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  1. Article ; Online: Early diagnosis of systemic sclerosis, where do we stand today?

    Lepri, Gemma / Bellando Randone, Silvia / Matucci Cerinic, Marco / Guiducci, Serena

    Expert review of clinical immunology

    2022  Volume 18, Issue 1, Page(s) 1–3

    MeSH term(s) Early Diagnosis ; Humans ; Raynaud Disease ; Scleroderma, Systemic/diagnosis
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2022.2015327
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The COVID-19 pandemic highlights the need for a psychological support in systemic sclerosis patients.

    Lepri, Gemma / Orlandi, Martina / Bellando-Randone, Silvia / Matucci-Cerinic, Marco / Guiducci, Serena

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 8, Page(s) 1575–1577

    MeSH term(s) Humans ; COVID-19 ; Pandemics ; SARS-CoV-2 ; Anxiety ; Scleroderma, Systemic/therapy ; Scleroderma, Systemic/epidemiology ; Stress, Psychological
    Language English
    Publishing date 2023-07-26
    Publishing country Italy
    Document type Editorial
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/hgkk7b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Systemic sclerosis: one year in review 2023.

    Di Battista, Marco / Lepri, Gemma / Codullo, Veronica / Da Rio, Mattia / Fiorentini, Elisa / Della Rossa, Alessandra / Guiducci, Serena

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 8, Page(s) 1567–1574

    Abstract: Systemic sclerosis is a rare and chronic connective tissue disease resulting from an intricate pathogenesis and is expressed in very heterogeneous clinical manifestations. Every year many studies try to unravel and shed new insight into the pathogenesis, ...

    Abstract Systemic sclerosis is a rare and chronic connective tissue disease resulting from an intricate pathogenesis and is expressed in very heterogeneous clinical manifestations. Every year many studies try to unravel and shed new insight into the pathogenesis, organ involvement and treatment of this complex and severe disease. We herein provide an overview of the most relevant studies published in the literature in 2022.
    MeSH term(s) Humans ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy ; Connective Tissue Diseases/complications
    Language English
    Publishing date 2023-05-17
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/ki76s5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Systemic sclerosis: one year in review 2022.

    Lepri, Gemma / Orlandi, Martina / Di Battista, Marco / De Mattia, Giammarco / Da Rio, Mattia / Codullo, Veronica / Guiducci, Serena / Della Rossa, Alessandra

    Clinical and experimental rheumatology

    2022  Volume 40, Issue 10, Page(s) 1911–1920

    Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy, immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into the pathogenesis, organ involvement and treatment of this severe disease are ... ...

    Abstract Systemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy, immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into the pathogenesis, organ involvement and treatment of this severe disease are published in the scientific community.In this review we report an overview of some of the most relevant contributions published in 2021.
    MeSH term(s) Humans ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy ; Fibrosis ; Autoimmune Diseases/complications ; Skin/pathology
    Language English
    Publishing date 2022-09-21
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/3401fl
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Potential Role of JAK Inhibitors in the Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease: A Narrative Review from Pathogenesis to Real-Life Data.

    Fiorentini, Elisa / Bonomi, Francesco / Peretti, Silvia / Orlandi, Martina / Lepri, Gemma / Matucci Cerinic, Marco / Bellando Randone, Silvia / Guiducci, Serena

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Background: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is one of the most relevant complications of SSc and the major cause of death. The pathogenesis of SSc-ILD involves a complex interplay of multiple cell types and different ... ...

    Abstract Background: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is one of the most relevant complications of SSc and the major cause of death. The pathogenesis of SSc-ILD involves a complex interplay of multiple cell types and different molecular pathways, with both inflammation and fibrosis as pathological hallmarks. To date, there are no treatments able to target both components of the disease. Janus kinase inhibitors (JAKinibs) represent an interesting therapeutic option because they exert both anti-inflammatory and anti-fibrotic properties.
    Methods: Here, we performed a narrative review concerning the potential role of JAKinibs in SSc-ILD to define the state of art and to evaluate the pathogenetic rationale behind this type of treatment.
    Results: Currently, few studies investigated SSc-ILD response to JAKinibs treatment. Data were analyzed from three clinical studies and four case reports and progression of SSc-ILD was not evident in 93.5% of patients treated with JAKinibs.
    Conclusions: Available evidence of efficacy of JAKinibs in SSc-ILD is sparse but promising. JAKinibs could be an interesting treatment in SSc-ILD because of their potential inhibition of the fibrotic processes combined with their anti-inflammatory action. Moreover, JAKinibs were also shown in some studies to have a potential effect on pulmonary arterial hypertension (PAH), another threatening complication in SSc. More data are necessary to define JAKinibs role in SSc-ILD treatment.
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12122101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of skin ultrasound in systemic sclerosis: looking below the surface to understand disease evolution.

    Lepri, Gemma / Hughes, Michael / Allanore, Yannick / Denton, Christopher P / Furst, Daniel E / Wang, Yukai / Santiago, Tânia / Galetti, Ilaria / Del Galdo, Francesco / Khanna, Dinesh / Matucci-Cerinic, Marco

    The Lancet. Rheumatology

    2023  Volume 5, Issue 7, Page(s) e422–e425

    Abstract: Skin ultrasound has shown promising results in the evaluation of skin involvement in patients with systemic sclerosis, as substantiated by a recent systematic literature review from the World Scleroderma Foundation Skin Ultrasound Working Group. In this ... ...

    Abstract Skin ultrasound has shown promising results in the evaluation of skin involvement in patients with systemic sclerosis, as substantiated by a recent systematic literature review from the World Scleroderma Foundation Skin Ultrasound Working Group. In this Viewpoint, we will discuss the role of ultrasound in evaluating skin involvement in patients with systemic sclerosis, particularly the possibility of using this technique to detect an early subclinical skin involvement from the very early phase, suggesting its possible use in both diagnosis and disease follow-up. To detect subclinical skin involvement, it is essential to understand the difference between the skin of patients with systemic sclerosis and that of healthy controls, including defining exactly which structures are affected by the disease and which are spared. The potential of this non-invasive technique might suggest its future role in both clinical practice and clinical trials, possibly replacing invasive and painful procedures such as skin biopsies and promoting patient retention in clinical trials.
    MeSH term(s) Humans ; Skin/diagnostic imaging ; Scleroderma, Systemic/diagnostic imaging ; Scleroderma, Localized ; Ultrasonography ; Biopsy
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00100-5
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  7. Article: One year in review 2021: systemic sclerosis.

    Di Battista, Marco / Barsotti, Simone / Orlandi, Martina / Lepri, Gemma / Codullo, Veronica / Della Rossa, Alessandra / Guiducci, Serena / Del Galdo, Francesco

    Clinical and experimental rheumatology

    2021  Volume 39 Suppl 131, Issue 4, Page(s) 3–12

    Abstract: Systemic sclerosis is a rare and chronic connective tissue disease with a multifaceted pathogenesis characterised by heterogeneous multi-organ clinical manifestations. Every year, many studies contribute to enrich the knowledge on the pathogenesis, organ ...

    Abstract Systemic sclerosis is a rare and chronic connective tissue disease with a multifaceted pathogenesis characterised by heterogeneous multi-organ clinical manifestations. Every year, many studies contribute to enrich the knowledge on the pathogenesis, organ involvement and treatment of this complex and severe disease. We herein provide an overview on the most relevant contributions published in the literature in 2020.
    MeSH term(s) Humans ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy
    Language English
    Publishing date 2021-07-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/izadb8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Recent advances steer the future of systemic sclerosis toward precision medicine.

    Lepri, Gemma / Hughes, Michael / Bruni, Cosimo / Cerinic, Marco Matucci / Randone, Silvia Bellando

    Clinical rheumatology

    2019  Volume 39, Issue 1, Page(s) 1–4

    MeSH term(s) Humans ; Precision Medicine/trends ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy
    Language English
    Publishing date 2019-11-23
    Publishing country Germany
    Document type Editorial
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-019-04834-5
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    Zs.A 1740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Menstruation-Related Disorders-Dysmenorrhea and Heavy Bleeding-as Significant Epiphenomena in Women With Rheumatic Diseases.

    Orlandi, Martina / Vannuccini, Silvia / El Aoufy, Khadija / Melis, Maria Ramona / Lepri, Gemma / Sambataro, Gianluca / Bellando-Randone, Silvia / Guiducci, Serena / Cerinic, Marco Matucci / Petraglia, Felice

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 807880

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.807880
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  10. Article: The Updated Role of Ultrasound in Assessing Dermatological Manifestations in Systemic Sclerosis.

    Ruaro, Barbara / Santiago, Tania / Hughes, Michael / Lepri, Gemma / Poillucci, Gabriele / Baratella, Elisa / Salton, Francesco / Confalonieri, Marco

    Open access rheumatology : research and reviews

    2021  Volume 13, Page(s) 79–91

    Abstract: Systemic sclerosis (SSc), an autoimmune connective tissue disease, characterized by skin fibrosis, increased dermal thickness and microvascular involvement. Fibroblasts and myofibroblasts deposit excessive amounts of collagenous and non-collagenous ... ...

    Abstract Systemic sclerosis (SSc), an autoimmune connective tissue disease, characterized by skin fibrosis, increased dermal thickness and microvascular involvement. Fibroblasts and myofibroblasts deposit excessive amounts of collagenous and non-collagenous extracellular matrix components in the skin. This leads to microvascular abnormalities and Raynaud's phenomenon, with painful digital ulcers (DU) at the fingertips adding to patient discomfort. The skin involvement and severity in SSc was evaluated by the Modified Rodnan skin score (mRSS). Although high-frequency ultrasound (HUS) has been widely researched in the study of skin thickness and DU in SSc, its adoption into clinical practice is not yet common. However, novel insights into the still relatively unknown disease pathogenesis in SSc and its evaluation may be provided by HUS, including early (pre-clinical) skin involvement. It may also be useful in both the evaluation and follow-up of DU. Indeed, it is a non-invasive, safe, inexpensive and reproducible method able to assess not only SSc patients' cutaneous structural changes, but also their vascular system changes. Moreover, several recent studies have reported that elastosonography (ES) is of use when investigating skin involvement in systemic sclerosis. This review aims at providing information as to role HUS and ES play in research advancements and the clinical perspectives in the evaluation of skin thickness and DU in SSc patients.
    Language English
    Publishing date 2021-04-28
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508169-X
    ISSN 1179-156X
    ISSN 1179-156X
    DOI 10.2147/OARRR.S282612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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