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Article: Autoimmune encephalitis: Early and late findings on serial MR imaging and correlation to treatment timepoints.

Abunada, Mahmoud / Nierobisch, Nathalie / Ludovichetti, Riccardo / Simmen, Cyril / Terziev, Robert / Togni, Claudio / Michels, Lars / Kulcsar, Zsolt / Hainc, Nicolin

European journal of radiology open

2024 Volume 12, Page(s) 100552

Abstract: Introduction: MRI is negative in a large percentage of autoimmune encephalitis cases or lacks findings specific to an antibody. Even rarer is literature correlating the evolution of imaging findings with treatment timepoints. We aim to characterize ... ...

Abstract	Introduction: MRI is negative in a large percentage of autoimmune encephalitis cases or lacks findings specific to an antibody. Even rarer is literature correlating the evolution of imaging findings with treatment timepoints. We aim to characterize imaging findings in autoimmune encephalitis at presentation and on follow up correlated with treatment timepoints for this rare disease. Methods: A full-text radiological information system search was performed for "autoimmune encephalitis" between January 2012 and June 2022. Patients with laboratory-identified autoantibodies were included. MRI findings were assessed in correlation to treatment timepoints by two readers in consensus. For statistical analysis, cell-surface vs intracellular antibody groups were assessed for the presence of early limbic, early extralimbic, late limbic, and late extralimbic findings using the χ Results: Thirty-seven patients (female n = 18, median age 58.8 years; range 25.7 to 82.7 years) with 15 different autoantibodies were included in the study. Twenty-three (62%) patients were MRI-negative at time of presentation; 5 of these developed MRI findings on short-term follow up. Of the 19 patients with early MRI findings, 9 (47%) demonstrated improvement upon treatment initiation (7/9 cell-surface group). There was a significant difference (p = 0.046) between the MRI spectrum of cell-surface vs intracellular antibody syndromes as cell-surface antibody syndromes demonstrated more early classic findings of limbic encephalitis and intracellular antibody syndromes demonstrated more late extralimbic abnormalities. Conclusion: MRI can be used to help narrow the differential diagnosis in autoimmune encephalitis and can be used as a monitoring tool for certain subtypes of this rare disease.
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2810314-2
ISSN	2352-0477
ISSN	2352-0477
DOI	10.1016/j.ejro.2024.100552
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Article: Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet.

Brown, Adam R / Alhallak, Iad / Simmen, Rosalia C M / Melnyk, Stepan B / Heard-Lipsmeyer, Melissa E / Montales, Maria Theresa E / Habenicht, Daniel / Van, Trang T / Simmen, Frank A

Cancers

2022 Volume 14, Issue 7

Abstract: Obesity, oxidative stress, and inflammation are risk factors for hepatocellular carcinoma (HCC). We examined, in mice, the effects of Krüppel-like factor 9 (KLF9) knockout on: adiposity, hepatic and systemic oxidative stress, and hepatic expression of ... ...

Abstract	Obesity, oxidative stress, and inflammation are risk factors for hepatocellular carcinoma (HCC). We examined, in mice, the effects of Krüppel-like factor 9 (KLF9) knockout on: adiposity, hepatic and systemic oxidative stress, and hepatic expression of pro-inflammatory and NOX/DUOX family genes, in a high-fat diet (HFD) context. Male and female
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14071737
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Article ; Online: The role of thyroid hormone signaling in the prevention of digestive system cancers.

Brown, Adam R / Simmen, Rosalia C M / Simmen, Frank A

International journal of molecular sciences

2013 Volume 14, Issue 8, Page(s) 16240–16257

Abstract: Thyroid hormones play a critical role in the growth and development of the alimentary tract in vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface receptor integrin αVβ3. Systemic thyroid hormone levels are controlled ...

Abstract	Thyroid hormones play a critical role in the growth and development of the alimentary tract in vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface receptor integrin αVβ3. Systemic thyroid hormone levels are controlled via activation and deactivation by iodothyronine deiodinases in the liver and other tissues. Given that thyroid hormone signaling has been characterized as a major effector of digestive system growth and homeostasis, numerous investigations have examined its role in the occurrence and progression of cancers in various tissues of this organ system. The present review summarizes current findings regarding the effects of thyroid hormone signaling on cancers of the esophagus, stomach, liver, pancreas, and colon. Particular attention is given to the roles of different thyroid hormone receptor isoforms, the novel integrin αVβ3 receptor, and thyroid hormone-related nutrients as possible protective agents and therapeutic targets. Future investigations geared towards a better understanding of thyroid hormone signaling in digestive system cancers may provide preventive or therapeutic strategies to diminish risk, improve outcome and avert recurrence in afflicted individuals.
MeSH term(s)	Digestive System Neoplasms/metabolism ; Digestive System Neoplasms/prevention & control ; Humans ; Integrin alphaVbeta3/metabolism ; Iodide Peroxidase/metabolism ; Liver/metabolism ; Protein Isoforms/metabolism ; Receptors, Thyroid Hormone/metabolism ; Signal Transduction ; Thyroid Gland/metabolism ; Thyroid Hormones/metabolism
Chemical Substances	Integrin alphaVbeta3 ; Protein Isoforms ; Receptors, Thyroid Hormone ; Thyroid Hormones ; Iodide Peroxidase (EC 1.11.1.8)
Language	English
Publishing date	2013-08-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms140816240
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Article ; Online: Krüppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling.

Brown, Adam R / Simmen, Rosalia C M / Raj, Vinay R / Van, Trang T / MacLeod, Stewart L / Simmen, Frank A

Carcinogenesis

2015 Volume 36, Issue 9, Page(s) 946–955

Abstract: Unlabelled: Expression of the transcription factor Krüppel-like factor 9 (KLF9) is frequently reduced in colorectal cancers, although a tumor suppressive role has not been established. To determine if KLF9 suppresses intestinal adenoma formation, we ... ...

Abstract	Unlabelled: Expression of the transcription factor Krüppel-like factor 9 (KLF9) is frequently reduced in colorectal cancers, although a tumor suppressive role has not been established. To determine if KLF9 suppresses intestinal adenoma formation, we generated mice of distinct Klf9 genotypes in the background of the Apc (Min/+) mouse and compared their adenoma burdens at 16 weeks of age. While small intestine adenoma burden remained unchanged among Klf9 genotypes, male and female Apc(Min/+)/Klf9(-/-) and Apc(Min/+)/Klf9(+/-) mice exhibited significantly more colon adenomas than their Apc(Min/+)/Klf9(+/+) counterparts. Microarray analysis showed significant increases in the expression of interferon-induced genes in the colon mucosa of female Apc (Min/+)/Klf9(+/-) and Apc(Min/+)/Klf9(-/-) compared to Apc(Min/+)/Klf9(+/+) mice, prior to overt adenoma occurrence. Gene upregulation was confirmed by qPCR of colon mucosa and by siRNA knockdown of KLF9 in human HT29 colorectal cancer cells. Increases in expression of these genes were further augmented by supplementation with Interferon β1. Circulating levels of the cytokine, interferon-stimulated gene 15 (ISG15) were increased in Apc(Min/+)/Klf9(+/-) and Apc(Min/+)/Klf9(-/-) mice relative to Apc(Min/+)/Klf9(+/+). Additionally, colon mucosal levels of ISG15 were increased in Apc(Min/+)/Klf9(+/-) mice. Chromatin immunoprecipitation demonstrated KLF9 recruitment to the ISG15 promoter. Lastly, treatment with ISG15 suppressed apoptosis in HT29 cells, in the presence and absence of 5-fluorouracil (5FU). Results show KLF9 to be a haploinsufficient suppressor of colon tumorigenesis in Apc(Min/+) mice in part, by repression of ISG15 and the latter's antiapoptotic function. Summary: Krüppel-like factor 9 (KLF9) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.
MeSH term(s)	Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Cytokines/genetics ; Cytokines/metabolism ; Cytokines/pharmacology ; Female ; Gene Expression Regulation, Neoplastic ; HT29 Cells ; Haploinsufficiency/genetics ; Humans ; Interferon-beta/pharmacology ; Intestinal Mucosa/pathology ; Kruppel-Like Transcription Factors/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Promoter Regions, Genetic/genetics ; RNA Interference ; RNA, Small Interfering ; Signal Transduction/genetics ; Ubiquitins/genetics ; Ubiquitins/metabolism ; Ubiquitins/pharmacology
Chemical Substances	Cytokines ; G1p2 protein, mouse ; KLF9 protein, human ; Klf9 protein, mouse ; Kruppel-Like Transcription Factors ; RNA, Small Interfering ; Ubiquitins ; ISG15 protein, human (60267-61-0) ; Interferon-beta (77238-31-4)
Language	English
Publishing date	2015-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgv104
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Article ; Online: The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers

Rosalia C. M. Simmen / Adam R. Brown / Frank A. Simmen

International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 16240-

2013 Volume 16257

Abstract	Thyroid hormones play a critical role in the growth and development of the alimentary tract in vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface receptor integrin αVβ3. Systemic thyroid hormone levels are controlled via activation and deactivation by iodothyronine deiodinases in the liver and other tissues. Given that thyroid hormone signaling has been characterized as a major effector of digestive system growth and homeostasis, numerous investigations have examined its role in the occurrence and progression of cancers in various tissues of this organ system. The present review summarizes current findings regarding the effects of thyroid hormone signaling on cancers of the esophagus, stomach, liver, pancreas, and colon. Particular attention is given to the roles of different thyroid hormone receptor isoforms, the novel integrin αVβ3 receptor, and thyroid hormone-related nutrients as possible protective agents and therapeutic targets. Future investigations geared towards a better understanding of thyroid hormone signaling in digestive system cancers may provide preventive or therapeutic strategies to diminish risk, improve outcome and avert recurrence in afflicted individuals.
Keywords	thyroid hormone ; thyroid hormone receptor ; esophageal cancer ; gastric cancer ; liver cancer ; pancreatic cancer ; colorectal cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2013-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety of digoxin in acute heart failure triggered by tachyarrhythmia.

Shrestha, Samyut / Lopez-Ayala, Pedro / Schaefer, Ibrahim / Nardiello, Svetlana S / Papachristou, Androniki / Aliyeva, Fatima / Simmen, Cornelia / Wussler, Desiree / Belkin, Maria / Gualandro, Danielle M / Puelacher, Christian / Michou, Eleni / Pfister, Otmar / Bingisser, Roland / Nickel, Christian H / Breidthardt, Tobias / Mueller, Christian

Journal of internal medicine

2022 Volume 292, Issue 6, Page(s) 969–972

MeSH term(s)	Humans ; Digoxin/adverse effects ; Tachycardia/chemically induced ; Tachycardia/drug therapy ; Heart Failure/complications ; Heart Failure/drug therapy
Chemical Substances	Digoxin (73K4184T59)
Language	English
Publishing date	2022-09-06
Publishing country	England
Document type	Letter
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13565
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Article ; Online: Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.

Zia, Sameera / Hammond, Brady P / Zirngibl, Martin / Sizov, Anastasia / Baaklini, Charbel S / Panda, Sharmistha P / Ho, Madelene F S / Lee, Kelly V / Mainali, Apurba / Burr, Mena K / Williams, Sioned / Caprariello, Andrew V / Power, Christopher / Simmen, Thomas / Kerr, Bradley J / Plemel, Jason R

Molecular neurodegeneration

2022 Volume 17, Issue 1, Page(s) 82

Abstract: Background: Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood.: Methods: ... ...

Abstract	Background: Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood. Methods: To understand how microglia respond during demyelination, we fed mice cuprizone-a potent demyelinating agent-and assessed the dynamics of genetically fate-mapped microglia. We then used single-cell RNA sequencing to identify and track the microglial subpopulations that arise during demyelination. To understand how microglia contribute to the clearance of dead oligodendrocytes, we ablated microglia starting at the peak of cuprizone-induced cell death and used the viability dye acridine orange to monitor apoptotic and lytic cell morphologies after microglial ablation. Lastly, we treated serum-free primary microglial cultures to model distinct aspects of cuprizone-induced demyelination and assessed the response. Results: The cuprizone diet generated a robust microglial response by week 4 of the diet. Single-cell RNA sequencing at this time point revealed the presence of several cuprizone-associated microglia (CAM) clusters. These clusters expressed a transcriptomic signature indicative of cytokine regulation and reactive oxygen species production with altered lysosomal and metabolic changes consistent with ongoing phagocytosis. Using acridine orange to monitor apoptotic and lytic cell death after microglial ablation, we found that microglia preferentially phagocytose lytic carcasses. In culture, microglia exposed to lytic carcasses partially recapitulated the CAM state, suggesting that phagocytosis contributes to this distinct microglial state during cuprizone demyelination. Conclusions: Microglia serve multiple roles during demyelination, yet their transcriptomic state resembles other neurodegenerative conditions. The phagocytosis of cellular debris is likely a universal cause for a common neurodegenerative microglial state.
MeSH term(s)	Animals ; Mice ; Cuprizone/toxicity ; Cuprizone/metabolism ; Microglia/metabolism ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/metabolism ; Transcriptome ; Acridine Orange/adverse effects ; Acridine Orange/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal
Chemical Substances	Cuprizone (5N16U7E0AO) ; Acridine Orange (F30N4O6XVV)
Language	English
Publishing date	2022-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2244557-2
ISSN	1750-1326 ; 1750-1326
ISSN (online)	1750-1326
ISSN	1750-1326
DOI	10.1186/s13024-022-00584-2
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Article ; Online: Assessment of long-term donor-site morbidity after harvesting the latissimus dorsi flap for neonatal myelomeningocele repair.

Osinga, R / Mazzone, L / Meuli, M / Meuli-Simmen, C / von Campe, A

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2014 Volume 67, Issue 8, Page(s) 1070–1075

Abstract: Background and aim: The latissimus dorsi flap (LDF) has been employed very successfully over decades to cover large soft-tissue defects. Its donor-site morbidity has been extensively investigated in adults - but not in children - and is considered to be ...

Abstract	Background and aim: The latissimus dorsi flap (LDF) has been employed very successfully over decades to cover large soft-tissue defects. Its donor-site morbidity has been extensively investigated in adults - but not in children - and is considered to be nonrestrictive. The aim of this long-term study was to assess donor-site morbidity with the modified Constant score more than 8 years after coverage of large myelomeningocele (MMC) defects with a reverse latissimus dorsi flap. Methods: Within the first days after birth, the reverse latissimus dorsi muscle flap was used uni- or bilaterally in three neonates to cover a large MMC defect. Bilateral shoulder function was tested more than 8 years postoperatively according to the modified Constant score. Results: The mean age at follow-up was 11.7 years. None of the patients experienced any pain or shoulder restrictions during normal daily activities. They all managed to position both of their arms comfortably above the head. Forward flexion was normal in all patients as was abduction and external rotation. Dorsal extension was minimally reduced on the operated side. Internal rotation was symmetric in all patients; the extent of active movement varied from excellent to poor. Conclusions: Our long-term data suggest that there is no specific and significant impairment of shoulder function after using the distally pedicled reverse LDF for neonatal MMC repair.
MeSH term(s)	Adolescent ; Child ; Female ; Follow-Up Studies ; Humans ; Infant, Newborn ; Male ; Meningomyelocele/surgery ; Movement/physiology ; Muscle Strength/physiology ; Rotation ; Shoulder/physiology ; Superficial Back Muscles/transplantation ; Surgical Flaps ; Transplant Donor Site
Language	English
Publishing date	2014-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2014.04.018
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Article ; Online: Estimates of inbreeding depression for serum insulin-like growth factor I concentrations, body weights, and body weight gains in Angus beef cattle divergently selected for serum insulin-like growth factor I concentration.

Davis, M E / Simmen, R C M

Journal of animal science

2010 Volume 88, Issue 2, Page(s) 552–561

Abstract: Data for the current study were obtained from a divergent selection experiment in which the selection criterion was the average serum IGF-I concentration of 3 postweaning blood samples collected from purebred Angus calves. Multiple trait derivative-free ... ...

Abstract	Data for the current study were obtained from a divergent selection experiment in which the selection criterion was the average serum IGF-I concentration of 3 postweaning blood samples collected from purebred Angus calves. Multiple trait derivative-free REML procedures were used to obtain estimates of inbreeding depression for IGF-I concentration and for BW and BW gains measured from birth to the conclusion of a 140-d postweaning performance test. Included in the analysis were 3,243 animals in the A(-1) matrix, 2,182 of which had valid records for IGF-I concentration. Over the course of the entire selection experiment, inbreeding of the calf averaged 3.3% (SD = 3.1%) and inbreeding of the dam averaged 1.8% (SD = 2.7%). Mean inbreeding levels at the end of the study were 6.82 +/- 0.38% and 4.20 +/- 0.36% for calves and dams, respectively. Annual rates of increase in inbreeding of calves and dams were 0.36 +/- 0.01 (P < 0.0001) and 0.25 +/- 0.01%/yr (P < 0.0001), respectively. Insulin-like growth factor I concentration at d 28 (IGF28), 42 (IGF42), and 56 (IGF56) of the 140-d postweaning test and mean IGF-I concentration decreased by 0.62 +/- 0.88, 1.86 +/- 0.96, 1.92 +/- 0.89, and 1.48 +/- 0.76 ng/mL per 1% increase in inbreeding of calf. Only the regression coefficient for IGF56 differed significantly from zero, although the regression coefficients for IGF42 and mean IGF-I approached significance (P < 0.10). Increases in inbreeding levels of the dams also tended to result in reduced IGF-I concentrations, although the regression coefficients were not significantly different from zero. Inbreeding of calf had highly significant negative effects on all BW and BW gain traits examined, except for birth weight, with regression coefficients ranging from -0.74 +/- 0.20 kg/% increase in calf inbreeding for postweaning BW gain to -1.68 +/- 0.33 kg/% increase in calf inbreeding for off-test BW. Inbreeding of dam had a significant negative effect on birth weight of progeny and tended to have a negative effect on postweaning BW gain (P < 0.10). Preweaning gain of the progeny and BW other than birth weight were not influenced by increases in dam inbreeding. Results indicate that reductions in serum IGF-I concentration due to inbreeding may contribute to the decline in BW and BW gains that is typically associated with increases in inbreeding within populations.
MeSH term(s)	Animal Husbandry ; Animals ; Body Weight/genetics ; Body Weight/physiology ; Cattle/blood ; Cattle/genetics ; Cattle/physiology ; Female ; Genetic Variation/genetics ; Inbreeding ; Insulin-Like Growth Factor I/analysis ; Insulin-Like Growth Factor I/genetics ; Least-Squares Analysis ; Male ; Quantitative Trait, Heritable ; Weight Gain/genetics ; Weight Gain/physiology
Chemical Substances	Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/jas.2009-2232
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Article ; Online: Nuclear receptor co-regulator Krüppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus.

Pabona, J M P / Velarde, M C / Zeng, Z / Simmen, F A / Simmen, R C M

The Journal of endocrinology

2009 Volume 200, Issue 1, Page(s) 63–73

Abstract: Estrogen, acting through its cognate receptor estrogen receptor-alpha (ESR1), is a critical regulator of uterine endometrial epithelial proliferation. Although the dynamic communication between endometrial stromal (ST) and epithelial cells is considered ... ...

Abstract	Estrogen, acting through its cognate receptor estrogen receptor-alpha (ESR1), is a critical regulator of uterine endometrial epithelial proliferation. Although the dynamic communication between endometrial stromal (ST) and epithelial cells is considered to be an important component in this process, key molecular players in particular compartments remain poorly defined. Here, we used mice null for Krüppel-like factor 9 (KLF9) to evaluate the contribution of this nuclear protein in ST-epithelial interactions underlying proliferative effects of estrogen. We found that in ovariectomized mice administered estradiol-17beta (E(2)) for 24 h, Klf9 null mutation resulted in lack of E(2)-induced proliferative response in all endometrial compartments. We demonstrated a negative association between Klf9 expression and nuclear levels of ESR1 transcriptional corepressor prohibitin (PHB) 2 in uterine ST and epithelial cells of E(2)-treated wild-type (WT) and Klf9 null mice. In early pregnancy uteri of WT mice, the temporal pattern of Klf9 transcript levels was inversely associated with that of Phb2. Deletion of Klf9 up-regulated uterine Phb2 expression and increased PHB2 nuclear localization in endometrial ST and epithelial cells, with no effects on the expression of the related Phb1. In the human endometrial ST cell line treated with E(2) for 24 h, Klf9 siRNA targeting augmented PHB2 transcript and increased nuclear PHB2 protein levels, albeit this effect was not to the extent seen in vivo with Klf9 null mutants. Our findings suggest a novel mechanism for control of estrogen-induced luminal epithelial proliferation involving ST KLF9 regulation of paracrine factor(s) to repress epithelial expression of corepressor PHB2.
MeSH term(s)	Animals ; Cell Nucleus/metabolism ; Cell Proliferation ; Endometrium/cytology ; Endometrium/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Estradiol/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogens/metabolism ; Female ; Gene Expression ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Mice ; Protein Binding ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Uterus/cytology ; Uterus/metabolism
Chemical Substances	Estrogen Receptor alpha ; Estrogens ; Klf9 protein, mouse ; Kruppel-Like Transcription Factors ; Repressor Proteins ; prohibitin ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2009-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3028-4
ISSN	1479-6805 ; 0022-0795
ISSN (online)	1479-6805
ISSN	0022-0795
DOI	10.1677/JOE-08-0383
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