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Article ; Online: Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis.

da Costa, Vivaldo Gomes / Saivish, Marielena Vogel / Lino, Nikolas Alexander Borsato / Bittar, Cíntia / de Freitas Calmon, Marília / Nogueira, Maurício Lacerda / Rahal, Paula

Viruses

2022 Volume 15, Issue 1

Abstract: Ilheus fever is a mosquito-borne, poorly known tropical disease. We aimed to report the pooled rate of exposure to the Ilheus virus (ILHV) and clinical outcomes of infection to determine the epidemiological patterns of ILHV. We conducted a meta-analysis ... ...

Abstract	Ilheus fever is a mosquito-borne, poorly known tropical disease. We aimed to report the pooled rate of exposure to the Ilheus virus (ILHV) and clinical outcomes of infection to determine the epidemiological patterns of ILHV. We conducted a meta-analysis of 37 studies (
MeSH term(s)	Animals ; Male ; Female ; Humans ; Infant, Newborn ; Infant ; Child, Preschool ; Child ; Adolescent ; Flavivirus ; Culicidae ; Brazil/epidemiology ; Phylogeny
Language	English
Publishing date	2022-12-29
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15010092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Predicting Antigenic Peptides from Rocio Virus NS1 Protein for Immunodiagnostic Testing Using Immunoinformatics and Molecular Dynamics Simulation.

Saivish, Marielena Vogel / Menezes, Gabriela de Lima / Costa, Vivaldo Gomes da / Silva, Gislaine Celestino Dutra da / Marques, Rafael Elias / Nogueira, Maurício Lacerda / Silva, Roosevelt Alves Da

International journal of molecular sciences

2022 Volume 23, Issue 14

Abstract: The mosquito-borne disease caused by the Rocio virus is a neglected threat, and new immune inputs for serological testing are urgently required for diagnosis in low-resource settings and epidemiological surveillance. We used in silico approaches to ... ...

Abstract	The mosquito-borne disease caused by the Rocio virus is a neglected threat, and new immune inputs for serological testing are urgently required for diagnosis in low-resource settings and epidemiological surveillance. We used in silico approaches to identify a specific antigenic peptide (p_ROCV2) in the NS1 protein of the Rocio virus that was theoretically predicted to be stable and exposed on its surface, where it demonstrated key properties allowing it to interact with antibodies. These findings related to the molecular dynamics of this peptide provide important insights for advancing diagnostic platforms and investigating therapeutic alternatives.
MeSH term(s)	Animals ; Flavivirus ; Immunologic Tests ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptides ; Viral Nonstructural Proteins/chemistry
Chemical Substances	Peptides ; Viral Nonstructural Proteins
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23147681
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Article ; Online: The emergence of SARS, MERS and novel SARS-2 coronaviruses in the 21st century.

da Costa, Vivaldo Gomes / Moreli, Marcos Lázaro / Saivish, Marielena Vogel

Archives of virology

2020 Volume 165, Issue 7, Page(s) 1517–1526

Abstract: At the beginning of the 21st century, a new deadly infectious disease known as severe acute respiratory syndrome (SARS) was recognized as a global public health threat. Subsequently, ten years after the initial SARS cases occurred in 2002, new cases of ... ...

Abstract	At the beginning of the 21st century, a new deadly infectious disease known as severe acute respiratory syndrome (SARS) was recognized as a global public health threat. Subsequently, ten years after the initial SARS cases occurred in 2002, new cases of another atypical respiratory disease caused worldwide concern. This disease became known as Middle East respiratory syndrome (MERS) and was even more lethal than SARS. Currently, history has repeated itself with the emergence of a new Chinese epidemic at the end of 2019. For this respiratory disease, called COVID-19, a novel coronavirus (SARS-CoV-2) was identified as the etiologic agent. In sum, SARS, MERS and COVID-19 are caused by recently discovered coronaviruses that cause flu-like illnesses, but with a clinical outcome that tends to be more severe. As a result of the current importance of coronaviruses in global public health, we conducted a review to summarize and update, above all, the epidemiological historical aspects of the three major diseases in humans caused by coronaviral infection.
MeSH term(s)	Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/virology ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/isolation & purification ; Middle East Respiratory Syndrome Coronavirus/physiology ; Pandemics ; Pneumonia, Viral/virology ; Severe acute respiratory syndrome-related coronavirus/genetics ; Severe acute respiratory syndrome-related coronavirus/isolation & purification ; Severe acute respiratory syndrome-related coronavirus/physiology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/virology
Keywords	covid19
Language	English
Publishing date	2020-04-22
Publishing country	Austria
Document type	Journal Article ; Review
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-020-04628-0
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Article ; Online: Structural Insights into Plasticity and Discovery of Flavonoid Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease

Marielena Vogel Saivish / Gabriela de Lima Menezes / Vivaldo Gomes da Costa / Liliane Nebo / Gislaine Celestino Dutra da Silva / Carolina Colombelli Pacca / Rafael Elias Marques / Maurício Lacerda Nogueira / Roosevelt Alves Da Silva

Biophysica, Vol 3, Iss 6, Pp 71-

2023 Volume 92

Abstract: Flaviviruses are among the most critical pathogens in tropical regions; they cause various severe diseases in developing countries but are not restricted to these countries. The development of antiviral therapeutics is crucial for managing flavivirus ... ...

Abstract	Flaviviruses are among the most critical pathogens in tropical regions; they cause various severe diseases in developing countries but are not restricted to these countries. The development of antiviral therapeutics is crucial for managing flavivirus outbreaks. Ten proteins are encoded in the flavivirus RNA. The N2B–NS3pro protein complex plays a fundamental role in flavivirus replication and is a promising drug target; however, no flavivirus protease inhibitors have progressed to the preclinical stage. This study analyzed the structural models and plasticity of the NS2B–NS3pro protein complex of five medically important non-dengue flaviviruses (West Nile, Rocio, Ilhéus, yellow fever, and Saint Louis encephalitis). The flavonoids amentoflavone, tetrahydrorobustaflavone, and quercetin were selected for their exceptional binding energies as potential inhibitors of the NS2B–NS3pro protein complex. AutoDock Vina results ranged from −7.0 kcal/mol to −11.5 kcal/mol and the compounds preferentially acted non-competitively. Additionally, the first structural model for the NS2B–NS3pro protein complex was proposed for Ilhéus and Rocio viruses. The NS2B–NS3pro protease is an attractive molecular target for drug development. The three identified natural flavonoids showed great inhibitory potential against the viral species. Nevertheless, further in silico and in vitro studies are required to obtain more information regarding NS2B–NS3pro inhibition by these flavonoids and their therapeutic potential.
Keywords	flaviviral protease inhibitors ; Rocio virus ; Ilhéus virus ; Saint Louis encephalitis virus ; yellow fever virus ; 3D pharmacophores ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study.

Costa, Vivaldo Gomes da / Gomes, Ana Júlia Chaves / Bittar, Cíntia / Geraldini, Dayla Bott / Previdelli da Conceição, Pâmela Jóyce / Cabral, Ágata Silva / Carvalho, Tamara / Biselli, Joice Matos / Provazzi, Paola Jocelan Scarin / Campos, Guilherme Rodrigues Fernandes / Sanches, Paulo Ricardo da Silva / Costa, Paulo Inácio / Nogueira, Maurício Lacerda / Araujo, João Pessoa / Spilki, Fernando Rosado / Calmon, Marília Freitas / Rahal, Paula

Viruses

2023 Volume 15, Issue 3

Abstract: Non-SARS-CoV-2 respiratory viral infections, such as influenza virus (FluV) and human respiratory syncytial virus (RSV), have contributed considerably to the burden of infectious diseases in the non-COVID-19 era. While the rates of co-infection in SARS- ... ...

Abstract	Non-SARS-CoV-2 respiratory viral infections, such as influenza virus (FluV) and human respiratory syncytial virus (RSV), have contributed considerably to the burden of infectious diseases in the non-COVID-19 era. While the rates of co-infection in SARS-CoV-2-positive group (SCPG) patients have been determined, the burden of other respiratory viruses in the SARS-CoV-2-negative group (SCNG) remains unclear. Here, we conducted a cross-sectional study (São José do Rio Preto county, Brazil), and we collected our data using a meta-analysis to evaluate the pooled prevalence of FluV and RSV among SCNG patients. Out of the 901 patients suspected of COVID-19, our molecular results showed positivity of FluV and RSV in the SCNG was 2% (15/733) and 0.27% (2/733), respectively. Co-infection with SARS-CoV-2 and FluV, or RSV, was identified in 1.7% of the patients (3/168). Following our meta-analysis, 28 studies were selected (
MeSH term(s)	Humans ; Coinfection/epidemiology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Influenza, Human/epidemiology ; Pandemics ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human ; SARS-CoV-2
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15030665
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Dimeric Peptide (KKYRYHLKPF)

Ayusso, Gabriela Miranda / Lima, Maria Letícia Duarte / da Silva Sanches, Paulo Ricardo / Santos, Igor Andrade / Martins, Daniel Oliveira Silva / da Conceição, Pâmela Jóyce Previdelli / Carvalho, Tamara / da Costa, Vivaldo Gomes / Bittar, Cíntia / Merits, Andres / Santos-Filho, Norival Alves / Cilli, Eduardo Maffud / Jardim, Ana Carolina Gomes / de Freitas Calmon, Marilia / Rahal, Paula

Viruses

2023 Volume 15, Issue 5

Abstract: Chikungunya virus (CHIKV) and Zika virus (ZIKV) are important disease-causing agents worldwide. Currently, there are no antiviral drugs or vaccines approved to treat these viruses. However, peptides have shown great potential for new drug development. A ... ...

Abstract	Chikungunya virus (CHIKV) and Zika virus (ZIKV) are important disease-causing agents worldwide. Currently, there are no antiviral drugs or vaccines approved to treat these viruses. However, peptides have shown great potential for new drug development. A recent study described (p-BthTX-I)
MeSH term(s)	Animals ; Chlorocebus aethiops ; Humans ; Zika Virus Infection/drug therapy ; Zika Virus/genetics ; Chikungunya Fever ; Vero Cells ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Virus Replication ; COVID-19 ; SARS-CoV-2 ; Chikungunya virus/genetics ; Viruses ; Peptides/pharmacology ; Peptides/therapeutic use
Chemical Substances	Antiviral Agents ; Peptides
Language	English
Publishing date	2023-05-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051168
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Article ; Online: First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil

Vivaldo Gomes da Costa / Marielena Vogel Saivish / Priscila Gomes de Oliveira / Abelardo Silva-Júnior / Marcos Lázaro Moreli / Ricardo Henrique Krüger

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the ... ...

Abstract	Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil.

da Costa, Vivaldo Gomes / Saivish, Marielena Vogel / de Oliveira, Priscila Gomes / Silva-Júnior, Abelardo / Moreli, Marcos Lázaro / Krüger, Ricardo Henrique

Scientific reports

2021 Volume 11, Issue 1, Page(s) 13039

Abstract: The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first ... ...

Abstract	The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Brazil ; Distemper/virology ; Distemper Virus, Canine/genetics ; Distemper Virus, Canine/isolation & purification ; Dogs/virology ; Genes, Viral ; Genome, Viral ; Genotype ; Glycosylation ; Phylogeny ; Recombination, Genetic/genetics ; Selection, Genetic ; Viral Proteins/chemistry ; Viral Proteins/genetics
Chemical Substances	Viral Proteins
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92183-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The emergence of SARS, MERS and novel SARS-2 coronaviruses in the 21st century

da Costa, Vivaldo Gomes / Moreli, Marcos Lázaro / Saivish, Marielena Vogel

Archives of virology. 2020 July, v. 165, no. 7

2020

Abstract	At the beginning of the 21st century, a new deadly infectious disease known as severe acute respiratory syndrome (SARS) was recognized as a global public health threat. Subsequently, ten years after the initial SARS cases occurred in 2002, new cases of another atypical respiratory disease caused worldwide concern. This disease became known as Middle East respiratory syndrome (MERS) and was even more lethal than SARS. Currently, history has repeated itself with the emergence of a new Chinese epidemic at the end of 2019. For this respiratory disease, called COVID-19, a novel coronavirus (SARS-CoV-2) was identified as the etiologic agent. In sum, SARS, MERS and COVID-19 are caused by recently discovered coronaviruses that cause flu-like illnesses, but with a clinical outcome that tends to be more severe. As a result of the current importance of coronaviruses in global public health, we conducted a review to summarize and update, above all, the epidemiological historical aspects of the three major diseases in humans caused by coronaviral infection.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; etiological agents ; public health ; respiratory tract diseases ; virology
Language	English
Dates of publication	2020-07
Size	p. 1517-1526.
Publishing place	Springer Vienna
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-020-04628-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Rocio Virus: An Updated View on an Elusive Flavivirus.

Saivish, Marielena Vogel / Gomes da Costa, Vivaldo / de Lima Menezes, Gabriela / Alves da Silva, Roosevelt / Dutra da Silva, Gislaine Celestino / Moreli, Marcos Lázaro / Sacchetto, Livia / Pacca, Carolina Colombelli / Vasilakis, Nikos / Nogueira, Maurício Lacerda

Viruses

2021 Volume 13, Issue 11

Abstract: Rocio virus (ROCV) is a mosquito-borne flavivirus and human pathogen. The virus is indigenous to Brazil and was first detected in 1975 in the Sao Paulo State, and over a period of two years was responsible for several epidemics of meningoencephalitis in ... ...

Abstract	Rocio virus (ROCV) is a mosquito-borne flavivirus and human pathogen. The virus is indigenous to Brazil and was first detected in 1975 in the Sao Paulo State, and over a period of two years was responsible for several epidemics of meningoencephalitis in coastal communities leading to over 100 deaths. The vast majority of ROCV infections are believed to be subclinical and clinical manifestations can range from uncomplicated fever to fatal meningoencephalitis. Birds are the natural reservoir and amplification hosts and ROCV is maintained in nature in a mosquito-bird-mosquito transmission cycle, primarily involving
MeSH term(s)	Animals ; Brazil/epidemiology ; Disease Outbreaks ; Flavivirus/classification ; Flavivirus/genetics ; Flavivirus Infections/epidemiology ; Flavivirus Infections/transmission ; Flavivirus Infections/virology ; Humans ; Mosquito Vectors/virology ; Viral Proteins/genetics
Chemical Substances	Viral Proteins
Language	English
Publishing date	2021-11-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13112293
Database	MEDical Literature Analysis and Retrieval System OnLINE

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