Article ; Online: Diuretic Use in Post-Kidney Transplant Patients: A Retrospective Chart Review.
2024 Volume 56, Issue 1, Page(s) 82–86
Abstract: ... to the no furosemide group at day 30 (56 ± 24 vs 71 ± 24 mL/min/1.73 m: Conclusions: Our results show ...
Abstract | Background: The occurrence of delayed graft function (DGF) significantly enhances the possibility of both acute and chronic rejection of the transplanted organ, thereby reducing patient quality of life and survival rates. To prevent and manage oliguria in renal transplant patients, loop diuretics are presently commonly used. In our study, we assessed the possible impact of furosemide on the incidence of DGF among kidney transplant recipients. Methods: A review of medical records was conducted to examine demographic characteristics and kidney transplant outcomes in an adult (older than 18 years old) population. The primary objective was to determine the incidence of delayed graft function (DGF), whereas the secondary objective was to compare the creatinine levels and estimated glomerular filtration rate (eGFR) at day 30 and day 90 post-transplantation in patients who were administered furosemide vs those who were not. Results: This study included 330 patients who underwent kidney transplantation. Furosemide was administered to 169 (51.3%), whereas 161(48.7%) patients did not receive continued dose of diuretic postoperatively. The rate of DGF was significantly higher in patients who received furosemide than in those who did not (furosemide 44% vs 4%; P < .001). The eGFR was lower in the furosemide group compared to the no furosemide group at day 30 (56 ± 24 vs 71 ± 24 mL/min/1.73 m Conclusions: Our results show that there is no benefit in treating an oliguric AKI with furosemide. Administration of furosemide, especially in high doses, may increase the risk of toxicity, delay dialysis, and increase the length of stay. |
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MeSH term(s) | Adolescent ; Adult ; Humans ; Delayed Graft Function/etiology ; Diuretics/adverse effects ; Furosemide/adverse effects ; Graft Rejection/etiology ; Graft Survival ; Kidney Transplantation/adverse effects ; Quality of Life ; Renal Dialysis/adverse effects ; Retrospective Studies ; Risk Factors |
Chemical Substances | Diuretics ; Furosemide (7LXU5N7ZO5) |
Language | English |
Publishing date | 2024-01-10 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 82046-5 |
ISSN | 1873-2623 ; 0041-1345 |
ISSN (online) | 1873-2623 |
ISSN | 0041-1345 |
DOI | 10.1016/j.transproceed.2023.11.024 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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