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Book ; Online ; E-Book: Super-resolution imaging in biomedicine

Diaspro, Alberto / Zandvoort, Marc A. M. J. van

(Series in cellular and clinical imaging)

2017

Author's details	edited by Alberto Diaspro, Marc A. M. J. van Zandvoort
Series title	Series in cellular and clinical imaging
Keywords	Microscopy / methods
Subject code	616.07/54
Language	English
Size	1 Online-Ressource (xxii, 425 Seiten), Illustrationen
Publisher	CRC Press, Taylor & Francis Group
Publishing place	Boca Raton
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019471754
ISBN	978-1-4822-4435-9 ; 9781482244342 ; 1-4822-4435-7 ; 1482244349
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Mortality among populations affected by armed conflict in northeast Nigeria, 2016 to 2019.

Checchi, Francesco / Jarvis, Christopher I / van Zandvoort, Kevin / Warsame, Abdihamid

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 30, Page(s) e2217601120

Abstract: Armed conflict, displacement and food insecurity have affected Adamawa, Borno, and Yobe states of northeast Nigeria (population ≈ 12 million) since 2009. Insecurity escalated in 2013 to 2015, but the humanitarian response was delayed and the crisis' ... ...

Abstract	Armed conflict, displacement and food insecurity have affected Adamawa, Borno, and Yobe states of northeast Nigeria (population ≈ 12 million) since 2009. Insecurity escalated in 2013 to 2015, but the humanitarian response was delayed and the crisis' health impact was unquantified due to incomplete death registration and limited ground access. We estimated mortality attributable to this crisis using a small-area estimation approach that circumvented these challenges. We fitted a mixed effects model to household mortality data collected as part of 70 ground surveys implemented by humanitarian actors. Model predictors, drawn from existing data, included livelihood typology, staple cereal price, vaccination geocoverage, and humanitarian actor presence. To project accurate death tolls, we reconstructed population denominators based on forced displacement. We used the model and population estimates to project mortality under observed conditions and varying assumed counterfactual conditions, had there been no crisis, with the difference providing excess mortality. Death rates were highly elevated across most ground surveys, with net negative household migration. Between April 2016 and December 2019, we projected 490,000 excess deaths (230,000 children under 5 y) in the most likely counterfactual scenario, with a range from 90,000 (best-case) to 550,000 (worst-case). Death rates were two to three times higher than counterfactual levels, double the projected national rate, and highest in 2016 to 2017. Despite limited scope (we could not study the situation before 2016 or in neighboring affected countries), our findings suggest a staggering health impact of this crisis. Further studies to document mortality in this and other crises are needed to guide decision-making and memorialize their human toll.
MeSH term(s)	Child ; Humans ; Nigeria/epidemiology ; Seizures ; Vaccination ; Forecasting ; Armed Conflicts
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2217601120
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Article ; Online: Cortical contributions to locomotor primitives in toddlers and adults.

Zandvoort, Coen S / Daffertshofer, Andreas / Dominici, Nadia

iScience

2022 Volume 25, Issue 10, Page(s) 105229

Abstract: The neural locomotor system strongly relies on spinal circuitries. Yet, the control of bipedal gait is accompanied by activity in motor cortex. In human gait control, the functional interaction between these cortical contributions and their spinal ... ...

Abstract	The neural locomotor system strongly relies on spinal circuitries. Yet, the control of bipedal gait is accompanied by activity in motor cortex. In human gait control, the functional interaction between these cortical contributions and their spinal counterparts are largely elusive. We focused on four spinal activation patterns during walking and explored their cortical signatures in toddlers and adults. In both groups, cortico-spinal coherence analysis revealed activity in primary motor cortex to be closely related to two of the four spinal patterns. Their corresponding muscle synergies are known to develop around the onset of independent walking. By hypothesis, the cortex hence contributes to the emergence of these synergies. In contrast, the other two spinal patterns investigated here resembled those present during newborn stepping. As expected, they did not show any cortical involvement. Together, our findings suggest a crucial role of motor cortex for independent walking in humans.
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2022.105229
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Article ; Online: Body Weight Control Is a Key Element of Motor Control for Toddlers' Walking.

Kerkman, Jennifer N / Zandvoort, Coen S / Daffertshofer, Andreas / Dominici, Nadia

Frontiers in network physiology

2022 Volume 2, Page(s) 844607

Abstract: New-borns can step when supported for about 70-80% of their own body weight. Gravity-related sensorimotor information might be an important factor in developing the ability to walk independently. We explored how body weight support alters motor control ... ...

Abstract	New-borns can step when supported for about 70-80% of their own body weight. Gravity-related sensorimotor information might be an important factor in developing the ability to walk independently. We explored how body weight support alters motor control in toddlers during the first independent steps and in toddlers with about half a year of walking experience. Sixteen different typically developing children were assessed during (un)supported walking on a running treadmill. Electromyography of 18-24 bilateral leg and back muscles and vertical ground reaction forces were recorded. Strides were grouped into four levels of body weight support ranging from no (<10%), low (10-35%), medium (35-55%), and high (55-95%) support. We constructed muscle synergies and muscle networks and assessed differences between levels of support and between groups. In both groups, muscle activities could be described by four synergies. As expected, the mean activity decreased with body weight support around foot strikes. The younger first-steps group showed changes in the temporal pattern of the synergies when supported for more than 35% of their body weight. In this group, the muscle network was dense with several interlimb connections. Apparently, the ability to process gravity-related information is not fully developed at the onset of independent walking causing motor control to be fairly disperse. Synergy-specific sensitivity for unloading implies distinct neural mechanisms underlying (the emergence of) these synergies.
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	2674-0109
ISSN (online)	2674-0109
DOI	10.3389/fnetp.2022.844607
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Article ; Online: Awake craniotomy does not lead to increased psychological complaints.

Wajer, I M C Huenges / Kal, J / Robe, P A / van Zandvoort, M J E / Ruis, C

Acta neurochirurgica

2023 Volume 165, Issue 9, Page(s) 2505–2512

Abstract: Background: Patients with brain tumours are increasingly treated by using the awake craniotomy technique. Some patients may experience anxiety when subjected to brain surgery while being fully conscious. However, there has been only limited research ... ...

Abstract	Background: Patients with brain tumours are increasingly treated by using the awake craniotomy technique. Some patients may experience anxiety when subjected to brain surgery while being fully conscious. However, there has been only limited research into the extent to which such surgeries actually result in anxiety or other psychological complaints. Previous research suggests that undergoing awake craniotomy surgery does not lead to psychological complaints, and that post-traumatic stress disorders (PTSD) are uncommon following this type of surgery. It must be noted, however, that many of these studies used small random samples. Method: In the current study, 62 adult patients completed questionnaires to identify the degree to which they experienced anxiety, depressive and post-traumatic stress complaints following awake craniotomy using an awake-awake-awake procedure. All patients were cognitively monitored and received coaching by a clinical neuropsychologist during the surgery. Results: In our sample, 21% of the patients reported pre-operative anxiety. Four weeks after surgery, 19% of the patients reported such complaints, and 24% of the patients reported anxiety complaints after 3 months. Depressive complaints were present in 17% (pre-operative), 15% (4 weeks post-operative) and 24% (3 months post-operative) of the patients. Although there were some intra-individual changes (improvement or deterioration) in the psychological complaints over time, on group-level postoperative levels of psychological complaints were not increased relative to the preoperative level of complaints. The severity of post-operative PTSD-related complaints were rarely suggestive of a PTSD. Moreover, these complaints were seldom attributed to the surgery itself, but appeared to be more related to the discovery of the tumour and the postoperative neuropathological diagnosis. Conclusions: The results of the present study do not indicate that undergoing awake craniotomy is associated with increased psychological complaints. Nevertheless, psychological complaints may well exist as a result of other factors. Consequently, monitoring the patient's mental wellbeing and offering psychological support where necessary remain important.
MeSH term(s)	Adult ; Humans ; Wakefulness ; Anxiety/etiology ; Anxiety/psychology ; Brain Neoplasms/surgery ; Brain Neoplasms/psychology ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/etiology ; Stress Disorders, Post-Traumatic/psychology ; Craniotomy/methods
Language	English
Publishing date	2023-05-24
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05615-5
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Article ; Online: IDEAL monitoring of musical skills during awake craniotomy: From step 1 to step 2.

Ferrier, C H / Ruis, C / Zadelhoff, D / Robe, P A J T / van Zandvoort, M J E

Journal of neuropsychology

2023 Volume 18 Suppl 1, Page(s) 48–60

Abstract: The aim of awake brain surgery is to perform a maximum resection on the one hand, and to preserve cognitive functions, quality of life and personal autonomy on the other hand. Historically, language and sensorimotor functions were most frequently ... ...

Abstract	The aim of awake brain surgery is to perform a maximum resection on the one hand, and to preserve cognitive functions, quality of life and personal autonomy on the other hand. Historically, language and sensorimotor functions were most frequently monitored. Over the years other cognitive functions, including music, have entered the operation theatre. Cases about monitoring musical abilities during awake brain surgery are emerging, and a systematic method how to monitor music would be the next step. According to the IDEAL framework for surgical innovations our study aims to present future recommendation based on a systematic literature search (PRISMA) in combination with lessons learned from three case reports from our own clinical practice with professional musicians (n = 3). We plead for structured procedures including individual tailored tasks. By embracing these recommendations, we can both improve clinical care and unravel music functions in the brain.
MeSH term(s)	Humans ; Music ; Wakefulness ; Quality of Life ; Brain/surgery ; Craniotomy/methods
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2380753-2
ISSN	1748-6653 ; 1748-6645
ISSN (online)	1748-6653
ISSN	1748-6645
DOI	10.1111/jnp.12347
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Article: Molecular Imaging in Oncology: Advanced Microscopy Techniques.

Kapsokalyvas, Dimitrios / van Zandvoort, Marc A M J

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

2020 Volume 216, Page(s) 533–561

Abstract: Preclinical studies usually require high levels of morphological, functional, and biochemical information at subcellular resolution. This type of information cannot be obtained from clinical imaging techniques, such as MRI, PET/CT, or US. Luckily, many ... ...

Abstract	Preclinical studies usually require high levels of morphological, functional, and biochemical information at subcellular resolution. This type of information cannot be obtained from clinical imaging techniques, such as MRI, PET/CT, or US. Luckily, many microscopy techniques exist that can offer this information, also for malignant tissues and therapeutic approaches. In this overview, we discuss the various advanced optical microscopy techniques and their applications in oncological research. After a short introduction in Sect. 16.1, we continue in Sect. 16.2 with a discussion on fluorescent labelling strategies, followed in Sect. 16.3 by an in-depth description of confocal, light-sheet, two-photon, and super-resolution microscopy. We end in Sect. 16.4 with a focus on the applications, specifically in oncology.
MeSH term(s)	Humans ; Medical Oncology ; Microscopy/methods ; Molecular Imaging ; Neoplasms/pathology
Language	English
Publishing date	2020-06-27
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	0080-0015
ISSN	0080-0015
DOI	10.1007/978-3-030-42618-7_16
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Article ; Online: Strengthening Medical Care for Young People in the Netherlands: A Reflection.

Jansen, Danielle / Vanneste-van Zandvoort, Yvonne / Illy, Károly / Popma, Arne / Berger, Marjolein Y

International journal of environmental research and public health

2022 Volume 19, Issue 18

Abstract: To improve medical care for young people in the Netherlands, various professional groups representing physicians who provide medical care to children have developed a vision called 'strengthening medical care for young people'. The purpose of this ... ...

Abstract	To improve medical care for young people in the Netherlands, various professional groups representing physicians who provide medical care to children have developed a vision called 'strengthening medical care for young people'. The purpose of this viewpoint is to reflect on the implementation of proposals to augment cooperation and coordination between the professional groups involved. Our reflection demonstrates that additional action regarding cooperation and coordination is still necessary to strengthen this care for young people. First, regarding the practical implementation of collaboration, the guidelines are unclear, and many are out-of-date. Second, adequate structured interdisciplinary training and intervision are lacking for physicians frequently collaborating in the care of young people. Third, interdisciplinary access to patient files is too complex and time-consuming. We recommend structured monitoring of the implementation of all improvement proposals, regarding both processes and outcomes. In addition, we recommend collaboration with physicians treating mentally disabled individuals to improve medical care for this group.
MeSH term(s)	Adolescent ; Child ; Disabled Persons ; Humans ; Netherlands ; Patient Care
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191811487
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Article ; Online: Reliability and validity of DTI-based indirect disconnection measures.

Smits, A R / van Zandvoort, M J E / Ramsey, N F / de Haan, E H F / Raemaekers, M

NeuroImage. Clinical

2023 Volume 39, Page(s) 103470

Abstract: White matter connections enable the interaction within and between brain networks. Brain lesions can cause structural disconnections that disrupt networks and thereby cognitive functions supported by them. In recent years, novel methods have been ... ...

Abstract	White matter connections enable the interaction within and between brain networks. Brain lesions can cause structural disconnections that disrupt networks and thereby cognitive functions supported by them. In recent years, novel methods have been developed to quantify the extent of structural disconnection after focal lesions, using tractography data from healthy controls. These methods, however, are indirect and their reliability and validity have yet to be fully established. In this study, we present our implementation of this approach, in a tool supplemented by uncertainty metrics for the predictions overall and at voxel-level. These metrics give an indication of the reliability and are used to compare predictions with direct measures from patients' diffusion tensor imaging (DTI) data in a sample of 95 first-ever stroke patients. Results show that, except for small lesions, the tool can predict fiber loss with high reliability and compares well to direct patient DTI estimates. Clinical utility of the method was demonstrated using lesion data from a subset of patients suffering from hemianopia. Both tract-based measures outperformed lesion localization in mapping visual field defects and showed a network consistent with the known anatomy of the visual system. This study offers an important contribution to the validation of structural disconnection mapping. We show that indirect measures of structural disconnection can be a reliable and valid substitute for direct estimations of fiber loss after focal lesions. Moreover, based on these results, we argue that indirect structural disconnection measures may even be preferable to lower-quality single subject diffusion MRI when based on high-quality healthy control datasets.
MeSH term(s)	Humans ; Diffusion Tensor Imaging/methods ; Reproducibility of Results ; Diffusion Magnetic Resonance Imaging ; White Matter/diagnostic imaging ; White Matter/pathology ; Stroke/diagnostic imaging ; Stroke/pathology
Language	English
Publishing date	2023-07-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701571-3
ISSN	2213-1582 ; 2213-1582
ISSN (online)	2213-1582
ISSN	2213-1582
DOI	10.1016/j.nicl.2023.103470
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Article: Development of running is not related to time since onset of independent walking, a longitudinal case study.

Bach, Margit M / Zandvoort, Coen S / Cappellini, Germana / Ivanenko, Yury / Lacquaniti, Francesco / Daffertshofer, Andreas / Dominici, Nadia

Frontiers in human neuroscience

2023 Volume 17, Page(s) 1101432

Abstract: Introduction: Children start to run after they master walking. How running develops, however, is largely unknown.: Methods: We assessed the maturity of running pattern in two very young, typically developing children in a longitudinal design spanning ...

Abstract	Introduction: Children start to run after they master walking. How running develops, however, is largely unknown. Methods: We assessed the maturity of running pattern in two very young, typically developing children in a longitudinal design spanning about three years. Leg and trunk 3D kinematics and electromyography collected in six recording sessions, with more than a hundred strides each, entered our analysis. We recorded walking during the first session (the session of the first independent steps of the two toddlers at the age of 11.9 and 10.6 months) and fast walking or running for the subsequent sessions. More than 100 kinematic and neuromuscular parameters were determined for each session and stride. The equivalent data of five young adults served to define mature running. After dimensionality reduction using principal component analysis, hierarchical cluster analysis based on the average pairwise correlation distance to the adult running cluster served as a measure for maturity of the running pattern. Results: Both children developed running. Yet, in one of them the running pattern did not reach maturity whereas in the other it did. As expected, mature running appeared in later sessions (>13 months after the onset of independent walking). Interestingly, mature running alternated with episodes of immature running within sessions. Our clustering approach separated them. Discussion: An additional analysis of the accompanying muscle synergies revealed that the participant who did not reach mature running had more differences in muscle contraction when compared to adults than the other. One may speculate that this difference in muscle activity may have caused the difference in running pattern.
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2023.1101432
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