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  1. Article ; Online: Multimodal brain tumor image segmentation based on DenseNet

    Xiaoqin Wu / Xiaoli Yang / Zhenwei Li / Lipei Liu / Yuxin Xia

    PLoS ONE, Vol 19, Iss

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  2. Article ; Online: Mechanism of large-scale reservoir landslides with double-sliding zones

    Yuting Yang / Chenyang Zhang / Yushi Lu / Zhenwei Dai

    Frontiers in Ecology and Evolution, Vol

    insights from long-term field monitoring

    2024  Volume 11

    Abstract: A significant number of ancient landslides with double or multi-sliding zones exist in reservoir areas. However, understanding large-scale reservoir landslides with double-sliding zones remains limited due to the challenges of studying deformation along ... ...

    Abstract A significant number of ancient landslides with double or multi-sliding zones exist in reservoir areas. However, understanding large-scale reservoir landslides with double-sliding zones remains limited due to the challenges of studying deformation along the sliding zone independently from surface deformation. In this study, the seepage and deformation characteristics of the Taping landslide were obtained through field investigations and long-term in-situ monitoring. For the first time, hydrological factors influencing double-sliding zones were revealed using an attribute reduction algorithm based on long-term field data. The results indicate that the Taping landslide undergoes significant step-like consistent creep deformation, exhibiting failure along double-sliding zones. For the toe part, reservoir water level (RWL) and precipitation are two critical hydrological factors triggering deformation. Shallow sliding is more susceptible to rainfall, while the deep sliding zone is more affected by RWL variations. In the rear part, precipitation has a greater impact than RWL. Daily precipitation is the primary hydrological factor affecting slope movement along the shallow sliding zone. However, accumulated precipitation over the previous seven days is the most crucial factor influencing slope movement along the deep sliding zone. During the RWL drawdown period, shallow sliding initially occurs at the toe, induced by the de-buttressing effect, while deep sliding occurs after the RWL reaches 145 m, induced by the downslope seepage force. Local damage and failure at the toe provide space for the instability of the rear part, reducing the anti-sliding force. Consequently, failure extends to the rear part. The findings of this study hold significant implications for gaining a deeper understanding of the deformation mechanisms of large-scale reservoir landslides with double-sliding zones and improving landslide management and mitigation strategies in reservoir area.
    Keywords reservoir landslides ; double-sliding zones ; deformation characteristics ; triggering factors ; failure mechanism ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 550
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  3. Article ; Online: Letter to the editor regarding "The efficacy and safety of radiotherapy with adjuvant temozolomide for glioblastoma: A meta-analysis of randomized controlled studies".

    Yang, Lihui / Ye, Zhenwei / Huang, Qinhong

    Clinical neurology and neurosurgery

    2023  Volume 227, Page(s) 107666

    MeSH term(s) Humans ; Antineoplastic Agents, Alkylating/adverse effects ; Brain Neoplasms/drug therapy ; Brain Neoplasms/radiotherapy ; Chemotherapy, Adjuvant ; Dacarbazine/therapeutic use ; Glioblastoma/drug therapy ; Glioblastoma/radiotherapy ; Radiotherapy, Adjuvant ; Temozolomide/therapeutic use
    Chemical Substances Antineoplastic Agents, Alkylating ; Dacarbazine (7GR28W0FJI) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2023-03-02
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2023.107666
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  4. Article: Preparation of RDX/F2311/Fe

    Zhang, Zhenwei / Jiang, Dong / Yang, Lanting / Song, Wenkui / Wang, Ruihao / Huang, Qiuan

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 7

    Abstract: Nanothermites and high-energy explosives have significantly improved the performance of high-energy composites and have broad application prospects. Therefore, in this study, RDX/F2311/ ... ...

    Abstract Nanothermites and high-energy explosives have significantly improved the performance of high-energy composites and have broad application prospects. Therefore, in this study, RDX/F2311/Fe
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17071623
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  5. Article ; Online: Reconstructing annual XCO

    Wu, Chao / Ju, Yuechuang / Yang, Shuo / Zhang, Zhenwei / Chen, Yixiang

    Environmental research

    2023  Volume 236, Issue Pt 2, Page(s) 116866

    Abstract: Long-time-series, high-resolution datasets of the column-averaged dry-air mole fraction of carbon dioxide ( ... ...

    Abstract Long-time-series, high-resolution datasets of the column-averaged dry-air mole fraction of carbon dioxide (XCO
    MeSH term(s) Environmental Monitoring/methods ; China
    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.116866
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: pH-dependent self-assembly mechanism of a single repetitive domain from a spider silk protein.

    Yang, Yadi / Gao, Zhenwei / Yang, Daiwen

    International journal of biological macromolecules

    2023  Volume 242, Issue Pt 1, Page(s) 124775

    Abstract: Spider silk is self-assembled from full-length silk proteins, and some silk protein fragments can also form silk-like fibers in vitro. However, the mechanism underlying the silk fiber formation is not understood well. In this study, we investigated the ... ...

    Abstract Spider silk is self-assembled from full-length silk proteins, and some silk protein fragments can also form silk-like fibers in vitro. However, the mechanism underlying the silk fiber formation is not understood well. In this study, we investigated the fiber formation of a single repetitive domain (RP) from a minor ampullate silk protein (MiSp). Our findings revealed that pH and salt concentration affect not only the stability of MiSp-RP but also its self-assembly into fibers and aggregates. Using nuclear magnetic resonance (NMR) spectroscopy, we solved the three-dimensional (3D) structure of MiSp RP in aqueous solution. On the basis of the structure and mutagenesis, we revealed that charge-dipole interactions are responsible for the pH- and salt-dependent properties of MiSp-RP. Our results indicate that fiber formation is regulated by a delicate balance between intermolecular and intramolecular interactions, rather than by the protein stability alone. These findings have implications for the design of silk proteins for mass production of spider silk.
    MeSH term(s) Animals ; Silk/chemistry ; Magnetic Resonance Spectroscopy ; Protein Stability ; Hydrogen-Ion Concentration ; Spiders/metabolism ; Fibroins/chemistry
    Chemical Substances Silk ; Fibroins (9007-76-5)
    Language English
    Publishing date 2023-05-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124775
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  7. Article ; Online: 2-Pyran-4-Ylidene Malononitrile Based Conjugated Microporous Polymers as Metal-Free Heterogeneous Photocatalysts for Organic Synthesis.

    Liu, Yuanbo / Yang, Liuliu / Hou, Yuxin / Zhang, Zhenwei / Xiao, Xiao / Yue, Huijuan / Liu, Xiaoming

    Macromolecular rapid communications

    2024  , Page(s) e2400083

    Abstract: Photoactive conjugated microporous polymers (CMPs) as heterogeneous photocatalysts provide a sustainable alternative to classical metal-based semiconductor photosensitizers. However, previously reported CMPs are typically synthesized through metal ... ...

    Abstract Photoactive conjugated microporous polymers (CMPs) as heterogeneous photocatalysts provide a sustainable alternative to classical metal-based semiconductor photosensitizers. However, previously reported CMPs are typically synthesized through metal catalyzed coupling reactions, which bears product separation, but also increases the price of materials. Herein, a new type of sp
    Language English
    Publishing date 2024-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475027-2
    ISSN 1521-3927 ; 1022-1336
    ISSN (online) 1521-3927
    ISSN 1022-1336
    DOI 10.1002/marc.202400083
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  8. Article ; Online: Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker.

    Li, Yanxing / Gao, Wentao / Yang, Zhen / Hu, Zhenwei / Li, Jianjun

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6517

    Abstract: Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating the replication of eukaryotic genomes. Recently, there has been a growing interest in investigating the ... ...

    Abstract Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating the replication of eukaryotic genomes. Recently, there has been a growing interest in investigating the significance of MCM4 in different types of cancer. Despite the existing research on this topic, a comprehensive analysis of MCM4 across various cancer types has been lacking. This study aims to bridge this knowledge gap by presenting a thorough pan-cancer analysis of MCM4, shedding light on its functional implications and potential clinical applications. The study utilized multi-omics samples from various databases. Bioinformatic tools were employed to explore the expression profiles, genetic alterations, phosphorylation states, immune cell infiltration patterns, immune subtypes, functional enrichment, disease prognosis, as well as the diagnostic potential of MCM4 and its responsiveness to drugs in a range of cancers. Our research demonstrates that MCM4 is closely associated with the oncogenesis, prognosis and diagnosis of various tumors and proposes that MCM4 may function as a potential biomarker in pan-cancer, providing a deeper understanding of its potential role in cancer development and treatment.
    MeSH term(s) Humans ; Minichromosome Maintenance Complex Component 4/genetics ; Minichromosome Maintenance Complex Component 4/metabolism ; Prognosis ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Multiomics ; Minichromosome Maintenance Complex Component 6/metabolism ; Neoplasms/diagnosis ; Neoplasms/genetics
    Chemical Substances Minichromosome Maintenance Complex Component 4 (EC 3.6.4.12) ; Cell Cycle Proteins ; Minichromosome Maintenance Complex Component 6 (EC 3.6.4.12) ; MCM4 protein, human (EC 3.6.4.12)
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57299-1
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  9. Article ; Online: Elastic properties of disordered binary hcp-Fe alloys under high pressure

    Zhenwei Niu / Shuqiong Zeng / Mei Tang / Zaixiu Yang

    ChemPhysMater, Vol 2, Iss 2, Pp 155-

    Effects of light elements

    2023  Volume 163

    Abstract: The effects of light elements on the elastic properties of disordered binary hcp-Fe alloys were investigated at high pressures using plane-wave density functional theory combined with the Monte Carlo special quasi-random structure method. We found that ... ...

    Abstract The effects of light elements on the elastic properties of disordered binary hcp-Fe alloys were investigated at high pressures using plane-wave density functional theory combined with the Monte Carlo special quasi-random structure method. We found that the increase in the O content in hcp-Fe had a more pronounced effect on the sound velocity than Si, S, and C. The longitudinal wave velocity was decreased by ∼ 6% with 2% O content, which was a much greater decrease than the values of 0.6% and 2% induced by the same content of Si and S, respectively, under high pressures. Compared with the other three light elements, the longitudinal wave velocity of the Fe-C alloy exhibited the most gradual decreasing with increasing C content. In addition, the effects of different O and S contents on the anisotropy of hcp-Fe alloys strongly depended on the variation in pressure, whereas the pressure only slightly affected the anisotropy of Fe-Si alloy systems.
    Keywords hcp-Fe alloys ; Elastic property ; Sound velocity ; Light elements ; Chemistry ; QD1-999 ; Physics ; QC1-999
    Subject code 669
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
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  10. Article ; Online: Screening and optimization of a water-soluble near-infrared fluorescent probe for drug-induced liver injury monitoring.

    Pan, Yanping / Yang, Qiuxing / Xu, Hong / Yuan, Zhenwei / Xu, Hui

    Analytica chimica acta

    2023  Volume 1276, Page(s) 341654

    Abstract: Peroxynitrite ( ... ...

    Abstract Peroxynitrite (ONOO
    MeSH term(s) Animals ; Fluorescent Dyes/toxicity ; Zebrafish ; Chemical and Drug Induced Liver Injury/diagnostic imaging ; Chemical and Drug Induced Liver Injury/etiology ; Optical Imaging ; Peroxynitrous Acid
    Chemical Substances Fluorescent Dyes ; Peroxynitrous Acid (14691-52-2)
    Language English
    Publishing date 2023-07-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341654
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