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Article ; Online: N

Mariwamy, Vinusha H / Kollur, Shiva Prasad / Shivananda, Bindya / Begum, Muneera / Shivamallu, Chandan / Dharmashekara, Chandan / Pradeep, Sushma / Jain, Anisha S / Prasad, Shashanka K / Syed, Asad / Elgorban, Abdallah M / Al-Rejaie, Salim / Ortega-Castro, Joaquín / Frau, Juan / Flores-Holguín, Norma / Glossman-Mitnik, Daniel

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 4

Abstract: Researchers are interested in Schiff bases and their metal complexes because they offer a wide range of applications. The chemistry of Schiff bases of heterocompounds has got a lot of attention because of the metal's ability to coordinate with Schiff ... ...

Abstract	Researchers are interested in Schiff bases and their metal complexes because they offer a wide range of applications. The chemistry of Schiff bases of heterocompounds has got a lot of attention because of the metal's ability to coordinate with Schiff base ligands. In the current study, a new bidentate Schiff base ligand,
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Chemistry Techniques, Synthetic ; Cobalt/chemistry ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Copper/chemistry ; Density Functional Theory ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Models, Chemical ; Models, Molecular ; Molecular Structure ; Schiff Bases/chemistry ; Spectrum Analysis
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Coordination Complexes ; Schiff Bases ; Cobalt (3G0H8C9362) ; Copper (789U1901C5)
Language	English
Publishing date	2022-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27041436
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Article ; Online: Influence of vascular imaging acquisition at local stroke centers on workflows in the drip-n-ship model: a RACECAT post hoc analysis.

Flores, Alan / Garcia-Tornel, Alvaro / Seró, Laia / Ustrell, Xavier / Requena, Manuel / Pellisé, Anna / Rodriguez, Paula / Monterde, Angela / Lara, Lidia / Gonzalez-de-Echavarri, Jose María / Molina, Carlos A / Doncel-Moriano, Antonio / Dorado, Laura / Cardona, Pedro / Cánovas, David / Krupinski, Jerzy / Más, Natalia / Purroy, Francisco / Zaragoza-Brunet, Jose /

Palomeras, Ernesto / Cocho, Dolores / Garcia, Jessica / Colom, Carla / Silva, Yolanda / Gomez-Cocho, Manuel / Jiménez, Xavier / Ros-Roig, Josep / Abilleira, Sonia / Pérez de la Ossa, Natalia / Ribo, Marc

Journal of neurointerventional surgery

2024 Volume 16, Issue 2, Page(s) 143–150

Abstract: ... randomized trial that compared drip-n-ship versus mothership triage paradigms in patients with suspected ...

Abstract	Background: The influence of vascular imaging acquisition on workflows at local stroke centers (LSCs) not capable of performing thrombectomy in patients with a suspected large vessel occlusion (LVO) stroke remains uncertain. We analyzed the impact of performing vascular imaging (VI+) or not (VI- at LSC arrival on variables related to workflows using data from the RACECAT Trial. Objective: To compare workflows at the LSC among patients enrolled in the RACECAT Trial with or without VI acquisition. Methods: We included patients with a diagnosis of ischemic stroke who were enrolled in the RACECAT Trial, a cluster-randomized trial that compared drip-n-ship versus mothership triage paradigms in patients with suspected acute LVO stroke allocated at the LSC. Outcome measures included time metrics related to workflows and the rate of interhospital transfers and thrombectomy among transferred patients. Results: Among 467 patients allocated to a LSC, vascular imaging was acquired in 277 patients (59%), of whom 198 (71%) had a LVO. As compared with patients without vascular imaging, patients in the VI+ group were transferred less frequently as thrombectomy candidates to a thrombectomy-capable center (58% vs 74%, P=0.004), without significant differences in door-indoor-out time at the LSC (median minutes, VI+ 78 (IQR 69-96) vs VI- 76 (IQR 59-98), P=0.6). Among transferred patients, the VI+ group had higher rate of thrombectomy (69% vs 55%, P=0.016) and shorter door to puncture time (median minutes, VI+ 41 (IQR 26-53) vs VI- 54 (IQR 40-70), P<0.001). Conclusion: Among patients with a suspected LVO stroke initially evaluated at a LSC, vascular imaging acquisition might improve workflow times at thrombectomy-capable centers and reduce the rate of futile interhospital transfers. These results deserve further evaluation and should be replicated in other settings and geographies.
MeSH term(s)	Humans ; Arterial Occlusive Diseases ; Brain Ischemia/drug therapy ; Endovascular Procedures ; Ischemic Stroke ; Stroke/diagnostic imaging ; Stroke/surgery ; Thrombectomy ; Thrombolytic Therapy ; Treatment Outcome ; Workflow
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-020125
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Article ; Online: The N-Acetylglucosamine Kinase from

Flores, Carmen-Lisset / Ariño, Joaquín / Gancedo, Carlos

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract: ... ...

Abstract	In
MeSH term(s)	Arabidopsis/enzymology ; Arabidopsis/genetics ; Cloning, Molecular ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Profiling/methods ; Gene Expression Regulation, Fungal ; Mutation ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Sequence Analysis, RNA ; Yarrowia/enzymology ; Yarrowia/genetics ; Yarrowia/growth & development
Chemical Substances	Fungal Proteins ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; N-acetylglucosamine kinase (EC 2.7.1.59)
Language	English
Publishing date	2021-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222313109
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Article: n-3 Polyunsaturated Fatty Acid Supplementation Affects Oxidative Stress Marker Levels in Patients with Type II Intestinal Failure: A Randomized Double Blind Trial.

Flores-López, Adriana / Guevara-Cruz, Martha / Avila-Nava, Azalia / González-Garay, Alejandro G / González-Salazar, Luis E / Reyes-Ramírez, Ana L / Pedraza-Chaverri, José / Medina-Campos, Omar N / Medina-Vera, Isabel / Reyes-García, Juan G / Tovar, Armando R / Serralde-Zúñiga, Aurora E

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: ... of parenteral nutrition (PN); oxidative stress has been implicated as one of the causes. Lipid emulsions containing n-3 ... polyunsaturated fatty acids (PUFAs) have been proposed for the treatment. We aimed to evaluate the effect of 7-day n ... enriched with n-3 PUFAs (intervention). Twenty patients were included (14 men, 49 ± 16.9 years ...

Abstract	Type II intestinal failure (IF-II) is a condition in which the gastrointestinal tract is compromised. Liver complications may occur because of the pathology and/or prolonged use of parenteral nutrition (PN); oxidative stress has been implicated as one of the causes. Lipid emulsions containing n-3 polyunsaturated fatty acids (PUFAs) have been proposed for the treatment. We aimed to evaluate the effect of 7-day n-3 PUFA supplementation on oxidative stress in IF-II patients receiving PN. This was a randomized, controlled, double-blinded, pilot trial of adult patients with IF-II, receiving either conventional PN (control) or PN enriched with n-3 PUFAs (intervention). Twenty patients were included (14 men, 49 ± 16.9 years), with the ANCOVA analysis the glucose (
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12081493
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Article ; Online: Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system.

Cantero-García, Noelia / Flores-Burgess, Antonio / Pineda-Gómez, Juan Pedro / Orio, Laura / Serrano, Antonia / Díaz-Cabiale, Zaida / Millón, Carmelo

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 153, Page(s) 113508

Abstract: Alcohol Use Disorder (AUD) is among the most prevalent mental illnesses, and due to the low efficacy of the current medication, it is essential to find new biological targets that could modulate alcohol consumption. Since Galanin (1-15) [GAL(1-15)] ... ...

Abstract	Alcohol Use Disorder (AUD) is among the most prevalent mental illnesses, and due to the low efficacy of the current medication, it is essential to find new biological targets that could modulate alcohol consumption. Since Galanin (1-15) [GAL(1-15)] produces a loss of motivational behaviour by an artificial reinforcer and decreases the preference an alcohol consumption in a voluntary alcohol intake, we have studied the role of GAL(1-15) in alcohol-seeking behaviour and the involvement of the corticomesolimbic system as well as the role of GAL(1-15) in context-induced alcohol relapse. In rats, we have studied GAL(1-15)-effects on alcohol-seeking in self-administration, in fixed-ratio (FR1) and progressive-ratio (PR), and the involvement of GAL receptors using siRNA GALR1 or GALR2 knockdown animals. We have analysed the transcriptional changes of C-Fos, dopamine receptors, GAL receptors and 5HT1A receptors in the corticomesolimbic system. Also, we have examined the effect of GAL(1-15) in context-induced alcohol relapse. GAL(1-15) substantially reduced alcohol-seeking behaviour in the operant self-administration model in an FR1 protocol and at the breaking point in a PR schedule. GALR1and GALR2 were involved in these effects, as indicated by the analysis by GALR2 antagonist and GALR1 and GALR2 knockdown animals. Notably, the mechanism of GAL(1-15)-mediated actions involved changes in C-Fos, Dopamine receptors and 5HT1A expression in the ventral tegmental area, accumbens nucleus and prefrontal cortex. Significantly, GAL(1-15) reduced the context-induced alcohol relapse. These results open up the possibility to use GAL(1-15) as a novel strategy in AUD.
MeSH term(s)	Alcoholism/drug therapy ; Alcoholism/metabolism ; Animals ; Ethanol ; Galanin/metabolism ; Galanin/pharmacology ; Galanin/therapeutic use ; Peptide Fragments ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Receptor, Galanin, Type 2/drug effects ; Receptor, Galanin, Type 2/metabolism ; Receptors, Dopamine ; Receptors, Galanin/drug effects ; Receptors, Galanin/metabolism ; Recurrence
Chemical Substances	Peptide Fragments ; Proto-Oncogene Proteins c-fos ; Receptor, Galanin, Type 2 ; Receptors, Dopamine ; Receptors, Galanin ; galanin (1-15) (112747-70-3) ; Ethanol (3K9958V90M) ; Galanin (88813-36-9)
Language	English
Publishing date	2022-08-04
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113508
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Article ; Online: Factores de riesgo/protección y prevalencias del consumo de sustancias psicoactivas en adolescentes de enseñanza media del “ I n s t i t u t o N a c i o n a l d e O c c i d e n t e ” L e ó n , J u n i o - m a y o . ; Risk / protection and prevalence of consumption psychoactive substances in adolescents of high school "I nstitute O N acionalde ccidente" L e o n, J une - May.

Flores Dolmus, Lenin A

2014

Abstract: La investigación se centró en determinar edad de inicio, factores de riesgo/protección, prevalencia e incidencia del consumo de sustancias psicoactivas lícitas e ilícitas. Se utilizó la metodología de la CICAD-OEA-SIDUC (sistema de vigilancia contra las ... ...

Abstract	La investigación se centró en determinar edad de inicio, factores de riesgo/protección, prevalencia e incidencia del consumo de sustancias psicoactivas lícitas e ilícitas. Se utilizó la metodología de la CICAD-OEA-SIDUC (sistema de vigilancia contra las drogas en el hemisferio) empleada en estudios nacionales, de Latinoamérica y el Caribe. La presente tesis contiene un enfoque clínico epidemiológico en la salud pública basada en un estudio descriptivo de corte transversal con una población constituida por 1,116 estudiantes adolescentes y una muestra representativa de 286 escolares de ambos sexos, se aplicó el cuestionario estandarizado SIDUC con indicadores predeterminados para medir tasas de prevalencia y patrones de consumo. Resultados y conclusiones evidencian que entre las drogas licitas el alcohol posee las mayores prevalencias entre los estudiantes: consumo experimental 45.5%, reciente 28.3% y actual 19.9%, seguido por el tabaco, entre las drogas ilícitas la mariguana posee las mayores prevalencias: consumo experimental 13.6%, reciente 6.3% y actual 2.8%, seguida por la cocaína. Las prevalencias indican mayores porcentajes de consumo entre los varones, la jornada vespertina, el décimo grado y las edades entre 15-17 años. Son factores de riesgo la calle y eventos sociales, las edades de inicio cada vez más tempranas, con una edad media de 11.6 años y el entorno de pares. Son factores protectores de los estudiantes las expectativas futuras positivas y la percepción de “gran riesgo” hacia el consumo de drogas.
Keywords	Adolescencia ; sustancias psicoactivas ; factores de riesgo/protección ; uso indebido ; prevalencia e incidencia. ; Teaching/Communication/Extension/Profession
Language	Spanish
Publishing date	2014-07-31
Publishing country	us
Document type	Article ; Online
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Article ; Online: Synergistic Interaction Effect of Artemisia cina n-hexane Extract and Tagetes lucida Ethyl Acetate Extract on Haemonchus Contortus.

Santiago-Figueroa, Itzel / González-Cortazar, Manases / Estrada-Flores, Julieta Gertrudis / Cuéllar-Ordaz, Jorge Alfredo / López-Arellano, María Eugenia / González-Reyes, Francisco Javier / Olmedo-Juárez, Agustín / Higuera-Piedrahita, Rosa Isabel

Acta parasitologica

2024

Abstract: Purpose: We analysed the possible synergistic activity among active extracts from Artemisia cina and Tagetes lucida combinations on Haemonchus contortus, a nematode parasitising sheep.: Methods: The work was carried out in vitro on eggs and infective ...

Abstract	Purpose: We analysed the possible synergistic activity among active extracts from Artemisia cina and Tagetes lucida combinations on Haemonchus contortus, a nematode parasitising sheep. Methods: The work was carried out in vitro on eggs and infective larvae (L3) of H. contortus. The results were analysed with SAS 9.1, applying the ANOVA and Tukey test, and the lethal concentration (LC) values LC50 and LC90 were determined with regression analysis, employing Proc Probit of SAS 9.1. Additionally, the lethal concentration (LC) was calculated with LC Results: The results demonstrated a high efficacy of the two plants studied on both nematode eggs and L3 larvae as well as of their combinations. The highest egg hatching inhibition was obtained with a 50/50 combination, and the best larvae mortality was obtained with 25% A. cina and 75% T. lucida at 10 mg/mL. Additionally, this combination showed a synergistic effect. Conclusion: The two plant species studied here can be applied as natural anthelmintic alternatives due to their high bioactive effect and synergistic response.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1132735-2
ISSN	1896-1851 ; 0065-1478 ; 1230-2821
ISSN (online)	1896-1851
ISSN	0065-1478 ; 1230-2821
DOI	10.1007/s11686-024-00839-6
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Article ; Online: Clinical effect of obesity on N-terminal pro-B-type natriuretic peptide cut-off concentrations for the diagnosis of acute heart failure.

Kozhuharov, Nikola / Martin, Jasmin / Wussler, Desiree / Lopez-Ayala, Pedro / Belkin, Maria / Strebel, Ivo / Flores, Dayana / Diebold, Matthias / Shrestha, Samyut / Nowak, Albina / Gualandro, Danielle M / Michou, Eleni / Zimmermann, Tobias / Rentsch, Katharina / von Eckardstein, Arnold / Keller, Dagmar I / Breidthardt, Tobias / Mueller, Christian

European journal of heart failure

2022 Volume 24, Issue 9, Page(s) 1545–1554

Abstract: ... the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for obesity could further increase ...

Abstract	Aims: Obese patients have lower natriuretic peptide concentrations. We hypothesized that adjusting the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for obesity could further increase its clinical utility in the early diagnosis of acute heart failure (AHF). Methods and results: This hypothesis was tested in a prospective diagnostic study enrolling unselected patients presenting to the emergency department with acute dyspnoea. Two independent cardiologists/internists centrally adjudicated the final diagnosis using all individual patient information including cardiac imaging. NT-proBNP plasma concentrations were applied: first, using currently recommended cut-offs; second, using cut-offs lowered by 33% with body mass index (BMI) of 30-34.9 kg/m<sup>2</sup> and by 50% with BMI ≥ 35 kg/m<sup>2</sup> . Among 2038 patients, 509 (25%) were obese, of which 271 (53%) had AHF. The diagnostic accuracy of NT-proBNP as quantified by the area under the receiver-operating characteristic curve was lower in obese versus non-obese patients (0.890 vs. 0.938). For rapid AHF rule-out in obese patients, the currently recommended cut-off of 300 pg/ml achieved a sensitivity of 96.7% (95% confidence interval [CI] 93.8-98.2%), ruling out 29% of patients and missing 9 AHF patients. For rapid AHF rule-in, the age-dependent cut-off concentrations (age <50 years: 450 pg/ml; age 50-75 years: 900 pg/ml; age >75 years: 1800 pg/ml) achieved a specificity of 84.9% (95% CI 79.8-88.9%). Proportionally lowering the currently recommended cut-offs by BMI increased sensitivity to 98.2% (95% CI 95.8-99.2%), missing 5 AHF patients; reduced the proportion of AHF patients remaining in the 'gray zone' (48% vs. 26%; p = 0.002), achieving a specificity of 76.5% (95% CI 70.7-81.4%). Conclusions: Adjusting NT-proBNP concentrations for obesity seems to further increase its clinical utility in the early diagnosis of AHF.
MeSH term(s)	Acute Disease ; Aged ; Biomarkers ; Heart Failure/diagnosis ; Humans ; Middle Aged ; Natriuretic Peptide, Brain ; Obesity/complications ; Obesity/diagnosis ; Peptide Fragments ; Prospective Studies
Chemical Substances	Biomarkers ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.2618
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Article: Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage: an intrinsic review of a hematoma resolving pathway.

Flores, Jerry / Tang, Jiping

Neural regeneration research

2023 Volume 19, Issue 2, Page(s) 350–354

Abstract: ... models of stroke. N-formyl peptide receptor 2 (FPR2), a G-protein-coupled receptor, has been shown to be ...

Abstract	Germinal matrix hemorrhage is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with little progress made in its clinical management. Blood clots have been shown to elicit secondary brain injury after germinal matrix hemorrhage, by disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage causing post-hemorrhagic hydrocephalus development. Current evidence suggests that rapid hematoma resolution is necessary to improve neurological outcomes after hemorrhagic stroke. Various articles have demonstrated the beneficial effects of stimulating the polarization of microglia cells into the M2 phenotype, as it has been suggested that they play an essential role in the rapid phagocytosis of the blood clot after hemorrhagic models of stroke. N-formyl peptide receptor 2 (FPR2), a G-protein-coupled receptor, has been shown to be neuroprotective after stroke. FPR2 activation has been associated with the upregulation of phagocytic macrophage clearance, yet its mechanism has not been fully explored. Recent literature suggests that FPR2 may play a role in the stimulation of scavenger receptor CD36. Scavenger receptor CD36 plays a vital role in microglia phagocytic blood clot clearance after germinal matrix hemorrhage. FPR2 has been shown to phosphorylate extracellular-signal-regulated kinase 1/2 (ERK1/2), which then promotes the transcription of the dual-specificity protein phosphatase 1 (DUSP1) gene. In this review, we present an intrinsic outline of the main components involved in FPR2 stimulation and hematoma resolution after germinal matrix hemorrhage.
Language	English
Publishing date	2023-07-24
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.379040
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Article ; Online: Molecular and biochemical characterization of Catharanthus roseus perivine-N

Levac, Dylan / Flores, Paulo Cázares / De Luca, Vincenzo

Phytochemistry

2022 Volume 201, Page(s) 113266

Abstract: ... expression of C. roseus perivine-N ...

Abstract	The biosynthesis of monoterpenoid indole alkaloids in Catharanthus roseus has been most extensively studied, leading to the detailed characterization of the pathway for the formation of their well-known anticancer alkaloids. The present study describes the identification, molecular cloning, and functional expression of C. roseus perivine-N
MeSH term(s)	Apocynaceae ; Catharanthus/metabolism ; Gene Expression Regulation, Plant ; Indole Alkaloids/chemistry ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Phytochemicals/metabolism ; Plant Proteins/metabolism ; Secologanin Tryptamine Alkaloids/metabolism
Chemical Substances	Indole Alkaloids ; Phytochemicals ; Plant Proteins ; Secologanin Tryptamine Alkaloids ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113266
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