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  1. Book ; Online ; E-Book: Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases

    Behl, Tapan / Singh, Sukhbir / Sharma, Neelam

    Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases

    (Basic and Clinical Angiogenesis Series)

    2024  

    Author's details Tapan Behl, Sukhbir Singh, and Neelam Sharma, editors
    Series title Basic and Clinical Angiogenesis Series
    Keywords Chronic diseases/Pathophysiology ; Chronic diseases/Prevention
    Subject code 616.044
    Language English
    Size 1 online resource (524 pages)
    Edition First edition.
    Publisher Elsevier Inc
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-13588-6 ; 9780443135873 ; 978-0-443-13588-0 ; 0443135878
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Natural Products for Chronic Diseases: A Ray of Hope

    Hassan, Syed Shams ul / Abdel-Daim, Mohamed M / Behl, Tapan / Bungau, Simona Gabriela

    2023  

    Keywords Research & information: general ; Chemistry ; guaiane dimer ; melanoma ; molecular docking ; ADMET ; MM-GBSA ; marine drugs ; diabetes mellitus ; cancer ; cardiovascular disorders ; neurodegeneration ; shrimp (Penaeus Chinensis) ; peptides ; immunosuppression gut microbiota ; cyclophosphamide ; gut health ; prostate cancer ; nummularic acid ; docking ; apoptosis ; BAX ; p53 ; echimidine ; echimidine isomers ; hepatotoxicity ; Echium plantagineum L. ; rat hepatocytes primary culture ; Fragaria indica ; α-glucosidase ; α-amylase ; antioxidant ; bioactives ; antidiabetic ; diabetes ; antibacterial activity ; total phenolic contents ; total flavonoid contents ; DPPH ; ABTS ; antidiabetic enzymes ; HPLC-UV ; GC-MS ; endogenous hydrogen sulfide ; breast cancer ; signaling pathway ; tumor growth ; Michael products ; anti-inflammatory ; analgesic ; carrageenan ; COX-2 ; 5-LOX ; Pleurospermum candollei ; natural compounds ; thrombolytic ; antibacterial ; pharmaceuticals ; berbamine ; bergapten ; carveol ; paclitaxel ; ELISA ; Western blot ; n/a
    Language English
    Size 1 electronic resource (232 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376394
    ISBN 9783036569543 ; 3036569545
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs.

    Akhtar, Ansab / Singh, Siddharth / Kaushik, Ravinder / Awasthi, Rajendra / Behl, Tapan

    Ageing research reviews

    2024  Volume 96, Page(s) 102289

    Abstract: Alzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further ... ...

    Abstract Alzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further takes several other categories of memories like working memory, spatial memory, fear memory, and long-term, and short-term memory into consideration. In this review, these memories have critically been elaborated based on context, duration, events, appearance, intensity, etc. The most important part and purpose of the review is the various pathological cascades as well as molecular levels of targets of AD, which have extracellular amyloid plaques and intracellular hyperphosphorylated tau protein as major disease hallmarks. There is another phenomenon that either leads to or arises from the above-mentioned hallmarks, such as oxidative stress, mitochondrial dysfunction, neuroinflammation, cholinergic dysfunction, and insulin resistance. Several potential drugs like antioxidants, anti-inflammatory drugs, acetylcholinesterase inhibitors, insulin mimetics or sensitizers, etc. studied in various previous preclinical or clinical reports were put as having the capacity to act on these pathological targets. Additionally, agents directly or indirectly targeting amyloid and tau were also discussed. This could be further investigated in future research.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Acetylcholinesterase ; Amyloid beta-Peptides/metabolism
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Amyloid beta-Peptides
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Role of Endostatin in Rheumatoid Arthritis.

    Nijhawan, Priya / Behl, Tapan

    Current rheumatology reviews

    2020  Volume 17, Issue 1, Page(s) 68–75

    Abstract: Background: Endostatin by its therapeutic value against rheumatoid arthritis has recently gained significant interest in biomedical science. A recent study revealed that various approaches have been made to prevent rheumatoid arthritis by either ... ...

    Abstract Background: Endostatin by its therapeutic value against rheumatoid arthritis has recently gained significant interest in biomedical science. A recent study revealed that various approaches have been made to prevent rheumatoid arthritis by either controlling or inhibiting the progression of angiogenesis.
    Objective: The main objective of the current manuscript is to enumerate the intrinsic role of endostatin in rheumatoid arthritis.
    Methods: A thorough and detailed review of literature from the papers published from the year 1997-2019 was studied for the preparation of the current article.
    Results: Endostatin is one such agent of the subfamily of ECM called as multiplexins obtained from proteolytic cleavage of XVIII and its carboxylic terminal fragments and is known for its antiangiogenic and antiproliferative property. The exact mechanism of endostatin is still unclear, but it acts by downregulating or inhibiting the responses of various factors, including Id1, Id3, matrix metalloproteinase, and Nuclear factor Kappa B that are liable for angiogenesis. The mutual effects on adipogenesis and angiogenesis, endostatin inhibits dietary-induced obesity and its related metabolic disorders, such as insulin resistance, glucose intolerance, and hepatic steatosis.
    Conclusion: The present review demonstrates the intrinsic usage of endostatin as a novel molecule in rheumatoid arthritis. It focuses on the status of the therapeutic potential of endostatin in inhibiting the activity of angiogenesis is also very well explored.
    MeSH term(s) Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/etiology ; Endostatins/therapeutic use ; Humans ; Neovascularization, Pathologic/complications
    Chemical Substances Endostatins
    Language English
    Publishing date 2020-04-28
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1875-6360
    ISSN (online) 1875-6360
    DOI 10.2174/1573397115666191127141801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Exploring the Intersection of Geophysics and Diagnostic Imaging in the Health Sciences.

    Singh, Rahul Kumar / Nayak, Nirlipta Priyadarshini / Behl, Tapan / Arora, Rashmi / Anwer, Md Khalid / Gulati, Monica / Bungau, Simona Gabriela / Brisc, Mihaela Cristina

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: To develop diagnostic imaging approaches, this paper emphasizes the transformational potential of merging geophysics with health sciences. Diagnostic imaging technology improvements have transformed the health sciences by enabling earlier and more ... ...

    Abstract To develop diagnostic imaging approaches, this paper emphasizes the transformational potential of merging geophysics with health sciences. Diagnostic imaging technology improvements have transformed the health sciences by enabling earlier and more precise disease identification, individualized therapy, and improved patient care. This review article examines the connection between geophysics and diagnostic imaging in the field of health sciences. Geophysics, which is typically used to explore Earth's subsurface, has provided new uses of its methodology in the medical field, providing innovative solutions to pressing medical problems. The article examines the different geophysical techniques like electrical imaging, seismic imaging, and geophysics and their corresponding imaging techniques used in health sciences like tomography, magnetic resonance imaging, ultrasound imaging, etc. The examination includes the description, similarities, differences, and challenges associated with these techniques and how modified geophysical techniques can be used in imaging methods in health sciences. Examining the progression of each method from geophysics to medical imaging and its contributions to illness diagnosis, treatment planning, and monitoring are highlighted. Also, the utilization of geophysical data analysis techniques like signal processing and inversion techniques in image processing in health sciences has been briefly explained, along with different mathematical and computational tools in geophysics and how they can be implemented for image processing in health sciences. The key findings include the development of machine learning and artificial intelligence in geophysics-driven medical imaging, demonstrating the revolutionary effects of data-driven methods on precision, speed, and predictive modeling.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14020139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Design and synthesis of neoteric benzylidene amino-benzimidazole scaffolds for antioxidant and anti-inflammatory activity.

    Swikriti / Babbar, Ritchu / Saini, Deepika / Rawat, Ravi / Chigurupati, Sridevi / Felemban, Shatha G / Vargas-De-La-Cruz, Celia / Behl, Tapan

    Future medicinal chemistry

    2023  

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2023-0058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research.

    Goyal, Ahsas / Verma, Aanchal / Agrawal, Anant / Dubey, Nandini / Kumar, Abhay / Behl, Tapan

    Chemical biology & drug design

    2023  Volume 101, Issue 6, Page(s) 1229–1240

    Abstract: Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects. Neuronal degeneration may arise due to a variety of pathological ... ...

    Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects. Neuronal degeneration may arise due to a variety of pathological events, like inflammatory responses, neurotransmitter dysregulation, oxidative damage, mitochondrial malfunction, apoptosis, and genetic factors. The health issue and financial burden brought on by Parkinson's disease can worsen as the population ages. In the search for new and secure therapeutic agents for Parkinson's disease, several natural compounds have been shown to exert considerable neuroprotective benefits. Crocin, a naturally occurring carotenoid molecule, was found to have neuroprotective potential in the therapy of this disorder. Taking into account, the outcomes of various studies and the restorative actions of crocin, the present study emphasized the protective ability of crocin in this disease. Given the strong evidence supporting the neuroprotective ability of crocin, it is inferred that crocin inhibits inflammatory, apoptotic, and antioxidant processes through multiple mechanisms. Therefore, this compound is considered a safe and effective therapeutic choice for neurodegenerative illnesses like Parkinson's disease. However, more research on its efficacy as a treatment of Parkinson's disease is needed, specifically examining its mechanisms and the results obtained in clinical trials.
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Carotenoids/pharmacology ; Carotenoids/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Oxidative Stress
    Chemical Substances crocin (877GWI46C2) ; Neuroprotective Agents ; Carotenoids (36-88-4) ; Antioxidants
    Language English
    Publishing date 2023-02-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2216600-2
    ISSN 1747-0285 ; 1747-0277
    ISSN (online) 1747-0285
    ISSN 1747-0277
    DOI 10.1111/cbdd.14210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Phytochemical Screening, Antioxidant Assay and Cytotoxic Profile for Different Extracts of Chrysopogon zizanioides Roots.

    Grover, Madhuri / Behl, Tapan / Virmani, Tarun

    Chemistry & biodiversity

    2021  Volume 18, Issue 8, Page(s) e2100012

    Abstract: The Chrysopogon zizanioides plant possesses multiple traditional uses, especially in therapeutics, but only a few articles have reported its biological activity. Hence, the present study was planned to explore the phytochemical constituents, cytotoxic ... ...

    Abstract The Chrysopogon zizanioides plant possesses multiple traditional uses, especially in therapeutics, but only a few articles have reported its biological activity. Hence, the present study was planned to explore the phytochemical constituents, cytotoxic potential, radical scavenging activity, and GC/MS (Gas chromatography & Mass spectrometry) analysis of the vetiver root extracts. The roots extracted with different solvents exhibited more significant phytochemical constituents in polar solvents in comparison to non-polar ones, favoring the extraction of a greater number of components in highly polar solvents. All the extracts were tested for their cytotoxicity using SRB (Sulforhodamine B) assay. They confirmed ethanolic extract as a potent extract with GI
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Cell Line, Tumor ; Cell Survival/drug effects ; Chlorocebus aethiops ; Chrysopogon/chemistry ; Chrysopogon/metabolism ; Gas Chromatography-Mass Spectrometry ; Humans ; Phytochemicals/chemistry ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Plant Roots/metabolism ; Solid Phase Extraction/methods ; Vero Cells
    Chemical Substances Antioxidants ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202100012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reconsidering and Reforming the Amyloid Cascade Hypothesis.

    Uddin, Md Sahab / Kabir, M Tanvir / Behl, Tapan / Ashraf, Ghulam Md

    Current protein & peptide science

    2021  Volume 22, Issue 6, Page(s) 449–457

    MeSH term(s) Alzheimer Disease ; Amyloid ; Amyloid beta-Peptides ; Amyloidogenic Proteins ; Humans
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Amyloidogenic Proteins
    Language English
    Publishing date 2021-03-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2045662-1
    ISSN 1875-5550 ; 1389-2037
    ISSN (online) 1875-5550
    ISSN 1389-2037
    DOI 10.2174/1389203722666210322151627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5884: Show issues Location:
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  10. Article ; Online: Caralluma edulis

    Ansari, Bushra / Behl, Tapan / Pirzada, Abdul Saboor / Khan, Haroon

    Current topics in medicinal chemistry

    2022  Volume 22, Issue 18, Page(s) 1501–1514

    Abstract: Caralluma edulis is a well-known species of the genus Caralluma from Apocynaceae, commonly known as chunga. Caralluma species are mostly succulent perennial herbs, several of which are edible species. The plant has an outstanding therapeutic background ... ...

    Abstract Caralluma edulis is a well-known species of the genus Caralluma from Apocynaceae, commonly known as chunga. Caralluma species are mostly succulent perennial herbs, several of which are edible species. The plant has an outstanding therapeutic background in the traditional system of treatment. It has been recommended for the treatment of a number medical disorders such as hypertension, Alzheimer's disease, rheumatism, gastric problems and leprosy. Traditionally the stem was boiled in water and this extract was then used to cure diabetes. The pharmacological effects of C. edulis have also been explored in various in vitro and in vivo experiments. In this regard, the extract of the plant exhibited strong antioxidant, and analgesic activity against inflammation as well as xylene-mediated ear edema as topical effects. The significant anti-hyperlipidemic effect of the plant extract is also reported. However, the extract was found insignificant in the reversal of alloxan-induced diabetes in the rabbit model at test doses. These pharmacological effects are strongly supported by the presence of different bioactive phytochemicals in the plant. These groups of compounds include sterols, terpenoids, flavonoids, and pregnane glycosides. C. edulis is a very potential member of the genus Caralluma with strong traditional history, phytochemistry and phytopharmacology, and needs further exploration for clinically used lead compounds. In this review, we have focused on combining different reported data on the traditional uses of the plant, its phytochemical profile and pharmacological effects in different experimental assay along with subsequent future prospects.
    MeSH term(s) Animals ; Antioxidants ; Apocynaceae ; Ethnopharmacology ; Flavonoids ; Phytochemicals ; Plant Extracts ; Rabbits
    Chemical Substances Antioxidants ; Flavonoids ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2022-05-30
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026622666220527092825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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