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  1. Article ; Online: The effects of environmental chemicals on renal function.

    Kataria, Anglina / Trasande, Leonardo / Trachtman, Howard

    Nature reviews. Nephrology

    2015  Volume 11, Issue 10, Page(s) 610–625

    Abstract: The global incidence of chronic kidney disease (CKD) is increasing among individuals of all ages. Despite advances in proteomics, genomics and metabolomics, there remains a lack of safe and effective drugs to reverse or stabilize renal function in ... ...

    Abstract The global incidence of chronic kidney disease (CKD) is increasing among individuals of all ages. Despite advances in proteomics, genomics and metabolomics, there remains a lack of safe and effective drugs to reverse or stabilize renal function in patients with glomerular or tubulointerstitial causes of CKD. Consequently, modifiable risk factors that are associated with a progressive decline in kidney function need to be identified. Numerous reports have documented the adverse effects that occur in response to graded exposure to a wide range of environmental chemicals. This Review summarizes the effects of such chemicals on four aspects of cardiorenal function: albuminuria, glomerular filtration rate, blood pressure and serum uric acid concentration. We focus on compounds that individuals are likely to be exposed to as a consequence of normal consumer activities or medical treatment, namely phthalates, bisphenol A, polyfluorinated alkyl acids, dioxins and furans, polycyclic aromatic hydrocarbons and polychlorinated biphenyls. Environmental exposure to these chemicals during everyday life could have adverse consequences on renal function and might contribute to progressive cumulative renal injury over a lifetime. Regulatory efforts should be made to limit individual exposure to environmental chemicals in an attempt to reduce the incidence of cardiorenal disease.
    MeSH term(s) Albuminuria/chemically induced ; Benzhydryl Compounds/adverse effects ; Blood Pressure/drug effects ; Dioxins/adverse effects ; Environmental Pollutants/adverse effects ; Furans/adverse effects ; Humans ; Hydrocarbons, Fluorinated/adverse effects ; Kidney/drug effects ; Kidney/physiopathology ; Kidney Diseases/chemically induced ; Phenols/adverse effects ; Phthalic Acids/adverse effects ; Polychlorinated Biphenyls/adverse effects ; Polycyclic Compounds/adverse effects
    Chemical Substances Benzhydryl Compounds ; Dioxins ; Environmental Pollutants ; Furans ; Hydrocarbons, Fluorinated ; Phenols ; Phthalic Acids ; Polycyclic Compounds ; Polychlorinated Biphenyls (DFC2HB4I0K) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2015.94
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association between perfluoroalkyl acids and kidney function in a cross-sectional study of adolescents.

    Kataria, Anglina / Trachtman, Howard / Malaga-Dieguez, Laura / Trasande, Leonardo

    Environmental health : a global access science source

    2015  Volume 14, Page(s) 89

    Abstract: Background: Perfluoroalkyl acids are synthetic compounds widely used in industrial and commercial applications. Laboratory studies suggest that these persistent and bioaccumulative chemicals produce oxidant stress and damage glomerular endothelial cells, ...

    Abstract Background: Perfluoroalkyl acids are synthetic compounds widely used in industrial and commercial applications. Laboratory studies suggest that these persistent and bioaccumulative chemicals produce oxidant stress and damage glomerular endothelial cells, raising concern regarding the impact of these compounds on renal function.
    Methods: We performed cross-sectional analyses of data 1960 participants aged 12-19 years of the 2003-2010 National Health and Nutrition Examination Surveys. PFAA exposure was assessed using levels of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid, and perfluorohexane sulfonic acid. Primary study outcomes were estimated glomerular filtration rate (eGFR) and serum uric acid.
    Results: While adjusting for demographics, cotinine, prehypertension, insulin resistance, body mass index, and hypercholesterolemia, adolescents in the highest PFOA and PFOS quartile had a lower eGFR, 6.84 mL/min/1.73 m(2) (95% CI: 2.19 to 11.48) and 9.69 mL/min/1.73 m(2) (95 % CI: -4.59 to 14.78), respectively, compared to the lowest quartile. Highest PFOA and PFOS quartiles were also associated with 0.21 mg/dL (95% CI: 0.056 to 0.37) and 0.19 mg/dL (95% CI: 0.032 to 0.34) increases in uric acid, respectively.
    Conclusions: PFAAs are associated with a reduction in kidney function and increased uric acid levels in otherwise healthy adolescents. Reverse causation and residual confounding could explain the results. Our study results confirm and amplify previous findings, though longitudinal studies examining prenatal and childhood biomarkers in relationship with robust measures of childhood renal function are needed.
    MeSH term(s) Adolescent ; Alkanesulfonic Acids/blood ; Alkanesulfonic Acids/toxicity ; Biomarkers/blood ; Caprylates/blood ; Caprylates/toxicity ; Child ; Cross-Sectional Studies ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Environmental Pollutants/blood ; Environmental Pollutants/toxicity ; Female ; Fluorocarbons/blood ; Fluorocarbons/toxicity ; Glomerular Filtration Rate/drug effects ; Humans ; Male ; Nutrition Surveys ; Sulfonic Acids/blood ; Sulfonic Acids/toxicity ; United States ; Uric Acid/blood
    Chemical Substances Alkanesulfonic Acids ; Biomarkers ; Caprylates ; Environmental Pollutants ; Fluorocarbons ; Sulfonic Acids ; Uric Acid (268B43MJ25) ; perfluorohexanesulfonic acid (355-46-4) ; perfluoro-n-nonanoic acid (375-95-1) ; perfluorooctanoic acid (947VD76D3L) ; perfluorooctane sulfonic acid (9H2MAI21CL)
    Language English
    Publishing date 2015-11-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1476-069X
    ISSN (online) 1476-069X
    DOI 10.1186/s12940-015-0077-9
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  3. Article ; Online: Reproducible deep-inspiration breath-hold irradiation with forward intensity-modulated radiotherapy for left-sided breast cancer significantly reduces cardiac radiation exposure compared to inverse intensity-modulated radiotherapy.

    Bolukbasi, Yasemin / Saglam, Yucel / Selek, Ugur / Topkan, Erkan / Kataria, Anglina / Unal, Zeynep / Alpan, Vildan

    Tumori

    2014  Volume 100, Issue 2, Page(s) 169–178

    Abstract: Aims and background: To investigate the objective utility of our clinical routine of reproducible deep-inspiration breath-hold irradiation for left-sided breast cancer patients on reducing cardiac exposure.: Methods and study design: Free-breathing ... ...

    Abstract Aims and background: To investigate the objective utility of our clinical routine of reproducible deep-inspiration breath-hold irradiation for left-sided breast cancer patients on reducing cardiac exposure.
    Methods and study design: Free-breathing and reproducible deep-inspiration breath-hold scans were evaluated for our 10 consecutive left-sided breast cancer patients treated with reproducible deep-inspiration breath-hold. The study was based on the adjuvant dose of 50 Gy in 25 fractions of 2 Gy/fraction. Both inverse and forward intensity-modulated radiotherapy plans were generated for each computed tomography dataset.
    Results: Reproducible deep-inspiration breath-hold plans with forward intensity-modulated radiotherapy significantly spared the heart and left anterior descending artery compared to generated free-breathing plans based on mean doses - free-breathing vs reproducible deep-inspiration breath-hold, left ventricle (296.1 vs 94.5 cGy, P = 0.005), right ventricle (158.3 vs 59.2 cGy, P = 0.005), left anterior descending artery (171.1 vs 78.1 cGy, P = 0.005), and whole heart (173.9 vs 66 cGy, P = 0.005), heart V20 (2.2% vs 0%, P = 0.007) and heart V10 (4.2% vs 0.3%, P = 0.007) - whereas they revealed no additional burden on the ipsilateral lung. Reproducible deep-inspiration breath-hold and free-breathing plans with inverse intensity-modulated radiotherapy provided similar organ at risk sparing by reducing the mean doses to the left ventricle, left anterior descending artery, heart, V10-V20 of the heart and right ventricle. However, forward intensity-modulated radiotherapy showed significant reduction in doses to the left ventricle, left anterior descending artery, heart, right ventricle, and contralateral breast (mean dose, 248.9 to 12.3 cGy, P = 0.005). The mean doses for free-breathing vs reproducible deep-inspiration breath-hold of the proximal left anterior descending artery were 1.78 vs 1.08 Gy and of the distal left anterior descending artery were 8.11 vs 3.89 Gy, whereas mean distances to the 50 Gy isodose line of the proximal left anterior descending artery were 6.6 vs 3.3 cm and of the distal left anterior descending artery were 7.4 vs 4.1 cm, with forward intensity-modulated radiotherapy. Overall reduction in mean doses to proximal and distal left anterior descending artery with deep-inspiration breath-hold irradiation was 39% (P = 0.02) and 52% (P = 0.002), respectively.
    Conclusions: We found a significant reduction of radiation exposure to the contralateral breast, left and right ventricles, as well as of proximal and especially distal left anterior descending artery with the deep-inspiration breath-hold technique with forward intensity-modulated radiotherapy planning.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Breath Holding ; Female ; Heart/radiation effects ; Humans ; Inhalation ; Middle Aged ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2014-03-13
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.1700/1491.16405
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  4. Article ; Online: Exposure to bisphenols and phthalates and association with oxidant stress, insulin resistance, and endothelial dysfunction in children.

    Kataria, Anglina / Levine, Dov / Wertenteil, Sara / Vento, Suzanne / Xue, Jingchuan / Rajendiran, Karthikraj / Kannan, Kurunthachalam / Thurman, Joshua M / Morrison, Debra / Brody, Rachel / Urbina, Elaine / Attina, Teresa / Trasande, Leonardo / Trachtman, Howard

    Pediatric research

    2017  Volume 81, Issue 6, Page(s) 857–864

    Abstract: Background: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully.: Methods: We conducted a ... ...

    Abstract Background: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully.
    Methods: We conducted a cross-sectional pilot study of 10-13 y old healthy children. We assessed descriptive, univariable, and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction. Possible associations with brachial artery distensibility, pulse wave velocity (markers of vascular stiffness), and serum endothelial cell-derived microparticle levels were also assessed.
    Results: We enrolled 41 participants, 12.1 ± 1.0 y, most of whom were Mexican Americans (42%) or other Hispanics (34%). Increased BPA levels were associated with increased levels of F2-isoprostane (ng/ml) (P = 0.02), with a similar trend for DEHP metabolites. Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with a 0.550 increase in Homeostatic Model Assessment of insulin resistance (HOMA-IR) units (P = 0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P = 0.026). Bisphenol S (BPS), a replacement for BPA, was associated with increased albumin (mg):creatinine (g) ratio (P = 0.04). Metabolites of HMW phthalates were also associated with decreased brachial artery distensibility (P = 0.047).
    Conclusion: Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children.
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/pr.2017.16
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  5. Article ; Online: Neonatal diabetes mellitus

    Kataria A / Palliyil Gopi R / Mally P / Shah B

    Research and Reports in Neonatology, Vol 2014, Iss default, Pp 55-

    current perspective

    2014  Volume 64

    Abstract: Anglina Kataria,1 Resmy Palliyil Gopi,2 Pradeep Mally,3 Bina Shah21Department of Pediatrics ...

    Abstract Anglina Kataria,1 Resmy Palliyil Gopi,2 Pradeep Mally,3 Bina Shah21Department of Pediatrics, 2Pediatric Endocrinology, Department of Pediatrics, 3Neonatology, Department of Pediatrics, NYU School of Medicine, New York, NY, USAAbstract: Neonatal diabetes mellitus (NDM) is a rare form of diabetes characterized by hyperglycemia occurring in the first few months of life. It can present as either transient NDM (TNDM), which resolves by a few months, or permanent NDM (PNDM), which continues throughout life. The etiology of this disease remained unclear until recently, when advances in molecular genetic techniques illuminated the mechanisms involved in the pathogenesis of the disease. Having delineated the genes involved in insulin production and secretion and their association with NDM, we currently understand the molecular basis of this disease. While most TNDM cases are caused by the overexpression of chromosome 6q24, the majority of PNDM cases are due to mutations in the adenosine triphosphate-sensitive potassium (KATP) channel. The improved understanding of the etiology of the disease had revolutionized the diagnosis and its management with oral sulfonylureas. The primary objective of this study was to review the current understanding of neonatal diabetes, including its genetic etiologies, clinical presentation, diagnosis, acute treatment, and long-term management.Keywords: hyperglycemia, intrauterine growth retardation, KATP channel mutations, sulfonylurea
    Keywords Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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