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Book ; Conference proceedings: Special issue: Euro Fed Lipid highlights 2014

Carrière, Frédéric

[... the twelfth edition of the Euro Fed Lipid Congress ... 2014]

(European journal of lipid science and technology ; 116,10)

2014

Title variant	Euro Fed Lipid highlights 2014
Event/congress	Euro Fed Lipid Congress (12., 2014, Montpellier)
Author's details	[Editorial: Frédéric Carrière ...]
Series title	European journal of lipid science and technology ; 116,10
Collection
Language	English
Size	S. 1257 - 1439 : Ill., graph. Darst.
Publisher	Wiley
Publishing place	Weinheim
Publishing country	Germany
Document type	Book ; Conference proceedings
HBZ-ID	HT018454227
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Shelf mark	Loan status	Location
Z 1917 (116,10)	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Lipids play music at the cellular membrane: From membranes dynamics to signaling via lipid mediators, vesicles and lipid droplets.

Lambeau, Gérard / Amri, Ez-Zoubir / Carrière, Frédéric

Biochimie

2023 Volume 215, Page(s) 1–3

MeSH term(s)	Lipid Droplets ; Music ; Cell Membrane ; Membranes ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2023-10-20
Publishing country	France
Document type	Editorial
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2023.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Special issue Lipids: From (bio)synthesis to function.

Carrière, Frédéric

Biochimie

2016 Volume 120, Page(s) 1–2

MeSH term(s)	Animals ; Humans ; Lipid Metabolism ; Periodicals as Topic
Language	English
Publishing date	2016-01
Publishing country	France
Document type	Editorial
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2015.11.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of gastrointestinal lipolysis on oral lipid-based formulations and bioavailability of lipophilic drugs.

Carrière, Frédéric

Biochimie

2016 Volume 125, Page(s) 297–305

Abstract: Oil-in-water emulsions are common vehicles for lipids as nutrients and for the delivery of poorly water-soluble drugs. Enhancing oral bioavailability of these drugs using lipid-based formulations (LBF) or self-emulsifying drug delivery systems is one of ... ...

Abstract	Oil-in-water emulsions are common vehicles for lipids as nutrients and for the delivery of poorly water-soluble drugs. Enhancing oral bioavailability of these drugs using lipid-based formulations (LBF) or self-emulsifying drug delivery systems is one of the current challenges in pharmaceutical industry. Many of the compounds found in LBF (acylglycerols, surfactants with esterified fatty acids, …) are however potential substrates for digestive enzymes. Their digestion (or lipolysis) in the gastrointestinal (GI) tract is critical for drug dissolution and absorption: it can be beneficial (drug solubilization/dispersion) or deleterous (drug precipitation) depending on the drug-LBF association. A better understanding of the fate of LBF in the GI tract is therefore required to engineer efficient lipid-based drug delivery systems. In vitro models for testing simultaneously LBF digestion and drug dispersion are in development to predict drug solubilization and bioavailability, select the best drug-LBF association and obtain better in vitro-in vivo correlations. So far, research in this area has focused on LBF lipolysis under intestinal conditions because the small intestine is the main target for drug delivery and absorption, as well as the main site of digestion by pancreatic enzymes. Lipolysis however starts within the stomach through the action of gastric lipase, the first enzyme involved in fat digestion in humans. In vitro digestion experiments show that most LBFs are submitted to gastric lipolysis, and therefore, both intragastric and intestinal digestions are critical for the fate of LBF and drug solubility.
MeSH term(s)	Animals ; Drug Delivery Systems/methods ; Gastrointestinal Absorption ; Humans ; Intestines/metabolism ; Lipids/chemistry ; Lipids/pharmacokinetics ; Lipids/pharmacology ; Lipolysis ; Stomach/metabolism
Chemical Substances	Lipids
Language	English
Publishing date	2016-06
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2015.11.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biogenesis and fate of lipid droplets.

Li-Beisson, Yonghua / Carrière, Frédéric

Biochimie

2020 Volume 169, Page(s) 1–2

MeSH term(s)	Animals ; Biofuels ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Diatoms/genetics ; Diatoms/metabolism ; Humans ; Lipid Droplets/chemistry ; Lipid Droplets/metabolism ; Lipid Droplets/ultrastructure ; Lipid Metabolism/genetics ; Mice ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Plants/genetics ; Plants/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Chemical Substances	Biofuels
Language	English
Publishing date	2020-01-07
Publishing country	France
Document type	Editorial
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2020.01.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Monitoring galactolipid digestion and simultaneous changes in lipid-bile salt micellar organization by real-time NMR spectroscopy.

Sahaka, Moulay / Bornet, Olivier / Marchand, Achille / Lafont, Dominique / Gontero, Brigitte / Carrière, Frédéric / Launay, Hélène

Chemistry and physics of lipids

2023 Volume 258, Page(s) 105361

Abstract: The use of Nuclear Magnetic Resonance spectroscopy for studying lipid digestion in vitro most often consists of quantifying lipolysis products after they have been extracted from the reaction medium using organic solvents. However, the current ... ...

Abstract	The use of Nuclear Magnetic Resonance spectroscopy for studying lipid digestion in vitro most often consists of quantifying lipolysis products after they have been extracted from the reaction medium using organic solvents. However, the current sensitivity level of NMR spectrometers makes possible to avoid the extraction step and continuously quantify the lipids directly in the reaction medium. We used real-time
MeSH term(s)	Animals ; Guinea Pigs ; Micelles ; Hydrolysis ; Galactolipids/chemistry ; Galactolipids/metabolism ; Bile Acids and Salts ; Lipolysis ; Fatty Acids/metabolism ; Magnetic Resonance Spectroscopy ; Digestion
Chemical Substances	Micelles ; Galactolipids ; Bile Acids and Salts ; Fatty Acids
Language	English
Publishing date	2023-11-21
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	213869-4
ISSN	1873-2941 ; 0009-3084
ISSN (online)	1873-2941
ISSN	0009-3084
DOI	10.1016/j.chemphyslip.2023.105361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pre-duodenal lipid digestion of emulsions: Relevance, colloidal aspects and mechanistic insight.

Infantes-Garcia, Marcos R / Verkempinck, Sarah H E / Carriére, Fréderic / Hendrickx, Marc E / Grauwet, Tara

Food research international (Ottawa, Ont.)

2023 Volume 168, Page(s) 112785

Abstract: The digestion of lipids in the human body has several health and nutritional implications. Lipid digestion is an interfacial phenomenon meaning that water-soluble lipases need to first adsorb to the oil-water interface before enzymatic conversions can ... ...

Abstract	The digestion of lipids in the human body has several health and nutritional implications. Lipid digestion is an interfacial phenomenon meaning that water-soluble lipases need to first adsorb to the oil-water interface before enzymatic conversions can start. The digestion of lipids mainly occurs on colloidal structures dispersed in water, such as oil-in-water (o/w) emulsions, which can be designed during food formulation/processing or structured during digestion. From a food design perspective, different in vitro studies have demonstrated that the kinetics of lipid digestion can be influenced by emulsion properties. However, most of these studies have been performed with pancreatic enzymes to simulate lipolysis in the small intestine. Only few studies have dealt with lipid digestion in the gastric phase and its subsequent impact on intestinal lipolysis. In this aspect, this review compiles information on the physiological aspects of gastric lipid digestion. In addition, it deals with colloidal and interfacial aspects starting from emulsion design factors and how they evolve during in vitro digestion. Finally, molecular mechanisms describing gastric lipolysis are discussed.
MeSH term(s)	Humans ; Emulsions/chemistry ; Lipids/chemistry ; Lipolysis ; Digestion ; Water/chemistry
Chemical Substances	Emulsions ; Lipids ; Water (059QF0KO0R)
Language	English
Publishing date	2023-04-01
Publishing country	Canada
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.112785
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interfacial adsorption and activity of pancreatic lipase-related protein 2 onto heterogeneous plant lipid model membranes.

Kergomard, Jeanne / Carrière, Frédéric / Paboeuf, Gilles / Chonchon, Lauriane / Barouh, Nathalie / Vié, Véronique / Bourlieu, Claire

Biochimie

2023 Volume 215, Page(s) 12–23

Abstract: Pancreatic lipase related-protein 2 (PLRP2) exhibits remarkable galactolipase and phospholipase A1 activities, which depend greatly on the supramolecular organization of the substrates and the presence of surfactant molecules such as bile salts. The ... ...

Abstract	Pancreatic lipase related-protein 2 (PLRP2) exhibits remarkable galactolipase and phospholipase A1 activities, which depend greatly on the supramolecular organization of the substrates and the presence of surfactant molecules such as bile salts. The objective of the study was to understand the modulation of the adsorption mechanisms and enzymatic activity of Guinea pig PLRP2 (gPLRP2), by the physical environment of the enzyme and the physical state of its substrate. Langmuir monolayers were used to reproduce homogeneous and heterogeneous photosynthetic model membranes containing galactolipids (GL), and/or phospholipids (PL), and/or phytosterols (pS), presenting uncharged or charged interfaces. The same lipid mixtures were also used to form micrometric liposomes, and their gPLRP2 catalyzed digestion kinetics were investigated in presence or in absence of bile salts (NaTDC) during static in vitro, so called "bulk", digestion. The enzymatic activity of gPLRP2 onto the galactolipid-based monolayers was characterized with an optimum activity at 15 mN/m, in the absence of bile salts. gPLRP2 showed enhanced adsorption onto biomimetic model monolayer containing negatively charged lipids. However, the compositional complexity in the heterogeneous uncharged model systems induced a lag phase before the initiation of lipolysis. In bulk, no enzymatic activity could be demonstrated on GL-based liposomes in the absence of bile salts, probably due to the high lateral pressure of the lipid bilayers. In the presence of NaTDC (4 mM), however, gPLRP2 showed both high galactolipase and moderate phospholipase A1 activities on liposomes, probably due to a decrease in packing and lateral pressure upon NaTDC adsorption, and subsequent disruption of liposomes.
MeSH term(s)	Animals ; Guinea Pigs ; Hydrolysis ; Liposomes ; Phospholipases A1 ; Adsorption ; Lipase/chemistry ; Phospholipids/metabolism ; Galactolipids ; Bile Acids and Salts
Chemical Substances	pancreatic lipase related protein 2 (EC 3.1.1.3) ; Liposomes ; Phospholipases A1 (EC 3.1.1.32) ; Lipase (EC 3.1.1.3) ; Phospholipids ; Galactolipids ; Bile Acids and Salts
Language	English
Publishing date	2023-04-14
Publishing country	France
Document type	Journal Article
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2023.04.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of gastrointestinal lipolysis on oral lipid-based formulations and bioavailability of lipophilic drugs

Carrière, Frédéric

Biochimie. 2016 June, v. 125

2016

Abstract	Oil-in-water emulsions are common vehicles for lipids as nutrients and for the delivery of poorly water-soluble drugs. Enhancing oral bioavailability of these drugs using lipid-based formulations (LBF) or self-emulsifying drug delivery systems is one of the current challenges in pharmaceutical industry. Many of the compounds found in LBF (acylglycerols, surfactants with esterified fatty acids, …) are however potential substrates for digestive enzymes. Their digestion (or lipolysis) in the gastrointestinal (GI) tract is critical for drug dissolution and absorption: it can be beneficial (drug solubilization/dispersion) or deleterous (drug precipitation) depending on the drug-LBF association. A better understanding of the fate of LBF in the GI tract is therefore required to engineer efficient lipid-based drug delivery systems. In vitro models for testing simultaneously LBF digestion and drug dispersion are in development to predict drug solubilization and bioavailability, select the best drug-LBF association and obtain better in vitro-in vivo correlations. So far, research in this area has focused on LBF lipolysis under intestinal conditions because the small intestine is the main target for drug delivery and absorption, as well as the main site of digestion by pancreatic enzymes. Lipolysis however starts within the stomach through the action of gastric lipase, the first enzyme involved in fat digestion in humans. In vitro digestion experiments show that most LBFs are submitted to gastric lipolysis, and therefore, both intragastric and intestinal digestions are critical for the fate of LBF and drug solubility.
Keywords	absorption ; acylglycerols ; bioavailability ; carboxylic ester hydrolases ; digestion ; digestive enzymes ; drug delivery systems ; drugs ; emulsions ; esterification ; fatty acids ; humans ; in vitro digestion ; lipolysis ; models ; nutrients ; pharmaceutical industry ; small intestine ; solubility ; solubilization ; stomach ; surfactants
Language	English
Dates of publication	2016-06
Size	p. 297-305.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	120345-9
ISSN	0300-9084
ISSN	0300-9084
DOI	10.1016/j.biochi.2015.11.016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The endosomal lipid bis(monoacylglycero) phosphate as a potential key player in the mechanism of action of chloroquine against SARS-COV-2 and other enveloped viruses hijacking the endocytic pathway.

Carrière, Frédéric / Longhi, Sonia / Record, Michel

Biochimie

2020 Volume 179, Page(s) 237–246

Abstract: The anti-malarial drug Chloroquine (CQ) and its derivative hydroxychloroquine have shown antiviral activities in vitro against many viruses, including coronaviruses, dengue virus and the biosafety level 4 Nipah and Hendra paramyxoviruses. The in vivo ... ...

Abstract	The anti-malarial drug Chloroquine (CQ) and its derivative hydroxychloroquine have shown antiviral activities in vitro against many viruses, including coronaviruses, dengue virus and the biosafety level 4 Nipah and Hendra paramyxoviruses. The in vivo efficacy of CQ in the treatment of COVID-19 is currently a matter of debate. CQ is a lysosomotrophic compound that accumulates in lysosomes, as well as in food vacuoles of Plasmodium falciparum. In the treatment of malaria, CQ impairs the digestion and growth of the parasite by increasing the pH of the food vacuole. Similarly, it is assumed that the antiviral effects of CQ results from the increase of lysosome pH and the inhibition of acidic proteases involved in the maturation of virus fusion protein. CQ has however other effects, among which phospholipidosis, characterized by the accumulation of multivesicular bodies within the cell. The increase in phospholipid species particularly concerns bis(monoacylglycero)phosphate (BMP), a specific lipid of late endosomes involved in vesicular trafficking and pH-dependent vesicle budding. It was shown previously that drugs like progesterone, the cationic amphiphile U18666A and the phospholipase inhibitor methyl arachidonyl fluoro phosphonate (MAFP) induce the accumulation of BMP in THP-1 cells and decrease cell infection by human immunodeficiency virus. HIV viral particles were found to be retained into large endosomal-type vesicles, preventing virus spreading. Since BMP was also reported to favour virus entry through hijacking of the endocytic pathway, we propose here that BMP could play a dual role in viral infection, with its antiviral effects triggered by lysosomotropic drugs like CQ.
MeSH term(s)	Antiviral Agents/pharmacology ; Chloroquine/pharmacology ; Endocytosis/drug effects ; Endosomes/drug effects ; Endosomes/metabolism ; Humans ; Lysophospholipids/metabolism ; Monoglycerides/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology
Chemical Substances	Antiviral Agents ; Lysophospholipids ; Monoglycerides ; bis(monoacylglyceryl)phosphate ; Chloroquine (886U3H6UFF)
Keywords	covid19
Language	English
Publishing date	2020-05-30
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2020.05.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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