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  1. Article ; Online: Cleaning protocols in forensic genetic laboratories.

    Kampmann, Marie-Louise / Tfelt-Hansen, Jacob / Børsting, Claus

    International journal of legal medicine

    2024  

    Abstract: It is pivotal to avoid cross-sample contamination in forensic genetic laboratories and optimal cleaning protocols for the removal of DNA are essential. A survey was performed, and ten forensic genetic laboratories shared their cleaning protocols in pre- ... ...

    Abstract It is pivotal to avoid cross-sample contamination in forensic genetic laboratories and optimal cleaning protocols for the removal of DNA are essential. A survey was performed, and ten forensic genetic laboratories shared their cleaning protocols in pre-PCR and post-PCR laboratories. The cleaning frequencies on different surface areas were somewhat similar, whereas none of the laboratories used the same cleaning reagents. Therefore, the efficiencies of the cleaning protocol utilised were tested and compared. The results showed that freshly made household bleach and Virkon® removed all amplifiable DNA from the surfaces, whereas DNA AWAY™ and the disinfection reagents ethanol, isopropanol, and ChemGene HLD
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-024-03232-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: To screen or not to screen: that is the question!

    Hansen, Carl Johann / Warming, Peder Emil / Tfelt-Hansen, Jacob

    European heart journal

    2023  Volume 44, Issue 24, Page(s) 2257

    MeSH term(s) Humans ; Mass Screening ; Surveys and Questionnaires ; Sports
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: The role of calcium-sensing receptor and signalling pathways in the pathophysiology in two in-vitro models of malignant hypercalcemia

    Tfelt-Hansen, Jacob

    the rat rice H-500 leydig testis cancer and prostate cancer (PC-3) cells; expression and regulation of pituitary tumor transforming gene in leydig testis cancer and astrocyte and astrocytoma cells

    2007  

    Author's details Jacob Tfelt-Hansen
    Language English
    Size 91 S. : Ill., graph. Darst.
    Publishing country Denmark
    Document type Book ; Thesis
    Thesis / German Habilitation thesis København, Univ., Diss., 2007
    HBZ-ID HT015381054
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 E 2616 order for loan Magazin

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  4. Article ; Online: Does depolarization or repolarization play a role in sudden cardiac death in the general population?

    Warming, Peder Emil / Winkel, Bo Gregers / Tfelt-Hansen, Jacob

    Heart rhythm

    2022  Volume 19, Issue 8, Page(s) 1304–1305

    MeSH term(s) Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Electrocardiography ; Heart Conduction System ; Humans
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2022.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparison of whole transcriptome sequencing of fresh, frozen, and formalin-fixed, paraffin-embedded cardiac tissue.

    Jacobsen, Stine Bøttcher / Tfelt-Hansen, Jacob / Smerup, Morten Holdgaard / Andersen, Jeppe Dyrberg / Morling, Niels

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283159

    Abstract: The use of fresh tissue for molecular studies is preferred but often impossible. Instead, frozen or formalin-fixed, paraffin-embedded (FFPE) tissues are widely used and constitute valuable resources for retrospective studies. We assessed the utility of ... ...

    Abstract The use of fresh tissue for molecular studies is preferred but often impossible. Instead, frozen or formalin-fixed, paraffin-embedded (FFPE) tissues are widely used and constitute valuable resources for retrospective studies. We assessed the utility of cardiac tissue stored in different ways for gene expression analyses by whole transcriptome sequencing of paired fresh, frozen, and FFPE tissues. RNA extracted from FFPE was highly degraded. Sequencing of RNA from FFPE tissues yielded higher proportions of intronic and intergenic reads compared to RNA from fresh and frozen tissues. The global gene expression profiles varied with the storage conditions, particularly mitochondrial and long non-coding RNAs. However, we observed high correlations among protein-coding transcripts (ρ > 0.94) with the various storage conditions. We did not observe any significant storage effect on the allele-specific gene expression. However, FFPE had statistically significantly (p < 0.05) more discordant variant calls compared to fresh and frozen tissue. In conclusion, we found that frozen and FFPE tissues can be used for reliable gene expression analyses, provided that proper quality control is performed and caution regarding the technical variability is withheld.
    MeSH term(s) Exome Sequencing ; Paraffin Embedding ; Retrospective Studies ; Tissue Fixation ; Gene Expression Profiling ; RNA/genetics ; Transcriptome ; Formaldehyde
    Chemical Substances RNA (63231-63-0) ; Formaldehyde (1HG84L3525)
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prediction of chronological age and its applications in forensic casework: methods, current practices, and future perspectives.

    Refn, Mie Rath / Kampmann, Marie-Louise / Morling, Niels / Tfelt-Hansen, Jacob / Børsting, Claus / Pereira, Vania

    Forensic sciences research

    2023  Volume 8, Issue 2, Page(s) 85–97

    Abstract: Estimating an individual's age can be relevant in several areas primarily related to the clinical and forensic fields. In the latter, estimation of an individual's chronological age from biological material left by the perpetrator at a crime scene may ... ...

    Abstract Estimating an individual's age can be relevant in several areas primarily related to the clinical and forensic fields. In the latter, estimation of an individual's chronological age from biological material left by the perpetrator at a crime scene may provide helpful information for police investigation. Estimation of age is also beneficial in immigration cases, where age can affect the person's protection status under the law, or in disaster victim identification to narrow the list of potential missing persons. In the last decade, research has focused on establishing new approaches for age prediction in the forensic field. From the first forensic age estimations based on morphological inspections of macroscopic changes in bone and teeth, the focus has shifted to molecular methods for age estimation. These methods allow the use of samples from human biological material that does not contain morphological age features and can, in theory, be investigated in traces containing only small amounts of biological material. Molecular methods involving DNA analyses are the primary choice and estimation of DNA methylation levels at specific sites in the genome is the most promising tool. This review aims to provide an overview of the status of forensic age prediction using molecular methods, with particular focus in DNA methylation. The frequent challenges that impact forensic age prediction model development will be addressed, together with the importance of validation efforts within the forensic community.
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2885963-7
    ISSN 2471-1411 ; 2096-1790
    ISSN (online) 2471-1411
    ISSN 2096-1790
    DOI 10.1093/fsr/owad021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: [Cardiac arrest in a patient with long QT syndrome receiving androgen deprivation therapy].

    Stampe, Niels Kjær / Tfelt-Hansen, Jacob / Winkel, Bo Gregers

    Ugeskrift for laeger

    2021  Volume 183, Issue 41

    Abstract: This is a case report of a 72-year-old male with a newly diagnosed prostate cancer, who was treated with androgen deprivation therapy and anti-androgen. The patient was diagnosed with congenital long QT syndrome (LQTS), and a markedly worsening of the QT- ...

    Abstract This is a case report of a 72-year-old male with a newly diagnosed prostate cancer, who was treated with androgen deprivation therapy and anti-androgen. The patient was diagnosed with congenital long QT syndrome (LQTS), and a markedly worsening of the QT-prolongation was observed, after the hormonal therapy was initiated. He ultimately suffered an initially resuscitated cardiac arrest but did not survive to discharge. Pharmaceutical treatments in patients with LQTS should always be handled with caution, and if a treatment with a known or probable QT-prolonging drug is initiated, a cardiologist should be consulted.
    MeSH term(s) Aged ; Androgen Antagonists/adverse effects ; Androgens ; Electrocardiography ; Heart Arrest/chemically induced ; Humans ; Long QT Syndrome/chemically induced ; Male ; Prostatic Neoplasms/drug therapy
    Chemical Substances Androgen Antagonists ; Androgens
    Language Danish
    Publishing date 2021-10-27
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  8. Article ; Online: Time matters: characterization of fibroblast-like cells harvested from pig profundus tendon stored at room temperature at different postmortem time intervals.

    Ozhathil, Lijo Cherian / Chen, Yingying / Nissen, Sarah Dalgas / Banner, Jytte / Tfelt-Hansen, Jacob / Jespersen, Thomas

    In vitro cellular & developmental biology. Animal

    2022  Volume 58, Issue 8, Page(s) 633–637

    MeSH term(s) Animals ; Fibroblasts ; Swine ; Temperature ; Tendons
    Language English
    Publishing date 2022-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1077810-x
    ISSN 1543-706X ; 0883-8364 ; 1071-2690
    ISSN (online) 1543-706X
    ISSN 0883-8364 ; 1071-2690
    DOI 10.1007/s11626-022-00712-8
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  9. Article ; Online: The '10 commandments' for the 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.

    Tfelt-Hansen, Jacob / Winkel, Bo Gregers / de Riva, Marta / Zeppenfeld, Katja

    European heart journal

    2022  Volume 44, Issue 3, Page(s) 176–177

    MeSH term(s) Humans ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/therapy ; Death, Sudden, Cardiac/prevention & control
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diabetes and the Risk of Sudden Cardiac Death.

    Svane, Jesper / Pedersen-Bjergaard, Ulrik / Tfelt-Hansen, Jacob

    Current cardiology reports

    2020  Volume 22, Issue 10, Page(s) 112

    Abstract: Purpose of review: Persons with diabetes mellitus (DM) have increased morbidity and mortality rates compared with persons without DM. Sudden cardiac death (SCD) is a leading cause of death, and multiple studies have found an increased risk of SCD among ... ...

    Abstract Purpose of review: Persons with diabetes mellitus (DM) have increased morbidity and mortality rates compared with persons without DM. Sudden cardiac death (SCD) is a leading cause of death, and multiple studies have found an increased risk of SCD among individuals with DM. This review sought to collect the latest knowledge of the epidemiological and pathophysiological interplay between DM and SCD.
    Recent findings: Persons with DM have a two- to tenfold increased risk of SCD compared with persons without DM. The underlying mechanisms for the increased risk of SCD are complex and multifactorial. The main pathophysiological contributors are DM-induced cardiac autonomic neuropathy (CAN), metabolic changes, silent ischemia, and polypharmacy. Persons with DM have an increased risk of SCD. Future studies should focus on CAN and the combined risk of QT prolongation from the interplay between CAN, hypoglycemia, and polypharmacy. Genes and pathways involved in control of the autonomic nervous system and cardiac ion channels could be a future focal point.
    MeSH term(s) Autonomic Nervous System ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Diabetes Mellitus/epidemiology ; Heart ; Humans ; Long QT Syndrome ; Risk Factors
    Language English
    Publishing date 2020-08-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-020-01366-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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