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  1. Article: Neither too much nor too little: mitochondrial calcium concentration as a balance between physiological and pathological conditions.

    D'Angelo, Donato / Vecellio Reane, Denis / Raffaello, Anna

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1336416

    Abstract: ... ...

    Abstract Ca
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1336416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inhibition of ERK/MAPK signaling as potential therapy to prevent optic pathway glioma in infants with neurofibromatosis type 1.

    D'Angelo, Fulvio / Lasorella, Anna

    Developmental cell

    2021  Volume 56, Issue 20, Page(s) 2785–2786

    Abstract: Pediatric low-grade gliomas (pLGGs) arise primarily at early stages of development. The molecular mechanisms of pLGG gliomagenesis are unclear, as is the progenitor cell of origin. In this issue of Developmental Cell, Jecrois et al. show that NF1- ... ...

    Abstract Pediatric low-grade gliomas (pLGGs) arise primarily at early stages of development. The molecular mechanisms of pLGG gliomagenesis are unclear, as is the progenitor cell of origin. In this issue of Developmental Cell, Jecrois et al. show that NF1-associated optic pathway gliomas originate from migrating glial progenitors that have distinct MEK/ERK dependency.
    MeSH term(s) Child ; Glioma ; Humans ; Neurofibromatosis 1 ; Neuroglia
    Language English
    Publishing date 2021-10-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.10.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
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    Zs.MG 76: Show issues

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  3. Book: Computational Intelligence Methods for Bioinformatics and Biostatistics

    Chicco, Davide / Facchiano, Angelo / Tavazzi, Erica / Cazzaniga, Paolo / Vettoretti, Martina / Bernasconi, Anna / Avesani, Simone / Longato, Enrico

    17th International Meeting, CIBB 2021, Virtual Event, November 15¿17, 2021, Revised Selected Papers

    (Lecture Notes in Bioinformatics)

    2022  

    Series title Lecture Notes in Bioinformatics
    Keywords artificial intelligence ; computational and systems biology ; computer networks ; Computer Systems ; Computer vision ; Correlation Analysis ; Data Mining ; education ; Image Analysis ; image processing ; Image segmentation ; Learning ; Machine Learning ; Neural Networks ; pattern recognition ; Signal Processing ; biostatistics ; computer systems ; computer vision ; correlation analysis ; data mining ; image analysis ; image segmentation ; learning ; machine learning ; neural networks ; signal processing
    Language English
    Size 272 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_17
    Format 155 x 235 x 15
    ISBN 9783031208362 ; 3031208366
    Database PDA

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  4. Article ; Online: Therapeutic potential of saffron in brain disorders: From bench to bedside.

    Bej, Erjola / Volpe, Anna Rita / Cesare, Patrizia / Cimini, Annamaria / d'Angelo, Michele / Castelli, Vanessa

    Phytotherapy research : PTR

    2024  

    Abstract: Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, ... ...

    Abstract Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders. Saffron and its constituents have been reported to exert neuroprotective effects through various mechanisms, such as modulating neurotransmitters, enhancing neurogenesis, reducing neuroinflammation, regulating oxidative stress, activating the Nrf2 signaling pathway, and modulating epigenetic factors. Several clinical and preclinical studies have demonstrated the efficacy and safety of saffron and its constituents in improving cognitive function, mood, and other neurological outcomes. In this review, we summarize the current evidence on the therapeutic potential of saffron and its constituents in neurological disorders, from bench to bedside. We also discuss the challenges and future directions for the development of saffron-based therapies for brain health.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.8169
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3092: Show issues Location:
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  5. Article ; Online: Neither too much nor too little

    Donato D’Angelo / Denis Vecellio Reane / Anna Raffaello

    Frontiers in Molecular Biosciences, Vol

    mitochondrial calcium concentration as a balance between physiological and pathological conditions

    2023  Volume 10

    Abstract: Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial Ca2+ (mitCa2+) is a key regulator of oxidative metabolism and cell death. ... ...

    Abstract Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial Ca2+ (mitCa2+) is a key regulator of oxidative metabolism and cell death. MitCa2+ uptake is mediated by the mitochondrial Ca2+ uniporter complex (MCUc) localized in the inner mitochondrial membrane (IMM). MitCa2+ uptake stimulates the activity of three key enzymes of the Krebs cycle, thereby modulating ATP production and promoting oxidative metabolism. As Paracelsus stated, “Dosis sola facit venenum,”in pathological conditions, mitCa2+ overload triggers the opening of the mitochondrial permeability transition pore (mPTP), enabling the release of apoptotic factors and ultimately leading to cell death. Excessive mitCa2+ accumulation is also associated with a pathological increase of reactive oxygen species (ROS). In this article, we review the precise regulation and the effectors of mitCa2+ in physiopathological processes.
    Keywords mitochondria ; calcium ; mitochondrial calcium uniporter (MCU) ; cell death ; metabolism ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: The mitochondrial calcium uniporter complex-A play in five acts.

    De Mario, Agnese / D'Angelo, Donato / Zanotti, Giuseppe / Raffaello, Anna / Mammucari, Cristina

    Cell calcium

    2023  Volume 112, Page(s) 102720

    Abstract: Mitochondrial ... ...

    Abstract Mitochondrial Ca
    MeSH term(s) Mitochondrial Membranes/metabolism ; Calcium/metabolism ; Mitochondria/metabolism ; Calcium Channels/metabolism
    Chemical Substances mitochondrial calcium uniporter ; Calcium (SY7Q814VUP) ; Calcium Channels
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2023.102720
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
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  7. Article ; Online: Contributions to Research and Practice Made by the National Cancer Institute's Health Communication and Informatics Research Branch.

    Vanderpool, Robin C / Blake, Kelly D / Chou, Wen-Ying Sylvia / D'Angelo, Heather / Everson, Nicole Senft / Iles, Irina A / Gaysynsky, Anna

    Health communication

    2024  , Page(s) 1–8

    Abstract: The Health Communication and Informatics Research Branch at the U.S. National Cancer Institute was founded in 1999 in response to increasing evidence demonstrating a link between effective health communication and improved cancer-related outcomes and in ... ...

    Abstract The Health Communication and Informatics Research Branch at the U.S. National Cancer Institute was founded in 1999 in response to increasing evidence demonstrating a link between effective health communication and improved cancer-related outcomes and in recognition of the rapid and dramatic technological changes that were transforming health communication at the turn of the 21st century. For the past 25 years, the Health Communication and Informatics Research Branch has been conducting and supporting research at the forefront of emerging cancer communication trends and technologies, making numerous contributions to health communication science, public health, and cancer control practice. In this essay, we provide a brief history of the branch and the context that led to its establishment, discuss contributions made by the branch to health communication research and practice through key projects and initiatives, and conclude by highlighting health communication and informatics research priorities that offer opportunities for significant impact going forward in light of the challenges posed by the current communication environment.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038723-7
    ISSN 1532-7027 ; 1041-0236
    ISSN (online) 1532-7027
    ISSN 1041-0236
    DOI 10.1080/10410236.2024.2326263
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2769: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: The Impact of Complex PTSD on Suicide Risk in Patients with Bipolar Disorder: A Cross-Sectional Study.

    Iazzolino, Anna Maria / Valenza, Marta / D'Angelo, Martina / Longobardi, Grazia / Stefano, Valeria Di / Visalli, Giulia / Steardo, Luca / Scuderi, Caterina

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Background: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The ... ...

    Abstract Background: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The presence of multiple traumas plays a relevant role from a psychopathological point of view, but little is known about the effect this may have on suicide attempts in patients with BD.
    Methods: A cross-sectional study was conducted comparing socio-demographic and clinical characteristics, recruiting 344 patients diagnosed with BD I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire (ITQ). Suicide attempts were assessed directly during the clinical interview and from the patient's medical record.
    Results: The results emerging from the study indicate that cPTSD can be considered a risk factor for suicide attempts in patients with BD. Furthermore, evidence is provided to support the idea that cPTSD is highly prevalent in patients with BD and is related to a higher psychopathological burden.
    Conclusions: The results recommend an urgent and comprehensive assessment of suicidal risk in patients with comorbidity of both bipolar disorder and cPTSD. There is a crucial demand for early intervention initiatives and proactive prevention strategies to address the intricate intersection of these mental health challenges.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030673
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  9. Article: The Conundrum of Cancer-Associated Thrombosis: Lesson Learned from Two Intriguing Cases and Literature Review.

    Laurino, Simona / Russi, Sabino / Omer, Ludmila Carmen / D'Angelo, Alberto / Bozza, Giovanni / Gallucci, Giuseppina / Falco, Geppino / Roviello, Giandomenico / Bochicchio, Anna Maria

    Diseases (Basel, Switzerland)

    2024  Volume 12, Issue 3

    Abstract: The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial thromboembolism (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent ... ...

    Abstract The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial thromboembolism (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent useful hints for a comprehensive review of the thrombotic issue. A 75-year-old man with advanced rectal cancer treated with fluoropyrimidines suffered two catheter-related VTE events managed according to current guidelines. There was no indication for "extended" anticoagulant therapy for him, but during antithrombotic wash-out and fluoropyrimidines plus panitumumab regimen, he suffered a massive right coronary artery (RCA) thrombosis. Another patient with no cardiovascular (CV) risk factors and affected by advanced bladder cancer was treated with a platinum-containing regimen and suffered an acute inferior myocardial infarction 2 days after chemotherapy administration. He was successfully treated with primary Percutaneous Transluminal Coronary Angioplasty of RCA, discontinuing platinum-based therapy. Our observations raise the issue of cancer-associated thrombosis (CAT) complexity and the potential correlation between arterial and venous thrombotic events. Moreover, physicians should be aware of the thrombotic risk associated with anticancer therapies, suggesting that an appropriate prophylaxis should be considered.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12030047
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  10. Article: How effective are mood stabilizers in treating bipolar patients comorbid with cPTSD? Results from an observational study.

    Iazzolino, Anna Maria / Valenza, Marta / D'Angelo, Martina / Longobardi, Grazia / Di Stefano, Valeria / Luca, Steardo / Scuderi, Caterina / Steardo, Luca

    International journal of bipolar disorders

    2024  Volume 12, Issue 1, Page(s) 9

    Abstract: Background: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have ... ...

    Abstract Background: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have suffered traumatic events than the general population. Consequently, cPTSD could be comorbid with BD, and this may negatively affect psychopathological manifestations. To date, no one has explored whether such comorbidity also affects the response to treatment with mood stabilizers in BD patients.
    Results: Here, a cross-sectional study was carried out by comparing the response to treatment, measured by the Alda scale, in a cohort of 344 patients diagnosed with BD type I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire. The main result that emerged from the present study is the poorer response to mood stabilizers in BD patients with comorbid cPTSD compared with BD patients without cPTSD.
    Conclusions: The results collected suggest the need for an add-on therapy focused on trauma in BD patients. This could represent an area of future interest in clinical research, capable of leading to more precise and quicker diagnoses as well as suggesting better tailored and more effective treatments.
    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2732954-9
    ISSN 2194-7511
    ISSN 2194-7511
    DOI 10.1186/s40345-024-00330-1
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