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  1. Article ; Online: Type 2 Diabetes and Atrial Fibrillation: Evaluating Causal and Pleiotropic Pathways Using Mendelian Randomization.

    Reddy, Rohin K / Ardissino, Maddalena / Ng, Fu Siong

    Journal of the American Heart Association

    2023  Volume 12, Issue 17, Page(s) e030298

    Abstract: Background Observational associations between type 2 diabetes (T2D) and atrial fibrillation (AF) have been established, but causality remains undetermined. We performed Mendelian randomization (MR) to study causal effects of genetically predicted T2D on ... ...

    Abstract Background Observational associations between type 2 diabetes (T2D) and atrial fibrillation (AF) have been established, but causality remains undetermined. We performed Mendelian randomization (MR) to study causal effects of genetically predicted T2D on AF risk, independent of cardiometabolic risk factors. Methods and Results Instrumental variables included 182 uncorrelated single nucleotide polymorphisms associated with T2D at genome-wide significance (
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/genetics ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Lipoproteins, LDL
    Chemical Substances Lipoproteins, LDL
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.030298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recommendations for Reducing Inequalities Experienced by Female and Ethnic Minority Doctors in the United Kingdom.

    Palmer, Emilia G / Reddy, Rohin K

    Academic medicine : journal of the Association of American Medical Colleges

    2021  Volume 96, Issue 7, Page(s) 934–935

    MeSH term(s) Career Choice ; Employment/statistics & numerical data ; Ethnicity/psychology ; Ethnicity/statistics & numerical data ; Female ; Humans ; Income/statistics & numerical data ; Minority Groups/psychology ; Minority Groups/statistics & numerical data ; Physicians/psychology ; Physicians/statistics & numerical data ; Socioeconomic Factors ; United Kingdom/ethnology
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004054
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    Zs.A 112: Show issues Location:
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  3. Article ; Online: Keeping it in the family: Use of the grandmother, mother, and child technique to navigate complex anatomy during Coronary sinus Reducer Implantation.

    Reddy, Rohin K / Foley, Michael / Giannini, Francesco / Al-Lamee, Rasha K

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2023  Volume 102, Issue 6, Page(s) 1057–1060

    Abstract: The Coronary Sinus Reducer® (CSR) is an emerging therapy for refractory angina recommended once no further pharmacologic or coronary revascularization options are available. We present the case of a 72-year-old man who underwent CSR implantation. Complex ...

    Abstract The Coronary Sinus Reducer® (CSR) is an emerging therapy for refractory angina recommended once no further pharmacologic or coronary revascularization options are available. We present the case of a 72-year-old man who underwent CSR implantation. Complex coronary sinus anatomy necessitated an innovative "grandmother, mother, and child" catheter approach.
    MeSH term(s) Aged ; Humans ; Male ; Angina Pectoris/therapy ; Coronary Sinus/diagnostic imaging ; Treatment Outcome
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30858
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    Zs.A 1226: Show issues Location:
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  4. Article ; Online: Response to: 'Medical students' preference for returning to the clinical setting during the COVID-19 pandemic'.

    Reddy, Rohin K / Palmer, Emilia G

    Medical education

    2020  Volume 54, Issue 12, Page(s) 1192

    MeSH term(s) Betacoronavirus ; COVID-19 ; Humans ; Pandemics ; Students, Medical
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.14283
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    Zs.B 312: Show issues Location:
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  5. Article ; Online: Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials.

    Reddy, Rohin K / Ahmad, Yousif / Arnold, Ahran D / Howard, James P

    Journal of the Society for Cardiovascular Angiography & Interventions

    2023  Volume 2, Issue 5, Page(s) None

    Abstract: Background: Stroke is a feared complication of transcatheter aortic valve replacement (TAVR), which embolic protection devices (EPDs) may mitigate. This systematic review and meta-analysis synthesized randomized controlled trials (RCTs) to evaluate the ... ...

    Abstract Background: Stroke is a feared complication of transcatheter aortic valve replacement (TAVR), which embolic protection devices (EPDs) may mitigate. This systematic review and meta-analysis synthesized randomized controlled trials (RCTs) to evaluate the effect of EPDs in TAVR.
    Methods: All RCTs comparing EPDs with control during TAVR were systematically identified. Prespecified primary end points were all stroke, disabling stroke, nondisabling stroke, and all-cause mortality. Safety and neuroimaging parameters were assessed. Sensitivity analyses were stratified by EPD type. Study registration was a priori (CRD42022377939).
    Results: Eight trials randomizing 4043 patients were included. There was no significant difference between EPDs and control for all stroke (relative risk [RR], 0.88; 95% CI, 0.65-1.18;
    Conclusions: The totality of randomized data for EPDs during TAVR demonstrated no safety concerns or significant differences in clinical or neuroimaging end points. Analyses restricted to the Sentinel EPD demonstrated large, clinically meaningful reductions in disabling stroke. Ongoing RCTs may help validate these results.
    Language English
    Publishing date 2023-10-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2772-9303
    ISSN (online) 2772-9303
    DOI 10.1016/j.jscai.2023.101031
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  6. Article ; Online: A Bibliometric Analysis of the Highest Cited Rhytidectomy Literature.

    Dutt, Atul / Dutt, Ajay P / Reddy, Rohin K / Charles, Walton N / Khademi Mansour, Hamid Reza / Nahai, Foad / Khajuria, Ankur

    Aesthetic surgery journal. Open forum

    2023  Volume 5, Page(s) ojad099

    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2631-4797
    ISSN (online) 2631-4797
    DOI 10.1093/asjof/ojad099
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  8. Article ; Online: Maternal hypertensive traits and adverse outcome in pregnancy: a Mendelian randomization study.

    Ardissino, Maddalena / Reddy, Rohin K / Slob, Eric A W / Griffiths, Jack / Girling, Joanna / Ng, Fu Siong

    Journal of hypertension

    2023  Volume 41, Issue 9, Page(s) 1438–1445

    Abstract: Introduction: Hypertensive disorders of pregnancy are associated with adverse feto-maternal outcomes. Existing evidence is mostly limited to observational studies, which are liable to confounding and bias. This study investigated the causal relevance of ...

    Abstract Introduction: Hypertensive disorders of pregnancy are associated with adverse feto-maternal outcomes. Existing evidence is mostly limited to observational studies, which are liable to confounding and bias. This study investigated the causal relevance of component hypertensive indices on multiple adverse pregnancy outcomes using Mendelian randomization.
    Methods: Uncorrelated ( r2  < 0.001) genome-wide significant ( P  < 5 × 10 -8 ) single-nucleotide polymorphisms associated with SBP, DBP and pulse pressure (PP) were selected as instrumental variables. Genetic association estimates for outcomes of preeclampsia or eclampsia, preterm birth, placental abruption and hemorrhage in early pregnancy were extracted from summary statistics of genome-wide association studies in the FinnGen cohort. Two-sample, inverse-variance weighted Mendelian randomization formed the primary analysis method. Odds ratios (OR) are presented per-10 mmHg higher genetically predicted hypertensive index.
    Results: Higher genetically predicted SBP were associated with higher odds of preeclampsia or eclampsia [OR 1.81, 95% confidence interval (CI) 1.68-1.96, P  = 5.45 × 10 -49 ], preterm birth (OR 1.09, 95% CI 1.03-1.16, P  = 0.005) and placental abruption (OR 1.33, 95% CI 1.05-1.68, P  = 0.016). Higher genetically-predicted DBP was associated with preeclampsia or eclampsia (OR 2.54, 95% CI 2.21-2.92, P  = 5.35 × 10 -40 ). Higher genetically predicted PP was associated with preeclampsia or eclampsia (OR 1.68, 95% CI 1.47-1.92, P  = 1.9 × 10 -14 ) and preterm birth (OR 1.18, 95% CI 1.06-1.30, P  = 0.002).
    Conclusion: This study provides genetic evidence to support causal associations of SBP, DBP and PP on multiple adverse outcomes of pregnancy. SBP and PP were associated with the broadest range of adverse outcomes, suggesting that optimized management of blood pressure, particularly SBP, is a key priority to improve feto-maternal health.
    MeSH term(s) Pregnancy ; Humans ; Infant, Newborn ; Female ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/genetics ; Premature Birth/genetics ; Eclampsia/epidemiology ; Eclampsia/genetics ; Abruptio Placentae/epidemiology ; Abruptio Placentae/genetics ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Placenta ; Hypertension ; Pregnancy Outcome ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003486
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
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    Zs.MO 614: Show issues

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  9. Article ; Online: Response to

    Reddy, Rohin K. / Palmer, Emilia G.

    Medical Education ; ISSN 0308-0110 1365-2923

    ‘Medical students’ preference for returning to the clinical setting during the COVID‐19 pandemic’

    2020  

    Keywords Education ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/medu.14283
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Teaching Professionalism to Medical Students Using Dissection-Based Anatomy Education: a Practical Guide.

    Palmer, Emilia G / Reddy, Rohin K / Laughey, William

    Medical science educator

    2020  Volume 31, Issue 1, Page(s) 203–213

    Abstract: Professionalism is a core competency for all healthcare professionals and is a subject of great interest within the academic community due to its vital importance in delivering the highest quality patient care. Despite this, professionalism remains ... ...

    Abstract Professionalism is a core competency for all healthcare professionals and is a subject of great interest within the academic community due to its vital importance in delivering the highest quality patient care. Despite this, professionalism remains difficult to define, teach and assess. The potential use of anatomy education in teaching professionalism has been increasingly highlighted within the literature, but still remains an underutilised tool in medical education. Therefore, this practical guide offers evidence-based practical points for successfully incorporating professionalism within a dissection-based anatomy course delivered to undergraduate medical students.
    Keywords covid19
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-020-01137-2
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