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Book ; Online: Geochemistry on core 202-1240A, supplementary data to: Pichevin, Laetitia E; Reynolds, Ben C; Ganeshram, Raja S; Cacho, Isabel; Pena, L; Keefe, K; Ellam, R M (2009): Enhanced carbon pump inferred from relaxation of nutrient limitation in the glacial ocean. Nature, 459, 1114-1117

Pichevin, Laetitia E / Cacho, Isabel / Ellam, R M / Ganeshram, Raja S / Keefe, K / Pena, L / Reynolds, Ben C

2009

Abstract: The modern Eastern Equatorial Pacific (EEP) Ocean is a large oceanic source of carbon to the atmosphere1. Primary productivity over large areas of the EEP is limited by silicic acid and iron availability, and because of this constraint the organic carbon ...

Abstract	The modern Eastern Equatorial Pacific (EEP) Ocean is a large oceanic source of carbon to the atmosphere1. Primary productivity over large areas of the EEP is limited by silicic acid and iron availability, and because of this constraint the organic carbon export to the deep ocean is unable to compensate for the outgassing of carbon dioxide that occurs through upwelling of deep waters. It has been suggested that the delivery of dust-borne iron to the glacial ocean could have increased primary productivity and enhanced deep-sea carbon export in this region, lowering atmospheric carbon dioxide concentrations during glacial periods. Such a role for the EEP is supported by higher organic carbon burial rates documented in underlying glacial sediments but lower opal accumulation rates cast doubts on the importance of the EEP as an oceanic region for significant glacial carbon dioxide drawdown. Here we present a new silicon isotope record that suggests the paradoxical decline in opal accumulation rate in the glacial EEP results from a decrease in the silicon to carbon uptake ratio of diatoms under conditions of increased iron availability from enhanced dust input. Consequently, our study supports the idea of an invigorated biological pump in this region during the last glacial period that could have contributed to glacial carbon dioxide drawdown. Additionally, using evidence from silicon and nitrogen isotope changes, we infer that, in contrast to the modern situation, the biological productivity in this region is not constrained by the availability of iron, silicon and nitrogen during the glacial period. We hypothesize that an invigorated biological carbon dioxide pump constrained perhaps only by phosphorus limitation was a more common occurrence in low-latitude areas of the glacial ocean.
Language	English
Dates of publication	2009-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1038/nature08101
DOI	10.1594/PANGAEA.727624
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: The Role of the Medical Profession in Occupational Lung Disease and Access to Compensation.

Weir, Sally / O'Keefe, Leah / Sottile, Ross

Journal of law and medicine

2023 Volume 29, Issue 4, Page(s) 1236–1240

Abstract: The relationship between exposure to toxins at work and lung diseases continues to be significantly under-recognised in Australia. Medical practitioners are well placed to identify occupational risk factors for disease. They can therefore play a vital ... ...

Abstract	The relationship between exposure to toxins at work and lung diseases continues to be significantly under-recognised in Australia. Medical practitioners are well placed to identify occupational risk factors for disease. They can therefore play a vital role in informing regulatory responses, highlighting dangerous workplaces and supporting access to compensation to assist with better health outcomes for their patients. Increased awareness among medical practitioners of occupational factors can aid early diagnosis and improve patient outcomes by improving access to justice. Medical practitioners should be cognisant of the occupational causes of lung disease in Australia to support appropriate specialist referral and ensure patients can access additional support systems available through legal compensation systems. More broadly, medical professionals and lawyers assisting workers share the common aim of highlighting preventable diseases and advocating for change to help make workplaces safer.
MeSH term(s)	Humans ; Lung Diseases ; Workplace ; Australia
Language	English
Publishing date	2023-02-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1236328-5
ISSN	1320-159X
ISSN	1320-159X
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Article ; Online: Implementation of a Clinic-Based Yoga Program for Chronic Pain.

Hall, Sara / O'Keefe, Lauren R / Janssen, Madisen K / Herrmann, Amanda A / Hanson, Leah R

Pain management nursing : official journal of the American Society of Pain Management Nurses

2024

Abstract: Purpose: Although many integrative therapies exist, studies increasingly demonstrate yoga can help change the negative neuroplastic effects experienced by people living with chronic pain. Despite encouraging findings, a gap exists in accessible yoga ... ...

Abstract	Purpose: Although many integrative therapies exist, studies increasingly demonstrate yoga can help change the negative neuroplastic effects experienced by people living with chronic pain. Despite encouraging findings, a gap exists in accessible yoga programs designed to meet the individual needs of those experiencing limitations from chronic pain. This study evaluated a yoga program designed for people living with chronic pain delivered in a health care setting. Although yoga began as a spiritual practice thousands of years ago, it is now widely practiced for its physical and mental well-being aspects achieved through movement and breathing techniques. Design: This was a piolt study that did not include a control group. Methods: Twenty-one people with chronic pain participated in an in-person group yoga program for 8 weeks that included an educational program and yoga practice. A prepost design was used to measure effectiveness of the program on pain interference (Brief Pain Inventory), physical function, opioid medication use, overall impression of change in pain, satisfaction with the program, and likelihood of continuation of yoga practice. Results: Data collected from participants demonstrated a decrease in pain interference as measured by the Brief Pain Inventory subscale between pre- and postintervention (5.6 ± 2.2 to 4.0 ± 2.3). In addition, the proportion of respondents with a pain interference rating of severe decreased by 15.4% (38.1% to 22.7%) between the pre- and postintervention time point. On follow-up from a survey 3 months after the completion of the study, more than 25% (N = 5) of participants were still practicing yoga daily. Conclusions: Despite yoga being practiced for thousands of years, studies evaluating the neural effects of yoga show possible reversal of persistent patterns leading to chronic pain, leading to new interest in an ancient practice. This study helps fill the gap in research findings addressing the benefits of yoga programs designed to meet the needs of people living in chronic pain and provides an accessible option. This program provides pain management nurses an innovative nonpharmacological intervention to consider for people living with chronic pain. Clinical implications: Evidence supporting the use of yoga in the treatment of chronic pain is growing, yet it remains an underutilized approach in a comprehensive treatment plan. Yoga can not only improve self-agency, but also reduces social isolation. Pain management nurses can play an important role in promoting the application of yoga for chronic pain and advocating for yoga programs that are focused on accessibility for people living with pain.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2213260-0
ISSN	1532-8635 ; 1524-9042
ISSN (online)	1532-8635
ISSN	1524-9042
DOI	10.1016/j.pmn.2024.01.002
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Zs.MO 514: Show issues

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Article ; Online: Evaluating Factors That Influence Patient Satisfaction in Otolaryngology Clinics.

Redding, Taylor S / Keefe, Katherine R / Stephens, Andrew R / Gurgel, Richard K

The Annals of otology, rhinology, and laryngology

2022 Volume 132, Issue 1, Page(s) 19–26

Abstract: Objectives: To identify factors that influence patient satisfaction during outpatient visits in various settings of otolaryngology clinics in an academic medical center.: Study design: Retrospective review.: Setting: Academic medical center.: ... ...

Abstract	Objectives: To identify factors that influence patient satisfaction during outpatient visits in various settings of otolaryngology clinics in an academic medical center. Study design: Retrospective review. Setting: Academic medical center. Methods: We reviewed Press Ganey patient satisfaction survey responses for new, outpatient visits between January 1, 2014 and December 31, 2018. Self-reported race was identified using electronic medical records. Multivariate binary logistic regression analyses were used to identify continuous and categorical variables associated with patient satisfaction. Results: There were 3998 unique new patient visits with completed surveys. Multivariate analysis revealed that responses for patients <18 years old are less likely to be satisfied with their care compared to patients ≥18 years old (OR 0.66; Conclusions: Wait time, clinic location, patient race, insurance provider, and age were all shown to significantly influence patient-reported satisfaction. Understanding how these variables influence patient satisfaction will hopefully lead to processes that improve patient satisfaction. Level of evidence: Level 3.
MeSH term(s)	Humans ; Aged ; United States ; Adolescent ; Patient Satisfaction ; Medicare ; Otolaryngology ; Ambulatory Care Facilities ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894211055531
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Article ; Online: Is Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? A Comparison of UV Mutational Signatures in Malignant Melanoma and Mycosis Fungoides.

Gniadecki, Robert / O'Keefe, Sandra / Hennessey, Dylan / Iyer, Aishwarya

Cells

2023 Volume 12, Issue 12

Abstract: Ultraviolet (UV) radiation is a strong environmental carcinogen responsible for the pathogenesis of most skin cancers, including malignant melanoma (MM) and non-melanoma (keratinocyte) skin cancers. The carcinogenic role of UV was firmly established ... ...

Abstract	Ultraviolet (UV) radiation is a strong environmental carcinogen responsible for the pathogenesis of most skin cancers, including malignant melanoma (MM) and non-melanoma (keratinocyte) skin cancers. The carcinogenic role of UV was firmly established based on epidemiological evidence and molecular findings of the characteristic mutation signatures which occur during the excision repair of cyclobutane pyrimidine dimers and 6,4-photoproducts. The role of UV in the pathogenesis of mycosis fungoides (MF), the most common type of primary cutaneous T-cell lymphoma, remains controversial. Here, we performed whole-exome sequencing of 61 samples of MF cells microdissected from cutaneous lesions, and compared their mutational signatures to 340 MMs. The vast majority of MM mutations had a typical UV mutational signature (SBS 7, SBS 38, or DSB 1), underscoring the key role of ultraviolet as a mutagen. In contrast, the SBS 7 signature in MF comprised < 5% of all mutations. SBS 7 was higher in the intraepidermal MF cells (when compared to the dermal cells) and in the cells from tumors as compared to that in early-stage plaques. In conclusion, our data do not support the pathogenic role of UV in the pathogenesis of MF and suggest that the UV mutations are the result of the cumulative environmental ultraviolet exposure of cutaneous lesions rather than an early mutagenic event.
MeSH term(s)	Humans ; Ultraviolet Rays/adverse effects ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Mycosis Fungoides/genetics ; Mycosis Fungoides/pathology ; Melanoma/genetics ; Mutation/genetics ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12121616
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Creating a Community-Level Document Library: Application Using Vision Zero Plans.

Evenson, Kelly R / Keefe, Elyse / LaJeunesse, Seth / Naumann, Rebecca B

Journal of public health management and practice : JPHMP

2023 Volume 29, Issue 3, Page(s) 284–286

Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2027860-3
ISSN	1550-5022 ; 1078-4659
ISSN (online)	1550-5022
ISSN	1078-4659
DOI	10.1097/PHH.0000000000001702
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Zs.A 5302: Show issues

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Article ; Online: Mixed-methods approach to describing Vision Zero initiatives in United States' municipalities.

Evenson, Kelly R / LaJeunesse, Seth / Keefe, Elyse / Naumann, Rebecca B

Accident; analysis and prevention

2023 Volume 184, Page(s) 107012

Abstract: Vision Zero (VZ) aims to reduce fatalities and serious injuries from road traffic crashes to zero through a Safe Systems approach. Little is known about the extent of uptake of VZ in the United States (US), or the attributes and functioning of the ... ...

Abstract	Vision Zero (VZ) aims to reduce fatalities and serious injuries from road traffic crashes to zero through a Safe Systems approach. Little is known about the extent of uptake of VZ in the United States (US), or the attributes and functioning of the initiatives. Using a mixed-methods design, our objectives were to describe the status of VZ implementation and characteristics of those initiatives among US municipalities. Websites of all US municipalities with a population of at least 50,000 (n = 788) were searched to identify involvement in VZ. When initiatives were identified, we abstracted information from their website and other published documents, using a comprehensive framework of best practice VZ components. From the VZ initiatives identified, we interviewed representatives from 12 municipalities with diversity by region of the country, population size, and VZ implementation. Interviews were recorded, transcribed, and coded for themes. Through systematic web-based searching, we identified 86 of 788 (10.9%) municipalities with a VZ initiative. Among 314 larger municipalities (population >=100,000), 68 (21.7%) were identified. Among 476 medium-size municipalities (population of 50,000-99,999), 18 (3.8%) were identified. VZ initiatives began as early as 2014, starting with larger municipalities, and followed in 2015 with medium-size municipalities. Among the VZ initiatives, 58 (67.4%) recorded a vision statement, with 51 (59.3%) setting a target year to reach zero deaths. Thirty-nine (45.3%) had published VZ plans, with another 22 (25.6%) working towards a plan. Twenty-five initiatives (29.1%) shared resources across stakeholder groups, such as funding or staff. Forty-six initiatives (53.5%) had an established coalition, and 18 (20.9%) proposed or were developing a coalition. Twenty-six initiatives (30.2%) provided regular updates or evaluation on progress towards performance metrics, but only 4 (4.7%) had implemented a performance management system to regularly track progress on VZ-related actions. The interviews provided further context and a more detailed understanding of results. Documenting the characteristics of VZ initiatives among US municipalities can contribute to an understanding of current practice, potential opportunities to support ongoing initiatives, and information to assist new initiatives. Ultimately, the impact of municipal-level VZ efforts should be evaluated with regards to traffic-related serious injuries and fatalities.
MeSH term(s)	Humans ; United States ; Accidents, Traffic/prevention & control ; Cities ; Benchmarking
Language	English
Publishing date	2023-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2023.107012
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Zs.A 2461: Show issues

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Article ; Online: Ocular extraintestinal manifestations and treatments in patients with inflammatory bowel disease

Mariana Rodriguez Duran / Ghazala A. Datoo O’Keefe

Frontiers in Ophthalmology, Vol

2024 Volume 3

Abstract: ... should be prioritized for female patients with Crohn’s disease and concurrent arthritis. Treatments for O ...

Abstract	Between 3-47% of patients with inflammatory bowel disease (IBD) have extraintestinal manifestations (EIMs), and between 1.3-86.9% of patients with IBD suffer from ocular EIMs (O-EIMs) making the eye the third most common organ affected. These O-EIMs exist among a spectrum, with a variety of types and amounts of inflammation which can lead to decreased vision, and in some cases, vision loss, without treatment. We performed a literature review concerning O-EIMs in patients who had or were later found to have a diagnosis of IBD in order to identify ocular EIMs that commonly occur with IBD and to assess which patients with IBD may be at higher risk of developing O-EIMs. We were also interested in ascertaining whether O-EIMs were more common in specific populations of people or in specific subtypes of IBD. Lastly, we explored the common treatments of O-EIMs in patients with IBD. Upon review of the literature, we found that the most common O-EIMs are episcleritis and uveitis. Anterior uveitis is more commonly seen, although, inflammation may occur in the posterior segment of the eye as well and may also manifest as retinal vasculitis. While these diagnoses are sometimes known retrospectively, most patients present with nonspecific eye complaints of which decreased vision with or without pain is the most common. Visual symptoms associated with ocular EIMs may be non-specific so physicians should have a low threshold to refer to ophthalmology for visual complaints. It is important to keep in mind that ocular EIMs can cluster with skin and joint EIMs. Screening should be prioritized for female patients with Crohn’s disease and concurrent arthritis. Treatments for O-EIMs are outlined and compared in this paper as well.
Keywords	uveitis ; Inflammatory bowel disease ; episcleritis ; Crohn’s disease ; ulcerative colitis ; scleritis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Geography, environment, and colonization history interact with morph type to shape genomic variation in an Arctic fish.

Salisbury, Sarah J / Perry, Robert / Keefe, Don / McCracken, Gregory R / Layton, Kara K S / Kess, Tony / Bradbury, Ian R / Ruzzante, Daniel E

Molecular ecology

2023 Volume 32, Issue 12, Page(s) 3025–3043

Abstract: Polymorphic species are useful models for investigating the evolutionary processes driving diversification. Such processes include colonization history as well as contemporary selection, gene flow, and genetic drift, which can vary between intraspecific ... ...

Abstract	Polymorphic species are useful models for investigating the evolutionary processes driving diversification. Such processes include colonization history as well as contemporary selection, gene flow, and genetic drift, which can vary between intraspecific morphs as a function of their distinct life histories. The interactive and relative influence of such evolutionary processes on morph differentiation critically informs morph-specific management decisions and our understanding of incipient speciation. We therefore investigated how geographic distance, environmental conditions, and colonization history interacted with morph migratory capacity in the highly polymorphic fish species, Arctic Charr (Salvelinus alpinus). Using an 87 k SNP chip we genetically characterized recently evolved anadromous, resident, and landlocked charr collected from 45 locations across a secondary contact zone of three charr glacial lineages in eastern Canada. A strong pattern of isolation by distance across all populations suggested geographic distance principally shaped genetic structure. Landlocked populations had lower genetic diversities and higher genetic differentiation than anadromous populations. However, effective population size was generally temporally stable in landlocked populations in comparison to anadromous populations. Genetic diversity positively correlated with latitude, potentially indicating southern anadromous populations' vulnerability to climate change and greater introgression between the Arctic and Atlantic glacial lineages in northern Labrador. Local adaptation was suggested by the observation of several environmental variables strongly associating with functionally relevant outlier genes including a region on chromosome AC21 potentially associated with anadromy. Our results demonstrate that gene flow, colonization history, and local adaptation uniquely interact to influence the genetic variation and evolutionary trajectory of populations.
MeSH term(s)	Animals ; Biological Evolution ; Genetic Drift ; Geography ; Canada ; Genomics
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.16913
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Article ; Online: Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

Langenau, David M / Keefe, Matthew D / Storer, Narie Y / Guyon, Jeffrey R / Kutok, Jeffery L / Le, Xiuning / Goessling, Wolfram / Neuberg, Donna S / Kunkel, Louis M / Zon, Leonard I

Genes & development

2024 Volume 38, Issue 5-6, Page(s) 289

Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.351747.124
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