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Article: Investigation of congestive heart failure in beef cattle in a feedyard at a moderate altitude in western Nebraska

Moxley, Rodney A / Smith, David R / Grotelueschen, Dale M / Edwards, Tom / Steffen, David J

Journal of veterinary diagnostic investigation. 2019 July, v. 31, no. 4

2019

Abstract: ... at elevations >2,500–3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska ... feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009–2010), we examined 17 cases (16 steers ...

Abstract	Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500–3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009–2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8–4.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: 2.4 ± 0.8) and 6 had replacement fibrosis of the right ventricle, whereas 14 had interstitial fibrosis (mean score: 1.2 ± 0.2) and 0 had replacement fibrosis of the left ventricle. Lesions of arteriosclerosis were seen in 9 of 16 cases in 51 of 571 (8.9%) right ventricular coronary arteries, and in 10 of 16 cases in 52 of 366 (14.2%) left ventricular coronary arteries. The probability of coronary arteriosclerosis was greater in papillary ventricular muscle (OR = 11.3; p < 0.0001), left ventricle (OR = 4.8; p < 0.0001), and larger arteries (OR = 1.01; p < 0.0001). Pulmonary arteries and arterioles had lesions compatible with hypoxia-induced pulmonary hypertension. We hypothesize that moderate hypobaric conditions significantly contributed to disease in cattle genetically predisposed to hypoxia-induced pulmonary hypertension. Adiposity, coronary arteriosclerosis, and left ventricular fibrosis may have contributed to the condition; however, the cattle died prior to development of advanced obesity.
Keywords	Angus ; adiposity ; altitude ; arterioles ; beef cattle ; cattle diseases ; coronary artery disease ; coronary vessels ; edema ; feedlots ; fibrosis ; heart failure ; heifers ; hypertension ; hypertrophy ; liver ; muscles ; obesity ; probability ; pulmonary artery ; purebreds ; steers ; Nebraska
Language	English
Dates of publication	2019-07
Size	p. 509-522.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/1040638719855108
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunotherapy targeting the Streptococcus pyogenes M protein or streptolysin O to treat or prevent influenza A superinfection.

Herrera, Andrea L / Van Hove, Christopher / Hanson, Mary / Dale, James B / Tweten, Rodney K / Huber, Victor C / Diel, Diego / Chaussee, Michael S

PloS one

2020 Volume 15, Issue 6, Page(s) e0235139

Abstract: ... the efficacy of passive immunotherapy using antisera against either the streptococcal M protein or streptolysin ... to either SLO or the M protein decreased morbidity compared to mice treated with non-immune sera ... the results suggest that further development of antibodies targeting the M protein or SLO may be a useful ...

Abstract	Viral infections complicated by a bacterial infection are typically referred to as coinfections or superinfections. Streptococcus pyogenes, the group A streptococcus (GAS), is not the most common bacteria associated with influenza A virus (IAV) superinfections but did cause significant mortality during the 2009 influenza pandemic even though all isolates are susceptible to penicillin. One approach to improve the outcome of these infections is to use passive immunization targeting GAS. To test this idea, we assessed the efficacy of passive immunotherapy using antisera against either the streptococcal M protein or streptolysin O (SLO) in a murine model of IAV-GAS superinfection. Prophylactic treatment of mice with antiserum to either SLO or the M protein decreased morbidity compared to mice treated with non-immune sera; however, neither significantly decreased mortality. Therapeutic use of antisera to SLO decreased morbidity compared to mice treated with non-immune sera but neither antisera significantly reduced mortality. Overall, the results suggest that further development of antibodies targeting the M protein or SLO may be a useful adjunct in the treatment of invasive GAS diseases, including IAV-GAS superinfections, which may be particularly important during influenza pandemics.
MeSH term(s)	Animals ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/immunology ; Antigens, Bacterial/metabolism ; Bacterial Outer Membrane Proteins/antagonists & inhibitors ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Outer Membrane Proteins/metabolism ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/immunology ; Bacterial Proteins/metabolism ; Carrier Proteins/antagonists & inhibitors ; Carrier Proteins/immunology ; Carrier Proteins/metabolism ; Coinfection/microbiology ; Coinfection/therapy ; Coinfection/virology ; Female ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/immunology ; Humans ; Immune Sera/immunology ; Immune Sera/pharmacology ; Immunotherapy/methods ; Influenza A virus/immunology ; Influenza A virus/physiology ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/therapy ; Orthomyxoviridae Infections/virology ; Rabbits ; Streptococcal Infections/immunology ; Streptococcal Infections/microbiology ; Streptococcal Infections/therapy ; Streptococcus pyogenes/immunology ; Streptococcus pyogenes/metabolism ; Streptococcus pyogenes/physiology ; Streptolysins/antagonists & inhibitors ; Streptolysins/immunology ; Streptolysins/metabolism ; Superinfection/microbiology ; Superinfection/therapy ; Superinfection/virology
Chemical Substances	Antibodies, Bacterial ; Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Proteins ; Carrier Proteins ; Immune Sera ; Streptolysins ; streptococcal M protein ; streptolysin O
Language	English
Publishing date	2020-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0235139
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Article ; Online: Investigation of congestive heart failure in beef cattle in a feedyard at a moderate altitude in western Nebraska.

Moxley, Rodney A / Smith, David R / Grotelueschen, Dale M / Edwards, Tom / Steffen, David J

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2019 Volume 31, Issue 4, Page(s) 509–522

Abstract: ... at elevations >2,500-3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska ... feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009-2010), we examined 17 cases (16 steers ...

Abstract	Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500-3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009-2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8-4.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: 2.4 ± 0.8) and 6 had replacement fibrosis of the right ventricle, whereas 14 had interstitial fibrosis (mean score: 1.2 ± 0.2) and 0 had replacement fibrosis of the left ventricle. Lesions of arteriosclerosis were seen in 9 of 16 cases in 51 of 571 (8.9%) right ventricular coronary arteries, and in 10 of 16 cases in 52 of 366 (14.2%) left ventricular coronary arteries. The probability of coronary arteriosclerosis was greater in papillary ventricular muscle (OR = 11.3;
MeSH term(s)	Altitude ; Animals ; Cattle ; Cattle Diseases/diagnosis ; Cattle Diseases/epidemiology ; Cattle Diseases/etiology ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/etiology ; Heart Failure/veterinary ; Housing, Animal ; Male ; Nebraska ; Obesity/complications ; Obesity/epidemiology ; Obesity/veterinary
Language	English
Publishing date	2019-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/1040638719855108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene.

Dale, Rodney M / Topczewski, Jacek

Developmental biology

2011 Volume 357, Issue 2, Page(s) 518–531

Abstract: Zebrafish (Danio rerio) is an excellent model organism for the study of vertebrate development including skeletogenesis. Studies of mammalian cartilage formation were greatly advanced through the use of a cartilage specific regulatory element of the ... ...

Abstract	Zebrafish (Danio rerio) is an excellent model organism for the study of vertebrate development including skeletogenesis. Studies of mammalian cartilage formation were greatly advanced through the use of a cartilage specific regulatory element of the Collagen type II alpha 1 (Col2a1) gene. In an effort to isolate such an element in zebrafish, we compared the expression of two col2a1 homologues and found that expression of col2a1b, a previously uncharacterized zebrafish homologue, only partially overlaps with col2a1a. We focused our analysis on col2a1a, as it is expressed in both the stacked chondrocytes and the perichondrium. By comparing the genomic sequence surrounding the predicted transcriptional start site of col2a1a among several species of teleosts we identified a small highly conserved sequence (R2) located 1.7 kb upstream of the presumptive transcriptional initiation site. Interestingly, neither the sequence nor location of this element is conserved between teleost and mammalian Col2a1. We generated transient and stable transgenic lines with just the R2 element or the entire 1.7 kb fragment 5' of the transcriptional initiation site. The identified regulatory elements enable the tracking of cellular development in various tissues by driving robust reporter expression in craniofacial cartilage, ear, notochord, floor plate, hypochord and fins in a pattern similar to the expression of endogenous col2a1a. Using a reporter gene driven by the R2 regulatory element, we analyzed the morphogenesis of the notochord sheath cells as they withdraw from the stack of initially uniform cells and encase the inflating vacuolated notochord cells. Finally, we show that like endogenous col2a1a, craniofacial expression of these reporter constructs depends on Sox9a transcription factor activity. At the same time, notochord expression is maintained after Sox9a knockdown, suggesting that other factors can activate expression through the identified regulatory element in this tissue.
MeSH term(s)	Animal Fins/embryology ; Animal Fins/metabolism ; Animals ; Cartilage/embryology ; Cartilage/metabolism ; Collagen Type II/genetics ; Collagen Type II/metabolism ; Conserved Sequence/genetics ; Down-Regulation/genetics ; Ear/embryology ; Embryo, Nonmammalian/metabolism ; Evolution, Molecular ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Genome/genetics ; Intervertebral Disc/embryology ; Intervertebral Disc/metabolism ; Larva/genetics ; Notochord/embryology ; Notochord/metabolism ; Regulatory Sequences, Nucleic Acid/genetics ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Sequence Homology, Amino Acid ; Synteny/genetics ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Collagen Type II ; SOX9 Transcription Factor ; Zebrafish Proteins
Language	English
Publishing date	2011-06-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1016/j.ydbio.2011.06.020
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Article ; Online: Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development.

Pogoda, Hans-Martin / Riedl-Quinkertz, Iris / Löhr, Heiko / Waxman, Joshua S / Dale, Rodney M / Topczewski, Jacek / Schulte-Merker, Stefan / Hammerschmidt, Matthias

Development (Cambridge, England)

2018 Volume 145, Issue 9

Abstract: Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-inactivating enzyme Cyp26b1 develop a hyper-mineralized spine with gradually fusing vertebral body precursors (centra). However, the underlying cellular mechanisms ... ...

Abstract	Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-inactivating enzyme Cyp26b1 develop a hyper-mineralized spine with gradually fusing vertebral body precursors (centra). However, the underlying cellular mechanisms remain incompletely understood. Here, we show that cells of the notochord epithelium named chordoblasts are sensitive to RA signaling. Chordoblasts are uniformly distributed along the anteroposterior axis and initially generate the continuous collagenous notochord sheath. However, subsequently and iteratively, subsets of these cells undergo further RA-dependent differentiation steps, acquire a stellate-like shape, downregulate expression of the collagen gene
MeSH term(s)	Animals ; Calcification, Physiologic/physiology ; Collagen/biosynthesis ; Collagen/genetics ; Gene Expression Regulation, Developmental/physiology ; Notochord/cytology ; Notochord/embryology ; Retinoic Acid 4-Hydroxylase/genetics ; Retinoic Acid 4-Hydroxylase/metabolism ; Spine/cytology ; Spine/embryology ; Tretinoin/metabolism ; Zebrafish/embryology ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Zebrafish Proteins ; Tretinoin (5688UTC01R) ; Collagen (9007-34-5) ; Retinoic Acid 4-Hydroxylase (EC 1.14.14.1) ; cyp26b1 protein, zebrafish (EC 1.14.14.1)
Language	English
Publishing date	2018-05-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.159418
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Article ; Online: Planar cell polarity signaling in craniofacial development.

Topczewski, Jacek / Dale, Rodney M / Sisson, Barbara E

Organogenesis

2011 Volume 7, Issue 4, Page(s) 255–259

Abstract: Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the ... ...

Abstract	Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.
MeSH term(s)	Animals ; Cell Polarity ; Face/embryology ; Neural Crest/cytology ; Signal Transduction ; Skull/cytology ; Skull/embryology ; Wnt Proteins/metabolism
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2011-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2159583-5
ISSN	1555-8592 ; 1555-8592
ISSN (online)	1555-8592
ISSN	1555-8592
DOI	10.4161/org.7.4.18797
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Koh, Eng-Siew / Gan, Hui K / Senko, Clare / Francis, Roslyn J / Ebert, Martin / Lee, Sze Ting / Lau, Eddie / Khasraw, Mustafa / Nowak, Anna K / Bailey, Dale L / Moffat, Bradford A / Fitt, Greg / Hicks, Rodney J / Coffey, Robert / Verhaak, Roel / Walsh, Kyle M / Barnes, Elizabeth H / De Abreu Lourenco, Richard / Rosenthal, Mark /

Adda, Lucas / Foroudi, Farshad / Lasocki, Arian / Moore, Alisha / Thomas, Paul A / Roach, Paul / Back, Michael / Leonard, Robyn / Scott, Andrew M

BMJ open

2023 Volume 13, Issue 8, Page(s) e071327

Abstract: Introduction: Glioblastoma is the most common aggressive primary central nervous system cancer in adults characterised by uniformly poor survival. Despite maximal safe resection and postoperative radiotherapy with concurrent and adjuvant temozolomide- ... ...

Abstract	Introduction: Glioblastoma is the most common aggressive primary central nervous system cancer in adults characterised by uniformly poor survival. Despite maximal safe resection and postoperative radiotherapy with concurrent and adjuvant temozolomide-based chemotherapy, tumours inevitably recur. Imaging with O-(2-[ Methods and analysis: The FET-PET in Glioblastoma (FIG) study is a prospective, multicentre, non-randomised, phase II study across 10 Australian sites and will enrol up to 210 adults aged ≥18 years with newly diagnosed glioblastoma. FET-PET will be performed at up to three time points: (1) following initial surgery and prior to commencement of chemoradiation (FET-PET1); (2) 4 weeks following concurrent chemoradiation (FET-PET2); and (3) within 14 days of suspected clinical and/or radiological progression on MRI (performed at the time of clinical suspicion of tumour recurrence) (FET-PET3). The co-primary outcomes are: (1) to investigate how FET-PET versus standard MRI impacts RT volume delineation and (2) to determine the accuracy and management impact of FET-PET in distinguishing pseudoprogression from true tumour progression. The secondary outcomes are: (1) to investigate the relationships between FET-PET parameters (including dynamic uptake, tumour to background ratio, metabolic tumour volume) and progression-free survival and overall survival; (2) to assess the change in blood and tissue biomarkers determined by serum assay when comparing FET-PET data acquired prior to chemoradiation with other prognostic markers, looking at the relationships of FET-PET versus MRI-determined site/s of progressive disease post chemotherapy treatment with MRI and FET-PET imaging; and (3) to estimate the health economic impact of incorporating FET-PET into glioblastoma management and in the assessment of post-treatment pseudoprogression or recurrence/true progression. Exploratory outcomes include the correlation of multimodal imaging, blood and tumour biomarker analyses with patterns of failure and survival. Ethics and dissemination: The study protocol V.2.0 dated 20 November 2020 has been approved by a lead Human Research Ethics Committee (Austin Health, Victoria). Other clinical sites will provide oversight through local governance processes, including obtaining informed consent from suitable participants. The study will be conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice. Results of the FIG study (TROG 18.06) will be disseminated via relevant scientific and consumer forums and peer-reviewed publications. Trial registration number: ANZCTR ACTRN12619001735145.
MeSH term(s)	Adult ; Humans ; Adolescent ; Glioblastoma/diagnostic imaging ; Glioblastoma/therapy ; Glioblastoma/pathology ; Positron Emission Tomography Computed Tomography ; Ficus ; Tyrosine ; Prospective Studies ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/therapy ; Brain Neoplasms/pathology ; Neoplasm Recurrence, Local/diagnostic imaging ; Australia ; Positron-Emission Tomography ; Magnetic Resonance Imaging ; Clinical Trials, Phase II as Topic ; Multicenter Studies as Topic
Chemical Substances	Tyrosine (42HK56048U)
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-071327
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Article ; Online: A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis.

Sisson, Barbara E / Dale, Rodney M / Mui, Stephanie R / Topczewska, Jolanta M / Topczewski, Jacek

Mechanisms of development

2015 Volume 138 Pt 3, Page(s) 279–290

Abstract: The Wnt/Planar Cell Polarity (PCP) pathway controls cell morphology and behavior during animal development. Several zebrafish mutants were identified as having perturbed Wnt/PCP signaling. Many of these mutants have defects in craniofacial formation. To ... ...

Abstract	The Wnt/Planar Cell Polarity (PCP) pathway controls cell morphology and behavior during animal development. Several zebrafish mutants were identified as having perturbed Wnt/PCP signaling. Many of these mutants have defects in craniofacial formation. To better understand the role that Wnt/PCP plays in craniofacial development we set out to identify which of the mutants, known to be associated with the Wnt/PCP pathway, perturb head cartilage formation by disrupting chondrocyte morphology. Here we demonstrate that while vang-like 2 (vangl2), wnt11 and scribbled (scrib) mutants have severe craniofacial morphogenesis defects they do not display the chondrocyte stacking and intercalation problems seen in glypican 4 (gpc4) and wnt5b mutants. The function of Gpc4 or Wnt5b appears to be important for chondrocyte organization, as the neural crest in both mutants is specified, undergoes migration, and differentiates into the same number of cells to compose the craniofacial cartilage elements. We demonstrate that Gpc4 activity is required cell autonomously in the chondrocytes and that the phenotype of single heterozygous mutants is slightly enhanced in embryos double heterozygous for wnt5b and gpc4. This data suggests a novel mechanism for Wnt5b and Gpc4 regulation of chondrocyte behavior that is independent of the core Wnt/PCP molecules and differs from their collaborative action of controlling cell movements during gastrulation.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Branchial Region/embryology ; Branchial Region/metabolism ; Cell Count ; Cell Movement/genetics ; Cell Size ; Chondrocytes/cytology ; Chondrocytes/metabolism ; Chondrogenesis/genetics ; Gastrulation/genetics ; Gene Expression Regulation, Developmental ; Glypicans/deficiency ; Glypicans/genetics ; Mutation ; Neural Crest/embryology ; Neural Crest/metabolism ; Phenotype ; Wnt Proteins/deficiency ; Wnt Proteins/genetics ; Wnt Signaling Pathway/genetics ; Wnt-5a Protein ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/deficiency ; Zebrafish Proteins/genetics
Chemical Substances	Glypicans ; Wnt Proteins ; Wnt-5a Protein ; Wnt5a protein, zebrafish ; Zebrafish Proteins
Language	English
Publishing date	2015-10-14
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1055986-3
ISSN	1872-6356 ; 0925-4773
ISSN (online)	1872-6356
ISSN	0925-4773
DOI	10.1016/j.mod.2015.10.001
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Article ; Online: Expression and characterization of the zebrafish orthologue of the human FOLR1 gene during embryogenesis.

Jones, RoJenia N / Erhard, Stephanie A / Malham, Mark R / Gen, Ayaz Y / Sullivan, Kyle / Olsen, Kenneth W / Dale, Rodney M

Gene expression patterns : GEP

2017 Volume 25-26, Page(s) 159–166

Abstract: It has been well established that many types of rapidly dividing normal and diseased cells require an increased amount of folate for DNA replication and repair as well as cellular metabolism. Thus one of folate's cognate receptors, Folate Receptor 1 ( ... ...

Abstract	It has been well established that many types of rapidly dividing normal and diseased cells require an increased amount of folate for DNA replication and repair as well as cellular metabolism. Thus one of folate's cognate receptors, Folate Receptor 1 (FOLR1) is usually up-regulated in rapidly dividing cells, including many types of cancerous tumors. Because zebrafish have become a model organism for understanding conserved vertebrate cellular pathways and human disease, there has been an increased need to identify and elucidate orthologous zebrafish genes that are central to known human maladies. The cells of all early animal embryos go through a phase of rapid division (cleavage) where particular cell cycle checkpoints are skipped until a specification event occurs directing these embryonic stem cells to their fated germ layer cell type. Interestingly, this rapid cell division that ignores cell cycle checkpoints is also observed in many cancers. Developing blastula and tumor cells both require folr1 expression to obtain folate. In this report we have identified the expression pattern of the zebrafish gene zgc:165502, located on chromosome 15. Using computational and comparative methods and molecular biology techniques such as reverse transcription polymerase chain reaction (RT-PCR) and whole mount in situ hybridization (WISH) during embryogenesis, we demonstrate that zgc:165502 is the zebrafish orthologue of the human FOLR1 gene. Understanding when and where FOLR1 orthologues are expressed in different biomedical model organisms such as the zebrafish will help researchers design better experiments to study the endogenous FOLR1 activity.
Language	English
Publishing date	2017-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2058346-1
ISSN	1872-7298 ; 1567-133X
ISSN (online)	1872-7298
ISSN	1567-133X
DOI	10.1016/j.gep.2017.08.002
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Article ; Online: The emerging role of Wnt/PCP signaling in organ formation.

Dale, Rodney M / Sisson, Barbara E / Topczewski, Jacek

Zebrafish

2009 Volume 6, Issue 1, Page(s) 9–14

Abstract: Over the last two decades zebrafish has been an excellent model organism to study vertebrate development. Mutant analysis combined with gene knockdown and other manipulations revealed an essential role of Wnt signaling, independent of beta-catenin, ... ...

Abstract	Over the last two decades zebrafish has been an excellent model organism to study vertebrate development. Mutant analysis combined with gene knockdown and other manipulations revealed an essential role of Wnt signaling, independent of beta-catenin, during development. Especially well characterized is the function of Wnt/planar cell polarity (PCP) signaling in the regulation of gastrulation movements and neurulation, described in other reviews within this special issue. Here, we set out to highlight some of the new and exciting research that is being carried out in zebrafish to elucidate the role that Wnt/PCP signaling plays in the formation of specific organs, including the lateral line, craniofacial development, and regeneration. We also summarized the emerging connection of the Wnt/PCP pathway with primary cilia function, an essential organelle in several organ activities.
MeSH term(s)	Animals ; Organogenesis ; Signal Transduction ; Wnt Proteins/metabolism ; Zebrafish/embryology ; Zebrafish/metabolism
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2009-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2156020-1
ISSN	1557-8542 ; 1545-8547
ISSN (online)	1557-8542
ISSN	1545-8547
DOI	10.1089/zeb.2008.0563
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Full text online

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Order via subito