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  1. Article ; Online: Lessons from a trial of colesevelam for bile acid diarrhoea.

    Walters, Julian R F

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 4, Page(s) 290–291

    MeSH term(s) Humans ; Colesevelam Hydrochloride ; Bile Acids and Salts ; Diarrhea ; Anticholesteremic Agents
    Chemical Substances Colesevelam Hydrochloride (P4SG24WI5Q) ; Bile Acids and Salts ; Anticholesteremic Agents
    Language English
    Publishing date 2023-02-06
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00436-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Treating bile acid diarrhoea with liraglutide.

    Walters, Julian R F

    The lancet. Gastroenterology & hepatology

    2022  Volume 7, Issue 10, Page(s) 897–899

    MeSH term(s) Bile Acids and Salts ; Diarrhea/drug therapy ; Feces ; Humans ; Liraglutide/therapeutic use
    Chemical Substances Bile Acids and Salts ; Liraglutide (839I73S42A)
    Language English
    Publishing date 2022-07-20
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00213-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of bile acids and their TGR5 receptor in irritable bowel syndrome and diarrhoea.

    Walters, Julian R F

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2021  Volume 53, Issue 9, Page(s) 1118–1119

    Abstract: This commentary looks at recent findings relating to bile acids in patients with irritable bowel syndrome with diarrhoea (IBS-D). Bile acid diarrhoea is recognised to be a frequent, treatable cause of chronic diarrhoea, with a clinical picture which ... ...

    Abstract This commentary looks at recent findings relating to bile acids in patients with irritable bowel syndrome with diarrhoea (IBS-D). Bile acid diarrhoea is recognised to be a frequent, treatable cause of chronic diarrhoea, with a clinical picture which overlaps IBS-D. In the study - by Wei and colleagues, a large proportion of IBS-D patients were shown to have increased faecal bile acids, and an increase in primary bile acids, reflecting changes in bacterial metabolism. Expression of the colonic membrane bile acid receptor, TGR5, was associated with faecal bile acids and the severity of symptoms.
    MeSH term(s) Bacteria ; Bile Acids and Salts ; Diarrhea/etiology ; Feces ; Humans ; Irritable Bowel Syndrome/complications
    Chemical Substances Bile Acids and Salts
    Language English
    Publishing date 2021-07-11
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2021.06.017
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    Zs.A 1134: Show issues Location:
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  4. Article: The Evolving Clinical Trajectory From a Sliding Hiatus Hernia to Mixed Sliding and Para-Oesophageal Subtype: A Case Report.

    Hughes, Aimee / Shahzad, Muhammad Ibrahim / Zafar, Mansoor / El Gendy, Khalil / Walters, Julian R F

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56287

    Abstract: We present a compelling case of a patient initially diagnosed with a simple sliding hiatus hernia (HH), which was managed conservatively through optimised medical therapy. Over the span of a few years, she developed new symptoms which included epigastric ...

    Abstract We present a compelling case of a patient initially diagnosed with a simple sliding hiatus hernia (HH), which was managed conservatively through optimised medical therapy. Over the span of a few years, she developed new symptoms which included epigastric discomfort and pain, prompting further clinical review and imaging investigation. These revealed the progression of her HH from a simple form to a more complex rolling or para-oesophageal type. This outcome highlights the importance of recognising a potential for progression during the clinical assessment of patients with a history of reflux symptoms and the onset of new epigastric discomfort or pain. Understanding this continuum of HHs is essential for physicians as management plans may need to switch from a conservative to a more invasive approach.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56287
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  5. Article ; Online: Making the Diagnosis of Bile Acid Diarrhea.

    Walters, Julian R F

    The American journal of gastroenterology

    2020  Volume 115, Issue 12, Page(s) 1974–1975

    Abstract: Bile acid diarrhea is a frequent, treatable cause of functional diarrhea but is difficult to diagnose when the nuclear medicine seleno-taurohomocholic acid test is unavailable. An alternative approach is testing blood for the bile acid precursor, 7α-OH-4- ...

    Abstract Bile acid diarrhea is a frequent, treatable cause of functional diarrhea but is difficult to diagnose when the nuclear medicine seleno-taurohomocholic acid test is unavailable. An alternative approach is testing blood for the bile acid precursor, 7α-OH-4-cholesten-3-one, which is raised with increased bile acid synthesis. A recent article has defined measurements that have high negative and positive predictive values, further exploring how they can be improved by incorporating measures such as age, stool number, fibroblast growth factor 19, or plasma sulfated bile acids. Other articles have looked at the percentage of fecal primary bile acids. Together, they promise better use of diagnostic biomarkers for this condition.
    MeSH term(s) Bile Acids and Salts ; Diarrhea/diagnosis ; Feces ; Humans ; Prospective Studies
    Chemical Substances Bile Acids and Salts
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Twist in the Tale of a Pig Model of Short-Bowel Syndrome.

    Walters, Julian R F

    Cellular and molecular gastroenterology and hepatology

    2017  Volume 4, Issue 1, Page(s) 201–202

    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Editorial
    ISSN 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2017.04.003
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  7. Article ; Online: Letter: long-term treatment of severe bile acid diarrhoea-obeticholic acid can normalise SeHCAT retention.

    Walters, Julian R F

    Alimentary pharmacology & therapeutics

    2018  Volume 48, Issue 9, Page(s) 1032–1034

    MeSH term(s) Bile Acids and Salts ; Chenodeoxycholic Acid/analogs & derivatives ; Diarrhea ; Humans ; Retrospective Studies ; Taurocholic Acid/analogs & derivatives
    Chemical Substances Bile Acids and Salts ; obeticholic acid (0462Z4S4OZ) ; Chenodeoxycholic Acid (0GEI24LG0J) ; Taurocholic Acid (5E090O0G3Z) ; 23-seleno-25-homotaurocholic acid (75018-70-1)
    Language English
    Publishing date 2018-09-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.14979
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    Zs.A 2206: Show issues Location:
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  8. Article ; Online: Role of endoscopy in chronic diarrhoea when functional bowel disease is suspected.

    Arasaradnam, Ramesh P / Walters, Julian R F

    Gut

    2018  Volume 69, Issue 1, Page(s) 190–191

    MeSH term(s) Adult ; Diarrhea ; Disease ; Endoscopy ; Gastroenterology ; Humans
    Language English
    Publishing date 2018-12-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2018-317730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Show issues Location:
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  9. Article ; Online: Common Genetic Variants in the Bile Acid Synthesis Enzyme CYP7A1 Are Associated With Severe Primary Bile Acid Diarrhea.

    Balesaria, Sara / Pattni, Sanjeev S / Johnston, Ian M / Nolan, Jonathan D / Appleby, Richard N / Walters, Julian R F

    Gastroenterology

    2022  Volume 163, Issue 2, Page(s) 517–519.e2

    MeSH term(s) Bile Acids and Salts ; Cholesterol 7-alpha-Hydroxylase/metabolism ; Diarrhea/genetics ; Humans ; Lipogenesis
    Chemical Substances Bile Acids and Salts ; CYP7A1 protein, human (EC 1.14.14.23) ; Cholesterol 7-alpha-Hydroxylase (EC 1.14.14.23)
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.05.005
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  10. Article: Diagnosis and management of bile acid diarrhoea: a survey of UK expert opinion and practice.

    Walters, Julian R F / Arasaradnam, Ramesh / Andreyev, H Jervoise N

    Frontline gastroenterology

    2019  Volume 11, Issue 5, Page(s) 358–363

    Abstract: Objective: Bile acid diarrhoea (BAD), which includes bile acid malabsorption, causes a variety of digestive symptoms. Diagnostic rates and management vary considerably. We conducted a survey of current practice to review expert opinion and provide ... ...

    Abstract Objective: Bile acid diarrhoea (BAD), which includes bile acid malabsorption, causes a variety of digestive symptoms. Diagnostic rates and management vary considerably. We conducted a survey of current practice to review expert opinion and provide guidance on diagnosis and management.
    Design/method: An online survey was conducted of clinical members of the UK Bile Acid Related Diarrhoea Network, who had all published research on BAD (n=21). Most were National Health Service consultants who had diagnosed over 50 patients with the condition.
    Results: The preferred terminology was to use BAD, with primary and secondary to classify causes. A wide range of presenting symptoms and associated conditions were recognised. SeHCAT (tauroselcholic acid) was the preferred diagnostic test, and 50% of respondents thought general practitioners should have access to this. Patients who met the Rome IV diagnostic criteria for functional diarrhoea, irritable bowel syndrome (IBS) with predominant diarrhoea or postcholecystectomy diarrhoea were usually investigated by SeHCAT, which was used sometimes in other types of IBS. Treatment with a bile acid sequestrant was offered to patients with low SeHCAT values, with expected response rates >70% in the most severe. Colestyramine was the usual sequestrant, starting between 2 g and 8 g daily; colesevelam was an alternative. In patients who had an incomplete response, increasing the dose, changing to an alternative sequestrant, use of loperamide and a low fat diet were suggested. Recommendations for follow-up and to improve the overall patient experience were made.
    Conclusion: This expert survey indicates current best practice in the diagnosis and management of BAD.
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2019-101301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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