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Article ; Online: Advancing

Wang, Jie / Du, Lin / Han, Yuwei / Zhang, Dawei / Jing, Dalei

2023 Volume 23, Issue 24, Page(s) 5165–5172

Abstract: The utilization of microfluidic analysis technology has resulted in the advancement of fast pathogenic bacteria detection, which can accurately provide information on biochemical reactions in a single cell and enhance detection efficiency. Nevertheless, ... ...

Abstract	The utilization of microfluidic analysis technology has resulted in the advancement of fast pathogenic bacteria detection, which can accurately provide information on biochemical reactions in a single cell and enhance detection efficiency. Nevertheless, the achievement of rapid and effective
MeSH term(s)	Escherichia coli ; Staphylococcus aureus ; Microfluidic Analytical Techniques/methods ; Wettability ; Single-Cell Analysis/methods
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d3lc00590a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The emerging ideological security dilemma between China and the U.S.

Jie, Dalei

China Int Strategy Rev.

Abstract: Historically, the impact of different ideologies on U.S.-China relations is determined by whether there is a strong strategic rationale for a positive relationship and whether China’s internal development is in line with the U.S. expectations. During the ...

Abstract	Historically, the impact of different ideologies on U.S.-China relations is determined by whether there is a strong strategic rationale for a positive relationship and whether China’s internal development is in line with the U.S. expectations. During the Trump era, U.S–China relations have become definitively more competitive, and the U.S. is disillusioned with China’s internal development. Consequently, the ideological factor becomes more pronounced in the bilateral relationship, and a certain degree of ideological competition may be inevitable. But this is and will likely remain limited in scope and intensity because neither side is bent on an ideological crusade or a Cold War-style ideological conflict. The current situation may best be characterized as a “security dilemma” in the ideological domain. It does not have to lead to the worst possible outcome that neither desires, but preventing such an outcome requires better understanding of each other’s intentions, increased appreciation for the impact of one’s own actions on the other’s insecurity, refraining from utilizing ideology for domestic mobilization, and prioritizing putting one’s own house in order.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/s42533-020-00059-3
Database	COVID19

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Article: Randomized Crossover Study of Auricular Plaster Therapy to Relieve Dental Anxiety in Children.

Wang, Jiangtao / Zhang, Jie / Sun, Dalei

Frontiers in psychiatry

2022 Volume 13, Page(s) 862575

Abstract: Objective: To determine if auricular plaster therapy (APT) can alleviate dental anxiety in children aged 9 or 10 years old.: Methods: A crossover research was conducted on children with at least two deep-arrested deciduous molar caries (: Results: ...

Abstract	Objective: To determine if auricular plaster therapy (APT) can alleviate dental anxiety in children aged 9 or 10 years old. Methods: A crossover research was conducted on children with at least two deep-arrested deciduous molar caries ( Results: Children treated with anti-anxiety APT demonstrated significantly higher levels of obedience than children treated with control APT ( Conclusion: Anti-anxiety APT can help relieve dental anxiety in children.
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.862575
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Article: Cost-Effective Droplet Generator for Portable Bio-Applications.

Du, Lin / Li, Yuxin / Wang, Jie / Zhou, Zijian / Lan, Tian / Jing, Dalei / Wu, Wenming / Zhou, Jia

Micromachines

2023 Volume 14, Issue 2

Abstract: The convenient division of aqueous samples into droplets is necessary for many biochemical and medical analysis applications. In this article, we propose the design of a cost-effective droplet generator for potential bio-chemical application, featuring ... ...

Abstract	The convenient division of aqueous samples into droplets is necessary for many biochemical and medical analysis applications. In this article, we propose the design of a cost-effective droplet generator for potential bio-chemical application, featuring two symmetric tubes. The new droplet generator revisits the relationship between capillary components and liquid flow rates. The size of generated droplets by prototype depends only on generator dimensions, without precisely needing to control external flow conditions or driving pressure, even when the relative extreme difference in flow rate for generating nL level droplets is over 57.79%, and the relative standard deviation (RSD) of the volume of droplets is barely about 9.80%. A dropper working as a pressure resource is used to verify the rapidity and robustness of this principle of droplet generation, which shows great potential for a wide range of droplet-based applications.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14020466
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Article ; Online: Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity.

Wang, Xiaotong / Chen, Xiaoyu / Wang, Zong-Jie / Zhuang, Mengwei / Zhong, Lin / Fu, Chengzhang / Garcia, Ronald / Müller, Rolf / Zhang, Youming / Yan, Jie / Wu, Dalei / Huo, Liujie

Journal of the American Chemical Society

2023 Volume 145, Issue 30, Page(s) 16924–16937

Abstract: The genomes of myxobacteria harbor a variety of biosynthetic gene clusters encoding numerous secondary metabolites, including ribosomally synthesized and post-translationally modified peptides (RiPPs) with diverse chemical structures and biological ... ...

Abstract	The genomes of myxobacteria harbor a variety of biosynthetic gene clusters encoding numerous secondary metabolites, including ribosomally synthesized and post-translationally modified peptides (RiPPs) with diverse chemical structures and biological activities. However, the biosynthetic potential of RiPPs from myxobacteria remains barely explored. Herein, we report a novel myxobacteria lanthipeptide myxococin identified from
MeSH term(s)	Myxococcales ; Peptides/chemistry ; Protein Processing, Post-Translational
Chemical Substances	Peptides
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c06014
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Article ; Online: Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids.

Nature microbiology

2024 Volume 9, Issue 2, Page(s) 434–450

Abstract: A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host-microbe interactions in the gut remain largely unknown. Here we report that the gut ... ...

Abstract	A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host-microbe interactions in the gut remain largely unknown. Here we report that the gut commensal Christensenella minuta modulates host metabolism by generating a previously undescribed class of secondary bile acids with 3-O-acylation substitution that inhibit the intestinal farnesoid X receptor. Administration of C. minuta alleviated features of metabolic disease in high fat diet-induced obese mice associated with a significant increase in these acylated bile acids, which we refer to as 3-O-acyl-cholic acids. Specific knockout of intestinal farnesoid X receptor in mice counteracted the beneficial effects observed in their wild-type counterparts. Finally, we showed that 3-O-acyl-CAs were prevalent in healthy humans but significantly depleted in patients with type 2 diabetes. Our findings indicate a role for C. minuta and acylated bile acids in metabolic diseases.
MeSH term(s)	Humans ; Animals ; Mice ; Bile Acids and Salts ; Diabetes Mellitus, Type 2 ; Clostridiales ; Diet, High-Fat
Chemical Substances	Bile Acids and Salts
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-023-01570-0
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Article: Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model.

Meng, Jie / Chen, Taoping / Zhao, Yu / Lu, Sucai / Yu, Huiling / Chang, Ying / Chen, Dalei

Archives of medical science : AMS

2018 Volume 15, Issue 5, Page(s) 1329–1335

Abstract: Introduction: This study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared to the standard drug (omeprazole).: Material and methods: Three groups of rats (6 rats per group for each ulcer ... ...

Abstract	Introduction: This study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared to the standard drug (omeprazole). Material and methods: Three groups of rats (6 rats per group for each ulcer model) were pre-treated with distilled water for the negative control group, 30 mg/kg of omeprazole for the positive control group and VCO (2 ml per rat) for the treatment group. Animals were pre-treated for 7 days and ulcers were induced with cold restraint stress, piroxicam, ethanol and pylorus ligation. On day eight, animals were sacrificed and ulcer scores were determined based on macroscopic evaluation. The gastric volume, pH, total acidity and mucus content were measured in the pylorus-ligated model. The levels of antioxidants were determined from the gastric tissue homogenates. Results: Virgin coconut oil significantly ( Conclusions: Virgin coconut oil shows a possible association with antioxidant properties to control the regulation of prostaglandin synthesis and protect against reactive oxygen species damage.
Language	English
Publishing date	2018-07-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms.2018.76943
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Article ; Online: The antinociceptive effects and molecular mechanisms of ghrelin(1-7)-NH

Wu, Bing / Liu, Yongling / Liu, Fuyan / Deng, Qing / Wang, Jinglei / Han, Renwen / Zhang, Dalei / Chen, Jiaxiang / Wei, Jie

Brain research bulletin

2018 Volume 146, Page(s) 112–123

Abstract: Ghrelin(1-7)- ... ...

Abstract	Ghrelin(1-7)-NH
MeSH term(s)	Analgesics/administration & dosage ; Analgesics, Opioid/pharmacology ; Animals ; Ghrelin/administration & dosage ; Injections, Intraventricular ; Male ; Mice ; Morphine ; Narcotic Antagonists/administration & dosage ; Oligopeptides/administration & dosage ; Pain/drug therapy ; Peptide Fragments/administration & dosage ; Receptors, Ghrelin/agonists ; Receptors, Ghrelin/metabolism ; Receptors, Opioid/drug effects
Chemical Substances	Analgesics ; Analgesics, Opioid ; Ghrelin ; Ghsr1a protein, mouse ; Narcotic Antagonists ; Oligopeptides ; Peptide Fragments ; Receptors, Ghrelin ; Receptors, Opioid ; growth hormone releasing hexapeptide (4H7N4I6X6A) ; Morphine (76I7G6D29C)
Language	English
Publishing date	2018-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2018.12.016
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Article: Rapid and large-scale mapping of flood inundation via integrating spaceborne synthetic aperture radar imagery with unsupervised deep learning

Jiang, Xin / Liang, Shijing / He, Xinyue / Ziegler, Alan D / Lin, Peirong / Pan, Ming / Wang, Dashan / Zou, Junyu / Hao, Dalei / Mao, Ganquan / Zeng, Yelu / Yin, Jie / Feng, Lian / Miao, Chiyuan / Wood, Eric F / Zeng, Zhenzhong

International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS) ISPRS journal of photogrammetry and remote sensing. 2021 Aug., v. 178

2021

Abstract: Synthetic aperture radar (SAR) has great potential for timely monitoring of flood information as it penetrates the clouds during flood events. Moreover, the proliferation of SAR satellites with high spatial and temporal resolution provides a tremendous ... ...

Abstract	Synthetic aperture radar (SAR) has great potential for timely monitoring of flood information as it penetrates the clouds during flood events. Moreover, the proliferation of SAR satellites with high spatial and temporal resolution provides a tremendous opportunity to understand the flood risk and its quick response. However, traditional algorithms to extract flood inundation using SAR often require manual parameter tuning or data annotation, which presents a challenge for the rapid automated mapping of large and complex flooded scenarios. To address this issue, we proposed a segmentation algorithm for automatic flood mapping in near-real-time over vast areas and for all-weather conditions by integrating Sentinel-1 SAR imagery with an unsupervised machine learning approach named Felz-CNN. The algorithm consists of three phases: (i) super-pixel generation; (ii) convolutional neural network-based featurization; (iii) super-pixel aggregation. We evaluated the Felz-CNN algorithm by mapping flood inundation during the Yangtze River flood in 2020, covering a total study area of 1,140,300 km². When validated on fine-resolution Planet satellite imagery, the algorithm accurately identified flood extent with producer and user accuracy of 93% and 94%, respectively. The results are indicative of the usefulness of our unsupervised approach for the application of flood mapping. Meanwhile, we overlapped the post-disaster inundation map with a 10-m resolution global land cover map (FROM-GLC10) to assess the damages to different land cover types. Of these types, cropland and residential settlements were most severely affected, with inundation areas of 9,430.36 km² and 1,397.50 km², respectively, results that are in agreement with statistics from relevant agencies. Compared with traditional supervised classification algorithms that require time-consuming data annotation, our unsupervised algorithm can be deployed directly to high-performance computing platforms such as Google Earth Engine and PIE-Engine to generate a large-spatial map of flood-affected areas within minutes, without time-consuming data downloading and processing. Importantly, this efficiency enables the fast and effective monitoring of flood conditions to aid in disaster governance and mitigation globally.
Keywords	Internet ; algorithms ; automation ; cropland ; governance ; land cover ; photogrammetry ; remote sensing ; risk ; synthetic aperture radar ; Yangtze River
Language	English
Dates of publication	2021-08
Size	p. 36-50.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1007774-1
ISSN	0924-2716
ISSN	0924-2716
DOI	10.1016/j.isprsjprs.2021.05.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plasma-based microsatellite instability detection strategy to guide immune checkpoint blockade treatment.

Wang, Zhenghang / Zhao, Xiaochen / Gao, Chan / Gong, Jifang / Wang, Xicheng / Gao, Jing / Li, Zhongwu / Wang, Jie / Yang, Bo / Wang, Lei / Zhang, Bei / Zhou, Yifan / Wang, Dalei / Li, Xiaofang / Bai, Yuezong / Li, Jian / Shen, Lin

Journal for immunotherapy of cancer

2020 Volume 8, Issue 2

Abstract: Background: Microsatellite instability (MSI) represents the first pan-cancer biomarker approved to guide immune checkpoint blockade (ICB) treatment. However its widespread testing, especially outside of gastrointestinal cancer, is hampered by tissue ... ...

Abstract	Background: Microsatellite instability (MSI) represents the first pan-cancer biomarker approved to guide immune checkpoint blockade (ICB) treatment. However its widespread testing, especially outside of gastrointestinal cancer, is hampered by tissue availability. Methods: An algorithm for detecting MSI from peripheral blood was established and validated using clinical plasma samples. Its value for predicting ICB efficacy was evaluated among 60 patients with advanced gastrointestinal cancer. The landscape of MSI in blood was also explored among 5138 advanced solid tumors. Results: The algorithm included 100 microsatellite markers with high capture efficiency, sensitivity, and specificity. In comparison with orthogonal tissue PCR results, the method displayed a sensitivity of 82.5% (33/40) and a specificity of 96.2% (201/209), for an overall accuracy of 94.0% (234/249). When the clinical validation cohort was dichotomized by pretreatment blood MSI (bMSI), bMSI-high (bMSI-H) predicted both improved progression-free survival and overall survival than the blood microsatellite stable (bMSS) patients (HRs: 0.431 and 0.489, p=0.005 and 0.034, respectively). Four patients with bMSS were identified to have high blood tumor mutational burden (bTMB-H) and trended towards a better survival than the bMSS-bTMB-low (bTMB-L) subset (HR 0.026, 95% CI 0 to 2.635, p=0.011). These four patients with bMSS-bTMB-H plus the bMSI-H group collectively displayed significantly improved survival over the bMSS-bTMB-L patients (HR 0.317, 95% CI 0.157 to 0.640, p<0.001). Pan-cancer prevalence of bMSI-H was largely consistent with that shown for tissue except for much lower rates in endometrial and gastrointestinal cancers, and a remarkably higher prevalence in prostate cancer relative to other cancer types. Conclusions: We have developed a reliable and robust next generation sequencing-based bMSI detection strategy which, in combination with a panel enabling concurrent profiling of bTMB from a single blood draw, may better inform ICB treatment.
MeSH term(s)	Biomarkers, Tumor/blood ; Female ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Microsatellite Instability/drug effects
Chemical Substances	Biomarkers, Tumor ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2020-11-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2020-001297
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