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Article ; Online: Translational oncology toward benefiting cancer patients: the Sun Yat-sen University Cancer Center experience.

Guerin, Mathilde / Qian, Chaonan / Zhong, Qian / Cui, Qian / Guo, Yunmiao / Bei, Jinxin / Shao, Jianyong / Zhu, Xiaofeng / Huang, Wenlin / Wu, Jiangxue / Liu, Ranyi / Liu, Qiang / Wang, Jing / Jia, Weihua / Zheng, Xiaohui / Zeng, Yixin

Science China. Life sciences

2016 Volume 59, Issue 10, Page(s) 1057–1062

MeSH term(s)	Animals ; China ; Disease Models, Animal ; Genetic Predisposition to Disease/genetics ; Humans ; Medical Oncology/methods ; Medical Oncology/trends ; Molecular Biology/methods ; Molecular Biology/trends ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Neoplasms/genetics ; Neoplasms/prevention & control ; Neoplasms/therapy ; Tissue Banks/standards ; Tissue Banks/trends ; Translational Medical Research/methods ; Translational Medical Research/trends ; Universities
Language	English
Publishing date	2016-10
Publishing country	China
Document type	Journal Article
ISSN	1869-1889
ISSN (online)	1869-1889
DOI	10.1007/s11427-012-4398-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differences in Staphylococcus aureus nasal carriage and molecular characteristics among community residents and healthcare workers at Sun Yat-Sen University, Guangzhou, Southern China.

Chen, Baiji / Dai, Xinlu / He, Bo / Pan, Kunyi / Li, Hongyu / Liu, Xiaoqiang / Bao, Yunwen / Lao, Weisi / Wu, Xiquan / Yao, Yandan / Huang, Songyin

BMC infectious diseases

2015 Volume 15, Page(s) 303

Abstract: ... of nasal colonization by S. aureus in community residents (CR) and healthcare workers (HW) at Sun Yat-Sen ... Yat-Sen University, Guangzhou. Differences in epidemiological and molecular characteristics of S ...

Abstract	Background: The pathogenic potential and commensal nature of Staphylococcus aureus allows for easy transmission both within and outside of the hospital environment, and nasal carriage may be responsible for some serious infections. This study aimed to determine the molecular and epidemiological characteristics of nasal colonization by S. aureus in community residents (CR) and healthcare workers (HW) at Sun Yat-Sen University, Guangzhou, China. Methods: A total of 589 volunteers, both CR (n = 297) and HW (n = 292), were recruited. Each subject completed a questionnaire, and specimens were obtained from the anterior nares for S. aureus screening. Genotypic analysis included pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) typing, and virulence gene detection. Results: A total of 138 S. aureus isolates were recovered from separate subjects (23.4%, 138/589), with four isolates showing methicillin resistance (0.7%, 4/589). The prevalence of S. aureus carriage was 25.3% (75/297) in CR and 21.6% (63/292) in HW. Methicillin-resistant S. aureus (MRSA) were isolated from one CR (0.3%, 1/297) and three HW (1.0%, 3/292). The most common risk factors for S. aureus carriage in CR were being male, age ≤ 30 years, and nasal cavity cleaning habits. Having a household member in the healthcare profession was associated with increased risk among HW. Sequence type (ST)188 and ST59 were the most prevalent among the 20 observed STs, accounting for 14.6% and 12.2% of all isolates, respectively. The four MRSA isolates presented four different STs, with one isolate carrying a type IVa SCCmec element and the other three isolates containing type III SCCmec. PFGE analysis grouped the 129 isolates into 23 pulsotypes, with profiles A, N, E, L, and O the most prevalent. The Panton-Valentine leucocidin gene (pvl) was identified in two of the 138 isolates, while 57.5% of isolates carried both the Staphylococcus aureus enterotoxin A (sea) and enterotoxin B (seb) genes. Conclusions: These data indicate a low prevalence of nasal MRSA carriage but evidence of molecular heterogeneity among S. aureus isolates from CR and HW at Sun Yat-Sen University, Guangzhou. Differences in epidemiological and molecular characteristics of S. aureus between CR and HW populations may be useful for the understanding and prevention of S. aureus infection.
MeSH term(s)	Adolescent ; Adult ; Aged ; Bacterial Typing Techniques/methods ; Child ; China/epidemiology ; Cross-Sectional Studies ; Female ; Health Personnel/statistics & numerical data ; Hospitals, University/statistics & numerical data ; Humans ; Inpatients/statistics & numerical data ; Male ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Middle Aged ; Multilocus Sequence Typing ; Nasal Cavity/microbiology ; Prevalence ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification ; Young Adult
Language	English
Publishing date	2015-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-015-1032-7
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Article ; Online: Molecular epidemiology and characteristic of virulence gene of community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus isolates in Sun Yat-sen Memorial hospital, Guangzhou, Southern China.

Xie, Xiaoying / Bao, Yunwen / Ouyang, Nengyong / Dai, Xinlu / Pan, Kunyi / Chen, Baiji / Deng, Yawen / Wu, Xiquan / Xu, Fengqin / Li, Hongyu / Huang, Songyin

BMC infectious diseases

2016 Volume 16, Page(s) 339

Abstract: Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both hospital and community infections globally. It's important to illuminate the differences between community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA- ... ...

Abstract	Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both hospital and community infections globally. It's important to illuminate the differences between community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA), but there have been confusions on the definition, especially for the MRSA isolates identified within 48 h of admission. This study aimed to determine the molecular characteristics and virulence genes profile of CA and HA-MRSA isolates identified less than 48 h after hospital admission in our region. Methods: A total 62 MRSA isolates identified within 48 h after admission and the clinical data were collected. Antimicrobial susceptibility test (AST) of collected isolates were performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI) 2015, and staphylococcal cassette chromosome mec (SCCmec) typing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and virulence gene profiling were performed to explore the molecular diversity. Results: SCCmec III and sequence type (ST) 239 were the most prevalent SCCmec type and ST in both CA and HA-MRSA groups. HA-MRSA group had higher prevalence of SCCmec III (87.2 %) and ST239 (79.5 %) compared with CA-MRSA (60.9 and 43.4 %, both P < 0.001), while the frequency of SCCmec IV (26.0 %) and ST59 (21.7 %) were higher in CA-MRSA than its counterpart (P < 0.001 and P = 0.003). MRSA-ST239-III was the predominant type in this study (61.3 %, 38/62), especially in HA-MRSA group (76.9 %, 30/39). However, CA-MRSA strains exhibited more diversity in genotypes in this study. Meanwhile, CA-MRSA tended to have lower resistant percentage to non-β-lactams antibiotics but more virulence genes carriage, especially the staphylococcal enterotoxins (SE) genes. Notably, seb gene was only detected in CA-MRSA isolates (52.2 %), likely a significant marker for CA-MRSA isolates. Panton-Valentine leukocidin gene (PVL) was highly detected in both groups, while appeared no significantly different between CA-MRSA (47.8 %) and HA-MRSA (43.6 %). Conclusions: Our findings support a difference in the molecular epidemiology and virulence genes profile of CA-MRSA and HA-MRSA. Furthermore, this study indicates a possible transmission from HA-MRSA to CA-MRSA, which may cause the overlap of the definition.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/microbiology ; Electrophoresis, Gel, Pulsed-Field ; Female ; Hospitals ; Humans ; Male ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Epidemiology ; Multilocus Sequence Typing ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/genetics ; Virulence/genetics ; Virulence Factors/genetics ; Young Adult
Chemical Substances	Virulence Factors
Language	English
Publishing date	2016-07-22
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-016-1684-y
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Article: Sun Yat-sen in Japan

Wu, John C. H / Sun Yat-sen

Chinese culture : a quarterly review Vol. 10, No. 3 , p. 33-66

1969 Volume 10, Issue 3, Page(s) 33–66

Author's details	John C. H. Wu
Publisher	Inst.
Publishing place	Taipei
Document type	Article
ZDB-ID	300100-3
Database	ECONomics Information System

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Article: Sun Yat-sen's philosophy of nationalism

Wu, John C. H / Sun Yat-sen

Chinese culture : a quarterly review Vol. 11, No. 1 , p. 1-20

1970 Volume 11, Issue 1, Page(s) 1–20

Author's details	John C. H. Wu
Publisher	Inst.
Publishing place	Taipei
Document type	Article
ZDB-ID	300100-3
Database	ECONomics Information System

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Article ; Online: Multiple Coronary Aneurysms Post-Drug-Eluting Stenting: A Rare Case of Hypersensitivity Reaction.

Kam, Kevin Ka-Ho / Fong, Fuk-Kei / Wong, Bernard / So, Chak-Yu / Chui, Ka-Lung / Wu-Yeung Ching, Eugene / Yat-Sun Chan, Joseph

JACC. Cardiovascular interventions

2022 Volume 15, Issue 12, Page(s) 1280–1282

MeSH term(s)	Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/etiology ; Coronary Aneurysm/therapy ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Restenosis ; Drug-Eluting Stents ; Humans ; Treatment Outcome
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2022.04.019
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Article ; Online: Synergistic Coronary Artery Calcium Modification With Combined Atherectomy and Intravascular Lithotripsy.

Wong, Bernard / Kam, Kevin Ka-Ho / So, Chak-Yu / Tam, Guang-Min / Chi, Wai Kin / Chui, Ka-Lung / Wu, Eugene B / Chan, Joseph Yat-Sun / Yan, Bryan P

The Journal of invasive cardiology

2023 Volume 35, Issue 3, Page(s) E128–E135

Abstract: Background: Severe coronary artery calcification (CAC) remains challenging during percutaneous coronary intervention (PCI) and often requires 1 or more advanced calcium modification tools.: Objectives: We describe the combination use of rotational ( ... ...

Abstract	Background: Severe coronary artery calcification (CAC) remains challenging during percutaneous coronary intervention (PCI) and often requires 1 or more advanced calcium modification tools. Objectives: We describe the combination use of rotational (RA) or orbital atherectomy (OA), with intravascular lithotripsy (IVL), termed rotatripsy and orbital-tripsy, respectively, for modifying CAC prior to stent implantation during PCI. Methods: We performed a retrospective analysis of patients treated with rotatripsy or orbital-tripsy at our center between July 2019 and March 2022. The primary efficacy endpoint was procedural success (successful stent implantation, <30% residual stenosis visually, Thrombolysis in Myocardial Infarction 3 flow; absence of types C to F dissection/perforation or loss of side branch ≥2.0mm visually) without in-hospital major adverse cardiovascular event (MACE, defined as cardiovascular death, myocardial infarction [MI], target-vessel revascularization). Results: A total of 25 patients (14 rotatripsy and 11 orbital-tripsy) were included in our study. The mean age was 72.2 ± 7.6 years and 76% were men. PCI was guided by intravascular imaging in 24 patients (96%). All cases were treated with either RA or OA before utilization of IVL. Procedural success was achieved in 22 cases (88%) with 1 sidebranch loss without periprocedural MI (4%) and 2 in-patient deaths (8%) unrelated to the procedure (1 intracerebral hemorrhage and 1 cardiac arrest). Conclusion: We describe efficacious use of both rotatripsy and orbital-tripsy to modify severe CAC during PCI in a real-world setting. Intravascular imaging can guide appropriate use of these devices to complement each other to modify severe CAC to achieve optimal outcomes.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Female ; Percutaneous Coronary Intervention/methods ; Atherectomy, Coronary/methods ; Calcium ; Retrospective Studies ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Treatment Outcome ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Myocardial Infarction/etiology ; Atherectomy ; Lithotripsy ; Vascular Calcification/diagnosis ; Vascular Calcification/surgery ; Coronary Angiography/methods
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Article ; Online: Double LAmbre technique for percutaneous occlusion of very large left atrial appendages: a case series.

Cruz-González, Ignacio / Trejo-Velasco, Blanca / Freixa, Xavier / Regueiro, Ander / Cubero-Gómez, Jose María / Villa Gil-Ortega, Manuel / So, Chak-Yu / Keng, Wu / LuJun, Chen / Lam, Yat-Yin

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2021 Volume 18, Issue 1, Page(s) 58–62

MeSH term(s)	Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Atrial Fibrillation/surgery ; Cardiac Catheterization ; Humans ; Septal Occluder Device ; Stroke ; Treatment Outcome
Language	English
Publishing date	2021-07-28
Publishing country	France
Document type	Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJ-D-21-00512
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Article: The feasibility and safety of "one-stop" left atrial appendage closure and percutaneous coronary intervention in atrial fibrillation patients with significant coronary artery disease (PCI-LAAC study).

Wang, Yubin / Wu, Dewei / Ma, Juan / Liu, Xiangping / Zhang, Haitong / So, Chak-Yu / Lam, Yin-Yat / Wang, Bincheng / Wang, Jiande / Zhang, Hongliang / Wang, Moyang / Song, Guangyuan / Wu, Yongjian

American journal of cardiovascular disease

2021 Volume 11, Issue 5, Page(s) 679–687

Abstract: Background: The anti-thrombotic strategy for patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI) for coronary artery disease (CAD) is a common and difficult challenge. This pilot study aimed to assess the ... ...

Abstract	Background: The anti-thrombotic strategy for patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI) for coronary artery disease (CAD) is a common and difficult challenge. This pilot study aimed to assess the feasibility and safety of "one-stop" left atrial appendage closure (LAAC) combined with PCI as an alternative stroke prophylaxis strategy. Methods: From March 2017 to October 2019, AF patients with elevated bleeding risk and significant stable CAD requiring PCI were recruited to undergo LAAC as alternative stroke prophylaxis in Fuwai Hospital, Beijing, China. LAAC was performed either in the same setting with PCI (i.e. "one-stop" LAAC/PCI), or as staged procedure after PCI. Dual antiplatelet therapy was given for all patients after LAAC. Peri-procedural and intermediate-term clinical outcomes were assessed through hospital clinical records review and standardized telephone interviews. Results: A total of 24 patients were recruited including 13 (54.2%) underwent stage procedure and 11 (45.8%) underwent "one-stop" procedure respectively. The mean CHA Conclusions: In this pilot study, "one-stop" LAAC with PCI was shown to be efficacious with no stroke, MI, VARC-2 major bleeding or CV death reported over a mean follow-up of 19 months, and safe with no major peri-procedural bleeding or device related complications.
Language	English
Publishing date	2021-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2616844-3
ISSN	2160-200X
ISSN	2160-200X
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Article ; Online: The diagnostic methods in the COVID-19 pandemic, today and in the future.

Wu, So Yat / Yau, Hoi Shan / Yu, Man Yee / Tsang, Hin Fung / Chan, Lawrence Wing Chi / Cho, William Chi Shing / Shing Yu, Allen Chi / Yuen Yim, Aldrin Kay / Li, Marco J W / Wong, Yin Kwan Evelyn / Pei, Xiao Meng / Cesar Wong, Sze Chuen

Expert review of molecular diagnostics

2020 Volume 20, Issue 9, Page(s) 985–993

Abstract: Introduction: The emergence of anovel coronavirus identified in patients with unknown cause of acute respiratory disease in Wuhan, China at the end of 2019 has caused aglobal outbreak. The causative coronavirus was later named as severe acute ... ...

Abstract	Introduction: The emergence of anovel coronavirus identified in patients with unknown cause of acute respiratory disease in Wuhan, China at the end of 2019 has caused aglobal outbreak. The causative coronavirus was later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the disease caused by SARS-CoV-2 was named as Coronavirus Disease-2019 (COVID-19). As of 10 August 2020, more than 19,718,030 confirmed cases and 728,013 deaths have been reported. COVID-19 is spread via respiratory droplets which are inhaled into the lungs. Areas covered: In this article, we summarized the knowledge about the causative pathogen of COVID-19 and various diagnostic methods in this pandemic for better understanding of the limitations and the nuances of virus testing for COVID-19. Expert opinion: In this pandemic, rapid and accurate identification of COVID-19 patients are critical to break the chain of infection in the community. RT-PCR provides a rapid and reliable identification of SARS-CoV-2 infection. In the future, molecular diagnostics will still be the gold standard and next-generation sequencing can help us to understand more on the pathogenesis and detect novel mutations. It is believed that more sophisticated detection methods will be introduced to detect SARS-CoV-2 as earliest as possible.
MeSH term(s)	Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Chromatography, Affinity/methods ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/genetics ; Coronavirus Infections/pathology ; Expert Testimony ; Humans ; Microscopy, Electron ; Pandemics ; Pneumonia, Viral/diagnosis ; Point-of-Care Testing ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tomography, X-Ray Computed
Chemical Substances	COVID-19 Vaccines ; Covid-19 aAPC vaccine
Keywords	covid19
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2112530-2
ISSN	1744-8352 ; 1473-7159
ISSN (online)	1744-8352
ISSN	1473-7159
DOI	10.1080/14737159.2020.1816171
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