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Article: Multimodal Management of Colorectal Liver Metastases: State of the Art.

Filoni, Elisabetta / Musci, Vittoria / Di Rito, Alessia / Inchingolo, Riccardo / Memeo, Riccardo / Mannavola, Francesco

2024 Volume 17, Page(s) 11799

Abstract: Liver is the most common site of colorectal cancer (CRC) metastases. Treatment of CRC liver metastases (CRLM) includes different strategies, prevalently based on the clinical and oncological intent. Valid approaches in liver-limited or liver-prevalent ... ...

Abstract	Liver is the most common site of colorectal cancer (CRC) metastases. Treatment of CRC liver metastases (CRLM) includes different strategies, prevalently based on the clinical and oncological intent. Valid approaches in liver-limited or liver-prevalent disease include surgery, percutaneous ablative procedures (radiofrequency ablation, microwave ablation), intra-arterial perfusional techniques (chemo-embolization, radio-embolization) as well as stereotactic radiotherapy. Systemic treatments, including chemotherapy, immunotherapy and other biological agents, are the only options for patients with no chance of locoregional approaches. The use of chemotherapy in other settings, such as neoadjuvant, adjuvant or conversion therapy of CRLM, is commonly accepted in the clinical practice, although data from several clinical trials have been mostly inconclusive. The optimal integration of all these strategies, when applicable and clinically indicated, should be ever considered in patients affected by CRLM based on clinical evidence and multidisciplinary experience. Here we revised in detail all the possible therapeutic approaches of CRLM focusing on the current evidences, the studies still in progress and the often contradictory data.
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2390302-8
ISSN	1970-5565 ; 1970-5565 ; 1970-5557
ISSN (online)	1970-5565
ISSN	1970-5565 ; 1970-5557
DOI	10.3389/or.2023.11799
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Article: A new era for hepatocellular carcinoma.

Memeo, Riccardo / Pisani, Antonio Rosario / Ammendola, Michele / de'Angelis, Nicola / Inchingolo, Riccardo

Hepatobiliary surgery and nutrition

2023 Volume 12, Issue 1, Page(s) 135–136

Language	English
Publishing date	2023-01-16
Publishing country	China (Republic : 1949- )
Document type	Editorial ; Comment
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-23-10
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Article ; Online: Trick or Trap? Reply to Vertical Artifacts as Lung Ultrasound Signs.

Smargiassi, Andrea / Zanforlin, Alessandro / Tursi, Francesco / Soldati, Gino / Inchingolo, Riccardo

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2023 Volume 43, Issue 1, Page(s) 215–216

MeSH term(s)	Humans ; Artifacts ; Lung/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Letter
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.16337
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Irreversible electroporation for the management of pancreatic cancer: Current data and future directions.

Spiliopoulos, Stavros / Reppas, Lazaros / Filippiadis, Dimitrios / Delvecchio, Antonella / Conticchio, Maria / Memeo, Riccardo / Inchingolo, Riccardo

World journal of gastroenterology

2023 Volume 29, Issue 2, Page(s) 223–231

Abstract: Pancreatic cancer is currently the seventh leading cause of cancer death (4.5% of all cancer deaths) while 80%-90% of the patients suffer from unresectable disease at the time of diagnosis. Prognosis remains poor, with a mean survival up to 15 mo ... ...

Abstract	Pancreatic cancer is currently the seventh leading cause of cancer death (4.5% of all cancer deaths) while 80%-90% of the patients suffer from unresectable disease at the time of diagnosis. Prognosis remains poor, with a mean survival up to 15 mo following systemic chemotherapy. Loco-regional thermal ablative techniques are rarely implemented due to the increased risk of thermal injury to the adjacent structures, which can lead to severe adverse events. Irreversible electroporation, a promising novel non-thermal ablative modality, has been recently introduced in clinical practice for the management of inoperable pancreatic cancer as a safer and more effective loco-regional treatment option. Experimental and initial clinical data are optimistic. This review will focus on the basic principles of IRE technology, currently available data, and future directions.
MeSH term(s)	Humans ; Pancreatic Neoplasms/therapy ; Treatment Outcome ; Prognosis ; Electroporation/methods ; Pancreatic Neoplasms
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v29.i2.223
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Article ; Online: Intra-patient and inter-observer image quality analysis in liver MRI study with gadoxetic acid using two different multi-arterial phase techniques.

Castagnoli, Francesca / Faletti, Riccardo / Inchingolo, Riccardo / Villanacci, Alberta / Ruggeri, Valeria / Zacà, Domenico / Koh, Dow-Mu / Grazioli, Luigi

The British journal of radiology

2024 Volume 97, Issue 1156, Page(s) 868–873

Abstract: Purpose: To evaluate intra-patient and interobserver agreement in patients who underwent liver MRI with gadoxetic acid using two different multi-arterial phase (AP) techniques.: Methods: A total of 154 prospectively enrolled patients underwent ... ...

Abstract	Purpose: To evaluate intra-patient and interobserver agreement in patients who underwent liver MRI with gadoxetic acid using two different multi-arterial phase (AP) techniques. Methods: A total of 154 prospectively enrolled patients underwent clinical gadoxetic acid-enhanced liver MRI twice within 12 months, using two different multi-arterial algorithms: CAIPIRINHA-VIBE and TWIST-VIBE. For every patient, breath-holding time, body mass index, sex, age were recorded. The phase without contrast media and the APs were independently evaluated by two radiologists who quantified Gibbs artefacts, noise, respiratory motion artefacts, and general image quality. Presence or absence of Gibbs artefacts and noise was compared by the McNemar's test. Respiratory motion artefacts and image quality scores were compared using Wilcoxon signed rank test. Interobserver agreement was assessed by Cohen kappa statistics. Results: Compared with TWIST-VIBE, CAIPIRINHA-VIBE images had better scores for every parameter except higher noise score. Triple APs were always acquired with TWIST-VIBE but failed in 37% using CAIPIRINHA-VIBE: 11% have only one AP, 26% have two. Breath-holding time was the only parameter that influenced the success of multi-arterial techniques. TWIST-VIBE images had worst score for Gibbs and respiratory motion artefacts but lower noise score. Conclusion: CAIPIRINHA-VIBE images were always diagnostic, but with a failure of triple-AP in 37%. TWIST-VIBE was successful in obtaining three APs in all patients. Breath-holding time is the only parameter which can influence the preliminary choice between CAIPIRINHA-VIBE and TWIST-VIBE algorithm. Advances in knowledge: If the patient is expected to perform good breath-holds, TWIST-VIBE is preferable; otherwise, CAIPIRINHA-VIBE is more appropriate.
MeSH term(s)	Humans ; Image Interpretation, Computer-Assisted/methods ; Image Enhancement/methods ; Reproducibility of Results ; Magnetic Resonance Imaging/methods ; Contrast Media ; Breath Holding ; Artifacts ; Liver/diagnostic imaging ; Gadolinium DTPA
Chemical Substances	gadolinium ethoxybenzyl DTPA ; Contrast Media ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1093/bjr/tqae045
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Article ; Online: Detection and management of bile duct injury during cholecystectomy.

Marchegiani, Francesco / Conticchio, Maria / Zadoroznyj, Alizée / Inchingolo, Riccardo / Memeo, Riccardo / De'angelis, Nicola

Minerva surgery

2023 Volume 78, Issue 5, Page(s) 545–557

Abstract: Introduction: Cholecystectomy represents one of the most performed surgical procedures. Bile duct injuries (BDIs) are a dangerous complication of this intervention. With the advent of the laparoscopy, the rate of BDIs showed a growing trend that was ... ...

Abstract	Introduction: Cholecystectomy represents one of the most performed surgical procedures. Bile duct injuries (BDIs) are a dangerous complication of this intervention. With the advent of the laparoscopy, the rate of BDIs showed a growing trend that was partially justified by the learning curve of this technique. Evidence acquisition: A literature search was conducted on Embase, Medline, and Cochrane databases to identify studies published up to October 2022 that analyzed the intraoperative detection and management of BDIs diagnosed during cholecystectomy. Evidence synthesis: According to the literature, approximately 25% of BDIs is diagnosed during the laparoscopic cholecystectomy. In the clinical suspicion of BDI, an intraoperative cholangiography is performed to confirm it. Complimentary technology, such as near-infrared cholangiography, can be also adopted. Intraoperative ultrasound represents a useful tool to furtherly define the biliary and the vascular anatomy. The proper classification of the type of BDI allows to identify the correct treatment. When a good expertise in hepato-pancreato-biliary surgery is available, a direct repair is performed with good outcomes both in case of simple and complex lesions. When the local resources are limited or there is a lack of dedicated surgical experience, patient referral to a reference center shows better outcomes. In particular, complex vasculo-biliary injuries require a highly specialized treatment. The key elements to transfer the patients are a good documentation of the injury, a proper drainage of the abdomen, and an antibiotic therapy. Conclusions: BDI management requires a proper diagnostic process and prompt treatment to reduce the morbidity and mortality of this feared complication occurring during cholecystectomy.
Language	English
Publishing date	2023-03-08
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.23.09866-0
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Article: Development and validation of a chromatin regulator signature for predicting prognosis hepatocellular carcinoma patient.

Mao, Jiazhen / Song, Fei / Zhang, Yu / Li, Yifan / Inchingolo, Riccardo / Chauhan, Aman / Midorikawa, Yutaka / Chen, Zhong / Tang, Weidong

Journal of gastrointestinal oncology

2024 Volume 15, Issue 1, Page(s) 397–414

Abstract: Background: Hepatocellular carcinoma (HCC) is a malignancy with a bleak prognosis. Although emerging research increasingly supports the involvement of chromatin regulators (CRs) in cancer development, CRs in HCC patients have not received proportionate ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a malignancy with a bleak prognosis. Although emerging research increasingly supports the involvement of chromatin regulators (CRs) in cancer development, CRs in HCC patients have not received proportionate attention. This study aimed to investigate the role and prognostic significance of CRs in HCC patients, providing new insights for clinical diagnosis and treatment strategies. Methods: We analyzed 424 samples in The Cancer Genome Atlas-Liver hepatocellular carcinoma (TCGA-LIHC) data to identify key CR genes associated with HCC prognosis by differential expression and univariate Cox regression analyses. LASSO-multivariate Cox regression method was used for construction of a prognostic signature and development of a CR-related prognosis model. The prognosis capacity of the model was evaluated via Kaplan-Meier method. Relationship between the model and tumor microenvironment (TME) was evaluated. Additionally, clinical variables and the model were incorporated to create a nomogram. The role of the prognostic gene MRG-binding protein ( Results: A risk score model, comprising B-lymphoma Mo-MLV insertion region 1 ( Conclusions: This CR-based signature shows promise as a valuable prognostic tool for HCC patients. It demonstrates predictive capabilities, independence from other clinical factors, and potential clinical applicability. In addition, we need more experiments to validate our findings. These findings offer insights into HCC prognosis and treatment, with implications for personalized medicine and improved patient outcomes.
Language	English
Publishing date	2024-02-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-23-996
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Article ; Online: Radiological findings in non-surgical recurrent hepatocellular carcinoma: From locoregional treatments to immunotherapy.

Ippolito, Davide / Maino, Cesare / Gatti, Marco / Marra, Paolo / Faletti, Riccardo / Cortese, Francesco / Inchingolo, Riccardo / Sironi, Sandro

World journal of gastroenterology

2023 Volume 29, Issue 11, Page(s) 1669–1684

Abstract: Since hepatocellular carcinoma (HCC) represents an important cause of mortality and morbidity all over the world. Currently, it is fundamental not only to achieve a curative treatment but also to manage in the best way any possible recurrence. Even if ... ...

Abstract	Since hepatocellular carcinoma (HCC) represents an important cause of mortality and morbidity all over the world. Currently, it is fundamental not only to achieve a curative treatment but also to manage in the best way any possible recurrence. Even if the latest update of the Barcelona Clinic Liver Cancer guidelines for HCC treatment has introduced new locoregional techniques and confirmed others as well-established clinical practices, there is still no consensus about the treatment of recurrent HCC (RHCC). Locoregional treatments and medical therapy represent two of the most widely accepted approaches for disease control, especially in the advanced stage of liver disease. Different medical treatments are now approved, and others are under investigation. On this basis, radiology plays a central role in the diagnosis of RHCC and the assessment of response to locoregional treatments and medical therapy for RHCC. This review summarized the actual clinical practice by underlining the importance of the radiological approach both in the diagnosis and treatment of RHCC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Immunotherapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Ablation Techniques ; Medication Therapy Management ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v29.i11.1669
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Article: Awake robotic liver surgery: A case report.

Delvecchio, Antonella / Pavone, Gaetano / Conticchio, Maria / Piacente, Claudia / Varvara, Miriam / Ferraro, Valentina / Stasi, Matteo / Casella, Annachiara / Filippo, Rosalinda / Tedeschi, Michele / Pullano, Carmine / Inchingolo, Riccardo / Delmonte, Vito / Memeo, Riccardo

World journal of gastrointestinal surgery

2024 Volume 15, Issue 12, Page(s) 2954–2961

Abstract: Background: In recent years, minimally invasive liver resection has become a standard of care for liver tumors. Considering the need to treat increasingly fragile patients, general anesthesia is sometimes avoided due to respiratory complications. ... ...

Abstract	Background: In recent years, minimally invasive liver resection has become a standard of care for liver tumors. Considering the need to treat increasingly fragile patients, general anesthesia is sometimes avoided due to respiratory complications. Therefore, surgical treatment with curative intent is abandoned in favor of a less invasive and less radical approach. Epidural anesthesia has been shown to reduce respiratory complications, especially in elderly patients with pre-existing lung disease. Case summary: A 77-year-old man with hepatitis-C-virus-related chronic liver disease underwent robotic liver resection for hepatocellular carcinoma. The patient was suffering from hypertension, diabetes and chronic obstructive pulmonary disease. The National Surgical Quality Improvement Program score for developing pneumonia was 9.2%. We planned a combined spinal-epidural anesthesia with conscious sedation to avoid general anesthesia. No modification of the standard surgical technique was necessary. Hemodynamics were stable and bleeding was minimal. The postoperative course was uneventful. Conclusion: Robotic surgery in locoregional anesthesia with conscious sedation could be considered a safe and suitable approach in specialized centers and in selected patients.
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2573700-4
ISSN	1948-9366
ISSN	1948-9366
DOI	10.4240/wjgs.v15.i12.2954
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Article ; Online: Radiomics and liver: Where we are and where we are headed?

Maino, Cesare / Vernuccio, Federica / Cannella, Roberto / Franco, Paolo Niccolò / Giannini, Valentina / Dezio, Michele / Pisani, Antonio Rosario / Blandino, Antonino Andrea / Faletti, Riccardo / De Bernardi, Elisabetta / Ippolito, Davide / Gatti, Marco / Inchingolo, Riccardo

European journal of radiology

2024 Volume 171, Page(s) 111297

Abstract: Hepatic diffuse conditions and focal liver lesions represent two of the most common scenarios to face in everyday radiological clinical practice. Thanks to the advances in technology, radiology has gained a central role in the management of patients with ...

Abstract	Hepatic diffuse conditions and focal liver lesions represent two of the most common scenarios to face in everyday radiological clinical practice. Thanks to the advances in technology, radiology has gained a central role in the management of patients with liver disease, especially due to its high sensitivity and specificity. Since the introduction of computed tomography (CT) and magnetic resonance imaging (MRI), radiology has been considered the non-invasive reference modality to assess and characterize liver pathologies. In recent years, clinical practice has moved forward to a quantitative approach to better evaluate and manage each patient with a more fitted approach. In this setting, radiomics has gained an important role in helping radiologists and clinicians characterize hepatic pathological entities, in managing patients, and in determining prognosis. Radiomics can extract a large amount of data from radiological images, which can be associated with different liver scenarios. Thanks to its wide applications in ultrasonography (US), CT, and MRI, different studies were focused on specific aspects related to liver diseases. Even if broadly applied, radiomics has some advantages and different pitfalls. This review aims to summarize the most important and robust studies published in the field of liver radiomics, underlying their main limitations and issues, and what they can add to the current and future clinical practice and literature.
MeSH term(s)	Humans ; Radiomics ; Tomography, X-Ray Computed ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Radiography ; Magnetic Resonance Imaging
Language	English
Publishing date	2024-01-12
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2024.111297
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