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  1. Article ; Online: University Student Mental Health: An Important Window of Opportunity for Prevention and Early Intervention.

    Duffy, Anne

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2023  Volume 68, Issue 7, Page(s) 495–498

    MeSH term(s) Humans ; Mental Health ; Universities ; Suicide ; Mental Disorders/prevention & control ; Students
    Language English
    Publishing date 2023-07-02
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0008-4824 ; 0706-7437
    ISSN (online) 1497-0015
    ISSN 0008-4824 ; 0706-7437
    DOI 10.1177/07067437231183747
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  2. Article ; Online: Advancing clinical practice and discovery research through revised taxonomy: Case in point bipolar disorder diagnosis: Commentary on "The diagnosis of bipolar disorder in children and adolescents: Past, present and future".

    Duffy, Anne / Grof, Paul

    Bipolar disorders

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13415
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  3. Article ; Online: A comment on an important question in psychiatry (QuiP): Whether paediatric bipolar disorder a valid diagnosis?

    Duffy, Anne

    Bipolar disorders

    2021  Volume 23, Issue 6, Page(s) 626–627

    MeSH term(s) Bipolar Disorder/diagnosis ; Child ; Humans ; Psychiatric Status Rating Scales ; Psychiatry
    Language English
    Publishing date 2021-08-02
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13117
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  4. Article: Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research.

    Duffy, Anne / Grof, Paul

    International journal of bipolar disorders

    2024  Volume 12, Issue 1, Page(s) 12

    Abstract: Background: Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-characterized patients and their ... ...

    Abstract Background: Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-characterized patients and their family members have identified lithium responsive (LiR) and lithium non-responsive (LiNR) subtypes that hold promise for advancement.
    Method: In this narrative review, relevant observations from published longitudinal studies of well-characterized bipolar patients and their families spanning six decades are highlighted. DSM diagnoses based on SADS-L interviews were decided in blind consensus reviews by expert clinicians. Genetic, neurobiological, and psychosocial factors were investigated in subsets of well-characterized probands and adult relatives. Systematic maintenance trials of lithium, antipsychotics, and lamotrigine were carried out. Clinical profiles that included detailed histories of the clinical course, symptom sets and disorders segregating in families were documented. Offspring of LiR and LiNR families were repeatedly assessed up to 20 years using KSADS-PL format interviews and DSM diagnoses and sub-threshold symptoms were decided by expert clinicians in blind consensus reviews using all available clinical and research data.
    Results: A characteristic clinical profile differentiated bipolar patients who responded to lithium stabilization from those who did not. The LiR subtype was characterized by a recurrent fully remitting course predominated by depressive episodes and a positive family history of episodic remitting mood disorders, and not schizophrenia. Response to lithium clustered in families and the characteristic clinical profile predicted lithium response, with the episodic remitting course being a strong correlate. There is accumulating evidence that genetic and neurobiological markers differ between LiR and LiNR subtypes. Further, offspring of bipolar parents subdivided by lithium response differed in developmental history, clinical antecedents and early course of mood disorders. Moreover, the nature of the emergent course bred true from parent to offspring, independent of the nature of emergent psychopathology.
    Conclusions: Bipolar disorders are heterogeneous and response to long-term lithium is associated with a familial subtype with characteristic course, treatment response, family history and likely pathogenesis. Incorporating distinctive clinical profiles that index valid bipolar subtypes into routine practice and research will improve patient outcomes and advance the development and translation of novel treatment targets to improve prevention and early intervention.
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2732954-9
    ISSN 2194-7511
    ISSN 2194-7511
    DOI 10.1186/s40345-024-00333-y
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  5. Article: Debate: Pediatric bipolar disorder - the elephant in the room.

    Duffy, Anne

    Child and adolescent mental health

    2018  Volume 24, Issue 1, Page(s) 99–100

    Language English
    Publishing date 2018-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073663-0
    ISSN 1475-3588 ; 1475-357X
    ISSN (online) 1475-3588
    ISSN 1475-357X
    DOI 10.1111/camh.12316
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  6. Article ; Online: Early intervention in bipolar disorders: Where we are now and need to go next.

    Duffy, Anne

    Bipolar disorders

    2018  

    Language English
    Publishing date 2018-01-15
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.12599
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  7. Article ; Online: Staging the bipolar disorders: Are early stages too early a stage for intervention?

    Duffy, Anne / Keown-Stoneman, Charles

    Bipolar disorders

    2022  Volume 25, Issue 1, Page(s) 76–78

    MeSH term(s) Humans ; Bipolar Disorder ; Disease Progression
    Language English
    Publishing date 2022-12-10
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13281
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  8. Article ; Online: Sleep-independent circadian rhythm of aldosterone secretion in healthy young adults.

    Scheuermaier, Karine / Chang, Anne-Marie / Duffy, Jeanne F

    Sleep health

    2023  Volume 10, Issue 1S, Page(s) S103–S107

    Abstract: Objective: A diurnal variation in urine output has been described in humans, whereby it is lowest at night. Fluid balance hormones such as vasopressin and aldosterone as well as urine output have a diurnal variation. Although the diurnal variation of ... ...

    Abstract Objective: A diurnal variation in urine output has been described in humans, whereby it is lowest at night. Fluid balance hormones such as vasopressin and aldosterone as well as urine output have a diurnal variation. Although the diurnal variation of vasopressin results in part from a circadian rhythm, the variation in aldosterone has until recently been reported to be due to the sleep/wake cycle. The present study used a specialized protocol to explore whether aldosterone has an underlying circadian rhythm.
    Methods: Ten healthy participants (average age 23.1) were enrolled in the 57.3-hour protocol that included an 8-hour baseline sleep episode, 40 hours in constant routine conditions (wakefulness, food and fluid intake, posture, and dim light), and a 9.3-hour recovery sleep. Blood samples for aldosterone were taken every 4 hours. Cosinor analysis was performed on the constant routine data to test the effect of the sleep/wake cycle on overall aldosterone secretion.
    Results: There was a significant circadian rhythm during the 40-hour constant routine, independent of sleep, with aldosterone higher at the end of the biological night and lower at the end of the biological day. When analyzing data from the entire 57.3-hour protocol and controlling for this circadian rhythm, aldosterone concentration was significantly higher during the recovery night following the 40-hour sleep deprivation compared to the night spent awake.
    Conclusion: We found a significant endogenous circadian rhythm in the secretion of aldosterone, independent of sleep. In addition, as shown previously, there was a significant effect of the sleep/wake cycle on aldosterone secretion.
    MeSH term(s) Humans ; Young Adult ; Adult ; Aldosterone ; Circadian Rhythm ; Sleep ; Vasopressins
    Chemical Substances Aldosterone (4964P6T9RB) ; Vasopressins (11000-17-2)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2813299-3
    ISSN 2352-7226 ; 2352-7218
    ISSN (online) 2352-7226
    ISSN 2352-7218
    DOI 10.1016/j.sleh.2023.10.019
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  9. Article: Review: Inelastic Constitutive Modeling: Polycrystalline Materials.

    Baig, Mirza / Owusu-Danquah, Josiah / Campbell, Anne A / Duffy, Stephen F

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 9

    Abstract: This article provides a literature review that details the development of inelastic constitutive modeling as it relates to polycrystalline materials. This review distinguishes between inelastic constitutive models that account for nonlinear behavior at ... ...

    Abstract This article provides a literature review that details the development of inelastic constitutive modeling as it relates to polycrystalline materials. This review distinguishes between inelastic constitutive models that account for nonlinear behavior at the microstructural level, time-independent classic plasticity models, and time-dependent unified models. Particular emphasis is placed on understanding the underlying theoretical framework for unified viscoplasticity models where creep and classical plasticity behavior are considered the result of applied boundary conditions instead of separable rates representing distinct physical mechanisms. This article establishes a clear understanding of the advantages of the unified approach to improve material modeling. This review also discusses recent topics in constitutive modeling that offer new techniques that bridge the gap between the microstructure and the continuum.
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16093564
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  10. Article ; Online: Comparison of Outcomes of Less Invasive Surfactant Administration in Prematurely Born Infants in the Delivery Suite and the Neonatal Unit.

    Shetty, Sandeep / Tolentino, Donna / Kulkarni, Anay / Duffy, Donovan / Greenough, Anne

    American journal of perinatology

    2023  

    Abstract: Objective:  This study aimed to compare outcomes of infants who received less invasive surfactant administration (LISA) in the delivery suite (LISA-DS) with those who received LISA on the neonatal unit (LISA-NNU).: Study design:  A prospective cohort ...

    Abstract Objective:  This study aimed to compare outcomes of infants who received less invasive surfactant administration (LISA) in the delivery suite (LISA-DS) with those who received LISA on the neonatal unit (LISA-NNU).
    Study design:  A prospective cohort study was undertaken of all infants who received LISA in a single center. Clinical outcomes included admission temperature, the need for intubation, durations of invasive and noninvasive ventilation, length of hospital stay and the incidences of bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and requirement for home oxygen were compared between the two groups as were complications of the procedure.
    Results:  The 54 LISA-DS infants had similar gestational ages and birth weights to the 26 LISA-NNU infants (
    Conclusion:  The outcomes of LISA performed on the DS were similar to those of LISA performed on the NNU.
    Key points: · Prematurely born infants who received LISA in the DS had comparable clinical outcomes to infants who received LISA on NNU.. · No significant differences in admission temperature was noticed in infants who received LISA, in DS versus NNU..
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/a-2142-9434
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