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  1. Book ; Online: Chapter Identità narrativa e memoria autobiografica: prospettive per un dialogo interdisciplinare

    FEYLES, MARTINO MARIA

    (Moderna/Comparata)

    2022  

    Series title Moderna/Comparata
    Keywords Literature & literary studies ; Literature ; Storytelling ; Social Media ; Digital Humanities
    Language Italian
    Size 1 electronic resource (11 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note Italian
    HBZ-ID HT030375845
    ISBN 9791221500455
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Chapter Disegno: letture integrate per l'interpretazione di conoscenze e competenze pre ingresso al PoliTO

    Bocconcino, Maurizio Marco / Zich, Ursula / Pavignano, Martino

    (diségno)

    2022  

    Series title diségno
    Keywords Semiotics / semiology ; History ; Impact of science & technology on society ; Discipline of representation, History, Semiotics, Science, Technology
    Language Italian
    Size 1 Online-Ressource
    Publisher FrancoAngeli
    Publishing place Milan
    Document type Book ; Online
    Note Italian ; English
    HBZ-ID HT030379545
    ISBN 9788835141938 ; 8835141931
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Surveillance for rat hepatitis E in wastewater networks, Italy.

    Palombieri, Andrea / Di Profio, Federica / Sarchese, Vittorio / Fruci, Paola / Suffredini, Elisabetta / Martella, Vito / Veneri, Carolina / Bonanno Ferraro, Giusy / Mancini, Pamela / La Rosa, Giuseppina / Di Martino, Barbara

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0267523

    Abstract: Importance: Hepatitis E virus (HEV) infection constitutes a significant health problem worldwide ...

    Abstract Importance: Hepatitis E virus (HEV) infection constitutes a significant health problem worldwide. In recent years, in addition to the zoonotic HEV3 and HEV4, emerging highly divergent hepevirus of rat origin (rat HEV [RHEV]) has been associated with human acute and chronic hepatitis. As environmental surveillance can be a complementary tool to explore emerging viruses of human and rodent origin, we investigated the epidemiology and the genetic variability of RHEV targeting 14 wastewater treatment plants in an Italian geographic area considered a hot spot for HEV infection in humans. Our results revealed that RHEV is a significant component of the wastewater microbiota with viral RNA detected in 43.9% of the specimens tested, adding further evidence to the need to investigate more in depth the real burden of RHEV infections in humans.
    MeSH term(s) Animals ; Humans ; Rats ; Hepatitis E/epidemiology ; Hepatitis E/veterinary ; Wastewater ; Phylogeny ; Genotype ; Hepatitis E virus/genetics ; Italy/epidemiology
    Chemical Substances Wastewater
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02675-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Label-Free Quantitative Analysis of Pig Liver Proteome after Hepatitis E Virus Infection.

    Martino, Camillo / Di Luca, Alessio / Bennato, Francesca / Ianni, Andrea / Passamonti, Fabrizio / Rampacci, Elisa / Henry, Michael / Meleady, Paula / Martino, Giuseppe

    Viruses

    2024  Volume 16, Issue 3

    Abstract: Hepatitis E represents an emerging zoonotic disease caused by the Hepatitis E virus (HEV ...

    Abstract Hepatitis E represents an emerging zoonotic disease caused by the Hepatitis E virus (HEV), for which the main route of transmission is foodborne. In particular, infection in humans has been associated with the consumption of contaminated undercooked meat of pig origin. The aim of this study was to apply comparative proteomics to determine if porcine liver protein profiles could be used to distinguish between pigs seropositive and seronegative for HEV. Preliminarily, an ELISA was used to evaluate the presence of anti-HEV antibodies in the blood serum of 136 animals sent to slaughter. Among the analyzed samples, a seroprevalence of 72.8% was estimated, and it was also possible to identify 10 animals, 5 positive and 5 negative, coming from the same farm. This condition created the basis for the quantitative proteomics comparison between homogeneous animals, in which only the contact with HEV should represent the discriminating factor. The analysis of the proteome in all samples of liver exudate led to the identification of 554 proteins differentially expressed between the two experimental groups, with 293 proteins having greater abundance in positive samples and 261 more represented in negative exudates. The pathway enrichment analysis allowed us to highlight the effect of the interaction between HEV and the host biological system in inducing the potential enrichment of 69 pathways. Among these, carbon metabolism stands out with the involvement of 41 proteins, which were subjected to interactomic analysis. This approach allowed us to focus our attention on three enzymes involved in glycolysis: glucose-6-phosphate isomerase (GPI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and fructose-bisphosphate aldolase A (ALDOA). It therefore appears that infection with HEV induced a strengthening of the process, which involves the breakdown of glucose to obtain energy and carbon residues useful for the virus's survival. In conclusion, the label-free LC-MS/MS approach showed effectiveness in highlighting the main differences induced on the porcine liver proteome by the interaction with HEV, providing crucial information in identifying a viral signature on the host metabolism.
    MeSH term(s) Humans ; Swine ; Animals ; Hepatitis E ; Hepatitis E virus ; Proteome ; Seroepidemiologic Studies ; Chromatography, Liquid ; Swine Diseases ; Tandem Mass Spectrometry ; Carbon ; RNA, Viral
    Chemical Substances Proteome ; Carbon (7440-44-0) ; RNA, Viral
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evidence of Circulation and Phylogenetic Analysis of Hepatitis E Virus (HEV) in Wild Boar in South-East Italy.

    La Bella, Gianfranco / Basanisi, Maria Grazia / Nobili, Gaia / Coppola, Rosa / Damato, Annita Maria / Donatiello, Adelia / Occhiochiuso, Gilda / Romano, Antonella Cristina / Toce, Mariateresa / Palazzo, Lucia / Pellegrini, Francesco / Fanelli, Angela / Di Martino, Barbara / Suffredini, Elisabetta / Lanave, Gianvito / Martella, Vito / La Salandra, Giovanna

    Viruses

    2023  Volume 15, Issue 10

    Abstract: Hepatitis E virus (HEV) is an important cause of acute viral hepatitis in humans worldwide ...

    Abstract Hepatitis E virus (HEV) is an important cause of acute viral hepatitis in humans worldwide. The food-borne transmission of HEV appears to be a major route in Europe through the consumption of pork and wild boar meat. HEV epidemiology in wild boars has been investigated mainly in Northern and Central Italian regions, whilst information from Southern Italy is limited. We investigated the occurrence of HEV in wild boar in the Apulia and Basilicata regions (Southern Italy). Thirteen (10.4%) out of one hundred and twenty-five wild boar samples tested positive for HEV using a quantitative reverse transcription PCR. HEV prevalence was 12% in Apulia and 9.3% in Basilicata. Seven samples were genotyped, and different subtypes (c, f, m) of genotype 3 were identified. The complete genome of a 3m strain was determined, and the virus showed the highest nucleotide identity to a human HEV strain identified in France in 2017. These findings demonstrate the substantial circulation of HEV in the wild boar population in Italian Southern regions. Gathering information on the HEV strains circulating in different geographical areas is useful for tracking the origin of HEV outbreaks and assessing the epidemiological role of wild boar as a potential virus reservoir for domestic pigs.
    MeSH term(s) Swine ; Animals ; Humans ; Sus scrofa ; Hepatitis E virus/genetics ; Phylogeny ; Hepatitis E/epidemiology ; Hepatitis E/veterinary ; Swine Diseases ; Italy/epidemiology ; RNA, Viral/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15102021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines.

    Coccolini, Federico / Sartelli, Massimo / Sawyer, Robert / Rasa, Kemal / Viaggi, Bruno / Abu-Zidan, Fikri / Soreide, Kjetil / Hardcastle, Timothy / Gupta, Deepak / Bendinelli, Cino / Ceresoli, Marco / Shelat, Vishal G / Broek, Richard Ten / Baiocchi, Gian Luca / Moore, Ernest E / Sall, Ibrahima / Podda, Mauro / Bonavina, Luigi / Kryvoruchko, Igor A /
    Stahel, Philip / Inaba, Kenji / Montravers, Philippe / Sakakushev, Boris / Sganga, Gabriele / Ballestracci, Paolo / Malbrain, Manu L N G / Vincent, Jean-Louis / Pikoulis, Manos / Beka, Solomon Gurmu / Doklestic, Krstina / Chiarugi, Massimo / Falcone, Marco / Bignami, Elena / Reva, Viktor / Demetrashvili, Zaza / Di Saverio, Salomone / Tolonen, Matti / Navsaria, Pradeep / Bala, Miklosh / Balogh, Zsolt / Litvin, Andrey / Hecker, Andreas / Wani, Imtiaz / Fette, Andreas / De Simone, Belinda / Ivatury, Rao / Picetti, Edoardo / Khokha, Vladimir / Tan, Edward / Ball, Chad / Tascini, Carlo / Cui, Yunfeng / Coimbra, Raul / Kelly, Michael / Martino, Costanza / Agnoletti, Vanni / Boermeester, Marja A / De'Angelis, Nicola / Chirica, Mircea / Biffl, Walt L / Ansaloni, Luca / Kluger, Yoram / Catena, Fausto / Kirkpatrick, Andrew W

    World journal of emergency surgery : WJES

    2023  Volume 18, Issue 1, Page(s) 41

    Abstract: Intra-abdominal infections (IAI) are among the most common global healthcare challenges and they are usually precipitated by disruption to the gastrointestinal (GI) tract. Their successful management typically requires intensive resource utilization, and ...

    Abstract Intra-abdominal infections (IAI) are among the most common global healthcare challenges and they are usually precipitated by disruption to the gastrointestinal (GI) tract. Their successful management typically requires intensive resource utilization, and despite the best therapies, morbidity and mortality remain high. One of the main issues required to appropriately treat IAI that differs from the other etiologies of sepsis is the frequent requirement to provide physical source control. Fortunately, dramatic advances have been made in this aspect of treatment. Historically, source control was left to surgeons only. With new technologies non-surgical less invasive interventional procedures have been introduced. Alternatively, in addition to formal surgery open abdomen techniques have long been proposed as aiding source control in severe intra-abdominal sepsis. It is ironic that while a lack or even delay regarding source control clearly associates with death, it is a concept that remains poorly described. For example, no conclusive definition of source control technique or even adequacy has been universally accepted. Practically, source control involves a complex definition encompassing several factors including the causative event, source of infection bacteria, local bacterial flora, patient condition, and his/her eventual comorbidities. With greater understanding of the systemic pathobiology of sepsis and the profound implications of the human microbiome, adequate source control is no longer only a surgical issue but one that requires a multidisciplinary, multimodality approach. Thus, while any breach in the GI tract must be controlled, source control should also attempt to control the generation and propagation of the systemic biomediators and dysbiotic influences on the microbiome that perpetuate multi-system organ failure and death. Given these increased complexities, the present paper represents the current opinions and recommendations for future research of the World Society of Emergency Surgery, of the Global Alliance for Infections in Surgery of Surgical Infection Society Europe and Surgical Infection Society America regarding the concepts and operational adequacy of source control in intra-abdominal infections.
    MeSH term(s) Female ; Humans ; Male ; Surgeons ; Abdominal Cavity ; Intraabdominal Infections
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2233734-9
    ISSN 1749-7922 ; 1749-7922
    ISSN (online) 1749-7922
    ISSN 1749-7922
    DOI 10.1186/s13017-023-00509-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A surveillance study of hepatitis E virus infection in household cats.

    Capozza, Paolo / Martella, Vito / Lanave, Gianvito / Beikpour, Farzad / Di Profio, Federica / Palombieri, Andrea / Sarchese, Vittorio / Marsilio, Fulvio / La Rosa, Giuseppina / Suffredini, Elisabetta / Camero, Michele / Buonavoglia, Canio / Di Martino, Barbara

    Research in veterinary science

    2021  Volume 137, Page(s) 40–43

    Abstract: Hepatitis E virus (HEV) typically causes self-limiting acute viral hepatitis, however chronic ...

    Abstract Hepatitis E virus (HEV) typically causes self-limiting acute viral hepatitis, however chronic infection and extrahepatic manifestations have increasingly become a significant health problem. Domestic pigs and wild boars are the main reservoirs of HEV genotype 3 and genotype 4 for human infections in industrialized countries, although molecular and serological evidence suggest that several additional animal species may act as HEV hosts. In this study, by assessing serologically and molecularly the sera of 324 household cats from Apulia region (Italy), HEV antibodies were detected with an overall prevalence of 3.1%. Viral RNA was not detected in the sera of the animals using both HEV-specific assays and a pan-hepevirus broadly reactive set of primers for Hepeviridae. These findings document a low seroprevalence to HEV in cats in the investigated geographical setting. The exact nature of the HEV-like strains circulating in feline population remains to be established.
    MeSH term(s) Animals ; Cat Diseases/blood ; Cat Diseases/epidemiology ; Cat Diseases/virology ; Cats ; Genotype ; Hepatitis Antibodies/blood ; Hepatitis Antibodies/genetics ; Hepatitis E/epidemiology ; Hepatitis E/genetics ; Hepatitis E/veterinary ; Hepatitis E virus/immunology ; Italy/epidemiology ; Prevalence ; Seroepidemiologic Studies
    Chemical Substances Hepatitis Antibodies
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2021.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Il programma di rete EASY-NET: razionale, struttura e metodologie.

    Acampora, Anna / Deroma, Laura / Ciccone, Giovannino / Marchesini Reggiani, Giulio / Marenzi, Giancarlo / Venturella, Roberta / Bramanti, Placido / Grilli, Roberto / Di Martino, Mirko / Spadea, Teresa / De Fiore, Luca / Agabiti, Nera

    Epidemiologia e prevenzione

    2023  Volume 47, Issue 1-2, Page(s) 80–89

    Abstract: This is the first contribution of a series of interventions describing the EASY-NET research program (Bando Ricerca Finalizzata 2016, funds 2014-2015; NET-2016-02364191). Here, the objective is to illustrate the background and the research question, the ... ...

    Title translation The EASY-NET research programme: background, structure, and methodology.
    Abstract This is the first contribution of a series of interventions describing the EASY-NET research program (Bando Ricerca Finalizzata 2016, funds 2014-2015; NET-2016-02364191). Here, the objective is to illustrate the background and the research question, the structure and organization, the methodologies and the expected results of the programme. The main theme is audit&feedback (A&F), a proven and widespread technique for improving the quality of health care. EASY-NET, funded by the Italian Ministry of Health and by the governments of the participating Italian Regions, starts its research activities in 2019 with the aim of evaluating the effectiveness of A&F in improving care for different clinical conditions in various organizational and legislative contexts. The research network involves seven Italian Regions, each conducting specific research activities described by as many work packages (WP): Lazio (the leading Region, coordinator of the research activities), Friuli Venezia Giulia, Piedmont, Lombardy, Emilia-Romagna, Calabria, and Sicily. The involved clinical areas include the management of chronic diseases, emergency care for acute conditions, surgery in the oncological area, the treatment of heart disease, obstetrics, and the use of caesarean section and post-acute rehabilitation. The involved settings concern the community, the hospital, the emergency room, and the rehabilitation facilities. Different experimental or quasi-experimental study designs are applied in each WP to achieve specific objectives of the specific clinical and organizational context. In all WPs, the process and outcome indicators are calculated on the basis of the Health Information Systems (HIS) and, in some cases, they are integrated with measures obtained from ad hoc data collections. The programme aims to contribute to the scientific evidence on A&F also exploring the obstacles and favourable factors for its effectiveness and to promote its implementation in the health service, with the ultimate aim of improving the access to healthcare and the health outcomes for citizens.
    MeSH term(s) Pregnancy ; Humans ; Female ; Cesarean Section ; Sicily ; Hospitals ; Heart Diseases ; Health Services
    Language Italian
    Publishing date 2023-03-24
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    DOI 10.19191/EP23.1-2.A583.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Validation of the Alternative International Prognostic Score-E (AIPS-E): Analysis of Binet stage A chronic lymphocytic leukemia patients enrolled into the O-CLL1-GISL protocol.

    Morabito, Fortunato / Tripepi, Giovanni / Vigna, Ernesto / Bossio, Sabrina / D'Arrigo, Graziella / Martino, Enrica Antonia / Storino, Francesca / Recchia, Anna Grazia / Fronza, Gilberto / Di Raimondo, Francesco / Colombo, Monica / Fais, Franco / Neri, Antonino / Cutrona, Giovanna / Ferrarini, Manlio / Gentile, Massimo

    European journal of haematology

    2021  Volume 106, Issue 6, Page(s) 831–835

    Abstract: Objectives: To validate the predictive value on time to first treatment (TTFT) of AIPS-E and IPS-E ... of both AIPS-E and IPS-E at the individual patient level. These data may be useful for a precise stratification ...

    Abstract Objectives: To validate the predictive value on time to first treatment (TTFT) of AIPS-E and IPS-E evaluated in an independent cohort of newly diagnosed and non-referred Binet stage A CLL patients enrolled in the O-CLL1-GISL protocol (clinicaltrial.gov identifier: NCT00917540).
    Methods: A cohort of 292 newly diagnosed Binet A CLL cases has been enrolled in the study. Patients from several Italian Institutions were prospectively enrolled within 12 months of diagnosis into the O-CLL1-GISL protocol.
    Results: The majority of patients were male (62%); median age was 60.4 years, 102 cases (34.9%) showed unmutated IGHV genes, 8 cases (2.8) the presence of del(11q)/del(17p), 142 cases (48.6%) the presence of palpable lymph nodes and 146 cases (50%) and ALC > 15 × 10
    Conclusions: Our data confirm an accurate prognostic utility of both AIPS-E and IPS-E at the individual patient level. These data may be useful for a precise stratification of early-stage patients.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Italy ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Male ; Middle Aged ; Prognosis ; Risk Factors
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Validation Study
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.13614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Studio osservazionale prospettico relativo all’assunzione giornaliera di farmaci, integratori e prodotti erboristici nei pazienti anziani e rilevazione delle reazioni avverse ai farmaci.

    Di Martino, Enrica / Provenzani, Alessio / Polidori, Piera

    Recenti progressi in medicina

    2020  Volume 112, Issue 4, Page(s) 294–301

    Abstract: Polytherapy is a common condition in the elderly patient and represents a risk factor for the onset of adverse drug reactions (ADRs). The objectives of this prospective study were the verification of the compliance with implicit criteria (Lipton, MAI and ...

    Title translation A prospective observational study on daily intake of drugs, supplements and herbal products and detection of adverse drug reactions in elderly patients.
    Abstract Polytherapy is a common condition in the elderly patient and represents a risk factor for the onset of adverse drug reactions (ADRs). The objectives of this prospective study were the verification of the compliance with implicit criteria (Lipton, MAI and POM) to geriatric prescriptions, the identification of ADRs and the estimatation of the intake of drugs, over-the-counter (OTC) drugs, supplements and herbal products through the administration of a questionnaire. A total of 400 elderly patients (average age 73 years) were analyzed between September 2018 and September 2019. 79.5% of them were in polytherapy (≥4 drugs). The most frequently prescribed drugs were antihypertensives (75%). The use of OTC drugs was reported for 12% patients; the use of supplements for 25% of patients and the use of herbal products only for 2% patients. The prescriptions analysed resulted in compliance with the implicit criteria in terms of dosage, therapeutic indications and the presence of any drug allergies. ADRs were reported for 10% of patients: those related to nintedanib (53%) and pirfenidone (34%) were the most frequent.
    MeSH term(s) Aged ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; Humans ; Patients ; Pharmaceutical Preparations ; Prospective Studies ; Pyridones
    Chemical Substances Pharmaceutical Preparations ; Pyridones
    Language Italian
    Publishing date 2020-10-24
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3584.35688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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