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Article ; Online: Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing.

Mishra, Abhinava K / Rodriguez, Melanie / Torres, Alba Yurani / Smith, Morgan / Rodriguez, Anthony / Bond, Annalise / Morrissey, Meghan A / Montell, Denise J

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 52, Page(s) e2310221120

Abstract: The 21kD GTPase Rac is an evolutionarily ancient regulator of cell shape and behavior. Rac2 is predominantly expressed in hematopoietic cells where it is essential for survival and motility. The hyperactivating mutation ... ...

Abstract	The 21kD GTPase Rac is an evolutionarily ancient regulator of cell shape and behavior. Rac2 is predominantly expressed in hematopoietic cells where it is essential for survival and motility. The hyperactivating mutation Rac2
MeSH term(s)	Animals ; Mice ; Humans ; rac GTP-Binding Proteins/genetics ; rac GTP-Binding Proteins/metabolism ; rac1 GTP-Binding Protein/metabolism ; Receptors, Chimeric Antigen ; Cannibalism ; Macrophages/metabolism ; Immunologic Deficiency Syndromes/genetics ; Cell Death ; Neoplasms
Chemical Substances	rac GTP-Binding Proteins (EC 3.6.5.2) ; rac1 GTP-Binding Protein (EC 3.6.5.2) ; Receptors, Chimeric Antigen
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2310221120
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Article ; Online: In situ observation of a macrourid fish at 7259 m in the Japan Trench: swimbladder buoyancy at extreme depth.

Priede, Imants G / Jamieson, Alan J / Bond, Todd / Kitazato, Hiroshi

The Journal of experimental biology

2024 Volume 227, Issue 3

Abstract: ... at 7259 m - the deepest ever observation of a fish species with a swim bladder. The buoyancy provided ...

Abstract	A macrourid, Coryphaenoides yaquinae sp. inc., was observed to be attracted to bait and exhibiting normal foraging behaviour during a period of 80 min within view of a baited video camera on the sea floor at 7259 m - the deepest ever observation of a fish species with a swim bladder. The buoyancy provided by an oxygen-filled swim bladder at 74.4 MPa pressure was estimated to be 0.164 N, at a theoretical energy cost of 20 kJ, 200 times less than the cost of equivalent lipid buoyancy. During normal metabolism, 192 days would be required to fill the swimbladder. At these depths, oxygen is very incompressible, so changes in volume during ascent or descent are small. However, swimbladder function is crucially dependent on a very low rate of diffusion of oxygen across the swimbladder wall. The oxygen in the swimbladder could theoretically sustain aerobic metabolism for over 1 year but is unlikely to be used as a reserve.
MeSH term(s)	Animals ; Air Sacs ; Japan ; Fishes/metabolism ; Oxygen/metabolism
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	218085-6
ISSN	1477-9145 ; 0022-0949
ISSN (online)	1477-9145
ISSN	0022-0949
DOI	10.1242/jeb.246522
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Zs.A 2629: Show issues

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Article ; Online: Multimodal approach utilising a weight management programme prior to bariatric surgery in patients with BMI ≥50 kg/m

Sari, Cetin / Santana, Connie / Seip, Richard L / Bond, Dale / Benbrahim, Aziz / Hannoush, Edward / McLaughlin, Tara / Li, Ya-Huei / Staff, Ilene / Wu, Yin / Papasavas, Pavlos / Tishler, Darren / Umashanker, Devika

Clinical obesity

2024 , Page(s) e12669

Abstract: ... 50 kg/m ...

Abstract	We evaluated preoperative weight loss and days from initial consult to surgery in patients with BMI ≥50 kg/m
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2625816-X
ISSN	1758-8111 ; 1758-8103
ISSN (online)	1758-8111
ISSN	1758-8103
DOI	10.1111/cob.12669
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Zs.A 6918: Show issues

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Article ; Online: Tribute to Paul M. Vanhoutte, MD, PhD (1940-2019).

Boulanger, Chantal M / Baretella, Oliver / Blaise, Gilbert / Bond, Richard A / Cai, Yin / Chan, Calvin K Y / Chataigneau, Thierry / Chen, Maggie Jie / Chen, Hui / Cheng, Yanhua / Clement, Denis L / Cohen, Richard A / Collis, Michael / Danser, A H Jan / de Mey, Jo / Detremmerie, Charlotte M S / Duprez, Daniel / Feletou, Michel / Flavahan, Nicolas /

Gao, Yuansheng / Guo, Yumeng / Hoeffner, Ute / Houston, Donald S / Huang, Ianto Boscheng / Huang, Yu / Iliano, Stephane / Junquero, Didier / Katusic, Zvonimir S / Komori, Kimihiro / Lee, Mary Y K / Leung, Susan W S / Li, Zhuoming / Liang, Sophie Chaofan / Liu, Jacky Tsz Chiu / Luscher, Thomas F / Michel, Frederic / Miller, Virginia M / Mombouli, Jean-Vivien / Morrison, Keith / Muldoon, Sheila M / O'Rourke, Steve / Perrault, Louis / Quignard, Jean Francois / Rusch, Nancy J / Sanchez-Ferrer, Carlos F / Schini-Kerth, Valerie / Shen, Kaikai / Shi, Yi / Song, Erfei / Sun, Kiwi W Y / Taddei, Stefano / Tang, Eva Hoi Ching / Tuncer, Meral / van den Ende, Romana / Vedernikov, Yuri / Verbeuren, Tony J / Webb, Clinton / Weigert, André / Wong, Kenneth H K / Xu, Cheng / Yang, Kangmin / Ying, Fan / Zellers, Thomas / Zhao, Yingzi / Zou, Qian / Shimokawa, Hiroaki

Arteriosclerosis, thrombosis, and vascular biology

2019 Volume 39, Issue 12, Page(s) 2445–2447

Language	English
Publishing date	2019-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.119.313461
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Zs.A 1705: Show issues

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Article ; Online: No recovery of a large-scale anthropogenic sediment disturbance on the Pacific seafloor after 77 years at 6460 m depth.

Jamieson, Alan J / Bond, Todd / Vescovo, Victor

Marine pollution bulletin

2022 Volume 175, Page(s) 113374

Abstract: ... to survey the current state of a large mechanical disturbance of sediments at 6460 m in the Pacific Ocean ...

Abstract	Habitat restoration and recolonisation of benthic communities after physical perturbation in the deep sea has long been thought to be extremely slow. This study reports on a serendipitous opportunity to survey the current state of a large mechanical disturbance of sediments at 6460 m in the Pacific Ocean. The impact was caused 77 years ago by the sinking of the USS Johnston. The surrounding debris field had little impact on the sedimentary habitat, other than in the provision of artificial hard substrates, while the troughs that formed as the ship impacted the seafloor and slid down the slope of the Philippine Trench were still completely void of animal tracks and burrows, or any observable epifauna, and in some areas subsurface stratification was still exposed at the surface. This suggests that mechanical perturbations of sediments in the deep Pacific may remain ecologically significant for, at the very least, 100 years.
MeSH term(s)	Animals ; Ecosystem ; Pacific Ocean ; Philippines
Language	English
Publishing date	2022-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2022.113374
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Article ; Online: Comparison of physiological demands in Warmblood show jumping horses over a standardized 1.10 m jumping course versus a standardized exercise test on a track.

Léguillette, Renaud / Bond, Stephanie L / Lawlor, Kelda / Haan, Tineke de / Weber, Lauren M

BMC veterinary research

2020 Volume 16, Issue 1, Page(s) 182

Abstract: ... of Warmblood show jumpers over a standardized 1.10 m course vs a 600 m standardized incremental exercise test ... to determine physiological variables after a standardized jumping course at 6.4 m/s (average speed) and track ... standardized incremental exercise test at 5 m/s, 8 m/s and 11 m/s. Heart rate, velocity, blood lactate ...

Abstract	Background: A greater understanding of exercise physiology and biochemistry is required for the sport horse disciplines, including show jumping. Conditioning of horses for show jumping is empirical because they are primarily trained on flat ground, however the equivalent workload between jumping and flat work is currently unknown. The objectives of the study were therefore to compare the physiological demands of Warmblood show jumpers over a standardized 1.10 m course vs a 600 m standardized incremental exercise test on flat ground, and to report reference field test values for competitive show jumping horses. In this prospective field study, 21 healthy, actively competing Warmblood show jumping horses were assessed to determine physiological variables after a standardized jumping course at 6.4 m/s (average speed) and track standardized incremental exercise test at 5 m/s, 8 m/s and 11 m/s. Heart rate, velocity, blood lactate, blood pH, pCO2, bicarbonate, PCV and TP concentrations were recorded. V200, V170 and VLa4 were calculated. Parametric statistics were performed on analysis of all 21 horses' variables. Results: Contrary to exercise at 5 m/s and 11 m/s, cantering at 8 m/s did not induce any significant difference in blood lactate, mean heart rate or mean venous blood pH compared to after completion of the jumping course. Conclusions: Jumping a 1.10 m course demands a statistically similar workload to cantering around a flat track at 8 m/s. This study will help to test fitness and design conditioning programs for Warmblood show jumping horses.
MeSH term(s)	Animals ; Blood Gas Analysis/veterinary ; Blood Proteins ; Exercise Test/methods ; Exercise Test/veterinary ; Heart Rate/physiology ; Hematocrit ; Horses/blood ; Horses/physiology ; Hydrogen-Ion Concentration ; Lactic Acid/blood ; Physical Conditioning, Animal/physiology ; Sports
Chemical Substances	Blood Proteins ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2020-06-08
Publishing country	England
Document type	Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-020-02400-9
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Article ; Online: Tunability of the M(II)M(III)/M(II)(2) and M(III)(2)/M(II)M(III) (M=Mn, Co) couples in bis-μ-O,O'-carboxylato-μ-OR bridged complexes.

Seidler-Egdal, Rune Kirk / Johansson, Frank B / Veltzé, Sune / Skou, Eivind M / Bond, Andrew D / McKenzie, Christine J

Dalton transactions (Cambridge, England : 2003)

2011 Volume 40, Issue 13, Page(s) 3336–3345

Abstract: A comparison of the electrochemical properties of a series of dinuclear complexes [M(2)(L)(RCO(2 ... 2)](+) with M = Mn or Co, L = 2,6-bis(N,N-bis-(2-pyridylmethyl)-sulfonamido)-4-methylphenolato ... in the backbone of bpsmp(-) stabilize the [M(2)(bpsmp)(RCO(2))(2)](+) complexes in their M(II)(2) oxidation state ...

Abstract	A comparison of the electrochemical properties of a series of dinuclear complexes [M(2)(L)(RCO(2))(2)](+) with M = Mn or Co, L = 2,6-bis(N,N-bis-(2-pyridylmethyl)-sulfonamido)-4-methylphenolato (bpsmp(-)) or 2,6-bis(N,N-bis(2-pyridylmethyl)aminomethyl)-4-tert-butylphenolato (bpbp(-)) and R = H, CH(3), CF(3) or 3,4-dimethoxybenzoate demonstrates: (i) The electron-withdrawing sulfonyl groups in the backbone of bpsmp(-) stabilize the [M(2)(bpsmp)(RCO(2))(2)](+) complexes in their M(II)(2) oxidation state compared to their [M(2)(bpbp)(RCO(2))(2)](+) analogues. Manganese complexes are stabilised by approximately 550 mV and cobalt complexes by 650 mV. (ii) The auxiliary bridging carboxylato ligands further attenuate the metal-based redox chemistry. Substitution of two acetato for two trifluoroacetato ligands shifts redox couples by 300-400 mV. Within the working potential window, reversible or quasi-reversible M(II)M(III)↔ M(II)(2) processes range from 0.31 to 1.41 V for the [Co(2)(L)(RCO(2))(2)](+/2+) complexes and from 0.54 to 1.41 V for the [Mn(2)(L)(RCO(2))(2)](+/2+) complexes versus Ag/AgCl for E(M(II)M(III)/M(II)(2)). The extreme limits are defined by the complexes [M(2)(bpbp)(CH(3)CO(2))(2)](+) and [M(2)(bpsmp)(CF(3)CO(2))(2)](+) for both metal ions. Thus, tuning the ligand field in these dinuclear complexes makes possible a range of around 0.9 V and 1.49 V for the one-electron E(M(II)M(III)/M(II)(2)) couple of the Mn and Co complexes, respectively. The second one-electron process, M(II)M(III)↔ M(III)(2) was also observed in some cases. The lowest potential recorded for the E°(M(III)(2)/M(II)M(III)) couple was 0.63 V for [Co(2)(bpbp)(CH(3)CO(2))(2)](2+) and the highest measurable potential was 2.23 V versus Ag/AgCl for [Co(2)(bpsmp)(CF(3)CO(2))(2)](2+).
MeSH term(s)	Carboxylic Acids/chemistry ; Cobalt/chemistry ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Crystallography, X-Ray ; Electrochemical Techniques ; Manganese/chemistry ; Molecular Conformation ; Oxidation-Reduction
Chemical Substances	Carboxylic Acids ; Coordination Complexes ; Cobalt (3G0H8C9362) ; Manganese (42Z2K6ZL8P)
Language	English
Publishing date	2011-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c0dt01552k
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Article ; Online: No recovery of a large-scale anthropogenic sediment disturbance on the Pacific seafloor after 77 years at 6460 m depth

Jamieson, Alan J. / Bond, Todd / Vescovo, Victor

Marine Pollution Bulletin. 2022 Feb., v. 175 p.113374-

2022

Abstract: ... to survey the current state of a large mechanical disturbance of sediments at 6460 m in the Pacific Ocean ...

Abstract	Habitat restoration and recolonisation of benthic communities after physical perturbation in the deep sea has long been thought to be extremely slow. This study reports on a serendipitous opportunity to survey the current state of a large mechanical disturbance of sediments at 6460 m in the Pacific Ocean. The impact was caused 77 years ago by the sinking of the USS Johnston. The surrounding debris field had little impact on the sedimentary habitat, other than in the provision of artificial hard substrates, while the troughs that formed as the ship impacted the seafloor and slid down the slope of the Philippine Trench were still completely void of animal tracks and burrows, or any observable epifauna, and in some areas subsurface stratification was still exposed at the surface. This suggests that mechanical perturbations of sediments in the deep Pacific may remain ecologically significant for, at the very least, 100 years.
Keywords	animals ; fauna ; habitat conservation ; habitats ; marine pollution ; sediments ; Pacific Ocean ; Environmental impact ; Habitat perturbation ; Deep-sea ; Hadal zone ; Shipwreck ; USS Johnston ; Philippine Trench
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2022.113374
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of physiological demands in Warmblood show jumping horses over a standardized 1.10 m jumping course versus a standardized exercise test on a track

Renaud Léguillette / Stephanie L. Bond / Kelda Lawlor / Tineke de Haan / Lauren M. Weber

BMC Veterinary Research, Vol 16, Iss 1, Pp 1-

2020 Volume 9

Abstract	Abstract Background A greater understanding of exercise physiology and biochemistry is required for the sport horse disciplines, including show jumping. Conditioning of horses for show jumping is empirical because they are primarily trained on flat ground, however the equivalent workload between jumping and flat work is currently unknown. The objectives of the study were therefore to compare the physiological demands of Warmblood show jumpers over a standardized 1.10 m course vs a 600 m standardized incremental exercise test on flat ground, and to report reference field test values for competitive show jumping horses. In this prospective field study, 21 healthy, actively competing Warmblood show jumping horses were assessed to determine physiological variables after a standardized jumping course at 6.4 m/s (average speed) and track standardized incremental exercise test at 5 m/s, 8 m/s and 11 m/s. Heart rate, velocity, blood lactate, blood pH, pCO2, bicarbonate, PCV and TP concentrations were recorded. V200, V170 and VLa4 were calculated. Parametric statistics were performed on analysis of all 21 horses’ variables. Results Contrary to exercise at 5 m/s and 11 m/s, cantering at 8 m/s did not induce any significant difference in blood lactate, mean heart rate or mean venous blood pH compared to after completion of the jumping course. Conclusions Jumping a 1.10 m course demands a statistically similar workload to cantering around a flat track at 8 m/s. This study will help to test fitness and design conditioning programs for Warmblood show jumping horses.
Keywords	V170 ; V200 ; VLa4 ; Exercise physiology ; Veterinary medicine ; SF600-1100
Subject code	796
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparison of physiological demands in Warmblood show jumping horses over a standardized 1.10 m jumping course versus a standardized exercise test on a track

Léguillette, Renaud / Bond, Stephanie L / Lawlor, Kelda / Haan, Tineke de / Weber, Lauren M

BMC veterinary research. 2020 Dec., v. 16, no. 1

2020

Abstract	BACKGROUND: A greater understanding of exercise physiology and biochemistry is required for the sport horse disciplines, including show jumping. Conditioning of horses for show jumping is empirical because they are primarily trained on flat ground, however the equivalent workload between jumping and flat work is currently unknown. The objectives of the study were therefore to compare the physiological demands of Warmblood show jumpers over a standardized 1.10 m course vs a 600 m standardized incremental exercise test on flat ground, and to report reference field test values for competitive show jumping horses. In this prospective field study, 21 healthy, actively competing Warmblood show jumping horses were assessed to determine physiological variables after a standardized jumping course at 6.4 m/s (average speed) and track standardized incremental exercise test at 5 m/s, 8 m/s and 11 m/s. Heart rate, velocity, blood lactate, blood pH, pCO2, bicarbonate, PCV and TP concentrations were recorded. V200, V170 and VLa4 were calculated. Parametric statistics were performed on analysis of all 21 horses’ variables. RESULTS: Contrary to exercise at 5 m/s and 11 m/s, cantering at 8 m/s did not induce any significant difference in blood lactate, mean heart rate or mean venous blood pH compared to after completion of the jumping course. CONCLUSIONS: Jumping a 1.10 m course demands a statistically similar workload to cantering around a flat track at 8 m/s. This study will help to test fitness and design conditioning programs for Warmblood show jumping horses.
Keywords	bicarbonates ; biochemistry ; blood ; blood pH ; design ; exercise ; exercise test ; heart rate ; horses ; jumping ; lactic acid ; objectives ; sports ; statistics ; velocity ; veterinary medicine
Language	English
Dates of publication	2020-12
Size	p. 182.
Publishing place	BioMed Central
Document type	Article
Note	NAL-light
ISSN	1746-6148
DOI	10.1186/s12917-020-02400-9
Database	NAL-Catalogue (AGRICOLA)

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