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  1. Article ; Online: REPLY.

    De Pasquale, Claudia / Campana, Stefania / Pollicino, Teresa / Ferlazzo, Guido

    Hepatology (Baltimore, Md.)

    2021  Volume 74, Issue 4, Page(s) 2326–2327

    Language English
    Publishing date 2021-08-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The Effectiveness and Safety of Autologous Platelet Concentrates as Hemostatic Agents after Tooth Extraction in Patients on Anticoagulant Therapy: A Systematic Review of Randomized, Controlled Trials.

    Campana, Maria Domenica / Aliberti, Angelo / Acerra, Alfonso / Sammartino, Pasquale / Dolce, Pasquale / Sammartino, Gilberto / Gasparro, Roberta

    Journal of clinical medicine

    2023  Volume 12, Issue 16

    Abstract: One of the common challenges in oral surgery is dealing with patients who are taking oral anticoagulant/antiaggregant drugs. Several local hemostatic agents have been proposed as an alternative to conventional suturing. Among these, autologous platelet ... ...

    Abstract One of the common challenges in oral surgery is dealing with patients who are taking oral anticoagulant/antiaggregant drugs. Several local hemostatic agents have been proposed as an alternative to conventional suturing. Among these, autologous platelet concentrates (APCs) have been widely used to decrease the risk of hemorrhage after dental extraction. Nevertheless, there is a lack of consensus regarding the superiority of any one specific hemostatic agent over the others. This systematic review is aimed at evaluating the effectiveness of APCs as hemostatic agents after tooth extraction in patients on anticoagulant therapy. A literature search was conducted of articles published before March 2023 on PubMed, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL). Studies on the use of APCs in patients undergoing dental extractions and being treated with anticoagulant drugs were included. Only randomized, controlled trials (RCTs) published up to March 2023 were included; the outcomes assessed were the time to hemostasis, the presence of post-operative bleeding and pain, and the effectiveness of wound healing. The risk of bias for each RCT was assessed by using the 'risk of bias' tool (RoB 1.0). The research revealed 6 RCTs. The findings indicated that patients on anticoagulant therapy who received APCs without discontinuing their medication experienced a decreased post-operative bleeding, a shorter hemostasis time, reduced pain, and accelerated wound healing. However, due to the high/unclear risk of bias of the studies included, no definitive conclusions can be drawn on the superiority of APCs as hemostatic agents over other similar products. Additional studies are required to validate these findings.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12165342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Can aldosterone increase interleukin-6 levels in Covid-19 pneumonia?

    Campana, Pasquale / Flocco, Veronica / Aruta, Francesco / Cacciatore, Francesco / Abete, Pasquale

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 622–623

    MeSH term(s) Aldosterone/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/immunology ; Cytokine Release Syndrome/immunology ; Female ; Guillain-Barre Syndrome/etiology ; Humans ; Interleukin-6/blood ; Middle Aged ; Receptors, Interleukin-6/blood
    Chemical Substances IL6 protein, human ; IL6R protein, human ; Interleukin-6 ; Receptors, Interleukin-6 ; Aldosterone (4964P6T9RB)
    Keywords covid19
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26382
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  4. Article ; Online: ILC in chronic inflammation, cancer and targeting with biologicals.

    De Pasquale, Claudia / Campana, Stefania / Bonaccorsi, Irene / Carrega, Paolo / Ferlazzo, Guido

    Molecular aspects of medicine

    2021  Volume 80, Page(s) 100963

    Abstract: Since their discovery, Innate Lymphoid Cells (ILC) have emerged as important effector cells, serving multiple roles in maintaining tissue homeostasis and responding to tissue insults. As such, dysregulations of their function and distribution have been ... ...

    Abstract Since their discovery, Innate Lymphoid Cells (ILC) have emerged as important effector cells, serving multiple roles in maintaining tissue homeostasis and responding to tissue insults. As such, dysregulations of their function and distribution have been observed in a variety of immune-mediated diseases, suggesting a specific role for ILC in the pathophysiology of several disorders including chronic inflammation and cancer. Here, we provide an updated view on ILC biology dissecting their pathological or protective contribution in chronic inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, psoriasis, rheumatoid arthritis, asthma and COPD, atherosclerosis, also exploring ILC role in tumor surveillance and progression. Throughout the review, we will also highlight how the potential dual role of these cells for protective or pathogenic immunity in many inflammatory diseases makes them interesting targets for the development of novel therapeutic strategies, particularly promising.
    MeSH term(s) Biological Products ; Humans ; Immunity, Innate ; Inflammation/drug therapy ; Lymphocytes ; Neoplasms/drug therapy
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2021.100963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Potential predictive role of gut microbiota to immunotherapy in HCC patients: a brief review.

    Muscolino, Paola / Granata, Barbara / Omero, Fausto / De Pasquale, Claudia / Campana, Stefania / Calabrò, Alessia / D'Anna, Federica / Drommi, Fabiana / Pezzino, Gaetana / Cavaliere, Riccardo / Ferlazzo, Guido / Silvestris, Nicola / Speranza, Desirèe

    Frontiers in oncology

    2023  Volume 13, Page(s) 1247614

    Abstract: The recent evolution of immunotherapy has revolutionised the treatment of hepatocellular carcinoma (HCC) and has led to new therapeutic standards. The advances in immunotherapy have been accompanied by the recognition of the role of the gut-liver axis in ...

    Abstract The recent evolution of immunotherapy has revolutionised the treatment of hepatocellular carcinoma (HCC) and has led to new therapeutic standards. The advances in immunotherapy have been accompanied by the recognition of the role of the gut-liver axis in the progression of HCC but also of the clinical relevance of the gut microbiota, which influences host homeostasis but also cancer development and the response to treatment. Dysbiosis, by altering the tumour microenvironment, favours the activation of intracellular signalling pathways and promotes carcinogenesis. The gut microbiota, through their composition and immunomodulatory role, are thus strong predictors of the response to immune checkpoint inhibitor (ICI) treatment as well as an available target to improve ICI efficacy and reduce drug toxicities. In this review we examine the novel role of the gut microbiota as biomarkers in both the diagnosis of HCC and the clinical response to immunotherapy as well as its potential impact on clinical practice in the future.
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1247614
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  7. Article ; Online: Can aldosterone increase interleukin‐6 levels in Covid‐19 pneumonia?

    Campana, Pasquale / Flocco, Veronica / Aruta, Francesco / Cacciatore, Francesco / Abete, Pasquale

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26382
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Crosstalk between ILC3s and Microbiota: Implications for Colon Cancer Development and Treatment with Immune Check Point Inhibitors.

    Drommi, Fabiana / Calabrò, Alessia / Vento, Grazia / Pezzino, Gaetana / Cavaliere, Riccardo / Omero, Fausto / Muscolino, Paola / Granata, Barbara / D'Anna, Federica / Silvestris, Nicola / De Pasquale, Claudia / Ferlazzo, Guido / Campana, Stefania

    Cancers

    2023  Volume 15, Issue 11

    Abstract: Type 3 innate lymphoid cells (ILC3s) are primarily tissue-resident cells strategically localized at the intestinal barrier that exhibit the fast-acting responsiveness of classic innate immune cells. Populations of these lymphocytes depend on the ... ...

    Abstract Type 3 innate lymphoid cells (ILC3s) are primarily tissue-resident cells strategically localized at the intestinal barrier that exhibit the fast-acting responsiveness of classic innate immune cells. Populations of these lymphocytes depend on the transcription factor RAR-related orphan receptor and play a key role in maintaining intestinal homeostasis, keeping host-microbial mutualism in check. Current evidence has indicated a bidirectional relationship between microbiota and ILC3s. While ILC3 function and maintenance in the gut are influenced by commensal microbiota, ILC3s themselves can control immune responses to intestinal microbiota by providing host defense against extracellular bacteria, helping to maintain a diverse microbiota and inducing immune tolerance for commensal bacteria. Thus, ILC3s have been linked to host-microbiota interactions and the loss of their normal activity promotes dysbiosis, chronic inflammation and colon cancer. Furthermore, recent evidence has suggested that a healthy dialog between ILC3s and gut microbes is necessary to support antitumor immunity and response to immune checkpoint inhibitor (ICI) therapy. In this review, we summarize the functional interactions occurring between microbiota and ILC3s in homeostasis, providing an overview of the molecular mechanisms orchestrating these interactions. We focus on how alterations in this interplay promote gut inflammation, colorectal cancer and resistance to therapies with immune check point inhibitors.
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15112893
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  9. Article ; Online: Mechanical bacterial lysate enhances antimicrobial barrier mechanisms in human airway epithelial cells.

    Sidoti Migliore, Giacomo / Campana, Stefania / Barberi, Chiara / De Pasquale, Claudia / Pezzino, Gaetana / Cavaliere, Riccardo / Orecchia, Paola / Ginestra, Giovanna / Mandalari, Giuseppina / Del Zotto, Genny / Bonaccorsi, Irene / Carrega, Paolo / Mingari, Maria Cristina / Ferlazzo, Guido

    Journal of leukocyte biology

    2023  Volume 113, Issue 5, Page(s) 535–540

    Abstract: Polyvalent mechanical bacterial lysate is effective in the prevention of respiratory tract infections, although its mechanism of action is not entirely elucidated. Because epithelial cells constitute the frontline defense against infections, we ... ...

    Abstract Polyvalent mechanical bacterial lysate is effective in the prevention of respiratory tract infections, although its mechanism of action is not entirely elucidated. Because epithelial cells constitute the frontline defense against infections, we investigated the molecular mechanisms of innate response exerted by bronchial epithelial cells in the presence of polyvalent mechanical bacterial lysate. By using primary human bronchial epithelial cells, we observed that polyvalent mechanical bacterial lysate was able to increase the expression of cellular adhesion molecules such as ICAM-1 and E-cadherin, as well as the expression of amphiregulin, a growth factor able to support human bronchial epithelial cell proliferation. Remarkably, polyvalent mechanical bacterial lysate promoted in human bronchial epithelial cells the de novo expression of human β-defensin-2, a major antimicrobial peptide, conferring them a direct antimicrobial activity. Moreover, polyvalent mechanical bacterial lysate-stimulated human bronchial epithelial cells provided signals for increased IL-22 production by innate lymphoid cells via IL-23, which could further contribute to the release of antimicrobial peptides by epithelial cells. In agreement with these in vitro data, the concentration of both IL-23 and antimicrobial peptides (human β-defensin-2 and LL-37) increased in the saliva of healthy volunteers after sublingual administration of polyvalent mechanical bacterial lysate. Altogether, these results indicate that polyvalent mechanical bacterial lysate administration might support mucosal barrier integrity and promote mechanisms of antimicrobial activity in airway epithelial cells.
    MeSH term(s) Humans ; beta-Defensins ; Immunity, Innate ; Lymphocytes/metabolism ; Anti-Infective Agents/metabolism ; Epithelial Cells/metabolism ; Interleukin-23
    Chemical Substances beta-Defensins ; Broncho-Vaxom ; Anti-Infective Agents ; Interleukin-23
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Aortic rupture in patient on oral therapy with levofloxacin.

    Campana, Pasquale / Leosco, Dario / Petraglia, Laura / Radice, Leonardo / Parisi, Valentina

    Aging clinical and experimental research

    2019  Volume 32, Issue 4, Page(s) 755–757

    Language English
    Publishing date 2019-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-019-01267-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3343: Show issues Location:
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