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  1. Article ; Online: Loss of Hematopoietic Cell-Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice.

    Albiero, Mattia / Ciciliot, Stefano / Rodella, Anna / Migliozzi, Ludovica / Amendolagine, Francesco Ivan / Boscaro, Carlotta / Zuccolotto, Gaia / Rosato, Antonio / Fadini, Gian Paolo

    Diabetes

    2023  Volume 72, Issue 4, Page(s) 483–495

    MeSH term(s) Mice ; Animals ; Oncostatin M/genetics ; Oncostatin M/metabolism ; Glucose Intolerance/metabolism ; Adipose Tissue/metabolism ; Diet, High-Fat/adverse effects ; Hematopoietic Stem Cell Transplantation
    Chemical Substances Oncostatin M (106956-32-5)
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db22-0054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Consideration in the evaluation of follow-up of resistant hypertension.

    Armanini, Decio / Sabbadin, Chiara / Manso, Jacopo / Boscaro, Marco

    Journal of hypertension

    2023  Volume 42, Issue 1, Page(s) 56–57

    MeSH term(s) Humans ; Follow-Up Studies ; Hypertension/diagnosis ; Hypertension/drug therapy ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Blood Pressure ; Drug Resistance
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-11-30
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Post-Transcriptional and Epigenetic Regulation of Estrogen Signaling.

    Cignarella, Andrea / Boscaro, Carlotta / Albiero, Mattia / Bolego, Chiara / Barton, Matthias

    The Journal of pharmacology and experimental therapeutics

    2023  Volume 386, Issue 3, Page(s) 288–297

    Abstract: Post-translational and epigenetic regulation are important mechanisms controlling functions of genes and proteins. Although the "classic" estrogen receptors (ERs) have been acknowledged to function in mediating estrogen effects via transcriptional ... ...

    Abstract Post-translational and epigenetic regulation are important mechanisms controlling functions of genes and proteins. Although the "classic" estrogen receptors (ERs) have been acknowledged to function in mediating estrogen effects via transcriptional mechanisms, estrogenic agents modulate the turnover of several proteins via post-transcriptional and post-translational pathways including epigenetics. For instance, the metabolic and angiogenic action of G-protein coupled estrogen receptor (GPER) in vascular endothelial cells has been recently elucidated. By interacting with GPER, 17
    MeSH term(s) Female ; Humans ; Endothelial Cells/metabolism ; Epigenesis, Genetic ; Estrogens ; Estradiol/metabolism ; Receptors, G-Protein-Coupled/metabolism ; MicroRNAs/genetics ; Neoplasms
    Chemical Substances Estrogens ; Estradiol (4TI98Z838E) ; Receptors, G-Protein-Coupled ; MicroRNAs
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.001613
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  4. Article ; Online: Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism.

    Armanini, Decio / Boscaro, Marco / Bordin, Luciana / Sabbadin, Chiara

    International journal of molecular sciences

    2022  Volume 23, Issue 8

    Abstract: Polycystic ovary syndrome (PCOS) is a heterogeneous and extremely common disease with symptoms that vary with the age of the patient, typically characterized by hyperandrogenism, chronic oligo-anovulation, and/or several metabolic disorders. The syndrome ...

    Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous and extremely common disease with symptoms that vary with the age of the patient, typically characterized by hyperandrogenism, chronic oligo-anovulation, and/or several metabolic disorders. The syndrome includes various phenotypes, and the pathogenesis is multifactorial, often involving insulin resistance. This feature is closely related to ovarian dysfunction, inflammation, hyperandrogenism, and metabolic disorders, which characterize and complicate the syndrome. Therapy currently considers both lifestyle improvements and medications, and must be tailored on a case-by-case basis. To date, the published studies have not arrived at a definition of the most suitable therapy for each individual case and many of the drugs used are still off-label. In this review, we discuss some controversial diagnostic and therapeutic aspects of PCOS, such as the role of insulin resistance, inflammation, and hyperandrogenism. We also evaluated the advantages and disadvantages of contraceptive therapy and antiandrogens.
    MeSH term(s) Female ; Humans ; Hyperandrogenism/diagnosis ; Hyperandrogenism/etiology ; Hyperandrogenism/therapy ; Inflammation/complications ; Inflammation/diagnosis ; Inflammation/therapy ; Insulin Resistance ; Male ; Metabolic Diseases/complications ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/etiology ; Polycystic Ovary Syndrome/therapy
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23084110
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  5. Article ; Online: Frequently asked questions and answers (if any) in patients with adrenal incidentaloma.

    Ceccato, F / Barbot, M / Scaroni, C / Boscaro, M

    Journal of endocrinological investigation

    2021  Volume 44, Issue 12, Page(s) 2749–2763

    Abstract: Purpose: Adrenal incidentalomas (AIs) are incidentally discovered adrenal masses, during an imaging study undertaken for other reasons than the suspicion of adrenal disease. Their management is not a minor concern for patients and health-care related ... ...

    Abstract Purpose: Adrenal incidentalomas (AIs) are incidentally discovered adrenal masses, during an imaging study undertaken for other reasons than the suspicion of adrenal disease. Their management is not a minor concern for patients and health-care related costs, since their increasing prevalence in the aging population. The exclusion of malignancy is the first question to attempt, then a careful evaluation of adrenal hormones is suggested. Surgery should be considered in case of overt secretion (primary aldosteronism, adrenal Cushing's Syndrome or pheochromocytoma), however the management of subclinical secretion is still a matter of debate.
    Methods: The aim of the present narrative review is to offer a practical guidance regarding the management of AI, by providing evidence-based answers to frequently asked questions.
    Conclusion: The clinical experience is of utmost importance: a personalized diagnostic-therapeutic approach, based upon multidisciplinary discussion, is suggested.
    MeSH term(s) Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/metabolism ; Adrenal Gland Neoplasms/pathology ; Adrenal Gland Neoplasms/physiopathology ; Adrenal Gland Neoplasms/surgery ; Adrenal Gland Neoplasms/therapy ; Adrenalectomy/methods ; Clinical Decision-Making ; Conservative Treatment/methods ; Humans ; Patient Selection
    Language English
    Publishing date 2021-06-23
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-021-01615-3
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    Zs.A 1480: Show issues Location:
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  6. Article ; Online: Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment.

    Armanini, D / Sabbadin, C / Boscaro, M

    Journal of endocrinological investigation

    2021  Volume 44, Issue 9, Page(s) 2009–2010

    MeSH term(s) Aldosterone/blood ; Antihypertensive Agents/therapeutic use ; Canrenone/administration & dosage ; Canrenone/pharmacokinetics ; Diagnostic Techniques, Endocrine/standards ; Duration of Therapy ; Humans ; Hyperaldosteronism/blood ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/drug therapy ; Hyperaldosteronism/physiopathology ; Hypertension/drug therapy ; Hypertension/etiology ; Hypokalemia/etiology ; Hypokalemia/therapy ; Mineralocorticoid Receptor Antagonists/administration & dosage ; Mineralocorticoid Receptor Antagonists/pharmacokinetics ; Renin/blood ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; Reproducibility of Results
    Chemical Substances Antihypertensive Agents ; Mineralocorticoid Receptor Antagonists ; Aldosterone (4964P6T9RB) ; Canrenone (78O20X9J0U) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2021-01-16
    Publishing country Italy
    Document type Letter
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-021-01500-z
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  7. Article ; Online: Dynamic Testing for Differential Diagnosis of ACTH-Dependent Cushing Syndrome: A Systematic Review and Meta-analysis.

    Ceccato, Filippo / Barbot, Mattia / Mondin, Alessandro / Boscaro, Marco / Fleseriu, Maria / Scaroni, Carla

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 5, Page(s) e178–e188

    Abstract: Context: Diagnostic accuracy of testing currently used for the differential diagnosis of Cushing disease (CD) vs ectopic adrenocorticotropic hormone secretion (EAS) is difficult to interpret.: Objective: The present study aimed to identify and ... ...

    Abstract Context: Diagnostic accuracy of testing currently used for the differential diagnosis of Cushing disease (CD) vs ectopic adrenocorticotropic hormone secretion (EAS) is difficult to interpret.
    Objective: The present study aimed to identify and evaluate the diagnostic accuracy of the corticotropin-releasing hormone (CRH) test, the desmopressin test, and the high-dose dexamethasone suppression test (HDDST) when used to establish a CD or EAS diagnosis.
    Methods: This study is a systematic review of the literature and meta-analysis. MEDLINE, OVID, and Web of Science databases were searched for articles published between 1990 and 2021. Articles included described at least 1 test(s) (CRH, desmopressin, or HDDST) and the diagnostic reference standard(s) (histopathology, petrosal sinus sampling, surgical remission, imaging, and long-term follow-up) used to establish a CD or EAS diagnosis.
    Results: Sixty-two studies were included: 43 reported the use of the HDDST; 32, the CRH test; and the 21, the desmopressin test. The CRH test was found to have the highest sensitivity in detecting CD (ACTH 86.9%, 95% CI 82.1-90.6, cortisol 86.2%, 95% CI 78.3-91.5) and the highest specificity in detecting EAS (ACTH 93.9%, 95% CI 87-98.3, cortisol 89.4%, 95% CI 82.8-93.7). This resulted in a high diagnostic odds ratio (58, 95% CI 43.25-77.47), large area under the curve, and a receiver operating characteristic of 0.934. The diagnostic accuracy of the HDDST and desmopressin test was lower than that of the CRH test.
    Conclusion: The meta-analysis indicates that a patient with a positive ACTH response after a CRH test is highly likely to have CD. Further studies analyzing role of dynamic testing in addition to imaging are needed.
    MeSH term(s) Humans ; Cushing Syndrome/diagnosis ; Deamino Arginine Vasopressin ; Hydrocortisone ; Diagnosis, Differential ; ACTH Syndrome, Ectopic/diagnosis ; Pituitary ACTH Hypersecretion/diagnosis ; Adrenocorticotropic Hormone ; Corticotropin-Releasing Hormone
    Chemical Substances Deamino Arginine Vasopressin (ENR1LLB0FP) ; Hydrocortisone (WI4X0X7BPJ) ; Adrenocorticotropic Hormone (9002-60-2) ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac686
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    Uh III Zs.134: Show issues Location:
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  8. Article ; Online: Diffusive model to assess the release of chemicals from a material under intermittent release conditions.

    Frezzato, Diego / Stocco, Gianluca / Boscaro, Enrico / Ferraro, Marco / Tapparo, Andrea

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3466

    Abstract: We consider the archetype situation of a chemical species that diffuses in a material and irreversibly escapes through the interface. In our setup, the interface switches between two states corresponding to 'release phase' (absorbing boundary) during ... ...

    Abstract We consider the archetype situation of a chemical species that diffuses in a material and irreversibly escapes through the interface. In our setup, the interface switches between two states corresponding to 'release phase' (absorbing boundary) during which the species is released to the exterior, and 'pause phase' (reflecting boundary) during which the species is not released and its concentration profile inside the material partially relaxes back to uniformity. By combining numerical solution of the diffusion equation and statistical analysis of the outcomes, we derive upper and lower bounds and an empirical approximation for the amount of species released up to a certain time, in which the only information about the release-pause alternation schedule is the number of release phases and the average duration of a release phase. The methodology is developed thinking especially to dermal exposure assessment in the case of a slab-like homogeneous material irreversibly releasing chemicals during a number of contacts. However, upon proper extensions, this approach might be useful for inspecting other situations that are encountered, for instance, when dealing with leakage of chemicals in environmental contexts and regulatory toxicology.
    MeSH term(s) Diffusion
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07144-0
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  9. Article ; Online: Pitfalls in website information on dietary sodium restriction.

    Armanini, Decio / Bordin, Luciana / Manso, Jacopo / Boscaro, Marco / Sabbadin, Chiara

    Journal of clinical hypertension (Greenwich, Conn.)

    2022  Volume 24, Issue 10, Page(s) 1293–1295

    MeSH term(s) Humans ; Sodium, Dietary/adverse effects ; Sodium ; Hypertension ; Sodium Chloride, Dietary ; Diet, Sodium-Restricted
    Chemical Substances Sodium, Dietary ; Sodium (9NEZ333N27) ; Sodium Chloride, Dietary
    Language English
    Publishing date 2022-10-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.14587
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    Zs.A 5723: Show issues Location:
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  10. Article ; Online: Metal Coordination Properties of a Chromophoric Desferrioxamine (DFO) Derivative: Insight on the Coordination Stoichiometry and Thermodynamic Stability of Zr

    Savastano, Matteo / Boscaro, Francesca / Bianchi, Antonio

    Molecules (Basel, Switzerland)

    2021  Volume 27, Issue 1

    Abstract: Desferrioxamine (DFO) is the current "gold standard" chelator ... ...

    Abstract Desferrioxamine (DFO) is the current "gold standard" chelator for
    MeSH term(s) Chelating Agents/chemistry ; Chemical Phenomena ; Coordination Complexes/chemistry ; Deferoxamine/analogs & derivatives ; Deferoxamine/chemistry ; Models, Theoretical ; Molecular Structure ; Spectrometry, Mass, Electrospray Ionization ; Spectrum Analysis ; Thermodynamics ; Zirconium/chemistry
    Chemical Substances Chelating Agents ; Coordination Complexes ; Zirconium (C6V6S92N3C) ; Deferoxamine (J06Y7MXW4D)
    Language English
    Publishing date 2021-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27010184
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