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  1. Article ; Online: Molecular dynamics in cells: A neutron view.

    Zaccai, Giuseppe

    Biochimica et biophysica acta. General subjects

    2019  Volume 1864, Issue 3, Page(s) 129475

    Abstract: Experiments to characterize intracellular molecular dynamics in vivo are discussed following a description of the incoherent neutron scattering method. Work reviewed includes water diffusion in bacteria, archaea, red blood cells, brain cells and cancer ... ...

    Abstract Experiments to characterize intracellular molecular dynamics in vivo are discussed following a description of the incoherent neutron scattering method. Work reviewed includes water diffusion in bacteria, archaea, red blood cells, brain cells and cancer cells, and the role of proteome molecular dynamics in adaptation to physiological temperature and pressure, and in response to low salt stress in an extremophile. A brief discussion of the potential links between neutron scattering results and MD simulations on in-cell dynamics concludes the review.
    MeSH term(s) Diffusion ; Molecular Dynamics Simulation/trends ; Neutron Diffraction/methods ; Neutron Diffraction/trends ; Neutrons ; Proteome ; Temperature ; Water
    Chemical Substances Proteome ; Water (059QF0KO0R)
    Language English
    Publishing date 2019-11-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2019.129475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Molecular dynamics in cells: A neutron view

    Zaccai, Giuseppe

    Biochimica et biophysica acta. 2020 Mar., v. 1864, no. 3

    2020  

    Abstract: Experiments to characterize intracellular molecular dynamics in vivo are discussed following a description of the incoherent neutron scattering method. Work reviewed includes water diffusion in bacteria, archaea, red blood cells, brain cells and cancer ... ...

    Abstract Experiments to characterize intracellular molecular dynamics in vivo are discussed following a description of the incoherent neutron scattering method. Work reviewed includes water diffusion in bacteria, archaea, red blood cells, brain cells and cancer cells, and the role of proteome molecular dynamics in adaptation to physiological temperature and pressure, and in response to low salt stress in an extremophile. A brief discussion of the potential links between neutron scattering results and MD simulations on in-cell dynamics concludes the review.
    Keywords Archaea ; bacteria ; brain ; erythrocytes ; extremophiles ; molecular dynamics ; neoplasm cells ; neoplasms ; neutron diffraction ; proteome ; salt stress ; temperature
    Language English
    Dates of publication 2020-03
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 840755-1
    ISSN 0304-4165
    ISSN 0304-4165
    DOI 10.1016/j.bbagen.2019.129475
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Relevance of Earth-Bound Extremophiles in the Search for Extraterrestrial Life.

    Carré, Lorenzo / Zaccai, Giuseppe / Delfosse, Xavier / Girard, Eric / Franzetti, Bruno

    Astrobiology

    2022  Volume 22, Issue 3, Page(s) 322–367

    Abstract: The recent discovery of extrasolar Earth-like planets that orbit in their habitable zone of their system, and the latest clues of the presence of liquid water in the subsurface of Mars and in the subglacial ocean of Jupiter's and Saturn's moons, has ... ...

    Abstract The recent discovery of extrasolar Earth-like planets that orbit in their habitable zone of their system, and the latest clues of the presence of liquid water in the subsurface of Mars and in the subglacial ocean of Jupiter's and Saturn's moons, has reopened debates about habitability and limits of life. Although liquid water, widely accepted as an absolute requirement for terrestrial life, may be present in other bodies of the solar system or elsewhere, physical and chemical conditions, such as temperature, pressure, and salinity, may limit this habitability. However, extremophilic microorganisms found in various extreme terrestrial environments are adapted to thrive in permanently extreme ranges of physicochemical conditions. This review first describes promising environments for life in the Solar System and the microorganisms that inhabit similar environments on the Earth. The effects of extreme temperatures, salt, and hydrostatic pressure conditions on biomolecules will be explained in some detail, and recent advances in understanding biophysical and structural adaptation strategies allowing microorganisms to cope with extreme physicochemical conditions are reviewed to discuss promising environments for life in the Solar System in terms of habitability.
    MeSH term(s) Earth, Planet ; Exobiology ; Extraterrestrial Environment ; Extremophiles ; Planets
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2047736-3
    ISSN 1557-8070 ; 1531-1074
    ISSN (online) 1557-8070
    ISSN 1531-1074
    DOI 10.1089/ast.2021.0033
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  4. Article ; Online: Hydration shells with a pinch of salt.

    Zaccai, Giuseppe

    Biopolymers

    2013  Volume 99, Issue 4, Page(s) 233–238

    Abstract: The discovery of extreme halophile microorganisms in the Dead Sea, which are specifically dependent on a multimolar salt environment to survive, stimulated major developments in biology and physical chemistry. The minireview focuses on the molecular ... ...

    Abstract The discovery of extreme halophile microorganisms in the Dead Sea, which are specifically dependent on a multimolar salt environment to survive, stimulated major developments in biology and physical chemistry. The minireview focuses on the molecular level. After a brief introduction to the history of halophile studies, protein and nucleic acid solvent interactions and their influence on macromolecular structure stabilization and dynamics are discussed.
    MeSH term(s) Proteins ; Sodium Chloride ; Water/chemistry
    Chemical Substances Proteins ; Water (059QF0KO0R) ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1123-x
    ISSN 1097-0282 ; 0006-3525
    ISSN (online) 1097-0282
    ISSN 0006-3525
    DOI 10.1002/bip.22154
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Straight lines of neutron scattering in biology: a review of basic controls in SANS and EINS.

    Zaccai, Giuseppe

    European biophysics journal : EBJ

    2012  Volume 41, Issue 10, Page(s) 781–787

    Abstract: Neutron and X-ray beams in scattering experiments have similar wavelengths and explore the same length scale (~1 Å or 0.1 nm). Data collection and analysis are also broadly similar for both radiation types. There are fundamental differences, however, ... ...

    Abstract Neutron and X-ray beams in scattering experiments have similar wavelengths and explore the same length scale (~1 Å or 0.1 nm). Data collection and analysis are also broadly similar for both radiation types. There are fundamental differences, however, between the interaction of X-rays and neutrons with matter, which makes them strongly complementary for structural studies in biology. The property of neutrons to distinguish natural abundance hydrogen from its deuterium isotope and the dispersion relation that leads to the energy of ~1 Å neutrons being of the order of thermal energy are well known. They form the basis, respectively, of contrast variation on the one hand and energy-resolved scattering experiments to study macromolecular dynamics-neutron-specific scattering methods on the other. Interestingly, analysis procedures for the structural and dynamics experiments display common aspects that can be expressed as straight-line relationships. These not only act as controls of good sample preparation, but also yield model-free parameters on an absolute scale that provide fundamental information on the structure and dynamics of the system under study.
    MeSH term(s) Neutron Diffraction/methods ; Nucleic Acids/chemistry ; Protein Conformation ; Proteins/chemistry ; Scattering, Small Angle ; X-Ray Diffraction/methods
    Chemical Substances Nucleic Acids ; Proteins
    Language English
    Publishing date 2012-05-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 283671-3
    ISSN 1432-1017 ; 0175-7571
    ISSN (online) 1432-1017
    ISSN 0175-7571
    DOI 10.1007/s00249-012-0825-5
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  6. Article: Behavior of Hydrated Lipid Bilayers at Cryogenic Temperatures.

    Meineke, Jakob / Weik, Martin / Zaccai, Giuseppe / Fragneto, Giovanna

    Frontiers in chemistry

    2020  Volume 8, Page(s) 455

    Abstract: Neutron diffraction was used to study the behavior of water present in phospholipid multilamellar stacks from 1,2-dimyristoyl- ...

    Abstract Neutron diffraction was used to study the behavior of water present in phospholipid multilamellar stacks from 1,2-dimyristoyl-
    Language English
    Publishing date 2020-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2020.00455
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  7. Article ; Online: The case for an empirical 'high-throughput' neutron scattering approach to protein dynamics.

    Zaccai, Giuseppe

    Acta crystallographica. Section D, Biological crystallography

    2010  Volume 66, Issue Pt 11, Page(s) 1224–1228

    Abstract: Recalling that there are currently more than 63,000 structures deposited in the Protein Data Bank, it is time for neutron scatterers studying protein dynamics to show a similar interest in the diversity that is the basis of biology. Sound experimental ... ...

    Abstract Recalling that there are currently more than 63,000 structures deposited in the Protein Data Bank, it is time for neutron scatterers studying protein dynamics to show a similar interest in the diversity that is the basis of biology. Sound experimental data that can underpin and complement molecular-dynamics simulations for fundamental research and health applications such as drug design can and should be provided. A proposal is presented to fulfil the two conditions that are required to enable such an approach: (i) the identification of measurable dynamics parameters that are correlated to biological function and activity and (ii) the design of experiments to measure these parameters efficiently with reasonable throughput.
    MeSH term(s) Energy Transfer ; Molecular Dynamics Simulation ; Neutron Diffraction ; Proteins/chemistry ; Proteins/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020492-9
    ISSN 1399-0047 ; 2059-7983 ; 0907-4449
    ISSN (online) 1399-0047 ; 2059-7983
    ISSN 0907-4449
    DOI 10.1107/S0907444910021086
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  8. Article ; Online: Biological physics at large facilities: from molecule to cell.

    Zaccai, Giuseppe

    Journal of the Royal Society, Interface

    2009  Volume 6 Suppl 5, Page(s) S565–6

    MeSH term(s) Biophysics/organization & administration ; Cell Physiological Phenomena ; Molecular Biology/organization & administration ; Research/organization & administration ; Synchrotrons
    Language English
    Publishing date 2009-07-29
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2009.0269.focus
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  9. Article ; Online: Regards croisés du MEDD et du PUCA sur l'état des recherches françaises en matière d'inégalités écologiques

    Edwin Zaccaï

    Développement Durable et Territoires (2007)

    2007  

    Abstract: ... de recherches relatives aux inégalités écologiques ?E. Lemercier & G. Guillaumin : Q. ...

    Abstract Evelyne Lemercier, du Plan Urbanisme Construction et Architecture (PUCA) et Gérard Guillaumin Ministère de l’Ecologie et du Développement Durable (MEDD) ont bien voulu répondre aux questions des responsables de ce dossier, afin d'illustrer leurs points de vue en tant que commanditaires et utilisateurs de recherches.E. Zaccaï : Pourquoi les institutions auxquelles vous appartenez ont-elles lancé des programmes de recherches relatives aux inégalités écologiques ?E. Lemercier & G. Guillaumin : Q.
    Keywords Environmental sciences ; GE1-350 ; Social Sciences ; H
    Language French
    Publishing date 2007-06-01T00:00:00Z
    Publisher Réseau Développement Durable et Territoires Fragiles
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Editor's overview.

    Zaccai, G

    Biophysical chemistry

    2006  Volume 53, Issue 1-2, Page(s) 1–3

    Language English
    Publishing date 2006-09-01
    Publishing country Netherlands
    Document type Introductory Journal Article
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/0301-4622(94)00122-7
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