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  1. Article ; Online: Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation.

    Mikhailov, Alexander T / Torrado, Mario

    Journal of molecular medicine (Berlin, Germany)

    2018  Volume 96, Issue 7, Page(s) 601–610

    Abstract: There is growing evidence that putative gene regulatory networks including cardio-enriched transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target genes along with downstream non-coding RNAs can play a potentially ... ...

    Abstract There is growing evidence that putative gene regulatory networks including cardio-enriched transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target genes along with downstream non-coding RNAs can play a potentially important role in the process of adaptive and maladaptive atrial rhythm remodeling. In turn, expression of atrial fibrillation-associated transcription factors is under the control of upstream regulatory non-coding RNAs. This review broadly explores gene regulatory mechanisms associated with susceptibility to atrial fibrillation-with key examples from both animal models and patients-within the context of both cardiac transcription factors and non-coding RNAs. These two systems appear to have multiple levels of cross-regulation and act coordinately to achieve effective control of atrial rhythm effector gene expression. Perturbations of a dynamic expression balance between transcription factors and corresponding non-coding RNAs can provoke the development or promote the progression of atrial fibrillation. We also outline deficiencies in current models and discuss ongoing studies to clarify remaining mechanistic questions. An understanding of the function of transcription factors and non-coding RNAs in gene regulatory networks associated with atrial fibrillation risk will enable the development of innovative therapeutic strategies.
    MeSH term(s) Animals ; Atrial Fibrillation/genetics ; Atrial Fibrillation/metabolism ; Atrial Fibrillation/physiopathology ; Biomarkers ; Disease Susceptibility ; Gene Expression Regulation ; Humans ; MicroRNAs/genetics ; Models, Biological ; Myocardium/metabolism ; RNA, Untranslated/genetics ; Transcription Factors/metabolism
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Untranslated ; Transcription Factors
    Language English
    Publishing date 2018-05-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-018-1647-4
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
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  2. Article ; Online: Russian comparative embryology takes form: a conceptual metamorphosis toward "evo-devo".

    Mikhailov, Alexander T

    Evolution & development

    2012  Volume 14, Issue 1, Page(s) 9–19

    Abstract: This essay recapitulates major paths followed by the Russian tradition of what we refer to today as evolutionary developmental biology ("evo-devo"). The article addresses several questions regarding the conceptual history of evolutionary embryological ... ...

    Abstract This essay recapitulates major paths followed by the Russian tradition of what we refer to today as evolutionary developmental biology ("evo-devo"). The article addresses several questions regarding the conceptual history of evolutionary embryological thought in its particularly Russian perspective: (1) the assertion by the St. Petersburg academician Wolff regarding the possible connections between environmental modifications during morphogenesis and the "transformation" of species, (2) the discovery of shared "principles" underlying animal development by von Baer, (3) the experimental expression of Baer's principles by Kowalevsky and Mechnikoff, (4) Severtsov's theory of phylembryogenesis, (5) Filatov's approach to the study of evolution using comparative "developmental mechanics", and (6) Shmalgausen's concept of "stabilizing" selection as an attempt to elucidate the evolution of developmental mechanisms. The focus on comparative evolutionary embryology, which was established by Kowalevsky and Mechnikoff, still continues to be popular in present-day "evo-devo" research in Russia.
    MeSH term(s) Anatomy, Comparative/history ; Biological Evolution ; Embryology/history ; History, 18th Century ; History, 19th Century ; History, 20th Century ; Natural History/history ; Russia ; Russia (Pre-1917) ; Zoology/history
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020288-X
    ISSN 1525-142X ; 1520-541X
    ISSN (online) 1525-142X
    ISSN 1520-541X
    DOI 10.1111/j.1525-142X.2011.00518.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.

    Mikhailov, Alexander T / Torrado, Mario

    Heart failure reviews

    2016  Volume 21, Issue 6, Page(s) 783–794

    Abstract: There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still ... ...

    Abstract There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially important role of core cardio-enriched transcription factors (TFs) in the control of cardiac diastolic function in health and disease through their ability to regulate the expression of target genes involved in the process of adaptive and maladaptive cardiac remodeling. The current relevant findings on the role of a variety of such TFs (TBX5, GATA-4/6, SRF, MYOCD, NRF2, and PITX2) in cardiac diastolic dysfunction and failure are updated, emphasizing their potential as promising targets for novel treatment strategies. In turn, the new animal models described here will be key tools in determining the underlying molecular mechanisms of disease. Since diastolic dysfunction is regulated by various TFs, which are also involved in cross talk with each other, there is a need for more in-depth research from a biomedical perspective in order to establish efficient therapeutic strategies.
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-016-9569-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Humoral Immune Responses in Patients with Severe COVID-19: A Comparative Pilot Study between Individuals Infected by SARS-CoV-2 during the Wild-Type and the Delta Periods.

    Sukhova, Maria / Byazrova, Maria / Mikhailov, Artem / Yusubalieva, Gaukhar / Maslova, Irina / Belovezhets, Tatyana / Chikaev, Nikolay / Vorobiev, Ivan / Baklaushev, Vladimir / Filatov, Alexander

    Microorganisms

    2023  Volume 11, Issue 9

    Abstract: Since the onset of the COVID-19 pandemic, humanity has experienced the spread and circulation of several SARS-CoV-2 variants that differed in transmissibility, contagiousness, and the ability to escape from vaccine-induced neutralizing antibodies. ... ...

    Abstract Since the onset of the COVID-19 pandemic, humanity has experienced the spread and circulation of several SARS-CoV-2 variants that differed in transmissibility, contagiousness, and the ability to escape from vaccine-induced neutralizing antibodies. However, issues related to the differences in the variant-specific immune responses remain insufficiently studied. The aim of this study was to compare the parameters of the humoral immune responses in two groups of patients with acute COVID-19 who were infected during the circulation period of the D614G and the Delta variants of SARS-CoV-2. Sera from 48 patients with acute COVID-19 were tested for SARS-CoV-2 binding and neutralizing antibodies using six assays. We found that serum samples from the D614G period demonstrated 3.9- and 1.6-fold increases in RBD- and spike-specific IgG binding with wild-type antigens compared with Delta variant antigens (
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11092347
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  5. Article: Assessment of Diagnostic Specificity of Anti-SARS-CoV-2 Antibody Tests and Their Application for Monitoring of Seroconversion and Stability of Antiviral Antibody Response in Healthcare Workers in Moscow.

    Kichatova, Vera S / Asadi Mobarkhan, Fedor A / Potemkin, Ilya A / Zlobin, Sergey P / Perfilieva, Oksana M / Valuev-Elliston, Vladimir T / Ivanov, Alexander V / Solonin, Sergey A / Godkov, Mikhail A / Belikova, Maria G / Mikhailov, Mikhail I / Kyuregyan, Karen K

    Microorganisms

    2022  Volume 10, Issue 2

    Abstract: Anti-SARS-CoV-2 antibody testing is an efficient tool to assess the proportion of seropositive population due to infection and/or vaccination. Numerous test systems utilizing various antigen composition(s) are routinely used for detection and ... ...

    Abstract Anti-SARS-CoV-2 antibody testing is an efficient tool to assess the proportion of seropositive population due to infection and/or vaccination. Numerous test systems utilizing various antigen composition(s) are routinely used for detection and quantitation of anti-SARS-CoV-2 antibodies. We determined their diagnostic specificity using archived true-negative samples collected before the onset of the COVID-19 pandemic. Using test systems demonstrating 98.5-100% specificity, we assessed the dynamics of SARS-CoV-2 seroconversion and durability of anti-spike (S) antibodies in healthcare professionals (
    Language English
    Publishing date 2022-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020429
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  6. Article ; Online: A Novel Heterozygous Intronic Mutation in the

    Torrado, Mario / Maneiro, Emilia / Trujillo-Quintero, Juan Pablo / Evangelista, Arturo / Mikhailov, Alexander T / Monserrat, Lorenzo

    BioMed research international

    2018  Volume 2018, Page(s) 3536495

    Abstract: Marfan syndrome (MFS) is an autosomal dominantly inherited connective tissue disorder, mostly caused by mutations in the fibrillin-1 ( ...

    Abstract Marfan syndrome (MFS) is an autosomal dominantly inherited connective tissue disorder, mostly caused by mutations in the fibrillin-1 (
    MeSH term(s) Adult ; Aorta/pathology ; Dilatation, Pathologic ; Fibrillin-1/genetics ; Heterozygote ; Humans ; Introns/genetics ; Male ; Marfan Syndrome/genetics ; Microfilament Proteins ; Mutation
    Chemical Substances FBN1 protein, human ; Fibrillin-1 ; Microfilament Proteins
    Language English
    Publishing date 2018-05-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/3536495
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  7. Article ; Online: In search of novel targets for heart disease: myocardin and myocardin-related transcriptional cofactors.

    Mikhailov, Alexander T / Torrado, Mario

    Biochemistry research international

    2012  Volume 2012, Page(s) 973723

    Abstract: Growing evidence suggests that gene-regulatory networks, which are responsible for directing cardiovascular development, are altered under stress conditions in the adult heart. The cardiac gene regulatory network is controlled by cardioenriched ... ...

    Abstract Growing evidence suggests that gene-regulatory networks, which are responsible for directing cardiovascular development, are altered under stress conditions in the adult heart. The cardiac gene regulatory network is controlled by cardioenriched transcription factors and multiple-cell-signaling inputs. Transcriptional coactivators also participate in gene-regulatory circuits as the primary targets of both physiological and pathological signals. Here, we focus on the recently discovered myocardin-(MYOCD) related family of transcriptional cofactors (MRTF-A and MRTF-B) which associate with the serum response transcription factor and activate the expression of a variety of target genes involved in cardiac growth and adaptation to stress via overlapping but distinct mechanisms. We discuss the involvement of MYOCD, MRTF-A, and MRTF-B in the development of cardiac dysfunction and to what extent modulation of the expression of these factors in vivo can correlate with cardiac disease outcomes. A close examination of the findings identifies the MYOCD-related transcriptional cofactors as putative therapeutic targets to improve cardiac function in heart failure conditions through distinct context-dependent mechanisms. Nevertheless, we are in support of further research to better understand the precise role of individual MYOCD-related factors in cardiac function and disease, before any therapeutic intervention is to be entertained in preclinical trials.
    Language English
    Publishing date 2012-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566725-7
    ISSN 2090-2255 ; 2090-2255
    ISSN (online) 2090-2255
    ISSN 2090-2255
    DOI 10.1155/2012/973723
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  8. Article ; Online: In Search of Novel Targets for Heart Disease

    Alexander T. Mikhailov / Mario Torrado

    Biochemistry Research International, Vol

    Myocardin and Myocardin-Related Transcriptional Cofactors

    2012  Volume 2012

    Keywords Biochemistry ; QD415-436 ; Organic chemistry ; QD241-441 ; Chemistry ; QD1-999 ; Science ; Q
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Agrobacterium

    Sidorova, Tatiana / Mikhailov, Roman / Pushin, Alexander / Miroshnichenko, Dmitry / Dolgov, Sergey

    Frontiers in plant science

    2019  Volume 10, Page(s) 286

    Abstract: In modern ... ...

    Abstract In modern horticulture
    Language English
    Publishing date 2019-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2019.00286
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  10. Article: Assessment of Diagnostic Specificity of Anti-SARS-CoV-2 Antibody Tests and Their Application for Monitoring of Seroconversion and Stability of Antiviral Antibody Response in Healthcare Workers in Moscow

    Kichatova, Vera S. / Asadi Mobarkhan, Fedor A. / Potemkin, Ilya A. / Zlobin, Sergey P. / Perfilieva, Oksana M. / Valuev-Elliston, Vladimir T. / Ivanov, Alexander V. / Solonin, Sergey A. / Godkov, Mikhail A. / Belikova, Maria G. / Mikhailov, Mikhail I. / Kyuregyan, Karen K.

    Microorganisms. 2022 Feb. 12, v. 10, no. 2

    2022  

    Abstract: Anti-SARS-CoV-2 antibody testing is an efficient tool to assess the proportion of seropositive population due to infection and/or vaccination. Numerous test systems utilizing various antigen composition(s) are routinely used for detection and ... ...

    Abstract Anti-SARS-CoV-2 antibody testing is an efficient tool to assess the proportion of seropositive population due to infection and/or vaccination. Numerous test systems utilizing various antigen composition(s) are routinely used for detection and quantitation of anti-SARS-CoV-2 antibodies. We determined their diagnostic specificity using archived true-negative samples collected before the onset of the COVID-19 pandemic. Using test systems demonstrating 98.5–100% specificity, we assessed the dynamics of SARS-CoV-2 seroconversion and durability of anti-spike (S) antibodies in healthcare professionals (n = 100) working in Moscow during the first two cycles of the pandemic (May 2020 to June 2021) outside of the “red zone”. Analysis revealed a rapid increase in anti-SARS-CoV-2 seropositivity from 19 to 80% (19/100 and 80/100, respectively) due to virus exposition/infection; only 16.3% of seroconversion cases (13/80) were due to vaccination, but not the virus exposure, although massive COVID-19 vaccination of healthcare workers was performed beginning in December 2020. In total, 12.7% (8/63) remained positive for anti-SARS-CoV-2 IgM for >6 months, indicating unsuitability of IgM for identification of newly infected individuals. All except one remained seropositive for anti-S antibodies for >9 months on average. Significant (>15%) declines in anti-SARS-CoV-2 antibody concentrations were observed in only 18% of individuals (9/50). Our data on the high seropositivity rate and stability of anti-SARS-CoV-2 antibody levels in healthcare personnel working outside of the “red zone” indicate their regular exposition to SARS-CoV-2/an increased risk of infection, while a low frequency of vaccine-induced antibody response acquired after the start of vaccination points to vaccine hesitancy.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; antibody formation ; antigens ; diagnostic specificity ; durability ; health care workers ; health services ; pandemic ; risk ; seroconversion ; seroprevalence ; vaccination ; vaccines ; viruses
    Language English
    Dates of publication 2022-0212
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020429
    Database NAL-Catalogue (AGRICOLA)

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