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  1. Article ; Online: Interferences in immunoassay: An estimate based on 'real-world' experience.

    Dittadi, Ruggero

    Annals of clinical biochemistry

    2024  , Page(s) 45632241240306

    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Letter
    ZDB-ID 390309-6
    ISSN 1758-1001 ; 0004-5632
    ISSN (online) 1758-1001
    ISSN 0004-5632
    DOI 10.1177/00045632241240306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 889: Show issues Location:
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  2. Article: Harmonization of Determination of SARS-CoV-2 Antibodies: Is It Always Possible?

    Dittadi, Ruggero

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: A WHO standard was prepared with the aim of harmonizing assays detecting antibodies against SARS-CoV-2, but the issue is currently being debated. We re-evaluated a previously studied set of cases (108 specimens of 48 patients and 60 specimens of 20 ... ...

    Abstract A WHO standard was prepared with the aim of harmonizing assays detecting antibodies against SARS-CoV-2, but the issue is currently being debated. We re-evaluated a previously studied set of cases (108 specimens of 48 patients and 60 specimens of 20 vaccinated subjects, collected after 14 days from the first dose and 14 days and 3 months after a second dose of the Comirnaty BNT162b2 vaccine), calculating the ratios between the results of two methods (SARS-CoV-2 IgG anti-RBD, SNIBE, and anti-SARS-CoV-2 QuantiVac ELISA IgG, Euroimmun). In the vaccinated subjects, the ratios of the results between methods according to the WHO standard were relatively dispersed, but the harmonization results were good. On the other hand, in patient samples, the variability between tests was very high, and the harmonization was unsatisfactory (median ratios between methods 2.23, 10th-90th percentile: 1.1-5.6). Interestingly, in patient samples, the harmonization depends on the time from the onset of symptoms and greatly improves after 6 months since the diagnosis. Forty patient specimens and thirty-one of the vaccinated subjects after the second dose were also evaluated with a third method (Access SARS-CoV-2 IgG (1st IS), Beckman Coulter), obtaining a similar trend. We can conclude that the actual effectiveness of harmonization between methods may vary depending on the scenario in which they will be used.
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12020483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Harmonization of Determination of SARS-CoV-2 Antibodies

    Ruggero Dittadi

    Diagnostics, Vol 12, Iss 483, p

    Is It Always Possible?

    2022  Volume 483

    Abstract: A WHO standard was prepared with the aim of harmonizing assays detecting antibodies against SARS-CoV-2, but the issue is currently being debated. We re-evaluated a previously studied set of cases (108 specimens of 48 patients and 60 specimens of 20 ... ...

    Abstract A WHO standard was prepared with the aim of harmonizing assays detecting antibodies against SARS-CoV-2, but the issue is currently being debated. We re-evaluated a previously studied set of cases (108 specimens of 48 patients and 60 specimens of 20 vaccinated subjects, collected after 14 days from the first dose and 14 days and 3 months after a second dose of the Comirnaty BNT162b2 vaccine), calculating the ratios between the results of two methods (SARS-CoV-2 IgG anti-RBD, SNIBE, and anti-SARS-CoV-2 QuantiVac ELISA IgG, Euroimmun). In the vaccinated subjects, the ratios of the results between methods according to the WHO standard were relatively dispersed, but the harmonization results were good. On the other hand, in patient samples, the variability between tests was very high, and the harmonization was unsatisfactory (median ratios between methods 2.23, 10th–90th percentile: 1.1–5.6). Interestingly, in patient samples, the harmonization depends on the time from the onset of symptoms and greatly improves after 6 months since the diagnosis. Forty patient specimens and thirty-one of the vaccinated subjects after the second dose were also evaluated with a third method (Access SARS-CoV-2 IgG (1st IS), Beckman Coulter), obtaining a similar trend. We can conclude that the actual effectiveness of harmonization between methods may vary depending on the scenario in which they will be used.
    Keywords SARS-CoV-2 ; antibodies assays ; harmonization ; COVID-19 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The challenge of the reference intervals determination: An example from two articles published in the present issue.

    Dittadi, Ruggero

    The International journal of biological markers

    2019  Volume 33, Issue 4, Page(s) 553–554

    MeSH term(s) Humans ; Reference Values
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645113-5
    ISSN 1724-6008 ; 0393-6155
    ISSN (online) 1724-6008
    ISSN 0393-6155
    DOI 10.1177/1724600818817561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2491: Show issues Location:
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  5. Article ; Online: Harmonization of SARS CoV-2 antibodies determination. Is it really possible?

    Dittadi, Ruggero

    medRxiv

    Abstract: The WHO standard was prepared with the aim of harmonizing assays detecting antibodies against SARS CoV-2. The aspect of the harmonization of the assays is to date under debate. We re-evaluated a previously studied set of cases (108 specimens of 48 ... ...

    Abstract The WHO standard was prepared with the aim of harmonizing assays detecting antibodies against SARS CoV-2. The aspect of the harmonization of the assays is to date under debate. We re-evaluated a previously studied set of cases (108 specimens of 48 patients and 60 specimens of 20 vaccinated subjects, collected after 14 days from the first dose, 14 days and 3 months after a second dose of the Comirnaty BNT162b2 vaccine), calculating the ratios between the results of two methods (SARS-CoV-2 IgG anti-RBD, SNIBE and anti-SARS-CoV-2 QuantiVac ELISA IgG, Euroimmun). In the vaccinated subjects the ratios of the results between methods according to the WHO standard were relatively dispersed, but the harmonization results good. On the other hand, in patient samples the variability between tests was very high and the harmonization was unsatisfactory (median ratios between methods 2.23, 10th-90th percentile: 1.1-5.6). Interestingly, in patient samples the harmonization depends on the time from the onset of symptoms, and greatly improves after 6 months from the diagnosis. 40 patient specimens and 31 of vaccinated subjects after the second dose were evaluated also with a third method (Access SARS-CoV-2 IgG (1st IS), Beckman Coulter), obtaining similar trend. We can conclude that the actual effectiveness of harmonization between methods may vary depending on the scenario in which they will be used.
    Keywords covid19
    Language English
    Publishing date 2021-12-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.12.13.21267669
    Database COVID19

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  6. Article ; Online: Age- and sex-related reference interval for free thyroxine: An indirect approach.

    Dittadi, Ruggero / Carraro, Paolo

    Annals of clinical biochemistry

    2021  Volume 58, Issue 6, Page(s) 675–677

    MeSH term(s) Humans ; Reference Values ; Thyroid Function Tests ; Thyroid Hormones ; Thyrotropin ; Thyroxine ; Triiodothyronine
    Chemical Substances Thyroid Hormones ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Letter
    ZDB-ID 390309-6
    ISSN 1758-1001 ; 0004-5632
    ISSN (online) 1758-1001
    ISSN 0004-5632
    DOI 10.1177/00045632211020027
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  7. Article ; Online: Biological variation and reference change value as decision criteria in clinical use of tumor biomarkers. Are they really useful?

    Dittadi, Ruggero / Fabricio, Aline S C / Gion, Massimo

    Clinical chemistry and laboratory medicine

    2022  Volume 60, Issue 6, Page(s) e136–e137

    MeSH term(s) Biomarkers ; Biomarkers, Tumor ; Humans ; Reference Values
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2022-03-10
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Establishing objective analytical quality requirements in the IgE specific assay: a message in a bottle.

    Dittadi, Ruggero

    Clinical chemistry and laboratory medicine

    2015  Volume 53, Issue 8, Page(s) e199–201

    MeSH term(s) Allergens/immunology ; Humans ; Immunoassay ; Immunoglobulin E/analysis ; Immunoglobulin E/immunology ; Quality Control
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2015-07
    Publishing country Germany
    Document type Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2015-0148
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    Zs.A 121: Show issues Location:
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  9. Article ; Online: Reportable range of quantitative assays for SARS-CoV-2 antibodies determination: An overlooked issue?

    Dittadi, Ruggero / Bertoli, Isabella / Carraro, Paolo

    Annals of clinical biochemistry

    2021  Volume 58, Issue 6, Page(s) 673–675

    MeSH term(s) Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19 Serological Testing/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Immunoglobulin G/blood ; SARS-CoV-2/immunology ; Sensitivity and Specificity ; Severity of Illness Index
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Letter
    ZDB-ID 390309-6
    ISSN 1758-1001 ; 0004-5632
    ISSN (online) 1758-1001
    ISSN 0004-5632
    DOI 10.1177/00045632211020047
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  10. Article ; Online: The early antibody response to SARS-Cov-2 infection.

    Dittadi, Ruggero / Afshar, Haleh / Carraro, Paolo

    Clinical chemistry and laboratory medicine

    2020  Volume 58, Issue 10, Page(s) e201–e203

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/immunology ; Antibody Formation/immunology ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/trends ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country Germany
    Document type Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0617
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