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  1. Article: Proyecciones de impacto de la pandemia COVID-19 en la población colombiana, según medidas de mitigación. Datos preliminares de modelos epidemiológicos para el periodo del 18 de marzo al 18 de abril de 2020.

    González-Jaramillo, Valentina / González-Jaramillo, Nathalia / Gómez-Restrepo, Carlos / Palacio-Acosta, Carlos A / Gómez-López, Arley / Franco, Oscar H

    Revista de salud publica (Bogota, Colombia)

    2023  Volume 22, Issue 2, Page(s) 117–122

    Abstract: Introduction: First case of COVID-19 in Colombia was diagnosed on March 6th. Two weeks later, cases have rapidly increased, leading the government to establish some mitigation measures.: Objectives: The first objective is to estimate and model the ... ...

    Title translation Impact of the COVID-19 pandemic on the Colombian population according to mitigation measures. Preliminary data from epidemiological models for the period March 18 to April 18, 2020.
    Abstract Introduction: First case of COVID-19 in Colombia was diagnosed on March 6th. Two weeks later, cases have rapidly increased, leading the government to establish some mitigation measures.
    Objectives: The first objective is to estimate and model the number of cases, use of hospital resources and mortality by using different R0 scenarios in a 1-month scenario (from March 18 to April 18, 2020), based on the different isolation measures applied. This work also aims to model, without establishing a time horizon, the same outcomes given the assumption that eventually 70% of the population will be infected.
    Materials and methods: Data on the number of confirmed cases in the country as of March 18, 2020 (n=93) were taken as the basis for the achievement of the first objective. An initial transmission rate of R0= 2.5 and a factor of 27 for undetected infections per each confirmed case were taken as assumptions for the model. The proportion of patients who may need intensive care or other in-hospital care was based on data from the Imperial College of London. On the other hand, an age-specific mortality rate provided by the Instituto Superiore di Sanità in Italy was used for the second objective.
    Results: Based on the 93 cases reported as of March 18, if no mitigation measures were applied, by April 18, the country would have 613 037 cases. Mitigation measures that reduce R0 by 10% generate a 50% reduction in the number of cases. However, despite halving the number of cases, there would still be a shortfall in the number of beds required and only one in two patients would have access to this resource.
    Conclusion: This model found that the mitigation measures implemented to date by the Colombian government and analyzed in this article are based on sufficient evidence and will help to slow the spread of SARS-CoV-2 in Colombia. Although a time horizon of one month was used for this model, it is plausible to believe that, if the current measures are sustained, the mitigation effect will also be sustained over time.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Colombia/epidemiology ; Pandemics/prevention & control ; Epidemiological Models ; Preliminary Data
    Language Spanish
    Publishing date 2023-01-18
    Publishing country Colombia
    Document type English Abstract ; Journal Article
    ZDB-ID 2060572-9
    ISSN 0124-0064
    ISSN 0124-0064
    DOI 10.15446/rsap.V22n2.85789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The 'Surprise question' in heart failure: a prospective cohort study.

    Gonzalez-Jaramillo, Valentina / Arenas Ochoa, Luisa Fernanda / Saldarriaga, Clara / Krikorian, Alicia / Vargas, John Jairo / Gonzalez-Jaramillo, Nathalia / Eychmüller, Steffen / Maessen, Maud

    BMJ supportive & palliative care

    2024  Volume 14, Issue 1, Page(s) 68–75

    Abstract: Objective: The Surprise Question (SQ) is a prognostic screening tool used to identify patients with limited life expectancy. We assessed the SQ's performance predicting 1-year mortality among patients in ambulatory heart failure (HF) clinics. We ... ...

    Abstract Objective: The Surprise Question (SQ) is a prognostic screening tool used to identify patients with limited life expectancy. We assessed the SQ's performance predicting 1-year mortality among patients in ambulatory heart failure (HF) clinics. We determined that the SQ's performance changes according to sex and other demographic (age) and clinical characteristics, mainly left ventricular ejection fraction (LVEF) and the New York Heart Association (NYHA) functional classifications.
    Methods: We conducted a prospective cohort study in two HF clinics. To assess the performance of the SQ in predicting 1-year mortality, we calculated the sensitivity, specificity, positive and negative likelihood ratios, and the positive and negative predictive values. To illustrate if the results of the SQ changes the probability that a patient dies within 1 year, we created Fagan's nomograms. We report the results from the overall sample and for subgroups according to sex, age, LVEF and NYHA functional class.
    Results: We observed that the SQ showed a sensitivity of 85% identifying ambulatory patients with HF who are in the last year of life. We determined that the SQ's performance predicting 1-year mortality was similar among women and men. The SQ performed better for patients aged under 70 years, for patients with reduced or mildly reduced ejection fraction, and for patients NYHA class III/IV.
    Conclusions: We consider the tool an easy and fast first step to identify patients with HF who might benefit from an advance care planning discussion or a referral to palliative care due to limited life expectancy.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Stroke Volume ; Prospective Studies ; Ventricular Function, Left ; Heart Failure/diagnosis ; Palliative Care/methods ; Prognosis
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/bmjspcare-2021-003143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Outcomes of care during the last month of life: a systematic review to inform the development of a core outcome set.

    González-Jaramillo, Valentina / Luethi, Nora / Egloff, Martina / Roa-Díaz, Zayne M / González-Jaramillo, Nathalia / Díaz-Ríos, Catalina / Rosero, Andri Christen-Cevallos / Dodd, Susanna / Eychmüller, Steffen / Zambrano, Sofía C

    Annals of palliative medicine

    2024  

    Abstract: Background: To date, there is a lack of standardization and consensus on which outcomes are central to assess the care provided to patients in the last month of life. Therefore, we aimed to conduct a systematic review to identify relevant outcomes to ... ...

    Abstract Background: To date, there is a lack of standardization and consensus on which outcomes are central to assess the care provided to patients in the last month of life. Therefore, we aimed to conduct a systematic review to identify relevant outcomes to inform the development of a core outcome set for the best care for the dying person.
    Methods: We conducted a systematic review of outcomes reported in the scientific literature about the care for the dying person in the last month of life. We searched for peer-reviewed studies published before February 2022 in four electronic databases. To categorise the outcomes, we employed the taxonomy developed by the "Core Outcome Measures in Effectiveness Trials" collaboration.
    Results: Out of the 2,933 articles retrieved, 619 were included for analyses. The majority of studies (71%) were retrospective and with data extracted from chart reviews (71%) . We extracted 1,951 outcomes in total, from which, after deletion of repeated outcomes, we identified 256 unique ones. The most frequently assessed outcomes were those related to medication or therapeutic interventions and those to hospital/ healthcare use. Outcomes related to psychosocial wellbeing were rarely assessed. The closer to death, the less frequently the outcomes were studied.
    Conclusions: Most outcomes were related to medical interventions or to hospital use. Only a few studies focused on other components of integrated care such as psychosocial aspects. It remains to be defined which of these outcomes are fundamental to achieve the best care for the dying.
    Language English
    Publishing date 2024-03-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-23-435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 vaccine acceptance in the general population and under-resourced communities from high-income countries: realist review.

    Gonzalez-Jaramillo, Nathalia / Abbühl, Dominik / Roa-Díaz, Zayne Milena / Kobler-Betancourt, Cristopher / Frahsa, Annika

    BMJ open

    2024  Volume 14, Issue 4, Page(s) e084560

    Abstract: Objective: To compare vaccination willingness before rollout and 1 year post-rollout uptake among the general population and under-resourced communities in high-income countries.: Design: A realist review.: Data sources: Embase, PubMed, Dimensions ...

    Abstract Objective: To compare vaccination willingness before rollout and 1 year post-rollout uptake among the general population and under-resourced communities in high-income countries.
    Design: A realist review.
    Data sources: Embase, PubMed, Dimensions ai and Google Scholar.
    Setting: High-income countries.
    Definitions: We defined
    Results: We included data from 62 studies and 18 high-income countries. For studies conducted among general populations, the proportion of vaccination willingness was 67% (95% CI 62% to 72%). In real-world settings, the overall proportion of vaccine uptake among those countries was 73% (95% CI 69% to 76%). 17 studies reported pre-rollout willingness for under-resourced communities. The summary proportion of vaccination willingness from studies reporting results among people from under-resourced communities was 52% (95% CI 0.46% to 0.57%). Real-world evidence about vaccine uptake after rollout among under-resourced communities was limited.
    Conclusion: Our review emphasises the importance of realist reviews for assessing vaccine acceptance. Limited real-world evidence about vaccine uptake among under-resourced communities in high-income countries is a call to context-specific actions and reporting.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Developed Countries ; COVID-19 ; Vaccination ; Income
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2024-084560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Impacto de diferentes medidas de mitigación en el curso de la pandemia de COVID-19 en Chile: proyección preliminar para el período del 14 de abril al 14 de mayo.

    Ochoa-Rosales, Carolina / González-Jaramillo, Nathalia / Vera-Calzaretta, Aldo / Franco, Oscar H

    Revista de salud publica (Bogota, Colombia)

    2023  Volume 22, Issue 2, Page(s) 144–149

    Abstract: Objetive: To model disease progression, healthcare demand and case fatality rate attributed to COVID-19 pandemic that may occur in Chile in 1-month time, by simulating different scenarios according to diverse mitigation measures hypothetically ... ...

    Title translation Impact of mitigation measures on the COVID-19 pandemic in Chile: preliminary data for the period April 14 to May 14.
    Abstract Objetive: To model disease progression, healthcare demand and case fatality rate attributed to COVID-19 pandemic that may occur in Chile in 1-month time, by simulating different scenarios according to diverse mitigation measures hypothetically implemented. Furthermore, we aimed to estimate the same outcomes assuming that 70% of the population will be infected by SARS-CoV-2, with no time limit assumption.
    Methods: We based on the number of confirmed COVID-19 cases in Chile up to April 14th 2020 (8 273 cases and 94 deaths). For the simulated scenarios we assumed basic reproduction numbers ranging from R0=2.5 to R0=1.5. The estimation of the number of patients that would require intensive care and the age-specific case fatality rate were based on data provided by the Imperial College of London and the Instituto Superiore di Sanità en Italia.
    Results: If no mitigation measures were applied (R0=2.5), by May 25, Chile would have 2 019 775 cases and 15 068 deaths. If mitigations measures were implemented to decrease R0 to 1.5 (early detection of cases, quarantine, social distancing of elderly), the number of cases and deaths would importantly decrease. Nonetheless, the demand for in-hospital care including intensive care would exceed the available resources. Our age-specific analysis showed that population over 60 years are at higher risk of needing intensive care and death.
    Conclusion: Our evidence supports the mitigation measures implemented by the Chilean government. Nevertheless, more stringent measures are needed to prevent the health care system's collapse due to shortfall of resources to confront the COVID-19 pandemic.
    MeSH term(s) Humans ; Aged ; Middle Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Chile/epidemiology ; Pandemics/prevention & control ; Preliminary Data
    Language Spanish
    Publishing date 2023-02-01
    Publishing country Colombia
    Document type English Abstract ; Journal Article
    ZDB-ID 2060572-9
    ISSN 0124-0064
    ISSN 0124-0064
    DOI 10.15446/rsap.V22n2.86380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In lifestyle and prevention, the whole is surely greater than the sum of its parts.

    Gonzalez-Jaramillo, Nathalia / Bano, Arjola / Franco, Oscar H

    European journal of preventive cardiology

    2022  Volume 29, Issue 12, Page(s) 1615–1617

    MeSH term(s) Adult ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Cohort Studies ; Coronary Disease/prevention & control ; Exercise ; Humans ; Life Style
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwac086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 130/80 is the new 140/90: Do we need a tailored approach for older patients?

    Gonzalez-Jaramillo, Nathalia / Bano, Arjola

    European journal of preventive cardiology

    2019  Volume 27, Issue 4, Page(s) 343–344

    MeSH term(s) Blood Pressure ; China ; Health Behavior ; Health Promotion ; Humans ; Prospective Studies
    Language English
    Publishing date 2019-08-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1177/2047487319868539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The double burden of disease of COVID-19 in cardiovascular patients: overlapping conditions could lead to overlapping treatments.

    Gonzalez-Jaramillo, Nathalia / Low, Nicola / Franco, Oscar H

    European journal of epidemiology

    2020  Volume 35, Issue 4, Page(s) 335–337

    MeSH term(s) COVID-19 ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-020-00628-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Time-Dependent Effect of Anthracycline-Based Chemotherapy on Central Arterial Stiffness: A Systematic Review and Meta-Analysis.

    Schneider, Caroline / González-Jaramillo, Nathalia / Marcin, Thimo / Campbell, Kristin L / Suter, Thomas / Bano, Arjola / Wilhelm, Matthias / Eser, Prisca

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 873898

    Abstract: Background and aims: Anthracycline-based chemotherapy (ANTH-BC) has been proposed to increase arterial stiffness, however, the time-dependency of these effects remain unclear. This systematic review and meta-analysis aimed to investigate the time- ... ...

    Abstract Background and aims: Anthracycline-based chemotherapy (ANTH-BC) has been proposed to increase arterial stiffness, however, the time-dependency of these effects remain unclear. This systematic review and meta-analysis aimed to investigate the time-dependent effect of ANTH-BC on markers of central aortic stiffness, namely aortic distensibility (AD) and pulse-wave-velocity (PWV) in cancer patients.
    Methods: An extensive literature search without language restrictions was performed to identify all studies presenting longitudinal data on the effect of ANTH-BC on either AD and/or central PWV in cancer patients of all ages. An inverse-variance weighted random-effect model was performed with differences from before to after chemotherapy, as well as for short vs. mid-term effects.
    Results: Of 2,130 articles identified, 9 observational studies with a total of 535 patients (mean age 52 ± 11; 73% women) were included, of which four studies measured AD and seven PWV. Short-term (2-4 months), there was a clinically meaningful increase in arterial stiffness, namely an increase in PWV of 2.05 m/s (95% CI 0.68-3.43) and a decrease in AD (albeit non-significant) of -1.49 mmHg-1 (-3.25 to 0.27) but a smaller effect was observed mid-term (6-12 months) for PWV of 0.88 m/s (-0.25 to 2.02) and AD of -0.37 mmHg-1 (-1.13 to 0.39). There was considerable heterogeneity among the studies.
    Conclusions: Results from this analysis suggest that in the short-term, ANTH-BC increases arterial stiffness, but that these changes may partly be reversible after therapy termination. Future studies need to elucidate the long-term consequences of ANTH-BC on arterial stiffness, by performing repeated follow-up measurements after ANTH-BC termination.
    Systematic review registration: [www.crd.york.ac.uk/prospero/], identifier [CRD42019141837].
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.873898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impaired glucose metabolism: Time for sex-based medicine?

    Gonzalez-Jaramillo, Nathalia / Muka, Taulant / Bano, Arjola

    European journal of preventive cardiology

    2019  Volume 26, Issue 10, Page(s) 1077–1079

    MeSH term(s) Glucose ; Glucose Intolerance ; Glucose Tolerance Test ; Humans
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1177/2047487319843081
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