Article ; Online: RNA stability controlled by m
Nature structural & molecular biology
2023 Volume 30, Issue 8, Page(s) 1207–1215
Abstract: ... are still under debate. Here we show that X-chromosomal transcripts have fewer m ...
| Abstract | In mammals, X-chromosomal genes are expressed from a single copy since males (XY) possess a single X chromosome, while females (XX) undergo X inactivation. To compensate for this reduction in dosage compared with two active copies of autosomes, it has been proposed that genes from the active X chromosome exhibit dosage compensation. However, the existence and mechanisms of X-to-autosome dosage compensation are still under debate. Here we show that X-chromosomal transcripts have fewer m |
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| MeSH term(s) | Male ; Female ; Animals ; Mice ; Methylation ; Dosage Compensation, Genetic ; X Chromosome/genetics ; Mammals/genetics ; RNA Stability |
| Language | English |
| Publishing date | 2023-05-18 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2126708-X |
| ISSN | 1545-9985 ; 1545-9993 |
| ISSN (online) | 1545-9985 |
| ISSN | 1545-9993 |
| DOI | 10.1038/s41594-023-00997-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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