LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2214

Search options

  1. Article ; Online: Toward reproducible tumor organoid culture: focusing on primary liver cancer.

    Guo, Lianming / Li, Chao / Gong, Weiqiang

    Frontiers in immunology

    2024  Volume 15, Page(s) 1290504

    Abstract: Organoids present substantial potential for pushing forward preclinical research and personalized medicine by accurately recapitulating tissue and tumor ... ...

    Abstract Organoids present substantial potential for pushing forward preclinical research and personalized medicine by accurately recapitulating tissue and tumor heterogeneity
    MeSH term(s) Humans ; Proteomics ; Reproducibility of Results ; Liver Neoplasms/pathology ; Drug Evaluation, Preclinical ; Organoids
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1290504
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Editorial: Immunomodulation of MSCs in tissue repairing and regeneration.

    Peng, Yanwen / Li, Weiqiang / Zhang, Qunzhou

    Frontiers in immunology

    2023  Volume 14, Page(s) 1150106

    MeSH term(s) Conservation of Natural Resources ; Immunomodulation ; Signal Transduction ; Wound Healing
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1150106
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Translational control of SOG1 expression in response to replication stress in Arabidopsis

    Jinchao Li / Weiqiang Qian

    Stress Biology, Vol 3, Iss 1, Pp 1-

    2023  Volume 3

    Abstract: Abstract DNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA ... ...

    Abstract Abstract DNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA damage response (DDR) to sense the stresses and activate downstream processes. The transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), a functional counterpart of mammalian p53, is a master regulator of the DDR in plants. It is activated by various types of DNA lesions and can activate the transcription of hundreds of genes to trigger downstream processes, including cell cycle arrest, DNA repair, endoreplication, and apoptosis. Since SOG1 plays a crucial role in DDR, the activity of SOG1 must be tightly regulated. A recent study published in Plant Cell (Chen et al., Plant Cell koad126, 2023) reports a novel mechanism by which the ATR-WEE1 kinase module promotes SOG1 translation to fine-tune replication stress response.
    Keywords DNA damage response ; ATR ; WEE1 ; SOG1 ; Translation ; Biology (General) ; QH301-705.5
    Subject code 580
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Advances in genetic manipulation of

    Wan, Weiqiang / Li, Danni / Li, Dan / Jiao, Jun

    Frontiers in immunology

    2023  Volume 14, Page(s) 1209879

    Abstract: Chlamydia ... ...

    Abstract Chlamydia trachomatis
    MeSH term(s) Humans ; Chlamydia trachomatis/genetics ; Mutagenesis ; Gene Knockout Techniques ; Chlamydia Infections/genetics ; Chlamydia Infections/microbiology
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1209879
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: GopGAN: Gradients Orthogonal Projection Generative Adversarial Network With Continual Learning.

    Li, Xiaobin / Wang, Weiqiang

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 1, Page(s) 215–227

    Abstract: The generative adversarial networks (GANs) in continual learning suffer from catastrophic forgetting. In continual learning, GANs tend to forget about previous generation tasks and only remember the tasks they just learned. In this article, we present a ... ...

    Abstract The generative adversarial networks (GANs) in continual learning suffer from catastrophic forgetting. In continual learning, GANs tend to forget about previous generation tasks and only remember the tasks they just learned. In this article, we present a novel conditional GAN, called the gradients orthogonal projection GAN (GopGAN), which updates the weights in the orthogonal subspace of the space spanned by the representations of training examples, and we also mathematically demonstrate its ability to retain the old knowledge about learned tasks in learning a new task. Furthermore, the orthogonal projection matrix for modulating gradients is mathematically derived and its iterative calculation algorithm for continual learning is given so that training examples for learned tasks do not need to be stored when learning a new task. In addition, a task-dependent latent vector construction is presented and the constructed conditional latent vectors are used as the inputs of generator in GopGAN to avoid the disappearance of orthogonal subspace of learned tasks. Extensive experiments on MNIST, EMNIST, SVHN, CIFAR10, and ImageNet-200 generation tasks show that the proposed GopGAN can effectively cope with the issue of catastrophic forgetting and stably retain learned knowledge.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2021.3093319
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases.

    Li, Ruojun / Huang, Weiqiang

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Yes-associated protein (YAP, also known as YAP1) and its paralogue TAZ (with a PDZ-binding motif) are transcriptional coactivators that switch between the cytoplasm and nucleus and regulate the organ size and tissue homeostasis. This review focuses on ... ...

    Abstract Yes-associated protein (YAP, also known as YAP1) and its paralogue TAZ (with a PDZ-binding motif) are transcriptional coactivators that switch between the cytoplasm and nucleus and regulate the organ size and tissue homeostasis. This review focuses on the research progress on YAP/TAZ signaling proteins in myocardial infarction, cardiac remodeling, hypertension and coronary heart disease, cardiomyopathy, and aortic disease. Based on preclinical studies on YAP/TAZ signaling proteins in cellular/animal models and clinical patients, the potential roles of YAP/TAZ proteins in some cardiovascular diseases (CVDs) are summarized.
    MeSH term(s) Animals ; Adaptor Proteins, Signal Transducing/metabolism ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Phosphoproteins/metabolism ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins/genetics ; YAP-Signaling Proteins/genetics ; YAP-Signaling Proteins/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Intracellular Signaling Peptides and Proteins ; Phosphoproteins ; Trans-Activators ; Transcription Factors ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; YAP-Signaling Proteins ; WWTR1 protein, human
    Language English
    Publishing date 2023-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021666
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Translational control of SOG1 expression in response to replication stress in Arabidopsis.

    Li, Jinchao / Qian, Weiqiang

    Stress biology

    2023  Volume 3, Issue 1, Page(s) 28

    Abstract: DNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA damage ... ...

    Abstract DNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA damage response (DDR) to sense the stresses and activate downstream processes. The transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), a functional counterpart of mammalian p53, is a master regulator of the DDR in plants. It is activated by various types of DNA lesions and can activate the transcription of hundreds of genes to trigger downstream processes, including cell cycle arrest, DNA repair, endoreplication, and apoptosis. Since SOG1 plays a crucial role in DDR, the activity of SOG1 must be tightly regulated. A recent study published in Plant Cell (Chen et al., Plant Cell koad126, 2023) reports a novel mechanism by which the ATR-WEE1 kinase module promotes SOG1 translation to fine-tune replication stress response.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-0450
    ISSN (online) 2731-0450
    DOI 10.1007/s44154-023-00112-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Enantioselective Divergent Syntheses of Diterpenoid Pyrones.

    Ji, Yunpeng / Liu, Yaqian / Guan, Weiqiang / Guo, Chuning / Jia, Hongli / Hong, Benke / Li, Houhua

    Journal of the American Chemical Society

    2024  Volume 146, Issue 13, Page(s) 9395–9403

    Abstract: Capitalizing a synergy between late-stage C( ... ...

    Abstract Capitalizing a synergy between late-stage C(sp
    MeSH term(s) Pyrones ; Stereoisomerism ; Biological Products
    Chemical Substances Pyrones ; Biological Products
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c01788
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Editorial

    Yanwen Peng / Weiqiang Li / Qunzhou Zhang

    Frontiers in Immunology, Vol

    Immunomodulation of MSCs in tissue repairing and regeneration

    2023  Volume 14

    Keywords MSC ; immunomodulation ; regenerative medicine ; tissue repair ; secretomes ; inflammatory diseases ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Regeneration of sedimentary manganese in coastal sediments deciphered by

    Lin, Zhongliang / Liu, Li / Lian, Ergang / Zhao, Weiqiang / Jiang, Xinyu

    The Science of the total environment

    2024  Volume 928, Page(s) 172493

    Abstract: Manganese (Mn) is a vital micronutrient and participates in multiple biochemical reactions and enzyme catalytic activities. Its cycling is tightly connected with iron (Fe) and nitrogen (N). Although coastal sediments are recognized as an important source ...

    Abstract Manganese (Mn) is a vital micronutrient and participates in multiple biochemical reactions and enzyme catalytic activities. Its cycling is tightly connected with iron (Fe) and nitrogen (N). Although coastal sediments are recognized as an important source of dissolved Mn to marine waters, this contribution remains inadequately quantified. In the summer of 2019 and 2020, we investigated benthic fluxes of dissolved Mn, Fe and ammonia (NH
    Language English
    Publishing date 2024-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172493
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top