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Article ; Online: Erratum for Wei et al., "IS

Wei, Da-Wei / Wong, Nai-Kei / Song, Yuqin / Zhang, Gang / Wang, Chao / Li, Juan / Feng, Jie

2022 Volume 13, Issue 2, Page(s) e0041422

Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00414-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Wei et al. Respond to "Safer, More Precise Management of Osteoarthritis Pain".

Wei, Jie / Li, Xiaoxiao / Lei, Guanghua / Zhang, Yuqing

American journal of epidemiology

2023 Volume 192, Issue 9, Page(s) 1452

MeSH term(s)	Humans ; Osteoarthritis/complications ; Osteoarthritis/drug therapy ; Anti-Inflammatory Agents, Non-Steroidal ; Pain/drug therapy ; Double-Blind Method
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwad093
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Article ; Online: Voices in Molecular Pharmaceutics: Meet Dr. Wei Zhang, a Pharmaceutical Scientist Developing Drug Products for Patients.

Zhang, Wei

Molecular pharmaceutics

2023 Volume 20, Issue 6, Page(s) 2764–2765

MeSH term(s)	Humans ; Biopharmaceutics ; Pharmacy ; Drug Compounding ; Pharmaceutical Preparations
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Editorial
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c00337
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Zs.A 6250: Show issues

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Article ; Online: Occurrence and seasonal variations of antibiotic micro-pollutants in the Wei River, China.

Cao, Shengkai / Zhang, Peng / Halsall, Crispin / Hou, Zhimin / Ge, Linke

Environmental research

2024 Volume 252, Issue Pt 1, Page(s) 118863

Abstract: ... macrolides (MLs), fluoroquinolones (FQs) and sulfonamides (SAs) was performed in the Xi'an section of the Wei ... that the distribution of antibiotics in the Wei River was affected by the confluence with dilution of tributaries and ...

Abstract	In this study, a systematic monitoring campaign of 30 antibiotics belonging to tetracyclines (TCs), macrolides (MLs), fluoroquinolones (FQs) and sulfonamides (SAs) was performed in the Xi'an section of the Wei River during three sampling events (December 2021, June 2022, and September 2022). The total concentrations of antibiotics in water ranged from 297 to 461 ng/L with high detection frequencies ranging from 45% to 100% for the various antibiotics. A marked seasonal variation in concentrations was found with total antibiotic concentrations in winter being 1.5 and 2 times higher than those in the summer and autumn seasons, respectively. The main contaminants in both winter and summer seasons were FQs, but in the autumn SAs were more abundant, suggesting different seasonal sources or more effective runoff for certain antibiotics during periods of rainfall. Combined analysis using redundancy and clustering analysis indicated that the distribution of antibiotics in the Wei River was affected by the confluence with dilution of tributaries and outlet of domestic sewage. Ecological risk assessment based on risk quotient (RQ) showed that most antibiotics in water samples posed insignificant risk to fish and green algae, as well as insignificant to low risk to Daphnia. The water-sediment distribution coefficients of SAs were higher than those of other antibiotics, indicating that particle-bound runoff could be a significant source for this class of antibiotics.
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118863
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Zs.A 726: Show issues

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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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Zs.A 5995: Show issues

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Article: Identification and characterization of extrachromosomal circular DNA in Wei and Large White pigs by high-throughput sequencing.

Wen, Aiyou / Zhang, Wei / Xu, Jingen / Wang, Kunping / Hu, Hong

Frontiers in veterinary science

2023 Volume 10, Page(s) 1085474

Abstract: Wei pig (WP) and Large White pig (LP) are fatty and lean breeds, respectively. Extrachromosomal ...

Abstract	Wei pig (WP) and Large White pig (LP) are fatty and lean breeds, respectively. Extrachromosomal circular DNA (eccDNA) plays an important role in regulating signaling pathway processes of cell. However, there are few reports regarding the eccDNA and ecDNA profiles in WP and LP. The present work aimed to investigate the eccDNA and ecDNA profiles between WP and LP. Three WPs and three LPs (100 ± 1.3 kg) were selected for analysis of eccDNA and ecDNA in the ear samples. Results showed that there were 39,686,953,656-58,411,217,258 and 53,824,168,657-58,311,810,737 clean data for WP and LP, respectively. Sequencing yielded 15,587-25,479 and 71,123-79,605 eccDNAs from the ear samples of WP and LP, respectively. There were 15,111 and 22,594 eccDNA-derived genes in the WP and LP, respectively, and 13,807 eccDNA-derived genes were common in the ear samples of both pigs. Sequencing yielded 13-19 and 27-43 ecDNAs in the ears of WP and LP, respectively. There were 1,005 and 1,777 ecDNA-derived genes in WP and LP, respectively, and 351 ecDNA-derived genes were common in the ear samples of both pigs. The most significant KEGG pathways of eccDNA-derived genes were axon guidance, focal adhesion, metabolic pathways, MAPK signaling pathway, Hedgehog signaling pathway, microRNAs in cancer, tight junction, phospholipase D signaling pathway, endocytosis, and sphingolipid signaling pathway. Furthermore, the most significant KEGG pathways of ecDNA-derived genes were olfactory transduction, B cell receptor signaling pathway, and chemical carcinogenesis. The eccDNA00044301 was lower abundance, while the ecDNA00000060 was higher abundance in WP compared with that in LP. Summary, we found that eccDNAs and ecDNAs are common in WP and LP and occur in sizes large enough to carry one or several partial or complete genes. These findings have expanded the knowledge repertoire of circular DNA in pig and will provide a reference for the use of pigs as a medical model and help discovery of new genetic markers to select high-quality breeds.
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1085474
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Article ; Online: Optimized Extraction, Identification and Anti-Biofilm Action of Wu Wei Zi (

Zhang, Zongyi / Zhao, Yanan / Cai, Jing / Wang, Tong / Song, Yujie / Lu, Jingyi / Du, Hairuo / Wang, Wenfang / Zhao, Yan / Guo, Lei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: The pathogenicity of ... ...

Abstract	The pathogenicity of foodborne
MeSH term(s)	Vibrio parahaemolyticus/genetics ; Schisandra ; Biofilms
Chemical Substances	schizandrol B (58546-54-6) ; schizandrer A (82042-38-4) ; schizandrin C (C8754W6B3G)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052268
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Article ; Online: Four Patterns of Canine Wei Syndrome Treated with Traditional Chinese Medicine.

Wang, Binxue / Liu, Yuting / Xiehe, Shuangyi / Ju, Xiao / Fan, Yunpeng / Liu, Yingqiu / Zhang, Weimin / Song, Xiaoping / Ma, Wuren

Complementary medicine research

2023 Volume 30, Issue 2, Page(s) 174–180

Abstract: ... this is known as wei syndrome (WS). According to TCM, the etiology of WS can be (1) lung heat and fluid ...

Abstract	Atrophy and weakness of the limbs is a common condition in animals, especially dogs. It typically presents with flaccidity and weakness of the limbs, especially the hind legs, muscle atrophy, and the inability to walk. In Traditional Chinese Medicine (TCM) and Traditional Chinese Veterinary Medicine (TCVM), this is known as wei syndrome (WS). According to TCM, the etiology of WS can be (1) lung heat and fluid consumption; (2) insufficiency of the liver and kidneys; (3) dampness-heat invasion; (4) damage to the spleen and stomach, which are also the patterns of WS. This report aims to provide an alternative option for the treatment of canine paralysis. Four dogs with different WS patterns were treated with acupuncture, moxibustion, and Chinese herbs based on the guidelines of the TCM literature. Three patients recovered normal functioning. The fourth patient could walk normally after 2 weeks of treatment, but his hind limbs became weak again 3 months later. Weekly acupuncture treatment was resumed until his death 18 months later. TCM application of acupuncture, moxibustion, and Chinese herbs can be an effective treatment for canine WS. It is hoped that this case report will broaden the treatment options of other veterinarians when patients present with this condition.
MeSH term(s)	Dogs ; Animals ; Medicine, Chinese Traditional ; Acupuncture Therapy ; Moxibustion ; Acupuncture ; Spleen
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2885931-5
ISSN	2504-2106 ; 2504-2092
ISSN (online)	2504-2106
ISSN	2504-2092
DOI	10.1159/000528047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4164: Show issues

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Article ; Online: Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease.

Zhi, Jiayi / Yin, Li / Zhang, Zhoudong / Lv, Yaozhong / Wu, Fan / Yang, Yang / Zhang, Enming / Li, Huanqiu / Lu, Ning / Zhou, Mengze / Hu, Qinghua

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 3, Page(s) 117291

Abstract: Ethnopharmacological relevance: Jin-Si-Wei (JSW), a traditional Chinese medicine (TCM) formula ...

Abstract	Ethnopharmacological relevance: Jin-Si-Wei (JSW), a traditional Chinese medicine (TCM) formula, have cognitive enhancing effect and delay the memory decline in an animal model of AD， which has been reported. However, the therapeutic mechanism of JSW in the treatment of AD remains unclear. Aim of the study: This study aimed to verify the pharmacodynamics of JSW in the treatment of AD, and to explore its potential mechanism based on network pharmacology, molecular docking and experimental validation both in vitro and in vivo. Materials and methods: In this study, the underlying mechanism of JSW against AD was investigated by the integration of network pharmacology. Then, the core pathways and biological process of JSW were verified by experiment, including behavioral test and pathological and biochemical assays with 6-month-old APP Results: A Drug-Ingredient-Target network was established, which included 363 ingredients and 116 targets related to the JSW treatment of AD. The main metabolic pathway of JSW treatment for AD is neuroactive ligand-receptor interaction pathway, and biological processes are mainly involved in Aβ metabolic process. In vivo experiments, compared with APP/PS1 mice, the cognitive and memory ability of mice was significantly improved after JSW administration. In brain tissue of APP/PS1 mice, JSW could increase the contents of low-density lipoprotein receptor-related protein 1 (LRP-1), enkephalinase (NEP) and Acetyl choline (ACh), and decrease the contents of Aβ Conclusions: JSW improves AD in APP/PS1 mice, and this therapeutic effect may be achieved in part by altering the neuroactive ligand-receptor interaction pathway.
MeSH term(s)	Humans ; Animals ; Mice ; Alzheimer Disease/drug therapy ; Ligands ; Molecular Docking Simulation ; Network Pharmacology ; Neuroblastoma ; Amyloid beta-Protein Precursor/genetics ; Amyloid Precursor Protein Secretases
Chemical Substances	Ligands ; Amyloid beta-Protein Precursor ; Amyloid Precursor Protein Secretases (EC 3.4.-)
Language	English
Publishing date	2023-11-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117291
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Article ; Online: The effects of land use types on microplastics in river water: A case study on the mainstream of the Wei River, China.

Zhang, Le / Li, Xi / Li, Qi / Xia, Xiaoqiang / Zhang, Hang

Environmental monitoring and assessment

2024 Volume 196, Issue 4, Page(s) 349

Abstract: ... ecological environment. The Wei River is a first-class tributary of the Yellow River, the fifth largest river ... in this river is not clear. Based on this, the spatiotemporal distribution of microplastics in the Wei River ...

Abstract	Microplastics are widely found in rivers and their sediments, which will cause harm to the water ecological environment. The Wei River is a first-class tributary of the Yellow River, the fifth largest river in the world, and has vulnerable ecological environment and most sediment in the world. However, understanding how anthropogenic activities and environmental factors affect the microplastics distribution in this river is not clear. Based on this, the spatiotemporal distribution of microplastics in the Wei River were investigated. The abundance of microplastics ranged from 1033 to 8333 items/m
MeSH term(s)	Microplastics ; Plastics ; Rivers ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Water ; China
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical ; Water (059QF0KO0R)
Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-024-12430-7
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