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Article ; Online: Reply to W. Hryniuk et al.

Rock, Cheryl L / Demark-Wahnefried, Wendy / Byers, Tim E / Colditz, Graham A / Liu, Jingxia / Pakiz, Bilgé / Sedjo, Rebecca L / Ganz, Patricia A

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2016 Volume 34, Issue 10, Page(s) 1153

MeSH term(s)	Behavior Therapy ; Breast Neoplasms/therapy ; Diet ; Exercise ; Female ; Humans ; Obesity/therapy ; Overweight/therapy ; Risk Reduction Behavior ; Survivors ; Weight Loss
Language	English
Publishing date	2016-04-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2015.65.7049
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: In Reply to Xue W, Ribalov R, Zhou Z-Y, et al. Re: Ganz ML, Chavan A, Dhanda R, et al. Cost-effectiveness of valbenazine compared with deutetrabenazine for the treatment of tardive dyskinesia. J Med Econ. 2021;24(1):103-113.

Serbin, Michael / Yonan, Charles / Ganz, Michael L

Journal of medical economics

2021 Volume 24, Issue 1, Page(s) 891–892

MeSH term(s)	Antipsychotic Agents ; Cost-Benefit Analysis ; Humans ; Tardive Dyskinesia/drug therapy ; Tetrabenazine/analogs & derivatives ; Tetrabenazine/therapeutic use ; Valine/analogs & derivatives
Chemical Substances	Antipsychotic Agents ; valbenazine (54K37P50KH) ; Valine (HG18B9YRS7) ; deutetrabenazine (P341G6W9NB) ; Tetrabenazine (Z9O08YRN8O)
Language	English
Publishing date	2021-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2270945-9
ISSN	1941-837X ; 1369-6998
ISSN (online)	1941-837X
ISSN	1369-6998
DOI	10.1080/13696998.2021.1948233
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Article: SOOTHER TRIAL: Observational study of an over-the-counter ointment to heal anal itch.

Felemovicius, Isaac / Ganz, Robert A / Saremi, Mohammad / Christopfel, William

Frontiers in medicine

2022 Volume 9, Page(s) 890883

Abstract: Introduction: Pruritus ani, or rectal or anal itch, is a common perianal disorder that affects ~5% of the population of the developed world. Treatments for this disorder are somewhat limited and include conservative non-medical perianal hygiene care, ... ...

Abstract	Introduction: Pruritus ani, or rectal or anal itch, is a common perianal disorder that affects ~5% of the population of the developed world. Treatments for this disorder are somewhat limited and include conservative non-medical perianal hygiene care, and topical medical treatments including topical steroids, antibacterial and antifungal agents, and topical anesthetic/analgesics such as lidocaine or capsaicin; astringents and vasoconstrictors such as ephedrine can also be used. Methods: The study was IRB approved. We assessed the efficacy of a novel, composite, over-the-counter, topical lidocaine ointment that included an epidermal barrier and antimicrobial effect along with the typical lidocaine anesthetizing effect, in a single arm, observational, longitudinal, population of 20 ambulatory pruritus ani patients. Patients applied the ointment twice daily, and were studied for 2 weeks; primary outcomes included time to symptom resolution and clinical exam resolution as measured on a 5-point visual analog scale. Results: Twenty-nine consecutive patients were screened and 20 patients (12 males; 8 females) were enrolled in the study. Ninety percent of patients achieved 100% symptom resolution by 2 weeks, and most were improved within 72 h of initiating treatment; 95% of patients had a normal visual exam by the 2 week endpoint. There were no significant adverse events attributable to the therapy. Conclusion: Use of a novel composite topical lidocaine agent, demonstrated rapid and effective relief of pruritus ani in an ambulatory population. Additional studies are underway. Clinical trial registered: Clinicaltrials.gov, identifier NCT05288907.
Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.890883
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Article ; Online: Type I interferons, inflammation, and fatigue in a longitudinal RNA study of women with breast cancer.

Bower, Julienne E / Ganz, Patricia A / Irwin, Michael R / Crespi, Catherine M / Petersen, Laura / Asher, Arash / Hurvitz, Sara A / Cole, Steve W

Brain, behavior, and immunity

2024 Volume 118, Page(s) 312–317

Abstract: Background: Fatigue is a common side effect of cancer and its treatment and is thought to be driven in part by activation of the proinflammatory cytokine network. However, the cellular and molecular underpinnings of cancer-related fatigue (CRF) have not ...

Abstract	Background: Fatigue is a common side effect of cancer and its treatment and is thought to be driven in part by activation of the proinflammatory cytokine network. However, the cellular and molecular underpinnings of cancer-related fatigue (CRF) have not been determined, nor have immune pathways beyond inflammation been carefully investigated. The goal of this study was to examine the association between CRF and activation of canonical proinflammatory gene regulation pathways and Type I interferon (IFN) signaling pathways in breast cancer patients during and after treatment. Methods: Women diagnosed with early-stage breast cancer (n = 181) completed assessments before and after treatment with radiation and/or chemotherapy and at 6, 12, and 18-month post-treatment follow-ups. Assessments included self-reported fatigue (Multidimensional Fatigue Symptom Inventory - Short Form) and expression of pre-specified sets of Type I IFN and pro-inflammatory immune response genes determined from mRNA sequencing of PBMCs. Mixed effect linear models examined changes in fatigue and immune gene expression over time and tested the hypothesis that fatigue would be associated with increased expression of Type I IFN and inflammatory response genes. Results: There were significant changes in fatigue and immune gene expression across the assessment period; all measures increased from pre- to post-treatment but showed diverging patterns over the follow-up, with declines in fatigue and persistent elevations in Type I IFN and proinflammatory gene expression. In mixed effect linear models, expression of Type I IFN response genes was elevated in association with fatigue across the assessment period, from pre-treatment to 18-month follow-up. In contrast, pro-inflammatory gene expression was associated with fatigue only at 6, 12, and 18-month follow-ups. Analyses controlling for changes in leukocyte subsets continued to show a significant association between fatigue and Type I IFN gene expression but reduced the time-dependent association with pro-inflammatory gene expression to non-significant. Conclusions: Results revealed unexpected complexity in the immune underpinnings of CRF and identify a novel role for IFN signaling as a robust contributor to this symptom before, during, and after treatment. Pro-inflammatory gene expression emerged as a predictor of fatigue later in the cancer trajectory, and that effect was primarily accounted for by a concurrent increase in monocyte prevalence.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/complications ; Interferon Type I ; RNA ; Fatigue/genetics ; Inflammation/complications
Chemical Substances	Interferon Type I ; RNA (63231-63-0)
Language	English
Publishing date	2024-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2024.02.003
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations.

Sepúlveda-Loyola, W / Rodríguez-Sánchez, I / Pérez-Rodríguez, P / Ganz, F / Torralba, R / Oliveira, D V / Rodríguez-Mañas, L

The journal of nutrition, health & aging

2020 Volume 24, Issue 9, Page(s) 938–947

Abstract: Objectives: To review the impact of social isolation during COVID-19 pandemic on mental and physical health of older people and the recommendations for patients, caregivers and health professionals.: Design: Narrative review.: Setting: Non- ... ...

Abstract	Objectives: To review the impact of social isolation during COVID-19 pandemic on mental and physical health of older people and the recommendations for patients, caregivers and health professionals. Design: Narrative review. Setting: Non-institutionalized community-living people. Participants: 20.069 individuals from ten descriptive cross-sectional papers. Measurements: Articles since 2019 to 2020 published on Pubmed, Scielo and Google Scholar databases with the following MeSh terms ('COVID-19', 'coronavirus', 'aging', 'older people', 'elderly', 'social isolation' and 'quarantine') in English, Spanish or Portuguese were included. The studies not including people over 60 were excluded. Guidelines, recommendations, and update documents from different international organizations related to mental and physical activity were also analysed. Results: 41 documents have been included in this narrative review, involving a total of 20.069 individuals (58% women), from Asia, Europe and America. 31 articles included recommendations and 10 addressed the impact of social distancing on mental or physical health. The main outcomes reported were anxiety, depression, poor sleep quality and physical inactivity during the isolation period. Cognitive strategies and increasing physical activity levels using apps, online videos, telehealth, are the main international recommendations. Conclusion: Mental and physical health in older people are negatively affected during the social distancing for COVID-19. Therefore, a multicomponent program with exercise and psychological strategies are highly recommended for this population during the confinement. Future investigations are necessary in this field.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Americas ; Anxiety/etiology ; Asia ; COVID-19/epidemiology ; Cross-Sectional Studies ; Depression/etiology ; Europe ; Exercise ; Female ; Humans ; Male ; Mental Disorders/etiology ; Middle Aged ; Pandemics ; Quarantine ; SARS-CoV-2 ; Sedentary Behavior ; Sleep Wake Disorders/etiology ; Social Isolation/psychology
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-020-1500-7
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Article ; Online: Cerner Millennium's Care Pathways for Specialty Care Referrals: Provider and Nurse Experiences, Perceptions, and Recommendations for Improvements.

Cordasco, Kristina M / Gable, Alicia R / Ganz, David A / Brunner, Julian W / Smith, Anita J / Hertz, Brian / Post, Edward P / Fix, Gemmae M

Journal of general internal medicine

2023 Volume 38, Issue Suppl 4, Page(s) 1007–1014

Abstract: Background: Using structured templates to guide providers in communicating key information in electronic referrals is an evidence-based practice for improving care quality. To facilitate referrals in Veterans Health Administration's (VA) Cerner ... ...

Abstract	Background: Using structured templates to guide providers in communicating key information in electronic referrals is an evidence-based practice for improving care quality. To facilitate referrals in Veterans Health Administration's (VA) Cerner Millennium electronic health record, VA and Cerner have created "Care Pathways"-templated electronic forms, capturing needed information and prompting ordering of appropriate pre-referral tests. Objective: To inform their iterative improvement, we sought to elicit experiences, perceptions, and recommendations regarding Care Pathways from frontline clinicians and staff in the first VA site to deploy Cerner Millennium. Design: Qualitative interviews, conducted 12-20 months after Cerner Millennium deployment. Participants: We conducted interviews with primary care providers, primary care registered nurses, and specialty providers requesting and/or receiving referrals. Approach: We used rapid qualitative analysis. Two researchers independently summarized interview transcripts with bullet points; summaries were merged by consensus. Constant comparison was used to sort bullet points into themes. A matrix was used to view bullet points by theme and participant. Results: Some interviewees liked aspects of the Care Pathways, expressing appreciation of their premise and logic. However, interviewees commonly expressed frustration with their poor usability across multiple attributes. Care Pathways were reported as being inefficient; lacking simplicity, naturalness, consistency, and effective use of language; imposing an unacceptable cognitive load; and not employing forgiveness and feedback for errors. Specialists reported not receiving the information needed for referral triaging. Conclusions: Cerner Millennium's Care Pathways, and their associated organizational policies and processes, need substantial revision across several usability attributes. Problems with design and technical limitations are compounding challenges in using standardized templates nationally, across VA sites having diverse organizational and contextual characteristics. VA is actively working to make improvements; however, significant additional investments are needed for Care Pathways to achieve their intended purpose of optimizing specialty care referrals for Veterans.
MeSH term(s)	United States ; Humans ; United States Department of Veterans Affairs ; Critical Pathways ; Veterans Health ; Veterans/psychology ; Referral and Consultation
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-023-08285-2
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Article: Internal medicine-important advances in clinical medicine: streptokinase and acute myocardial infarction.

Ganz, W

The Western journal of medicine

2008 Volume 138, Issue 5, Page(s) 707–708

Language	English
Publishing date	2008-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	189235-6
ISSN	1476-2978 ; 0093-0415 ; 0008-1264
ISSN (online)	1476-2978
ISSN	0093-0415 ; 0008-1264
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Article ; Online: Swisher Sweets 'Artist Project': using musical events to promote cigars.

Ganz, Ollie / Rose, Shyanika W / Cantrell, Jennifer

Tobacco control

2018 Volume 27, Issue e1, Page(s) e93–e95

MeSH term(s)	Humans ; Marketing/methods ; Music ; Tobacco Industry/methods ; Tobacco Products
Language	English
Publishing date	2018-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1146554-2
ISSN	1468-3318 ; 0964-4563
ISSN (online)	1468-3318
ISSN	0964-4563
DOI	10.1136/tobaccocontrol-2017-054047
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Article ; Online: Psychosocial Resilience to Inflammation-Associated Depression: A Prospective Study of Breast-Cancer Survivors.

Manigault, Andrew W / Kuhlman, Kate R / Irwin, Michael R / Cole, Steve W / Ganz, Patricia A / Crespi, Catherine M / Bower, Julienne E

Psychological science

2022 Volume 33, Issue 8, Page(s) 1328–1339

Abstract: Stress can lead to depression, in part because of activation of inflammatory mechanisms. It is therefore critical to identify resilience factors that can buffer against these effects, but no research to date has evaluated whether psychosocial resilience ... ...

Abstract	Stress can lead to depression, in part because of activation of inflammatory mechanisms. It is therefore critical to identify resilience factors that can buffer against these effects, but no research to date has evaluated whether psychosocial resilience mitigates the effects of stress on inflammation-associated depressive symptoms. We therefore examined psychosocial resources known to buffer against stress in a longitudinal study of women with breast cancer (
MeSH term(s)	Breast Neoplasms/complications ; Breast Neoplasms/psychology ; Cancer Survivors/psychology ; Depression/psychology ; Female ; Humans ; Inflammation/complications ; Longitudinal Studies ; Prospective Studies
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2022256-7
ISSN	1467-9280 ; 0956-7976
ISSN (online)	1467-9280
ISSN	0956-7976
DOI	10.1177/09567976221079633
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Article ; Online: Proteomics of neurodegenerative diseases: analysis of human post-mortem brain.

Li, K W / Ganz, Andrea B / Smit, August B

Journal of neurochemistry

2018 Volume 151, Issue 4, Page(s) 435–445

Abstract: Dementias are prevalent brain disorders in the aged population. Dementias pose major socio-medical burden, but currently there is no cure available. Novel proteomics approaches hold promise to identify alterations of the brain proteome that could provide ...

Abstract	Dementias are prevalent brain disorders in the aged population. Dementias pose major socio-medical burden, but currently there is no cure available. Novel proteomics approaches hold promise to identify alterations of the brain proteome that could provide clues on disease etiology, and identify candidate proteins to develop further as a biomarker. In this review, we focus on recent proteomics findings from brains affected with Alzheimer's Disease, Parkinson Disease Dementia, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis. These studies confirmed known cellular changes, and in addition identified novel proteins that may underlie distinct aspects of the diseases. This article is part of the special issue "Proteomics".
MeSH term(s)	Alzheimer Disease/complications ; Alzheimer Disease/metabolism ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/metabolism ; Biomarkers/metabolism ; Brain/metabolism ; Dementia/complications ; Dementia/metabolism ; Disease Progression ; Frontotemporal Dementia/complications ; Frontotemporal Dementia/metabolism ; Humans ; Neurodegenerative Diseases/complications ; Neurodegenerative Diseases/metabolism ; Parkinson Disease/complications ; Parkinson Disease/metabolism ; Proteome/metabolism ; Proteomics
Chemical Substances	Biomarkers ; Proteome
Language	English
Publishing date	2018-11-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.14603
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