed more frequently with advanced-stage disease (21-54%). Moreover, upstaging clinical early-stage infiltrative MOC based on positive cytology, peritoneum and omentum metastases occurred in 10.3% of the patients. Therefore, we recommend that patients with early-stage infiltrative MOC undergo peritoneal staging and LNS. However, in addition to omitting LNS, we can also safely recommend omitting peritoneal staging in patients with clinical early stage expansile MOC.
    Summary: Peritoneal metastases are rare in clinical early-stage expansile MOC and peritoneal staging can therefore safely be omitted.
    MeSH term(s) Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/surgery ; Biopsy ; Carcinoma, Ovarian Epithelial/surgery ; Female ; Humans ; Neoplasm Staging ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/surgery
    Language English
    Publishing date 2022-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3046: Show issues Location:
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  6. Article ; Online: Scenarios of future mpox outbreaks among men who have sex with men: a modelling study based on cross-sectional seroprevalence data from the Netherlands, 2022.

    Shamier, Marc C / Zaeck, Luca M / Götz, Hannelore M / Vieyra, Bruno / Verstrepen, Babs E / Wijnans, Koen / Welkers, Matthijs Ra / Hoornenborg, Elske / van Cleef, Brigitte Agl / van Royen, Martin E / Jonas, Kai J / Koopmans, Marion Pg / de Vries, Rory D / van de Vijver, David Amc / GeurtsvanKessel, Corine H

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2024  Volume 29, Issue 17

    Abstract: ... in a future outbreak would be markedly reduced because of vaccination. Simultaneously, the current level ...

    Abstract BackgroundFollowing the 2022-2023 mpox outbreak, crucial knowledge gaps exist regarding orthopoxvirus-specific immunity in risk groups and its impact on future outbreaks.AimWe combined cross-sectional seroprevalence studies in two cities in the Netherlands with mathematical modelling to evaluate scenarios of future mpox outbreaks among men who have sex with men (MSM).MethodsSerum samples were obtained from 1,065 MSM attending Centres for Sexual Health (CSH) in Rotterdam or Amsterdam following the peak of the Dutch mpox outbreak and the introduction of vaccination. For MSM visiting the Rotterdam CSH, sera were linked to epidemiological and vaccination data. An in-house developed ELISA was used to detect vaccinia virus (VACV)-specific IgG. These observations were combined with published data on serial interval and vaccine effectiveness to inform a stochastic transmission model that estimates the risk of future mpox outbreaks.ResultsThe seroprevalence of VACV-specific antibodies was 45.4% and 47.1% in Rotterdam and Amsterdam, respectively. Transmission modelling showed that the impact of risk group vaccination on the original outbreak was likely small. However, assuming different scenarios, the number of mpox cases in a future outbreak would be markedly reduced because of vaccination. Simultaneously, the current level of immunity alone may not prevent future outbreaks. Maintaining a short time-to-diagnosis is a key component of any strategy to prevent new outbreaks.ConclusionOur findings indicate a reduced likelihood of large future mpox outbreaks among MSM in the Netherlands under current conditions, but emphasise the importance of maintaining population immunity, diagnostic capacities and disease awareness.
    MeSH term(s) Humans ; Male ; Netherlands/epidemiology ; Seroepidemiologic Studies ; Cross-Sectional Studies ; Disease Outbreaks ; Homosexuality, Male/statistics & numerical data ; Adult ; Middle Aged ; Vaccinia/epidemiology ; Antibodies, Viral/blood ; Vaccination/statistics & numerical data ; Young Adult ; Models, Theoretical ; Enzyme-Linked Immunosorbent Assay ; Immunoglobulin G/blood
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2024-04-11
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2024.29.17.2300532
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    Zs.A 5066: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: De-escalation of axillary treatment in the event of a positive sentinel lymph node biopsy in cT1-2 N0 breast cancer treated with mastectomy: nationwide registry study (BOOG 2013-07).

    de Wild, Sabine R / van Roozendaal, Lori M / de Wilt, Johannes H W / van Dalen, Thijs / van der Hage, Jos A / van Duijnhoven, Frederieke H / Simons, Janine M / Schipper, Robert-Jan / de Munck, Linda / van Kuijk, Sander M J / Boersma, Liesbeth J / Linn, Sabine C / Lobbes, Marc B I / Poortmans, Philip M P / Tjan-Heijnen, Vivianne C G / van de Vijver, Koen K B T / de Vries, Jolanda / Westenberg, A Helen / Strobbe, Luc J A /
    Smidt, Marjolein L

    The British journal of surgery

    2024  Volume 111, Issue 4

    Abstract: Background: Trials have demonstrated the safety of omitting completion axillary lymph node dissection in patients with cT1-2 N0 breast cancer operated with breast-conserving surgery who have limited metastatic burden in the sentinel lymph node. The aim ... ...

    Abstract Background: Trials have demonstrated the safety of omitting completion axillary lymph node dissection in patients with cT1-2 N0 breast cancer operated with breast-conserving surgery who have limited metastatic burden in the sentinel lymph node. The aim of this registry study was to provide insight into the oncological safety of omitting completion axillary treatment in patients operated with mastectomy who have limited-volume sentinel lymph node metastasis.
    Methods: Women diagnosed in 2013-2014 with unilateral cT1-2 N0 breast cancer treated with mastectomy, with one to three sentinel lymph node metastases (pN1mi-pN1a), were identified from the Netherlands Cancer Registry, and classified by axillary treatment: no completion axillary treatment, completion axillary lymph node dissection, regional radiotherapy, or completion axillary lymph node dissection followed by regional radiotherapy. The primary endpoint was 5-year regional recurrence rate. Secondary endpoints included recurrence-free interval and overall survival, among others.
    Results: In total, 1090 patients were included (no completion axillary treatment, 219 (20.1%); completion axillary lymph node dissection, 437 (40.1%); regional radiotherapy, 327 (30.0%); completion axillary lymph node dissection and regional radiotherapy, 107 (9.8%)). Patients in the group without completion axillary treatment had more favourable tumour characteristics and were older. The overall 5-year regional recurrence rate was 1.3%, and did not differ significantly between the groups. The recurrence-free interval was also comparable among groups. The group of patients who did not undergo completion axillary treatment had statistically significantly worse 5-year overall survival, owing to a higher percentage of non-cancer deaths.
    Conclusion: In this registry study of patients with cT1-2 N0 breast cancer treated with mastectomy, with low-volume sentinel lymph node metastasis, the 5-year regional recurrence rate was low and comparable between patients with and without completion axillary treatment.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy ; Breast Neoplasms/pathology ; Mastectomy ; Lymphatic Metastasis/pathology ; Lymph Node Excision ; Sentinel Lymph Node/pathology ; Mastectomy, Segmental ; Axilla/pathology ; Registries ; Lymph Nodes/surgery ; Lymph Nodes/pathology
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae077
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    Uk I Zs.66: Show issues Location:
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  8. Article ; Online: Corrigendum to "A case-control study to identify molecular risk factors for local recurrence in young breast cancer patients" [Radiother Oncol 156 (2021) 127-135].

    Bosma, Sophie C J / Hoogstraat, Marlous / van Werkhoven, Erik / de Maaker, Michiel / van der Leij, Femke / Elkhuizen, Paula H M / Fourquet, Alain / Poortmans, Philip / Boersma, Liesbeth J / Bartelink, Harry / van de Vijver, Marc J

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2021  Volume 163, Page(s) 244

    Language English
    Publishing date 2021-06-10
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2021.03.037
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    Zs.A 1926: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Detecting KRAS mutations in pancreatic cystic neoplasms: droplet digital PCR versus targeted next-generation sequencing.

    van Huijgevoort, Nadine C M / Halfwerk, Hans B G / Lekkerkerker, Selma J / Reinten, Roy J / Ramp, Frederique / Fockens, Paul / Besselink, Marc G / Busch, Olivier R / van Noesel, Carel J M / van de Vijver, Marc J / Verheij, Joanne / van Hooft, Jeanin E / Dijk, Frederike

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2022  Volume 25, Issue 1, Page(s) 155–159

    MeSH term(s) Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/diagnosis ; Polymerase Chain Reaction ; High-Throughput Nucleotide Sequencing ; Mutation ; Neoplasms, Cystic, Mucinous, and Serous/genetics ; DNA Mutational Analysis ; Biomarkers, Tumor/genetics
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Biomarkers, Tumor ; KRAS protein, human
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2022.10.007
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    Zs.A 6326: Show issues Location:
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  10. Article ; Online: Molecular tests as prognostic factors in breast cancer.

    van de Vijver, Marc J

    Virchows Archiv : an international journal of pathology

    2014  Volume 464, Issue 3, Page(s) 283–291

    Abstract: In early breast cancer, prognostic tests are used to guide decisions on adjuvant systemic hormonal therapy, chemotherapy and targeted therapy treatment. This has led to large research efforts to identify novel prognostic markers in breast cancer. At ... ...

    Abstract In early breast cancer, prognostic tests are used to guide decisions on adjuvant systemic hormonal therapy, chemotherapy and targeted therapy treatment. This has led to large research efforts to identify novel prognostic markers in breast cancer. At present, the tissue factors used to guide treatment of breast cancer patients are tumor size, lymph node status, histologic grade, ER status, PR status, and HER2 status; in addition, multigene-expression-based prognostic tests are rapidly emerging. While identification of prognostic gene expression profiles has been successful, it has not been possible yet to identify robust clinically useful predictors of response to systemic treatment. As a result of rapid advances in technology and bioinformatics, it has become possible to analyze large series of breast carcinomas using high-throughput genetic techniques, including whole genome sequence analysis and gene expression profiling. These genomic studies will lead to the development of additional prognostic and predictive tissue-based tests. The most important aspects of the currently used tissue-based prognostic and predictive tests and the research in this area are reviewed.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Gene Expression Profiling/methods ; Humans ; Pathology, Molecular/methods ; Prognosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2014-02-01
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-014-1539-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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