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  1. Article ; Online: GSKβ as a target in podocyte aging.

    Shankland, Stuart J / Wessely, Oliver

    Kidney international

    2022  Volume 102, Issue 3, Page(s) 463–465

    MeSH term(s) Aging ; Glomerulosclerosis, Focal Segmental ; Humans ; Kidney Glomerulus ; Podocytes
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.04.041
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    Zs.A 797: Show issues Location:
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  2. Article ; Online: Zoning in on podocytes.

    Shankland, Stuart J / Wessely, Oliver

    Kidney international

    2022  Volume 102, Issue 5, Page(s) 966–968

    Abstract: Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a ... ...

    Abstract Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary glomeruli are not only morphologically heterogeneous per se, but respond differently to stressors, such as age and hypertension. This suggests that zonal glomerular changes harbor critical information to understand glomerulopathies.
    MeSH term(s) Humans ; Podocytes ; Kidney Glomerulus ; Kidney Diseases ; Hypertension
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.08.030
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  3. Article ; Online: The proliferative and the antifibrotic side of PAX2 in tubular repair.

    Wessely, Oliver / Shankland, Stuart J

    Kidney international

    2022  Volume 102, Issue 1, Page(s) 12–13

    Abstract: Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box ... ...

    Abstract Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box transcription factor Pax2 in PTECs is required for their regenerative proliferation and repair. However, a loss-of-function study now shows that the absence of Pax2 not only impacts PTEC proliferation but also causes myofibroblast recruitment leading to excessive tubulointerstitial fibrosis.
    MeSH term(s) Acute Kidney Injury/pathology ; Animals ; Epithelial Cells/metabolism ; Fibrosis ; Kidney/metabolism ; Kidney Tubules, Proximal/pathology ; PAX2 Transcription Factor/genetics ; PAX2 Transcription Factor/metabolism
    Chemical Substances PAX2 Transcription Factor
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.04.016
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  4. Article ; Online: Repurposing drugs for diseases associated with podocyte dysfunction.

    Shankland, Stuart J / Jefferson, J Ashley / Wessely, Oliver

    Kidney international

    2023  Volume 104, Issue 3, Page(s) 455–462

    Abstract: The majority of podocyte disorders are progressive in nature leading to chronic kidney disease and often kidney failure. The scope of current therapies is typically nonspecific immunosuppressant medications, which are accompanied by unwanted and serious ... ...

    Abstract The majority of podocyte disorders are progressive in nature leading to chronic kidney disease and often kidney failure. The scope of current therapies is typically nonspecific immunosuppressant medications, which are accompanied by unwanted and serious side effects. However, many exciting clinical trials are underway to reduce the burden of podocyte diseases in our patients. Major advances and discoveries have recently been made experimentally in our understanding of the molecular and cellular mechanisms underlying podocyte injury in disease. This begs the question of how best to take advantage of these impressive strides. One approach to consider is the repurposing of therapeutics that have already been approved by the Food and Drug Administration, European Medicines Agency, and other regulatory agencies for indications beyond the kidney. The advantages of therapy repurposing include known safety profiles, drug development that has already been completed, and overall reduced costs for studying alternative indications for selected therapies. The purpose of this mini review is to examine the experimental literature of podocyte damage and determine if there are mechanistic targets in which prior approved therapies can be considered for repurposing to podocyte disorders.
    MeSH term(s) Humans ; Podocytes ; Pharmaceutical Preparations ; Drug Repositioning ; Kidney ; Renal Insufficiency, Chronic/drug therapy
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.05.018
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  5. Article ; Online: Training Nephrology Fellows in Temporary Hemodialysis Catheters and Kidney Biopsies Is Not Needed and Should Not Be Required.

    Shankland, Stuart J

    Clinical journal of the American Society of Nephrology : CJASN

    2018  Volume 13, Issue 7, Page(s) 1102–1104

    MeSH term(s) Biopsy ; Catheterization ; Education, Medical, Graduate/standards ; Fellowships and Scholarships ; Humans ; Kidney/pathology ; Nephrology/education ; Renal Dialysis/methods ; Time Factors ; United States
    Language English
    Publishing date 2018-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.01260118
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    Zs.A 6584: Show issues Location:
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  6. Article ; Online: Does treating with anti-PD-1 to improve glomerular health come without a cost? Reply.

    Shankland, Stuart J / Pippin, Jeffrey W / Wessely, Oliver

    The Journal of clinical investigation

    2022  Volume 132, Issue 22

    MeSH term(s) Programmed Cell Death 1 Receptor ; B7-H1 Antigen
    Chemical Substances Programmed Cell Death 1 Receptor ; B7-H1 Antigen
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI165287
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    Ua VI Zs.184: Show issues Location:
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  7. Article ; Online: Does treating with anti–PD-1 to improve glomerular health come without a cost? Reply.

    Stuart J. Shankland / Jeffrey W. Pippin / Oliver Wessely

    The Journal of Clinical Investigation, Vol 132, Iss

    2022  Volume 22

    Keywords Aging ; Medicine ; R
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Podocyte Senescence and Aging.

    Shankland, Stuart J / Rule, Andrew D / Kutz, J Nathan / Pippin, Jeffrey W / Wessely, Oliver

    Kidney360

    2023  Volume 4, Issue 12, Page(s) 1784–1793

    Abstract: As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we ... ...

    Abstract As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we focus on the effect of aging on glomerular podocytes, the post-mitotic epithelial cells critical for the normal integrity and function of the glomerular filtration barrier. The podocytes undergo senescence and transition to a senescence-associated secretory phenotype typified by the production and secretion of inflammatory cytokines that can influence neighboring glomerular cells by paracrine signaling. In addition to senescence, the aging podocyte phenotype is characterized by ultrastructural and functional changes; hypertrophy; cellular, oxidative, and endoplasmic reticulum stress; reduced autophagy; and increased expression of aging genes. This results in a reduced podocyte health span and a shortened life span. Importantly, these changes in the pathways/processes characteristic of healthy podocyte aging are also often similar to pathways in the disease-induced injured podocyte. Finally, the better understanding of podocyte aging and senescence opens therapeutic options to slow the rate of podocyte aging and promote kidney health.
    MeSH term(s) Humans ; Podocytes/metabolism ; Aging/metabolism ; Kidney Glomerulus/metabolism ; Kidney Diseases/metabolism ; Epithelial Cells
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A bone marrow factor contributes to kidney disease.

    Shankland, Stuart J / Jefferson, J Ashley

    Nature medicine

    2017  Volume 23, Issue 1, Page(s) 13–14

    Language English
    Publishing date 2017-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4263
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  10. Article ; Online: CD9 Is a Novel Target in Glomerular Diseases Typified by Parietal Epithelial Cell Activation.

    Smeets, Bart / Miesen, Laura / Shankland, Stuart J

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2019  Volume 75, Issue 5, Page(s) 812–814

    MeSH term(s) Epithelial Cells ; Glomerulosclerosis, Focal Segmental ; Humans ; Kidney Diseases
    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2019.08.012
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