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Article: Spiritual Beliefs, Mental Health and the 2019 Coronavirus (2019-nCoV) Outbreak: What Does Literature Have to Tell Us?

Gonçalves Júnior, Jucier / de Sales, Jair Paulino / Moreira, Marcial Moreno / de Lima, Carlos Kennedy Tavares / Rolim Neto, Modesto Leite

Frontiers in psychiatry

2020 Volume 11, Page(s) 570439

Keywords	covid19
Language	English
Publishing date	2020-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2020.570439
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In vitro biochemical characterization and genotoxicity assessment of Sapindus saponaria seed extract.

Bocayuva Tavares, Gustavo Duarte / Fortes Aiub, Claudia Alessandra / Felzenszwalb, Israel / Carrão Dantas, Eduardo Kennedy / Araújo-Lima, Carlos Fernando / Siqueira Júnior, César Luis

Journal of ethnopharmacology

2021 Volume 276, Page(s) 114170

Abstract: Ethnopharmacological relevance: Sapindus saponaria, also popularly known as soapberry, has been used in folk medicinal values because of its therapeutic properties and several compounds in its composition, which represent a target in potential for drug ... ...

Abstract	Ethnopharmacological relevance: Sapindus saponaria, also popularly known as soapberry, has been used in folk medicinal values because of its therapeutic properties and several compounds in its composition, which represent a target in potential for drug discovery. However, few data about its potential toxicity has been reported. Aim of the study: Plant proteins can perform essential roles in survival, acting as defense mechanism, as well functioning as important molecular reserves for its natural metabolism. The aim of the current study was to investigate the in vitro toxicity profile of protein extract of S. saponaria and detect protein potentially involved in biological effects such as collagen hydrolysis and inhibition of viral proteases. Materials and methods: Protein extract of soapberry seeds was investigated for its cytotoxic and genotoxic action using the Ames test. The protein extract was also subjected to a partial purification process of a protease and a protease inhibitor by gel chromatography filtration techniques and the partially isolated proteins were characterized biochemically. Results: Seed proteins extract of S. saponaria was evaluated until 100 μg/mL concentration, presenting cytotoxicity and mutagenicity in bacterial model mostly when exposed to exogenous metabolic system and causing cytotoxic and genotoxic effects in HepG2 cells. The purification and partial characterization of a serine protease (43 kDa) and a cysteine protease inhibitor (32.8 kDa) from protein extract of S. Saponaria, corroborate the idea of the biological use of the plant as an insecticide and larvicide. Although it shows cytotoxic, mutagenic and genotoxic effects. Conclusion: The overall results of the present study provide supportive data on the potential use of proteins produced in S. saponaria seeds as pharmacological and biotechnological agents that can be further explored for the development of new drugs.
MeSH term(s)	Biochemical Phenomena ; Cell Death/drug effects ; Cystatins/chemistry ; Cystatins/isolation & purification ; Cystatins/pharmacology ; DNA Damage/drug effects ; Hep G2 Cells ; Humans ; Lethal Dose 50 ; Micronucleus Tests ; Mutagenicity Tests ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/toxicity ; Salmonella typhimurium/drug effects ; Sapindus/chemistry ; Seeds/chemistry ; Serine Proteases/chemistry ; Serine Proteases/isolation & purification ; Serine Proteases/pharmacology
Chemical Substances	Cystatins ; Plant Extracts ; Serine Proteases (EC 3.4.-)
Language	English
Publishing date	2021-04-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114170
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Article: In vitro biochemical characterization and genotoxicity assessment of Sapindus saponaria seed extract

Bocayuva Tavares, Gustavo Duarte / Fortes Aiub, Claudia Alessandra / Felzenszwalb, Israel / Carrão Dantas, Eduardo Kennedy / Araújo-Lima, Carlos Fernando / Siqueira Júnior, César Luis

Journal of ethnopharmacology. 2021 Aug. 10, v. 276

2021

Abstract: Sapindus saponaria, also popularly known as soapberry, has been used in folk medicinal values because of its therapeutic properties and several compounds in its composition, which represent a target in potential for drug discovery. However, few data ... ...

Abstract	Sapindus saponaria, also popularly known as soapberry, has been used in folk medicinal values because of its therapeutic properties and several compounds in its composition, which represent a target in potential for drug discovery. However, few data about its potential toxicity has been reported.Plant proteins can perform essential roles in survival, acting as defense mechanism, as well functioning as important molecular reserves for its natural metabolism. The aim of the current study was to investigate the in vitro toxicity profile of protein extract of S. saponaria and detect protein potentially involved in biological effects such as collagen hydrolysis and inhibition of viral proteases.Protein extract of soapberry seeds was investigated for its cytotoxic and genotoxic action using the Ames test. The protein extract was also subjected to a partial purification process of a protease and a protease inhibitor by gel chromatography filtration techniques and the partially isolated proteins were characterized biochemically.Seed proteins extract of S. saponaria was evaluated until 100 μg/mL concentration, presenting cytotoxicity and mutagenicity in bacterial model mostly when exposed to exogenous metabolic system and causing cytotoxic and genotoxic effects in HepG2 cells. The purification and partial characterization of a serine protease (43 kDa) and a cysteine protease inhibitor (32.8 kDa) from protein extract of S. Saponaria, corroborate the idea of the biological use of the plant as an insecticide and larvicide. Although it shows cytotoxic, mutagenic and genotoxic effects.The overall results of the present study provide supportive data on the potential use of proteins produced in S. saponaria seeds as pharmacological and biotechnological agents that can be further explored for the development of new drugs.
Keywords	Ames test ; Sapindus saponaria ; Saponaria ; collagen ; cysteine proteinase inhibitors ; cytotoxicity ; filtration ; gel chromatography ; genotoxicity ; hydrolysis ; insecticides ; larvicides ; metabolism ; models ; mutagenicity ; mutagens ; purification methods ; seed extracts ; serine proteinases ; therapeutics ; traditional medicine
Language	English
Dates of publication	2021-0810
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114170
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A crisis within the crisis: The mental health situation of refugees in the world during the 2019 coronavirus (2019-nCoV) outbreak.

Júnior, Jucier Gonçalves / de Sales, Jair Paulino / Moreira, Marcial Moreno / Pinheiro, Woneska Rodrigues / Lima, Carlos Kennedy Tavares / Neto, Modesto Leite Rolim

Psychiatry research

2020 Volume 288, Page(s) 113000

Abstract: Background: 68.5 million people around the world have been forced to leave their houses. Refugees have mainly to face their adaption in a host country, which involves bureaucracy, different culture, poverty, and racism. The already fragile situation of ... ...

Abstract	Background: 68.5 million people around the world have been forced to leave their houses. Refugees have mainly to face their adaption in a host country, which involves bureaucracy, different culture, poverty, and racism. The already fragile situation of refugees becomes worrying and challenged in the face of the new coronavirus (COVID-19) epidemic. Therefore, we aimed to describe the factors that can worsen the mental health of refugees. Method: The studies were identified in well-known international journals found in three electronic databases: PubMed, Scopus, and Embase. The data were cross-checked with information from the main international newspapers. Results: According to the literature, the difficulties faced by refugees with the COVID-19 pandemic are potentiated by the pandemic state. There are several risk factors common to coronavirus and psychiatric illnesses as overcrowding, disruption of sewage disposal, poor standards of hygiene, poor nutrition, negligible sanitation, lack of access to shelter, health care, public services, and safety. These associated with fear and uncertainty create a closed ground for psychological sickness and COVID-19 infection. Conclusions: There should be not only a social mobilization to contain the virus, but also a collective effort on behalf of the most vulnerable populations.
MeSH term(s)	Anxiety ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Disease Outbreaks ; Fear ; Humans ; Mental Disorders/epidemiology ; Mental Health ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Refugees/psychology ; Risk Factors ; SARS-CoV-2 ; Sanitation ; Uncertainty
Keywords	covid19
Language	English
Publishing date	2020-04-15
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.113000
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Article ; Online: When health professionals look death in the eye: the mental health of professionals who deal daily with the 2019 coronavirus outbreak.

Neto, Modesto Leite Rolim / Almeida, Hiure Gomes / Esmeraldo, Joana D'arc / Nobre, Camila Bezerra / Pinheiro, Woneska Rodrigues / de Oliveira, Cícera Rejane Tavares / Sousa, Itamara da Costa / Lima, Onélia Maria Moreira Leite / Lima, Nádia Nara Rolim / Moreira, Marcial Moreno / Lima, Carlos Kennedy Tavares / Júnior, Jucier Gonçalves / da Silva, Claúdio Gleideston Lima

Psychiatry research

2020 Volume 288, Page(s) 112972

Abstract: Background: The fact that COVID-19 is transmissible from human to human and associated with high morbidity and potentially fatality can intensify the perception of personal danger. In addition, the foreseeable shortage of supplies and an increasing flow ...

Abstract	Background: The fact that COVID-19 is transmissible from human to human and associated with high morbidity and potentially fatality can intensify the perception of personal danger. In addition, the foreseeable shortage of supplies and an increasing flow of suspected and real cases of COVID-19 contribute to the pressures and concerns of health professionals. Method: The studies were identified in well-known international journals found in two electronic databases: Scopus and Embase. The data were cross-checked with information from the main international newspapers. Results: Work-related stress is a potential cause of concern for health professionals. It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. Therefore, it is an important indicator of psychic exhaustion. Conclusions: As coronavirus cases increase and deaths surge in Italy, new figures show an "enormous" level of contagion among the country's medical personnel. At least 2,629 health workers have been infected with coronavirus since the outbreak onset in February, representing 8.3% of total cases. The percentage of infected health workers has almost doubled the number registered in China throughout the epidemic. Intensive care unit physicians are on their stress limit, especially when dealing with older patients and with death prospects. Doctors, not a relative, are inevitably the last people a dying COVID-19 patient will see.
MeSH term(s)	Adult ; Anxiety ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Coronavirus Infections/transmission ; Death ; Depression ; Disease Outbreaks ; Health Personnel/psychology ; Humans ; Infectious Disease Transmission, Professional-to-Patient ; Italy/epidemiology ; Mental Health ; Pandemics ; Physician-Patient Relations ; Physicians/psychology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Terminal Care
Keywords	covid19
Language	English
Publishing date	2020-04-13
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.112972
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease).

Lima, Carlos Kennedy Tavares / Carvalho, Poliana Moreira de Medeiros / Lima, Igor de Araújo Araruna Silva / Nunes, José Victor Alexandre de Oliveira / Saraiva, Jeferson Steves / de Souza, Ricardo Inácio / da Silva, Claúdio Gleidiston Lima / Neto, Modesto Leite Rolim

Psychiatry research

2020 Volume 287, Page(s) 112915

Abstract: Background: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable.: Method: Studies were identified using large- ...

Abstract	Background: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. Method: Studies were identified using large-circulation international journals found in two electronic databases: Scopus and Embase. Results: Populations of patients that may require tailored interventions are older adults and international migrant workers. Older adults with psychiatric conditions may be experiencing further distress. The COVID-19 epidemic has underscored potential gaps in mental health services during emergencies. Conclusions: Most health professionals working in isolation units and hospitals do not receive any training for providing mental health care. Fear seems more certainly a consequence of mass quarantine.
MeSH term(s)	Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/psychology ; Emotions ; Female ; Health Personnel ; Health Services Needs and Demand ; Humans ; Mental Disorders ; Mental Health Services ; Pandemics ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Stress, Psychological
Keywords	covid19
Language	English
Publishing date	2020-03-12
Publishing country	Ireland
Document type	Letter ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.112915
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Article ; Online: The mental health of those whose rights have been taken away: An essay on the mental health of indigenous peoples in the face of the 2019 Coronavirus (2019-nCoV) outbreak.

Júnior, Jucier Gonçalves / Moreira, Marcial Moreno / Pinheiro, Woneska Rodrigues / de Amorim, Liromaria Maria / Lima, Carlos Kennedy Tavares / da Silva, Claúdio Gleidiston Lima / Neto, Modesto Leite Rolim

Psychiatry research

2020 Volume 289, Page(s) 113094

Abstract: Background: : In Latin America there are about 45 million indigenous people in 826 communities that represent 8.3% of the population. An estimated 798,365 Aboriginal and Torres Strait Islander were in Australia, 5,2 million indigenous people living in ... ...

Abstract	Background: : In Latin America there are about 45 million indigenous people in 826 communities that represent 8.3% of the population. An estimated 798,365 Aboriginal and Torres Strait Islander were in Australia, 5,2 million indigenous people living in America and 2,13 million in Canada. Racial/ethnic disparities in mental health service use have increased especially in the context of the new coronavirus pandemic. Thus, we aimed to describe the mental health situation of the indigenous population in the context of the COVID-19 pandemic. Method: : The studies were identified in well-known international journals found in three electronic databases: PubMed, Scopus, and MEDLINE. The data were cross-checked with information from the main international newspapers. Results: : According to the literature, due to the COVID-19 pandemic there is a lack of specialized mental health services and professionals, a restricted access to quality information and a lack of access to inputs, causing negative feelings and it can exacerbate pre-existing mental problems (eg: depression, suicidal ideation, smoking and binge drink). The cultural differences are a risk factor to worsen the mental health of this already vulnerable population. Conclusion: : providing psychological first aid is an essential care component for indigenous populations that have been victims COVID-19 pandemic.
MeSH term(s)	American Native Continental Ancestry Group/psychology ; Australia/epidemiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/ethnology ; Coronavirus Infections/psychology ; Disease Outbreaks ; Female ; Health Status Disparities ; Healthcare Disparities ; Human Rights/psychology ; Humans ; Indigenous Peoples/psychology ; Male ; Mental Disorders/epidemiology ; Mental Disorders/ethnology ; Mental Health/ethnology ; Native Hawaiian or Other Pacific Islander/psychology ; North America/epidemiology ; Pandemics ; Pneumonia, Viral/ethnology ; Pneumonia, Viral/psychology ; Risk Factors ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-13
Publishing country	Ireland
Document type	Letter ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.113094
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Article: A crisis within the crisis: The mental health situation of refugees in the world during the 2019 coronavirus (2019-nCoV) outbreak

Júnior, Jucier Gonçalves / de Sales, Jair Paulino / Moreira, Marcial Moreno / Pinheiro, Woneska Rodrigues / Lima, Carlos Kennedy Tavares / Neto, Modesto Leite Rolim

Psychiatry Res

Abstract: BACKGROUND: 68.5 million people around the world have been forced to leave their houses. Refugees have mainly to face their adaption in a host country, which involves bureaucracy, different culture, poverty, and racism. The already fragile situation of ... ...

Abstract	BACKGROUND: 68.5 million people around the world have been forced to leave their houses. Refugees have mainly to face their adaption in a host country, which involves bureaucracy, different culture, poverty, and racism. The already fragile situation of refugees becomes worrying and challenged in the face of the new coronavirus (COVID-19) epidemic. Therefore, we aimed to describe the factors that can worsen the mental health of refugees. METHOD: The studies were identified in well-known international journals found in three electronic databases: PubMed, Scopus, and Embase. The data were cross-checked with information from the main international newspapers. RESULTS: According to the literature, the difficulties faced by refugees with the COVID-19 pandemic are potentiated by the pandemic state. There are several risk factors common to coronavirus and psychiatric illnesses as overcrowding, disruption of sewage disposal, poor standards of hygiene, poor nutrition, negligible sanitation, lack of access to shelter, health care, public services, and safety. These associated with fear and uncertainty create a closed ground for psychological sickness and COVID-19 infection. CONCLUSIONS: There should be not only a social mobilization to contain the virus, but also a collective effort on behalf of the most vulnerable populations.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #60415
Database	COVID19

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Article: When health professionals look death in the eye: the mental health of professionals who deal daily with the 2019 coronavirus outbreak

Neto, Modesto Leite Rolim / Almeida, Hiure Gomes / Esmeraldo, Joana D039 / arc, / Nobre, Camila Bezerra / Pinheiro, Woneska Rodrigues / de Oliveira, Cícera Rejane Tavares / Sousa, Itamara da Costa / Lima, Onélia Maria Moreira Leite / Lima, Nádia Nara Rolim / Moreira, Marcial Moreno / Lima, Carlos Kennedy Tavares / Júnior, Jucier Gonçalves / da Silva, Claúdio Gleideston Lima

Psychiatry Res

Abstract: BACKGROUND: The fact that COVID-19 is transmissible from human to human and associated with high morbidity and potentially fatality can intensify the perception of personal danger. In addition, the foreseeable shortage of supplies and an increasing flow ... ...

Abstract	BACKGROUND: The fact that COVID-19 is transmissible from human to human and associated with high morbidity and potentially fatality can intensify the perception of personal danger. In addition, the foreseeable shortage of supplies and an increasing flow of suspected and real cases of COVID-19 contribute to the pressures and concerns of health professionals. METHOD: The studies were identified in well-known international journals found in two electronic databases: Scopus and Embase. The data were cross-checked with information from the main international newspapers. RESULTS: Work-related stress is a potential cause of concern for health professionals. It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. Therefore, it is an important indicator of psychic exhaustion. CONCLUSIONS: As coronavirus cases increase and deaths surge in Italy, new figures show an "enormous" level of contagion among the country's medical personnel. At least 2,629 health workers have been infected with coronavirus since the outbreak onset in February, representing 8.3% of total cases. The percentage of infected health workers has almost doubled the number registered in China throughout the epidemic. Intensive care unit physicians are on their stress limit, especially when dealing with older patients and with death prospects. Doctors, not a relative, are inevitably the last people a dying COVID-19 patient will see.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46480
Database	COVID19

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Article: The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease)

Psychiatry Res

Abstract: BACKGROUND: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. METHOD: Studies were identified using large- ... ...

Abstract	BACKGROUND: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. METHOD: Studies were identified using large-circulation international journals found in two electronic databases: Scopus and Embase. RESULTS: Populations of patients that may require tailored interventions are older adults and international migrant workers. Older adults with psychiatric conditions may be experiencing further distress. The COVID-19 epidemic has underscored potential gaps in mental health services during emergencies. CONCLUSIONS: Most health professionals working in isolation units and hospitals do not receive any training for providing mental health care. Fear seems more certainly a consequence of mass quarantine.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #8256
Database	COVID19

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