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  1. AU=Barnett Stephen M
  2. AU="Motuzas, Juliuz"
  3. AU="Chata Quispe, Yulisa"
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  1. Article ; Online: Identifying content-invariant neural signatures of perceptual vividness.

    Barnett, Benjy / Andersen, Lau M / Fleming, Stephen M / Dijkstra, Nadine

    PNAS nexus

    2024  Volume 3, Issue 2, Page(s) pgae061

    Abstract: Some conscious experiences are more vivid than others. Although perceptual vividness is a key component of human consciousness, how variation in this magnitude property is registered by the human brain is unknown. A striking feature of neural codes for ... ...

    Abstract Some conscious experiences are more vivid than others. Although perceptual vividness is a key component of human consciousness, how variation in this magnitude property is registered by the human brain is unknown. A striking feature of neural codes for magnitude in other psychological domains, such as number or reward, is that the magnitude property is represented independently of its sensory features. To test whether perceptual vividness also covaries with neural codes that are invariant to sensory content, we reanalyzed existing magnetoencephalography and functional MRI data from two distinct studies which quantified perceptual vividness via subjective ratings of awareness and visibility. Using representational similarity and decoding analyses, we find evidence for content-invariant neural signatures of perceptual vividness distributed across visual, parietal, and frontal cortices. Our findings indicate that the neural correlates of subjective vividness may share similar properties to magnitude codes in other cognitive domains.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgae061
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  2. Article ; Online: Spatiotemporal Trends in Group A Streptococcal Pharyngitis in the United States.

    Kline, Madeleine C / Kissler, Stephen M / Whittles, Lilith K / Barnett, Michael L / Grad, Yonatan H

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  Volume 78, Issue 5, Page(s) 1345–1351

    Abstract: Background: Group A Streptococcus (GAS) causes an estimated 5.2 million outpatient visits for pharyngitis annually in the United States, with incidence peaking in winter, but the annual spatiotemporal pattern of GAS pharyngitis across the United States ... ...

    Abstract Background: Group A Streptococcus (GAS) causes an estimated 5.2 million outpatient visits for pharyngitis annually in the United States, with incidence peaking in winter, but the annual spatiotemporal pattern of GAS pharyngitis across the United States is poorly characterized.
    Methods: We used outpatient claims data from individuals with private medical insurance between 2010 and 2018 to quantify GAS pharyngitis visit rates across U.S. census regions, subregions, and states. We evaluated seasonal and age-based patterns of geographic spread and the association between school start dates and the summertime upward inflection in GAS visits.
    Results: The South had the most visits per person (yearly average, 39.11 visits per 1000 people; 95% confidence interval, 36.21-42.01) and the West had the fewest (yearly average, 17.63 visits per 1000 people; 95% confidence interval, 16.76-18.49). Visits increased earliest in the South and in school-age children. Differences in visits between the South and other regions were most pronounced in the late summer through early winter. Visits peaked earliest in central southern states, in December to January, and latest on the coasts, in March. The onset of the rise in GAS pharyngitis visits correlated with, but preceded, average school start times.
    Conclusions: The burden and timing of GAS pharyngitis varied across the continental United States, with the South experiencing the highest overall rates and earliest onset and peak in outpatient visits. Understanding the drivers of these regional differences in GAS pharyngitis will help in identifying and targeting prevention measures.
    MeSH term(s) Humans ; Pharyngitis/microbiology ; Pharyngitis/epidemiology ; United States/epidemiology ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes ; Child ; Child, Preschool ; Adolescent ; Female ; Male ; Adult ; Seasons ; Young Adult ; Middle Aged ; Infant ; Incidence ; Spatio-Temporal Analysis ; Aged
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae083
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  3. Article ; Online: Barnett Replies.

    Barnett, Stephen M

    Physical review letters

    2017  Volume 119, Issue 2, Page(s) 29502

    Language English
    Publishing date 2017-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.119.029502
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  4. Article ; Online: Drivers of Geographic Patterns in Outpatient Antibiotic Prescribing in the United States.

    Kissler, Stephen M / Oliveira Roster, Kirstin I / Petherbridge, Rachel / Mehrotra, Ateev / Barnett, Michael L / Grad, Yonatan H

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: In a retrospective, ecological analysis of US medical claims, visit rates explained more of the geographic variation in outpatient antibiotic prescribing rates than per-visit prescribing. Efforts to reduce antibiotic use may benefit from addressing the ... ...

    Abstract In a retrospective, ecological analysis of US medical claims, visit rates explained more of the geographic variation in outpatient antibiotic prescribing rates than per-visit prescribing. Efforts to reduce antibiotic use may benefit from addressing the factors that drive higher rates of outpatient visits, in addition to continued focus on stewardship.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae111
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  5. Article ; Online: Relativistic Electron Vortices.

    Barnett, Stephen M

    Physical review letters

    2017  Volume 118, Issue 11, Page(s) 114802

    Abstract: The desire to push recent experiments on electron vortices to higher energies leads to some theoretical difficulties. In particular the simple and very successful picture of phase vortices of vortex charge ℓ associated with ℓℏ units of orbital angular ... ...

    Abstract The desire to push recent experiments on electron vortices to higher energies leads to some theoretical difficulties. In particular the simple and very successful picture of phase vortices of vortex charge ℓ associated with ℓℏ units of orbital angular momentum per electron is challenged by the facts that (i) the spin and orbital angular momentum are not separately conserved for a Dirac electron, which suggests that the existence of a spin-orbit coupling will complicate matters, and (ii) that the velocity of a Dirac electron is not simply the gradient of a phase as it is in the Schrödinger theory suggesting that, perhaps, electron vortices might not exist at a fundamental level. We resolve these difficulties by showing that electron vortices do indeed exist in the relativistic theory and show that the charge of such a vortex is simply related to a conserved orbital part of the total angular momentum, closely related to the familiar situation for the orbital angular momentum of a photon.
    Language English
    Publishing date 2017-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.118.114802
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  6. Article: Simulated impact of lift car sizes on transport of critical care patients: Informing the design of the New Dunedin Hospital.

    Barnett, Sheila G / Stephens, Katherine M

    Anaesthesia and intensive care

    2024  Volume 52, Issue 3, Page(s) 188–196

    Abstract: The New Dunedin Hospital (NDH) is New Zealand's largest health infrastructure build. Here we describe the use of a simple simulation-based hospital design exercise to inform the appropriate lift car size for critical care intrahospital transfers in the ... ...

    Abstract The New Dunedin Hospital (NDH) is New Zealand's largest health infrastructure build. Here we describe the use of a simple simulation-based hospital design exercise to inform the appropriate lift car size for critical care intrahospital transfers in the NDH. The intensive care unit (ICU) user group tested a series of entries and exits of simulated complex patient transfers in mocked-up lift cars of three different dimensions. Time taken to enter and exit the lift were recorded, reflecting the relative difficulty of transfer. Qualitative assessments were made of ease and perceived safety of transfer. These simulations demonstrated that recommended standard patient lift cars, often proposed for critical care transfers, could not physically accommodate all complex ICU transfers. A size of 1800 mm wide (W) × 3000 mm deep (D) had the physical capacity to permit all simulated ICU transfers, but with staff and patient risk. As lift car size increased to 2200 mm W × 3300 mm D, the simulation demonstrated reduced transfer times, smoother entry and exit, improved access to the head end of the bed, and reduced risk of disconnection or dislodgement of lines and airway support. The resultant clinical recommendations for the dimensions of a critical care lift car surpass current international health architecture guidelines and may help to inform future updates. The NDH project benefited from an objective assessment of risk, in language familiar to clinicians and healthcare architects. The outcome was an upsizing of the two ICU-capable lifts.
    MeSH term(s) Humans ; New Zealand ; Critical Care/methods ; Intensive Care Units ; Automobiles ; Hospital Design and Construction ; Transportation of Patients/methods ; Patient Transfer
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
    DOI 10.1177/0310057X241226720
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    Zs.A 1017: Show issues Location:
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  7. Article ; Online: MRI and laboratory monitoring of disease-modifying therapy efficacy and risks.

    Barnett, Michael / Barnett, Yael / Reddel, Stephen

    Current opinion in neurology

    2022  Volume 35, Issue 3, Page(s) 278–285

    Abstract: Purpose of review: Increasingly, therapeutic strategy in multiple sclerosis (MS) is informed by imaging and laboratory biomarkers, in addition to traditional clinical factors. Here, we review aspects of monitoring the efficacy and risks of disease- ... ...

    Abstract Purpose of review: Increasingly, therapeutic strategy in multiple sclerosis (MS) is informed by imaging and laboratory biomarkers, in addition to traditional clinical factors. Here, we review aspects of monitoring the efficacy and risks of disease-modifying therapy (DMT) with both conventional and emerging MRI and laboratory measures.
    Recent findings: The adoption of consensus-driven, stable MRI acquisition protocols and artificial intelligence-based, quantitative image analysis is heralding an era of precision monitoring of DMT efficacy. New MRI measures of compartmentalized inflammation, neuro-degeneration and repair complement traditional metrics but require validation before use in individual patients. Laboratory markers of brain cellular injury, such as neurofilament light, are robust outcomes in DMT efficacy trials; their use in clinical practice is being refined. DMT-specific laboratory monitoring for safety is critical and may include lymphocytes, immunoglobulins, autoimmunity surveillance, John Cunningham virus serology and COVID-19 vaccination seroresponse.
    Summary: A biomarker-enhanced monitoring strategy has immediate clinical application, with growing evidence of long-term reductions in disability accrual when both clinically symptomatic and asymptomatic inflammatory activity is fully suppressed; and amelioration of the risks associated with therapy. Emerging MRI and blood-based measures will also become important tools for monitoring agents that target the innate immune system and promote neuro-repair.
    MeSH term(s) Artificial Intelligence ; Biomarkers ; COVID-19/diagnostic imaging ; COVID-19 Vaccines ; Humans ; Magnetic Resonance Imaging/methods ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/drug therapy
    Chemical Substances Biomarkers ; COVID-19 Vaccines
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001067
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    Zs.A 2524: Show issues Location:
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  8. Article: Spatiotemporal Trends in Group A Streptococcal Pharyngitis in the United States.

    Kline, Madeleine C / Kissler, Stephen M / Whittles, Lilith K / Barnett, Michael L / Grad, Yonatan H

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: Group A : Methods: We used outpatient claims data from individuals with private medical insurance between 2010-2018 to quantify GAS pharyngitis visit rates across U.S. census regions, subregions, and states. We evaluated seasonal and age- ... ...

    Abstract Background: Group A
    Methods: We used outpatient claims data from individuals with private medical insurance between 2010-2018 to quantify GAS pharyngitis visit rates across U.S. census regions, subregions, and states. We evaluated seasonal and age-based patterns of geographic spread and the association between school start dates and the summertime upward inflection in GAS visits.
    Results: The South had the most visits per person (yearly average 39.11 visits per 1000 people, 95% CI: 36.21-42.01), and the West had the fewest (yearly average 17.63 visits per 1000 people, 95% CI: 16.76-18.49). Visits increased earliest in the South and in school-age children. Differences in visits between the South and other regions were most pronounced in the late summer through early winter. Visits peaked earliest in central southern states, in December to January, and latest on the coasts, in March. The onset of the rise in GAS pharyngitis visits correlated with, but preceded, average school start times.
    Conclusions: The burden and timing of GAS pharyngitis varied across the continental U.S., with the South experiencing the highest overall rates and earliest onset and peak in outpatient visits. Understanding the drivers of these regional differences in GAS pharyngitis will help in identifying and targeting prevention measures.
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.16.23298647
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  9. Article ; Online: Generally Applicable Holographic Torque Measurement for Optically Trapped Particles.

    Strasser, Franziska / Barnett, Stephen M / Ritsch-Marte, Monika / Thalhammer, Gregor

    Physical review letters

    2022  Volume 128, Issue 21, Page(s) 213604

    Abstract: We present a method to measure the optical torque applied to particles of arbitrary shape such as micrometer-sized micro-organisms or cells held in an optical trap, inferred from the change of angular momentum of light induced by the particle. All torque ...

    Abstract We present a method to measure the optical torque applied to particles of arbitrary shape such as micrometer-sized micro-organisms or cells held in an optical trap, inferred from the change of angular momentum of light induced by the particle. All torque components can be determined from a single interference pattern recorded by a camera in the back focal plane of a high-NA condenser lens provided that most of the scattered light is collected. We derive explicit expressions mapping the measured complex field in this plane to the torque components. The required phase is retrieved by an iterative algorithm, using the known position of the optical traps as constraints. The torque pertaining to individual particles is accessible, as well as separate spin or orbital parts of the total torque.
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.213604
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  10. Article ; Online: A rapid environmental risk assessment of the Kakhovka Dam breach during the Ukraine conflict.

    Spears, Bryan M / Harpham, Quillon / Brown, Emma / Barnett, Catherine L / Barwell, Louise / Collell, Marta Roca / Davison, Mark / Dixon, Harry / Elliott, J Alex / Garbutt, Angus / Hazlewood, Caroline / Hofmann, Barbara / Lanyon, James / Lofts, Stephen / MacKechnie, Colin / Medinets, Sergiy / Noble, James / Ramsbottom, David / Redhead, John W /
    Riera, Alberto / Spurgeon, David J / Svendsen, Claus / Taylor, Philip / Thackeray, Stephen J / Turvey, Katharine / Wood, Michael D

    Nature ecology & evolution

    2024  Volume 8, Issue 5, Page(s) 834–836

    MeSH term(s) Ukraine ; Risk Assessment ; Rivers
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Letter ; Journal Article
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-024-02373-0
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