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  1. Article ; Online: Estudo anatômico do circuito arterial do encéfalo em Eira barbara – relato de dois casos.

    Breno Costa de Macedo / Érika Branco / Luiza Corrêa Pereira / Ana Rita de Lima

    Biotemas, Vol 27, Iss 2, Pp 177-

    2014  Volume 183

    Abstract: http://dx.doi.org/10.5007/2175-7925.2014v27n2p177 O Eira barbara é um mustelídeo de ampla ... e a composição do circuito arterial da base do encéfalo do E. barbara fornecendo dados para estudos futuros ...

    Abstract http://dx.doi.org/10.5007/2175-7925.2014v27n2p177 O Eira barbara é um mustelídeo de ampla distribuição na América latina vulgarmente conhecido como Papa-mel. Tendo em vista a carência de informações a respeito da anatomia dos mustelídeos, assim como a importância de um modelo vascular para a compreensão das lesões neurológicas no sistema nervoso central, este trabalho objetivou descrever a morfologia e a composição do circuito arterial da base do encéfalo do E. barbara fornecendo dados para estudos futuros. Para tal utilizou-se dois espécimes, machos, jovens, provenientes, da área de Mina Bauxita Paragominas-PA, doados após morte ao LaPMA. Os espécimes tiveram o sistema arterial preenchido com látex Neoprene 650 corado em vermelho e foram fixados em formaldeído 10% sendo posteriormente dissecados para sistematização dos vasos. Os animais estudados apresentaram o circuito arterial da base do encéfalo suprido pelas artérias carótidas internas e artéria basilar. A artéria carótida interna, após atravessar a dura-máter, continuou cranialmente emitindo as artérias cerebrais médias e terminando como artérias cerebrais craniais que se anastomosam fechando rostralmente o circuito arterial. As artérias comunicantes caudais integraram a artéria basilar ao circulo arterial e emitiram as artérias cerebrais caudais e cerebelares rostrais. A artéria basilar revelou como principais ramos, as artérias cerebelares médias e caudais.
    Keywords Círculo do Willis ; Eira Barbara ; Vascularização encefálica ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher Universidade Federal de Santa Catarina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Virus-Induced Epilepsy vs. Epilepsy Patients Acquiring Viral Infection: Unravelling the Complex Relationship for Precision Treatment.

    Costa, Bárbara / Vale, Nuno

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: The intricate relationship between viruses and epilepsy involves a bidirectional interaction. Certain viruses can induce epilepsy by infecting the brain, leading to inflammation, damage, or abnormal electrical activity. Conversely, epilepsy patients may ... ...

    Abstract The intricate relationship between viruses and epilepsy involves a bidirectional interaction. Certain viruses can induce epilepsy by infecting the brain, leading to inflammation, damage, or abnormal electrical activity. Conversely, epilepsy patients may be more susceptible to viral infections due to factors, such as compromised immune systems, anticonvulsant drugs, or surgical interventions. Neuroinflammation, a common factor in both scenarios, exhibits onset, duration, intensity, and consequence variations. It can modulate epileptogenesis, increase seizure susceptibility, and impact anticonvulsant drug pharmacokinetics, immune system function, and brain physiology. Viral infections significantly impact the clinical management of epilepsy patients, necessitating a multidisciplinary approach encompassing diagnosis, prevention, and treatment of both conditions. We delved into the dual dynamics of viruses inducing epilepsy and epilepsy patients acquiring viruses, examining the unique features of each case. For virus-induced epilepsy, we specify virus types, elucidate mechanisms of epilepsy induction, emphasize neuroinflammation's impact, and analyze its effects on anticonvulsant drug pharmacokinetics. Conversely, in epilepsy patients acquiring viruses, we detail the acquired virus, its interaction with existing epilepsy, neuroinflammation effects, and changes in anticonvulsant drug pharmacokinetics. Understanding this interplay advances precision therapies for epilepsy during viral infections, providing mechanistic insights, identifying biomarkers and therapeutic targets, and supporting optimized dosing regimens. However, further studies are crucial to validate tools, discover new biomarkers and therapeutic targets, and evaluate targeted therapy safety and efficacy in diverse epilepsy and viral infection scenarios.
    MeSH term(s) Humans ; Anticonvulsants/therapeutic use ; Neuroinflammatory Diseases ; Virus Diseases/complications ; Virus Diseases/drug therapy ; Epilepsy/drug therapy ; Epilepsy/etiology ; Viruses ; Biomarkers
    Chemical Substances Anticonvulsants ; Biomarkers
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Problemas de Historiografia Helenística

    Sebastiani, Breno Battistin / Jr, Fernando Rodrigues / Silva, Bárbara da Costa e

    2019  

    Abstract: Some of the texts gathered in this book were produced for the international event Hellenistic Historiography: new theoretical-methodological approaches, held at DLCV / FFLCH / USP and MAE / USP between September 15 and 16, 2016. Both the event and the ... ...

    Abstract Some of the texts gathered in this book were produced for the international event Hellenistic Historiography: new theoretical-methodological approaches, held at DLCV / FFLCH / USP and MAE / USP between September 15 and 16, 2016. Both the event and the book problematize by their formats, the very notion of Hellenism in which they are based: both take it in the broad chronological sense as proposed by Droysen in the Vorrede of 1836, that is, a period of antiquity which would extend approximately from the death of Alexander in 323 BC until the founding of Constantinople in 330 BC.
    Size 1 electronic resource (248 pages)
    Publisher Coimbra University Press
    Document type Book ; Online
    Note Hellenistic Historiography, Hellenism, Polybius ; Open Access
    HBZ-ID HT020589294
    ISBN 9789892617671 ; 9892617673
    DOI 10.14195/978-989-26-1768-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy.

    Costa, Bárbara / Vale, Nuno

    Pharmaceutics

    2023  Volume 15, Issue 1

    Abstract: The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and ... ...

    Abstract The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated. Immunological and viral processes interact in extremely complex and non-linear ways. For reliable analysis and quantitative forecasts that may be used to follow the immune system and create a disease profile for each patient, mathematical models are helpful in characterizing these non-linear interactions. To increase our ability to treat patients and identify individual differences in disease development, immune response profiling might be useful. Identifying which patients are moving from mild to severe disease would be more beneficial using immune system parameters. Prioritize treatments based on their inability to control the immune response and prevent T cell exhaustion. To increase treatment efficacy and spur additional research in this field, this review intends to provide examples of the effects of modelling immune response in viral infections, as well as the impact of pharmaceuticals on immune response.
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15010167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions.

    Costa, Bárbara / Vale, Nuno

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: This review investigates the intricate role of human endogenous retroviruses (HERVs) in cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper sheds light on the latest research advancements and potential treatment ... ...

    Abstract This review investigates the intricate role of human endogenous retroviruses (HERVs) in cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper sheds light on the latest research advancements and potential treatment strategies by examining the historical context of HERVs and their involvement in critical biological processes such as embryonic development, immune response, and disease progression. This review covers computational modeling for drug-target binding assessment, systems biology modeling for simulating HERV-K viral cargo dynamics, and using antiviral drugs to combat HERV-induced diseases. The findings presented in this review contribute to our understanding of HERV-mediated disease mechanisms and provide insights into future therapeutic approaches. They emphasize why HERV-K holds significant promise as a biomarker and a target.
    MeSH term(s) Humans ; Endogenous Retroviruses ; Neoplasms/virology ; Tumor Virus Infections/virology
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Understanding Lamotrigine's Role in the CNS and Possible Future Evolution.

    Costa, Bárbara / Vale, Nuno

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action in the central nervous system (CNS) still needs to be determined. ... ...

    Abstract The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action in the central nervous system (CNS) still needs to be determined. Recent studies have highlighted the involvement of LTG in modulating the activity of voltage-gated ion channels, particularly those related to the inhibition of neuronal excitability. Additionally, LTG has been found to have neuroprotective effects, potentially through the inhibition of glutamate release and the enhancement of GABAergic neurotransmission. LTG's unique mechanism of action compared to other anti-epileptic drugs has led to the investigation of its use in treating other CNS disorders, such as neuropathic pain, PTSD, and major depressive disorder. Furthermore, the drug has been combined with other anti-epileptic drugs and mood stabilizers, which may enhance its therapeutic effects. In conclusion, LTG's potential to modulate multiple neurotransmitters and ion channels in the CNS makes it a promising drug for treating various neurological disorders. As our understanding of its mechanism of action in the CNS continues to evolve, the potential for the drug to be used in new indications will also be explored.
    MeSH term(s) Humans ; Lamotrigine/therapeutic use ; Depressive Disorder, Major/drug therapy ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Epilepsy/drug therapy ; Central Nervous System ; Glutamic Acid ; Ion Channels ; Triazines/pharmacology ; Triazines/therapeutic use
    Chemical Substances Lamotrigine (U3H27498KS) ; Anticonvulsants ; Glutamic Acid (3KX376GY7L) ; Ion Channels ; Triazines
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076050
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  7. Article ; Online: Understanding Lamotrigine’s Role in the CNS and Possible Future Evolution

    Bárbara Costa / Nuno Vale

    International Journal of Molecular Sciences, Vol 24, Iss 6050, p

    2023  Volume 6050

    Abstract: The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action in the central nervous system (CNS) still needs to be determined. ... ...

    Abstract The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action in the central nervous system (CNS) still needs to be determined. Recent studies have highlighted the involvement of LTG in modulating the activity of voltage-gated ion channels, particularly those related to the inhibition of neuronal excitability. Additionally, LTG has been found to have neuroprotective effects, potentially through the inhibition of glutamate release and the enhancement of GABAergic neurotransmission. LTG’s unique mechanism of action compared to other anti-epileptic drugs has led to the investigation of its use in treating other CNS disorders, such as neuropathic pain, PTSD, and major depressive disorder. Furthermore, the drug has been combined with other anti-epileptic drugs and mood stabilizers, which may enhance its therapeutic effects. In conclusion, LTG’s potential to modulate multiple neurotransmitters and ion channels in the CNS makes it a promising drug for treating various neurological disorders. As our understanding of its mechanism of action in the CNS continues to evolve, the potential for the drug to be used in new indications will also be explored.
    Keywords LTG ; anti-epileptic drugs ; central nervous system ; cancer research ; GABAergic neurotransmission ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Efavirenz: History, Development and Future.

    Costa, Bárbara / Vale, Nuno

    Biomolecules

    2022  Volume 13, Issue 1

    Abstract: Efavirenz ( ... ...

    Abstract Efavirenz (Sustiva
    MeSH term(s) Humans ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Reverse Transcriptase Inhibitors/therapeutic use ; Reverse Transcriptase Inhibitors/adverse effects ; Benzoxazines/adverse effects ; HIV Infections/drug therapy
    Chemical Substances efavirenz (JE6H2O27P8) ; Anti-HIV Agents ; Reverse Transcriptase Inhibitors ; Benzoxazines
    Language English
    Publishing date 2022-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13010088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Self-perception of cognitive sequels in post-COVID-19 individuals.

    Alves, Emily Viega / Beber, Bárbara Costa

    Dementia & neuropsychologia

    2023  Volume 17, Page(s) e20220080

    Abstract: COVID-19 is an infection, primarily respiratory, caused by the SARS-CoV-2, which can also affect the central nervous system, causing neuropsychological damage. There are studies describing post-COVID-19 cognitive deficits, but it is important to know ... ...

    Abstract COVID-19 is an infection, primarily respiratory, caused by the SARS-CoV-2, which can also affect the central nervous system, causing neuropsychological damage. There are studies describing post-COVID-19 cognitive deficits, but it is important to know this outcome in populations with different social, biological, and cultural characteristics.
    Objective: The aim of this study was to assess the self-perception of cognitive sequelae in post-COVID-19 individuals and identify whether there is a possible relationship between the outcome of the participants' self-perception and sociodemographic and clinical data.
    Methods: This is a cross-sectional study, carried out through an online questionnaire on the Google Forms platform, in which sociodemographic data, general health data, clinical manifestations of COVID-19, and post-COVID-19 self-perception of the cognitive domains of memory, attention, language, and executive functions were collected.
    Results: The final sample consisted of 137 participants, and it was possible to identify that memory and attention were the domains with the highest impression of worsening post-COVID-19, followed by executive functions and language. In addition, it was identified that being female may be related to a worse self-perception of all cognitive functions and that having depression or other psychiatric diseases and obesity can significantly affect at least half of the cognitive domains evaluated.
    Conclusions: This study pointed to a post-COVID-19 cognitive worsening of the participants.
    Language English
    Publishing date 2023-05-05
    Publishing country Brazil
    Document type Journal Article
    ISSN 1980-5764
    ISSN 1980-5764
    DOI 10.1590/1980-5764-DN-2022-0080
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  10. Article ; Online: Dostarlimab: A Review.

    Costa, Bárbara / Vale, Nuno

    Biomolecules

    2022  Volume 12, Issue 8

    Abstract: Dostarlimab (JEMPERLI) is a PD-1 monoclonal antibody for the treatment of adult patients, with mismatch repair deficient (dMMR), recurrent or advanced endometrial cancer that has progressed on or following prior therapy with a platinum-containing regimen. ...

    Abstract Dostarlimab (JEMPERLI) is a PD-1 monoclonal antibody for the treatment of adult patients, with mismatch repair deficient (dMMR), recurrent or advanced endometrial cancer that has progressed on or following prior therapy with a platinum-containing regimen. As determined by an FDA-approved test this indication was granted rapid approval based on the rate of tumor response and the duration of the response. Continued approval for this indication is conditioned on further confirmatory trials demonstrating and documenting clinical benefit. In June 2022, the clinical trial NCT04165772 reported a 100% remission rate for rectal cancer. This clinical trial brought proof that we can match a tumor and the genetics of what is driving it, with therapy. This clinical trial continues to enroll patient and is currently enrolling patients with gastric, prostate, and pancreatic cancers. Dostarlamib is being recommended for rectal cancer. The focus of this review is to summarize the existing knowledge regarding Dostarlimab and explore the possibilities of mono- and combination therapies.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Endometrial Neoplasms/drug therapy ; Female ; Humans ; Immune Checkpoint Inhibitors ; Male ; Rectal Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immune Checkpoint Inhibitors ; dostarlimab
    Language English
    Publishing date 2022-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12081031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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