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  1. Article: Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review.

    Saffioti, Carolina / Nebiolo, Marta / Caorsi, Roberta / Mesini, Alessio / Severino, Mariasavina / Brisca, Giacomo / Castagnola, Elio / Gattorno, Marco

    Infectious disease reports

    2024  Volume 16, Issue 2, Page(s) 269–280

    Abstract: We describe an atypical case of Whipple disease exclusively involving the spinal cord in an adolescent receiving immunosuppressive therapy for systemic lupus erythematosus. The diagnosis was particularly difficult since lupus and Whipple disease can ... ...

    Abstract We describe an atypical case of Whipple disease exclusively involving the spinal cord in an adolescent receiving immunosuppressive therapy for systemic lupus erythematosus. The diagnosis was particularly difficult since lupus and Whipple disease can present similar clinical features and the patient's prolonged contact with sewage was initially not mentioned. A literature review of the clinical, imaging, diagnostic, and therapeutic challenges of Whipple disease is also performed.
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16020022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Experience of an Italian Pediatric Third Level Emergency Department during the 2022-2023 Bronchiolitis Epidemic: A Focus on Discharged Patients and Revisits.

    Iudica, Giovanna / Franzone, Daniele / Ferretti, Marta / Tubino, Barbara / Santaniello, Stefania / Brisca, Giacomo / Formigoni, Clelia / Data, Erica / Piccotti, Emanuela

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 3

    Abstract: The aim of this study was to describe the 2022-2023 bronchiolitis epidemic season (the second after COVID-19 pandemic and the first without social restriction), focusing on patients discharged home from a pediatric emergency department (PED) and on those ...

    Abstract The aim of this study was to describe the 2022-2023 bronchiolitis epidemic season (the second after COVID-19 pandemic and the first without social restriction), focusing on patients discharged home from a pediatric emergency department (PED) and on those revisited within 72 h. We performed a retrospective observational study in an Italian tertiary care children's hospital, reviewing PED accesses from 1 October 2022 to 31 March 2023. The number of hospitalizations for bronchiolitis was extracted from hospital discharge forms. A total of 512 patients diagnosed with bronchiolitis were admitted to PED (2.8% of total admissions). Accesses increased sharply from November to January, with a peak in December, in both admissions and hospitalizations. More than half of the patients (55.5%) were safely discharged home, while 38 (13.4%) came back to PED for a revisit. Overall PED accesses and hospitalizations for bronchiolitis increased since the previous epidemic season, and particularly compared to the pandemic and pre-pandemic eras. Empowering the collaboration between all healthcare provisioners is fundamental to suitable management of patients. Monitoring the epidemiology and seasonality of bronchiolitis is a starting point for an effective internal organization of pediatric departments and to further evaluate its socio-economic burden.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11030268
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  3. Article ; Online: Neurological Presentation in Roseola Infantum is Seldom Encephalitis in Immunocompetent Children.

    Buffoni, Isabella / Sette, Claudia / Brisca, Giacomo / Mallamaci, Marisa F / Tardini, Giacomo / Buratti, Silvia / Moscatelli, Andrea

    Indian journal of pediatrics

    2022  Volume 89, Issue 10, Page(s) 1057

    MeSH term(s) Child ; Diagnosis, Differential ; Encephalitis/diagnosis ; Exanthema Subitum/diagnosis ; Humans
    Language English
    Publishing date 2022-08-22
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-022-04344-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Efficacy of Ketamine Use in Refractory Status Epilepticus Associated With Hemimegalencephaly.

    Brisca, Giacomo / Pirlo, Daniela / Prato, Giulia / Tortora, Domenico / Siri, Laura / Nobili, Lino / Tardini, Giacomo / Consales, Alessandro / Moscatelli, Andrea / Buratti, Silvia

    Pediatric emergency care

    2022  Volume 38, Issue 3, Page(s) e1090–e1091

    MeSH term(s) Anticonvulsants/therapeutic use ; Hemimegalencephaly ; Humans ; Ketamine/therapeutic use ; Status Epilepticus/drug therapy ; Status Epilepticus/etiology
    Chemical Substances Anticonvulsants ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2022-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002654
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2083: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Necrotizing pneumonia and severe COVID-19 in an infant with catheter-related bloodstream infection by methicillin-sensitive Staphylococcus aureus.

    Brisca, Giacomo / Buratti, Silvia / Basso, Luca / Miano, Maurizio / Salvati, Pietro / Castagnola, Elio / Moscatelli, Andrea

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 65, Issue 1, Page(s) e15401

    MeSH term(s) Humans ; Infant ; Staphylococcus aureus ; Methicillin ; Pneumonia, Necrotizing/diagnosis ; Pneumonia, Necrotizing/drug therapy ; COVID-19 ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Methicillin-Resistant Staphylococcus aureus ; Vascular Diseases ; Sepsis ; Catheters ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Methicillin (Q91FH1328A) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-11-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15401
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 848: Show issues Location:
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  6. Article: A Rare Pediatric Case of Allopurinol-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Successfully Treated With Intravenous Immunoglobulins.

    Rotulo, Gioacchino Andrea / Campanello, Claudia / Battaglini, Marcella / Bassi, Marta / Pastorino, Carlotta / Angeletti, Andrea / Brisca, Giacomo / Signa, Sara / Caorsi, Roberta / Ghiggeri, Gian Marco

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

    2024  Volume 29, Issue 2, Page(s) 195–199

    Abstract: Allopurinol-induced drug reaction syndrome with eosinophilia and systemic symptoms (A-DRESS) is a well-described condition in adults, whereas it is uncommon among children. We describe a case of A-DRESS in a 16-year-old male with steroid-dependent ... ...

    Abstract Allopurinol-induced drug reaction syndrome with eosinophilia and systemic symptoms (A-DRESS) is a well-described condition in adults, whereas it is uncommon among children. We describe a case of A-DRESS in a 16-year-old male with steroid-dependent nephrotic syndrome. He presented a life-threatening clinical course with persisting fever, skin rash, eosinophilia, lymphadenopathy, distributive shock, and herpesvirus 6 detection. The withdrawal of allopurinol and a combination of intravenous immunoglobulins (IVIGs) and systemic corticosteroids led to the patient's recovery without sequelae. Drug reaction with eosinophilia and systemic symptoms (DRESS) in pediatrics is rare and can present in a severe form. Early diagnosis and timely treatment are critical for prognostic purposes. This report suggests the potentially crucial role of IVIG in the treatment of patients with A-DRESS.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028543-4
    ISSN 1551-6776
    ISSN 1551-6776
    DOI 10.5863/1551-6776-29.2.195
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  7. Article ; Online: Individual, environmental and demographic factors may play a role in the prognosis of fatal and non-fatal paediatric drowning.

    Bellini, Tommaso / Baffi, Susanna / Brisca, Giacomo / Calevo, Maria Grazia / Franzone, Daniele / Misley, Silvia / D'Alessandro, Matteo / Piccotti, Emanuela / Moscatelli, Andrea

    Acta paediatrica (Oslo, Norway : 1992)

    2023  

    Abstract: Aim: Drowning is a leading cause of unintentional death. Ongoing efforts are dedicated to preventing these tragic incidents. Our aim was to evaluate whether demographic, environmental and epidemiological characteristics of drowned children influence ... ...

    Abstract Aim: Drowning is a leading cause of unintentional death. Ongoing efforts are dedicated to preventing these tragic incidents. Our aim was to evaluate whether demographic, environmental and epidemiological characteristics of drowned children influence their prognosis.
    Methods: Single-centre retrospective study spanning 12 years. Each patient's record included: age, sex, place of residence, presence of siblings, season of incident, location of event, associated trauma, loss of consciousness, need for cardiopulmonary resuscitation, intubation, admission to intensive care unit, length of stay and mortality.
    Results: We enrolled 60 patients, with a mean age of 5.9 ± 3.4 years; 63.5% were male. Children who did not reside near the sea were significantly older than those who did (p = 0.01) and faced a higher risk of experiencing sea-related drowning (p = 0.05). No patients died. Loss of consciousness and need for cardiopulmonary resuscitation were recorded in 30 and 19 patients respectively. Seven patients sustained trauma. Only one patient requiring intubation. Pool-related drowning were associated with a higher incidence of needing cardiopulmonary resuscitation (p = 0.02). The need for cardiopulmonary resuscitation (p = 0.05) and the occurrence of trauma (p = 0.02) were identified as risk factors for a longer hospitalisation.
    Conclusion: Prevention and early initiation of cardiopulmonary resuscitation are essential for achieving a favourable prognosis. Identifying demographic and environmental risk factors may help identify other effective preventive measures.
    Language English
    Publishing date 2023-10-27
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17016
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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
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  8. Article ; Online: SARS-CoV-2 Infection May Present as Acute Hepatitis in Children.

    Brisca, Giacomo / Mallamaci, Marisa / Tardini, Giacomo / Martino, Lucia / Chianucci, Benedetta / Ricci, Margherita / Buffoni, Isabella / Romanengo, Marta

    The Pediatric infectious disease journal

    2021  Volume 40, Issue 5, Page(s) e214–e215

    MeSH term(s) COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/virology ; Diagnosis, Differential ; Hepatitis/diagnosis ; Hepatitis/physiopathology ; Hepatitis/virology ; Humans ; Infant ; Male ; SARS-CoV-2/isolation & purification
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003098
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Clinical and Radiological Features of

    Ricci, Erica / Bartalucci, Claudia / Russo, Chiara / Mariani, Marcello / Saffioti, Carolina / Massaccesi, Erika / Pierri, Filomena / Brisca, Giacomo / Moscatelli, Andrea / Caorsi, Roberta / Bruzzone, Bianca / Damasio, Maria Beatrice / Marchese, Anna / Mesini, Alessio / Castagnola, Elio

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 4

    Abstract: Background: Pneumocytis jirovecii: Description of cases: All PJP cases in non-HIV/AIDS patients diagnosed at Istituto Giannina Gaslini Pediatric Hospital in Genoa (Italy) from January 2012 until October 2022 were retrospectively evaluated. Nine cases ...

    Abstract Background: Pneumocytis jirovecii
    Description of cases: All PJP cases in non-HIV/AIDS patients diagnosed at Istituto Giannina Gaslini Pediatric Hospital in Genoa (Italy) from January 2012 until October 2022 were retrospectively evaluated. Nine cases were identified (median age: 8.3 years), and of these, 6/9 underwent prophylaxis with trimethoprim/sulfamethoxazole (TMP/SMX; five once-a-week schedules and one three times-a-week schedule), while 3/9 did not receive this. PJP was diagnosed by real-time PCR for
    Discussion: Due to the difficulty in obtaining biopsy specimens, PJP diagnosis is usually considered probable in most cases. Moreover, the severity of the clinical presentation often leads physicians to start TMP/SMX treatment empirically. BDG proved to be a useful tool for diagnosis, and CT showed good accuracy in identifying typical patterns. In our center, single-day/week prophylaxis was ineffective in high-risk patients; the three-day/week schedule would, therefore, seem preferable and, in any case, should be started promptly in all patients who have an indication of pneumonia.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10040276
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  10. Article: Clinical Course, Laboratory Findings, and Prognosis of SARS-CoV-2 Infection in Infants up to 90 Days of Age: A Single-Center Experience and a Proposal for a Management Pathway.

    Bellini, Tommaso / Brisca, Giacomo / Orfanos, Ioannis / Mariani, Marcello / Pezzotta, Federico / Giordano, Benedetta / Pastorino, Andrea / Misley, Silvia / Formigoni, Clelia / Fueri, Elena / Ferretti, Marta / Marin, Marta / Finetti, Martina / Piccotti, Emanuela / Castagnola, Elio / Moscatelli, Andrea

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 5

    Abstract: Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway.: ... ...

    Abstract Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway.
    Methods: Retrospective single-center study spanning three years. Patient data includes age, sex, symptoms, comorbidities, blood and urine test results, cultures, admission, length of stay, therapies, intensive care unit admission, and mortality.
    Results: A total of 274 patients were enrolled in the study, comprising 55% males. Among them, 60 patients (22%) were under the age of 29 days, while 214 (78%) fell within the 29 to 90 days age range. The overall incidence of SARS-CoV-2 infections was 0.28 per 10,000 Pediatric Emergency Department admissions. Blood inflammatory markers showed no significant abnormalities, and there were no recorded instances of positive blood cultures. Less than 1% of infants showed urinary tract infections with positive urine cultures, and 1.5% of patients had a concurrent RSV infection. Hospitalization rates were 83% for neonates and 67% for infants, with a median length of stay (LOS) of 48 h for both age groups. None of the patients required admission to the Pediatric or Neonatal Intensive Care Unit, and only one required High Flow Nasal Cannula (HFNC). No secondary serious bacterial infections were observed, and all hospitalized patients were discharged without short-term sequelae. No deaths were reported.
    Discussion and conclusions: Infants with COVID-19 generally exhibit milder or asymptomatic forms of the disease, making home management a viable option in most cases. Blood tests, indicative of a mild inflammatory response, are recommended primarily for children showing symptoms of illness. Hospitalization precautions for infants without apparent illness or comorbidities are deemed unnecessary. Given the evolving nature of experiences with COVID-19 in infants, maintaining a high level of clinical suspicion remains imperative.
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12050528
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