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  1. Article: Assessing a Video-Based Intervention to Promote Parent Communication Strategies with a Deaf Infant: A Feasibility and Acceptability Study.

    Kelly, Ciara / Crawford, Ellen / Morgan, Gary / Matthews, Danielle

    Journal of clinical medicine

    2022  Volume 11, Issue 18

    Abstract: Infant-parent interaction forms the foundation for language learning. For the majority of deaf infants, hearing loss can impact access to, and the quality of communicative interactions, placing language development at risk. Support for families to meet ... ...

    Abstract Infant-parent interaction forms the foundation for language learning. For the majority of deaf infants, hearing loss can impact access to, and the quality of communicative interactions, placing language development at risk. Support for families to meet the challenges faced during interaction is highly variable in the United Kingdom. In a step towards more standardized but tailorable family support, we co-produced an instructional, video-based intervention, testing for feasibility in terms of behavior change in seven communicative strategies and acceptability with 9 parents, forming study 1. Parents increased their use of the majority of behaviors and found content and delivery acceptable. However, further development was required to: (a) support use of semantically contingent talk and attention getting strategies to elicit infant attention, and (b) ensure the information was provided in a bite-size format that could be tailored to individual families. In study 2, the intervention was refined based on findings from study 1 and assessed for acceptability with 9 parents and 17 professionals, who reported similar high acceptability scores. Final refinements and modifications could be addressed in future interventions. The current studies provide a positive early step towards a standardized intervention to support communication that could be used in routine practice.
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11185272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expression and distribution of synaptotagmin family members in the zebrafish retina.

    Henry, Diane / Joselevitch, Christina / Matthews, Gary G / Wollmuth, Lonnie P

    The Journal of comparative neurology

    2021  Volume 530, Issue 4, Page(s) 705–728

    Abstract: Synaptotagmins belong to a large family of proteins. Although various synaptotagmins have been implicated as ... ...

    Abstract Synaptotagmins belong to a large family of proteins. Although various synaptotagmins have been implicated as Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium-Binding Proteins/metabolism ; Exocytosis/physiology ; Retina/metabolism ; Synapses/metabolism ; Synaptotagmin I/genetics ; Synaptotagmin I/metabolism ; Zebrafish/metabolism
    Chemical Substances Calcium-Binding Proteins ; Synaptotagmin I ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.25238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.66: Show issues Location:
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  3. Book: Cellular physiology of nerve and muscle

    Matthews, Gary G.

    1991  

    Author's details Gary G. Matthews
    Keywords Cell Membrane / physiology ; Membrane Potentials ; Muscles / physiology ; Synaptic Transmission ; Neurons / physiology
    Size XIII, 226 S. : Ill., graph. Darst.
    Edition 2. ed., 1. [Dr.]
    Publisher Blackwell
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003988706
    ISBN 0-86542-159-5 ; 978-0-86542-159-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1992 A 514 order for loan Magazin

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  4. Article ; Online: Cardiovascular health of patients with cancer: challenges abound.

    Chan, Jeffrey Shi Kai / Chan, Raymond Ngai Chiu / Lee, Yan Hiu Athena / Satti, Danish Iltaf / Dee, Edward Christopher / Ng, Kenrick / Achim, Alexandru / Ng, Chi Fai / Liu, Tong / Matthews, Gareth D K / Tse, Gary / Vassiliou, Vassilios S

    Trends in cardiovascular medicine

    2024  

    Abstract: Patients with cancer have elevated cardiovascular risks compared to those without cancer. As cancer incidence increases and cancer-related mortality decreases, cardiovascular diseases in patients with a history of cancer will become increasingly ... ...

    Abstract Patients with cancer have elevated cardiovascular risks compared to those without cancer. As cancer incidence increases and cancer-related mortality decreases, cardiovascular diseases in patients with a history of cancer will become increasingly important. This in turn is reflected by the exponentially increasing amount of cardio-oncology research in recent years. This narrative review aims to summarize the key existing literature in several main areas of cardio-oncology, including the epidemiology, natural history, prevention, management, and determinants of the cardiovascular health of patients with cancer, and identify relevant gaps in evidence for further research.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2024.04.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3419: Show issues Location:
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  5. Article: Meeting Texas Nursing Workforce Needs Through Recruitment and Retention Initiatives.

    Gary, Jodie C / Gosselin, Kevin / Mulcahy, Abigail / Wise Matthews, Debra

    Nursing education perspectives

    2019  Volume 40, Issue 6, Page(s) 355–357

    Abstract: Evidence demonstrates health inequities can be ameliorated by a workforce whose diversity reflects the population served. The diversity of the Texas nursing workforce, however, is not reflective of the Texas population. This article reports on a project ... ...

    Abstract Evidence demonstrates health inequities can be ameliorated by a workforce whose diversity reflects the population served. The diversity of the Texas nursing workforce, however, is not reflective of the Texas population. This article reports on a project to recruit and retain minority nurses in Texas. The project goals were to improve enrollment for minority students, specifically Hispanic students, in an online South Texas baccalaureate nursing program (traditional BSN, second-degree BSN, and RN to BSN); facilitate student success; and promote student satisfaction. These goals were successfully achieved at one academic institution.
    MeSH term(s) Education, Distance ; Education, Nursing, Baccalaureate/organization & administration ; Health Workforce/organization & administration ; Hispanic Americans/statistics & numerical data ; Humans ; Minority Groups/statistics & numerical data ; Nursing Education Research ; Nursing Evaluation Research ; Nursing Staff/statistics & numerical data ; Personnel Selection ; Students, Nursing/psychology ; Students, Nursing/statistics & numerical data ; Texas
    Language English
    Publishing date 2019-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2075410-3
    ISSN 1943-4685 ; 1536-5026
    ISSN (online) 1943-4685
    ISSN 1536-5026
    DOI 10.1097/01.NEP.0000000000000452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3023: Show issues Location:
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  6. Article: Antimicrobial activity of bovine lactoferrin against

    Pino, Alessandra / Mazza, Tommaso / Matthews, Maura-Ann H / Castellana, Stefano / Caggia, Cinzia / Randazzo, Cinzia L / Gelbfish, Gary A

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1000822

    Abstract: ... ...

    Abstract Gardnerella
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1000822
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  7. Article ; Online: Unexpected shock in a fallen older adult: a case report.

    Matthews, Gary / Booth, Helen / Whitley, Gregory Adam

    British paramedic journal

    2020  Volume 5, Issue 1, Page(s) 15–19

    Abstract: Introduction: Falls are common in older adults and frequently require ambulance service assistance. They are the most frequent cause of injury and associated morbidity and mortality in older adults. In recent years, the typical major trauma patient has ... ...

    Abstract Introduction: Falls are common in older adults and frequently require ambulance service assistance. They are the most frequent cause of injury and associated morbidity and mortality in older adults. In recent years, the typical major trauma patient has changed from being young and male to being older in age, with falls of < 2 metres being the most common mechanism of injury. We present a case of an 84-year-old male who had fallen in his home. This case highlights the complex nature of a relatively common incident.
    Case presentation: The patient was laid on the floor in the prone position unable to move for 12 hours. He did not complain of any pain in his neck, back, hips or legs, and wished to be lifted off the floor promptly. On examination, he had bruising to his chest and abdomen and had suffered a suspected cervical spine injury due to a step-like protrusion around C5-C6. Distal sensory and motor function was intact. While in the ambulance his blood pressure dropped from 154/119 mmHg to 49/28 mmHg unexpectedly. We successfully reversed the shock using the modified Trendelenburg position and intravenous fluids. On follow-up he was diagnosed with dislocated C3, C6 and C7 vertebrae.
    Conclusion: The unexpected episode of shock witnessed in this patient may have been caused by a number of phenomena, including but not limited to crush syndrome, spinal cord concussion and orthostatic hypotension. We recommend that clinicians anticipate sudden shock in older adult patients who have fallen and a) have remained static on the floor for an extended period of time or b) are suspected of a spinal injury. We recommend assertive management of these patients to mitigate the impact of shock through postural positioning and consideration of early cannulation.
    Language English
    Publishing date 2020-12-30
    Publishing country England
    Document type Case Reports
    ISSN 1478-4726
    ISSN (online) 1478-4726
    DOI 10.29045/14784726.2020.06.5.1.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Early Pragmatics in Deaf and Hard of Hearing Infants.

    Kelly, Ciara / Morgan, Gary / Bannard, Colin / Matthews, Danielle

    Pediatrics

    2020  Volume 146, Issue Suppl 3, Page(s) S262–S269

    Abstract: Background and objectives: A set of important pragmatic skills emerge during infancy and pave the way for later language learning. It is thought these early social communication skills develop through infant-caregiver interaction. In a microanalysis, we ...

    Abstract Background and objectives: A set of important pragmatic skills emerge during infancy and pave the way for later language learning. It is thought these early social communication skills develop through infant-caregiver interaction. In a microanalysis, we tested whether deaf and hard of hearing (DHH) infants (typically at high risk of reduced access to rich communicative interaction in infancy) are less likely to engage in gestural and vocal pragmatic behaviors.
    Methods: We coded the naturalistic communication of 8 DHH infants who had no additional needs, who were not preterm or low birth weight, whose parents were hearing, monolingual English speakers, and who had spoken English as their primary target language. The frequency of use of 5 types of infant communication known to positively predict later language development (show gestures, give gestures, index-finger pointing, communicative vocalizations, and early word use) was compared with that of 8 typically hearing infants matched for age, sex, and socioeconomic status.
    Results: Hearing loss had a significant negative effect on the frequency with which infants engaged in all types of early communication that predict later language development.
    Conclusions: DHH infants are at high risk of delay in the gestural and vocal communicative skills that lay the foundations for later language. Delay in the gestural domain suggests this is not simply a consequence of difficulties in imitating auditory stimuli. There is significant potential to lift DHH infants onto a positive developmental trajectory by supporting caregivers to nurture interaction from the first year.
    MeSH term(s) Child Language ; Deafness/psychology ; Humans ; Infant ; Nonverbal Communication ; Parent-Child Relations ; Persons With Hearing Impairments/psychology ; Social Interaction ; Social Skills ; Verbal Behavior
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-0242E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 357: Show issues

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  9. Article: Role of Ribeye PXDLS/T-binding cleft in normal synaptic ribbon function.

    Zhu, Jie / Lv, Caixia / Henry, Diane / Viviano, Stephen / Santos-Sacchi, Joseph / Matthews, Gary / Zenisek, David

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Non-spiking sensory hair cells of the auditory and vestibular systems encode a dynamic range of graded signals with high fidelity by vesicle exocytosis at ribbon synapses. Ribeye, the most abundant protein in the synaptic ribbon, is composed of a unique ... ...

    Abstract Non-spiking sensory hair cells of the auditory and vestibular systems encode a dynamic range of graded signals with high fidelity by vesicle exocytosis at ribbon synapses. Ribeye, the most abundant protein in the synaptic ribbon, is composed of a unique A domain specific for ribbons and a B-domain nearly identical to the transcriptional corepressor CtBP2. CTBP2 and the B-domain of Ribeye contain a surface cleft that binds to proteins harboring a PXDLS/T peptide motif. Little is known about the importance of this binding site in synaptic function. Piccolo has a well-conserved PVDLT motif and we find that overexpressed Ribeye exhibits striking co-localization with Piccolo in INS-cells, while two separate mutants containing mutations in PXDLS/T-binding region, fail to co-localize with Piccolo. Similarly, co-transfected Ribeye and a piccolo fragment containing the PVDLT region co-localize in HEK cells. Expression of wild-type Ribeye-YFP in zebrafish neuromast hair cells returns electron densities to ribbon structures and mostly rescued normal synaptic transmission and morphological phenotypes in a mutant zebrafish lacking most Ribeye. By contrast, Ribeye-YFP harboring a mutation in the PXDLS/T-binding cleft resulted in ectopic electron dense aggregates that did not collect vesicles and the persistence of ribbons lacking electron densities. Furthermore, overexpression failed to return capacitance responses to normal levels. These results point toward a role for the PXDLS/T-binding cleft in the recruitment of Ribeye to ribbons and in normal synaptic function.
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.12.571266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Dynamics of synaptic vesicle trafficking at the active zone of ribbon synapses

    Matthews, Gary G

    (NIH neuroscience series seminar)

    2016  

    Abstract: CIT): NIH Neuroscience Series Seminar The research in Dr. Matthews' laboratory is concerned ...

    Institution National Institutes of Health (U.S.),
    Author's details Gary G. Matthews
    Series title NIH neuroscience series seminar
    Abstract (CIT): NIH Neuroscience Series Seminar The research in Dr. Matthews' laboratory is concerned with how neurons communicate. One focus of their work is the synaptic vesicle cycle, the process of exocytosis and endocytosis that mediates chemical neurotransmission. To study the regulation of synaptic exocytosis and endocytosis, they use electrophysiological assays, such as capacitance measurements, together with a variety of imaging techniques, including calcium imaging, confocal microscopy, evanescent field microscopy, and electron microscopy.
    MeSH term(s) Synaptic Transmission/physiology ; Synaptic Vesicles/physiology
    Language English
    Size 1 online resource (1 streaming video file (1 hr., 10 min.)) :, color, sound.
    Document type Book
    Note Closed-captioned.
    Database Catalogue of the US National Library of Medicine (NLM)

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