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Article ; Online: Temperature sensing and context-dependent thermal behavior in nematodes.

Glauser, Dominique A

2022 Volume 73, Page(s) 102525

Abstract: As small ectotherms, whose temperature equilibrates almost instantly with that of their environment, free-living nematodes rely on their behavior for thermoregulation. Caenorhabditis elegans has been extensively used as a model to address the fundamental ...

Abstract	As small ectotherms, whose temperature equilibrates almost instantly with that of their environment, free-living nematodes rely on their behavior for thermoregulation. Caenorhabditis elegans has been extensively used as a model to address the fundamental mechanisms involved in thermosensation and the production of temperature-dependent behaviors. Behavioral responses include avoidance of acute noxious heat or cold stimuli and thermotactic responses to innocuous temperatures to produce oriented navigation in spatial thermogradients. In order to produce these behaviors, C. elegans relies on its ability to detect thermal cues with exquisite sensitivity, orchestrate a set of specific behavioral responses and adapt these responses in specific contexts, including according to past sensory experience and current internal states. The present review focuses on recent advances in our understanding of the processes occurring at the molecular, cellular, and circuit levels that enable thermosensory information processing and plasticity.
MeSH term(s)	Adaptation, Physiological ; Animals ; Behavior, Animal/physiology ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins ; Temperature ; Thermosensing/physiology
Chemical Substances	Caenorhabditis elegans Proteins
Language	English
Publishing date	2022-03-16
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2022.102525
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Article ; Online: Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a

Ippolito, Domenica / Glauser, Dominique A

eLife

2023 Volume 12

Abstract: Nociceptive habituation is a conserved process through which pain sensitivity threshold is adjusted based on past sensory experience and which may be dysregulated in human chronic pain conditions. Noxious heat habituation ... ...

Abstract	Nociceptive habituation is a conserved process through which pain sensitivity threshold is adjusted based on past sensory experience and which may be dysregulated in human chronic pain conditions. Noxious heat habituation in
MeSH term(s)	Animals ; Active Transport, Cell Nucleus ; Caenorhabditis elegans/metabolism ; Calcium/metabolism ; Cell Nucleus/metabolism ; Nociceptors/metabolism ; Nuclear Localization Signals/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Caenorhabditis elegans Proteins/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Nuclear Localization Signals ; cmk-1 protein, C elegans (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.85260
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Article ; Online: Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity.

Jordan, Aurore / Glauser, Dominique A

Genetics

2023 Volume 224, Issue 1

Abstract: The detection and avoidance of harmful stimuli are essential animal capabilities. The molecular and cellular mechanisms controlling nociception and its plasticity are conserved, genetically controlled processes of broad biomedical interest given their ... ...

Abstract	The detection and avoidance of harmful stimuli are essential animal capabilities. The molecular and cellular mechanisms controlling nociception and its plasticity are conserved, genetically controlled processes of broad biomedical interest given their relevance to understand and treat pain conditions that represent a major health burden. Recent genome-wide association studies (GWAS) have identified a rich set of polymorphisms related to different pain conditions and pointed to many human pain gene candidates, whose connection to the pain pathways is however often poorly understood. Here, we used a computer-assisted Caenorhabditis elegans thermal avoidance analysis pipeline to screen for behavioral defects in a set of 109 mutants for genes orthologous to human pain-related genes. We measured heat-evoked reversal thermosensitivity profiles, as well as spontaneous reversal rate, and compared naïve animals with adapted animals submitted to a series of repeated noxious heat stimuli, which in wild type causes a progressive habituation. Mutations affecting 28 genes displayed defects in at least one of the considered parameters and could be clustered based on specific phenotypic footprints, such as high-sensitivity mutants, nonadapting mutants, or mutants combining multiple defects. Collectively, our data reveal the functional architecture of a network of conserved pain-related genes in C. elegans and offer novel entry points for the characterization of poorly understood human pain genes in this genetic model.
MeSH term(s)	Animals ; Humans ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Nociception/physiology ; Genome-Wide Association Study ; Pain
Chemical Substances	Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyad047
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Article ; Online: Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

Domenica Ippolito / Dominique A Glauser

eLife, Vol

2023 Volume 12

Abstract	Nociceptive habituation is a conserved process through which pain sensitivity threshold is adjusted based on past sensory experience and which may be dysregulated in human chronic pain conditions. Noxious heat habituation in Caenorhabditis elegans involves the nuclear translocation of CaM kinase-1 (CMK-1) in the FLP thermo-nociceptors neurons, causing reduced animal heat sensitivity and avoidance responses. The phosphorylation of CMK-1 on T179 by CaM kinase kinase-1 (CKK-1) is required for nuclear entry. Recently, we identified a specific nuclear export sequence (NES) required to maintain CMK-1 in the cytoplasm at rest (20°C) and showed that Ca2+/CaM binding is sufficient to enhance CMK-1 affinity for IMA-3 via a specific nuclear localization signal (NLS) in order to promote nuclear entry after persistent heat stimulation (90 min at 28°C) (Ippolito et al., 2021). Here, we identified additional functional NES and NLS on CMK-1, whose activity can counteract previously identified elements. Furthermore, we clarify the relationship between the CaM-binding-dependent and T179-dependent effects. T179 phosphorylation can promote nuclear entry both downstream of CaM binding and as part of an independent/parallel pathway. Moreover, T179 phosphorylation can also produce the opposite effect by promoting nuclear export. Taken together, our studies suggest that multiple calcium-dependent regulatory mechanisms converge to bias the activity pattern across a network of NES/NLS elements, in order to control CMK-1 nucleo-cytoplasmic shuttling, and actuate stimulation-dependent nociceptive plasticity.
Keywords	nociceptive plasticity ; thermosensation ; calcium signaling ; protein subcellular localization ; CaM kinase ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immature leaves are the dominant volatile-sensing organs of maize.

Wang, Lei / Jäggi, Simon / Cofer, Tristan M / Waterman, Jamie M / Walthert, Mario / Glauser, Gaétan / Erb, Matthias

Current biology : CB

2023 Volume 33, Issue 17, Page(s) 3679–3689.e3

Abstract: ... induced volatiles. In conclusion, our work identifies immature maize leaves as dominant stress volatile ...

Abstract	Plants perceive herbivory-induced volatiles and respond to them by upregulating their defenses. To date, the organs responsible for volatile perception remain poorly described. Here, we show that responsiveness to the herbivory-induced green leaf volatile (Z)-3-hexenyl acetate (HAC) in terms of volatile emission, transcriptional regulation, and jasmonate defense hormone activation is largely constrained to younger maize leaves. Older leaves are much less sensitive to HAC. In a given leaf, responsiveness to HAC is high at immature developmental stages and drops off rapidly during maturation. Responsiveness to the non-volatile elicitor ZmPep3 shows an opposite pattern, demonstrating that this form of hyposmia (i.e., decreased sense of smell) is not due to a general defect in jasmonate defense signaling in mature leaves. Neither stomatal conductance nor leaf cuticle composition explains the unresponsiveness of older leaves to HAC, suggesting perception mechanisms upstream of jasmonate signaling as driving factors. Finally, we show that hyposmia in older leaves is not restricted to HAC and extends to the full blend of herbivory-induced volatiles. In conclusion, our work identifies immature maize leaves as dominant stress volatile-sensing organs. The tight spatiotemporal control of volatile perception may facilitate within plant defense signaling to protect young leaves and may allow plants with complex architectures to explore the dynamic odor landscapes at the outer periphery of their shoots.
MeSH term(s)	Zea mays/genetics ; Anosmia ; Cyclopentanes ; Herbivory
Chemical Substances	jasmonic acid (6RI5N05OWW) ; Cyclopentanes
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.07.045
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Article ; Online: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans.

Thapliyal, Saurabh / Beets, Isabel / Glauser, Dominique A

Nature communications

2023 Volume 14, Issue 1, Page(s) 3052

Abstract: Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent multidimensional ... ...

Abstract	Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent multidimensional behavioral changes remains poorly understood. Here, we show that C. elegans integrates environmental temperature and food availability over different timescales to engage in persistent dwelling, scanning, global or glocal search strategies matching thermoregulatory and feeding needs. Transition between states, in each case, involves regulating multiple processes including AFD or FLP tonic sensory neurons activity, neuropeptide expression and downstream circuit responsiveness. State-specific FLP-6 or FLP-5 neuropeptide signaling acts on a distributed set of inhibitory GPCR(s) to promote scanning or glocal search, respectively, bypassing dopamine and glutamate-dependent behavioral state control. Integration of multimodal context via multisite regulation in sensory circuits might represent a conserved regulatory logic for a flexible prioritization on the valence of multiple inputs when operating persistent behavioral state transitions.
MeSH term(s)	Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Sensory Receptor Cells/metabolism ; Neuropeptides/metabolism ; Signal Transduction
Chemical Substances	Caenorhabditis elegans Proteins ; Neuropeptides
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38685-1
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Article ; Online: Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of

Rudgalvyte, Martina / Atzei, Paola / de Brito Francisco, Rita / Naef, Reto / Glauser, Dominique A

microPublication biology

2024 Volume 2024

Abstract: The quest for extending lifespan and promoting a healthy aging has been a longstanding pursuit in the field of aging research. The control of aging and age-related diseases by nitric oxide (NO) and cGMP signaling is a broadly conserved process from worms ...

Abstract	The quest for extending lifespan and promoting a healthy aging has been a longstanding pursuit in the field of aging research. The control of aging and age-related diseases by nitric oxide (NO) and cGMP signaling is a broadly conserved process from worms to human. Here we show that TOP-N53, a dual-acting NO donor and PDE5 inhibitor, can increase both lifespan and health span in
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.001090
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Article ; Online: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans

Saurabh Thapliyal / Isabel Beets / Dominique A. Glauser

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 19

Abstract: Abstract Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent ... ...

Abstract	Abstract Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent multidimensional behavioral changes remains poorly understood. Here, we show that C. elegans integrates environmental temperature and food availability over different timescales to engage in persistent dwelling, scanning, global or glocal search strategies matching thermoregulatory and feeding needs. Transition between states, in each case, involves regulating multiple processes including AFD or FLP tonic sensory neurons activity, neuropeptide expression and downstream circuit responsiveness. State-specific FLP-6 or FLP-5 neuropeptide signaling acts on a distributed set of inhibitory GPCR(s) to promote scanning or glocal search, respectively, bypassing dopamine and glutamate-dependent behavioral state control. Integration of multimodal context via multisite regulation in sensory circuits might represent a conserved regulatory logic for a flexible prioritization on the valence of multiple inputs when operating persistent behavioral state transitions.
Keywords	Science ; Q
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A system for the high-throughput analysis of acute thermal avoidance and adaptation in

Lia, Andrei-Stefan / Glauser, Dominique A

Journal of biological methods

2020 Volume 7, Issue 1, Page(s) e129

Abstract: Nociception and its plasticity are essential biological processes controlling adaptive behavioral responses in animals. These processes are also linked to different pain conditions in human and have received considerable attention, ... ...

Abstract	Nociception and its plasticity are essential biological processes controlling adaptive behavioral responses in animals. These processes are also linked to different pain conditions in human and have received considerable attention, notably
Language	English
Publishing date	2020-03-17
Publishing country	United States
Document type	Journal Article
ISSN	2326-9901
ISSN (online)	2326-9901
DOI	10.14440/jbm.2020.324
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Article ; Online: Tissue-specific DamID protocol using nanopore sequencing.

Gómez-Saldivar, Georgina / Glauser, Dominique A / Meister, Peter

Journal of biological methods

2021 Volume 8, Issue 3, Page(s) e152

Abstract: DNA adenine methylation identification (DamID) is a powerful method to determine DNA binding profiles of proteins at a genomic scale. The method leverages the fusion between a protein of interest and the Dam methyltransferase ... ...

Abstract	DNA adenine methylation identification (DamID) is a powerful method to determine DNA binding profiles of proteins at a genomic scale. The method leverages the fusion between a protein of interest and the Dam methyltransferase of
Language	English
Publishing date	2021-08-27
Publishing country	United States
Document type	Journal Article
ISSN	2326-9901
ISSN (online)	2326-9901
DOI	10.14440/jbm.2021.362
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