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  1. Article ; Online: A comprehensive observation on the pollution characteristics of peroxyacetyl nitrate (PAN) in Beijing, China.

    Zhang, Hailiang / Tong, Shengrui / Zhang, Wenqian / Xu, Yanyong / Zhai, Mingzhu / Guo, Yucong / Li, Xin / Wang, Lili / Tang, Guiqian / Liu, Zirui / Hu, Bo / Liu, Chengtang / Liu, Pengfei / Sun, Xu / Mu, Yujing / Ge, Maofa

    The Science of the total environment

    2023  Volume 905, Page(s) 166852

    Abstract: Peroxyacetyl nitrate (PAN) is a typical secondary photochemical product in the atmospheric ... environment with significant adverse effects on human health and plant growth. In this study, PAN and ... at a typical urban sampling site in Beijing, China. The mean and maximum PAN concentrations during ...

    Abstract Peroxyacetyl nitrate (PAN) is a typical secondary photochemical product in the atmospheric environment with significant adverse effects on human health and plant growth. In this study, PAN and other pollutants, as well as meteorological conditions were observed intensively from August to September in 2022 at a typical urban sampling site in Beijing, China. The mean and maximum PAN concentrations during the observation period were 1.00 ± 0.97 ppb and 4.84 ppb, respectively. Severe photochemical pollution occurred during the observation period, with the mean PAN concentration about 3.1 times higher than that during the clean period. There was a good positive correlation between O
    Language English
    Publishing date 2023-09-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.166852
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    Zs.A 949: Show issues Location:
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  2. Article ; Online: Pan-cancer analysis implicates novel insights of lactate metabolism into immunotherapy response prediction and survival prognostication.

    Chen, Dongjie / Liu, Pengyi / Lu, Xiongxiong / Li, Jingfeng / Qi, Debin / Zang, Longjun / Lin, Jiayu / Liu, Yihao / Zhai, Shuyu / Fu, Da / Weng, Yuanchi / Li, Hongzhe / Shen, Baiyong

    Journal of experimental & clinical cancer research : CR

    2024  Volume 43, Issue 1, Page(s) 125

    Abstract: ... A novel LM-related signature (LM.SIG) was formulated through an extensive examination of 40 pan-cancer ... immunotherapy transcriptomic cohorts and 30 The Cancer Genome Atlas (TCGA) pan-cancer datasets. Moreover ... relationship with immunotherapy resistance in 2 immunotherapy scRNA-seq cohorts. Based on large-scale pan ...

    Abstract Background: Immunotherapy has emerged as a potent clinical approach for cancer treatment, but only subsets of cancer patients can benefit from it. Targeting lactate metabolism (LM) in tumor cells as a method to potentiate anti-tumor immune responses represents a promising therapeutic strategy.
    Methods: Public single-cell RNA-Seq (scRNA-seq) cohorts collected from patients who received immunotherapy were systematically gathered and scrutinized to delineate the association between LM and the immunotherapy response. A novel LM-related signature (LM.SIG) was formulated through an extensive examination of 40 pan-cancer scRNA-seq cohorts. Then, multiple machine learning (ML) algorithms were employed to validate the capacity of LM.SIG for immunotherapy response prediction and survival prognostication based on 8 immunotherapy transcriptomic cohorts and 30 The Cancer Genome Atlas (TCGA) pan-cancer datasets. Moreover, potential targets for immunotherapy were identified based on 17 CRISPR datasets and validated via in vivo and in vitro experiments.
    Results: The assessment of LM was confirmed to possess a substantial relationship with immunotherapy resistance in 2 immunotherapy scRNA-seq cohorts. Based on large-scale pan-cancer data, there exists a notably adverse correlation between LM.SIG and anti-tumor immunity as well as imbalance infiltration of immune cells, whereas a positive association was observed between LM.SIG and pro-tumorigenic signaling. Utilizing this signature, the ML model predicted immunotherapy response and prognosis with an AUC of 0.73/0.80 in validation sets and 0.70/0.87 in testing sets respectively. Notably, LM.SIG exhibited superior predictive performance across various cancers compared to published signatures. Subsequently, CRISPR screening identified LDHA as a pan-cancer biomarker for estimating immunotherapy response and survival probability which was further validated using immunohistochemistry (IHC) and spatial transcriptomics (ST) datasets. Furthermore, experiments demonstrated that LDHA deficiency in pancreatic cancer elevated the CD8
    Conclusions: We unveiled the tight correlation between LM and resistance to immunotherapy and further established the pan-cancer LM.SIG, holds the potential to emerge as a competitive instrument for the selection of patients suitable for immunotherapy.
    MeSH term(s) Humans ; Immunotherapy/methods ; Prognosis ; Neoplasms/immunology ; Neoplasms/therapy ; Neoplasms/mortality ; Neoplasms/metabolism ; Neoplasms/genetics ; Lactic Acid/metabolism ; Mice ; Animals ; Female
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-024-03042-7
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    Zs.A 2065: Show issues Location:
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  3. Article ; Online: Targeting Pan-ETS Factors Inhibits Melanoma Progression.

    Huang, Lee / Zhai, Yougang / La, Jennifer / Lui, Jason W / Moore, Stephen P G / Little, Elizabeth C / Xiao, Sixia / Haresi, Adil J / Brem, Candice / Bhawan, Jag / Lang, Deborah

    Cancer research

    2021  Volume 81, Issue 8, Page(s) 2071–2085

    Abstract: The failure of once promising target-specific therapeutic strategies often arises from redundancies in gene expression pathways. Even with new melanoma treatments, many patients are not responsive or develop resistance, leading to disease progression in ... ...

    Abstract The failure of once promising target-specific therapeutic strategies often arises from redundancies in gene expression pathways. Even with new melanoma treatments, many patients are not responsive or develop resistance, leading to disease progression in terms of growth and metastasis. We previously discovered that the transcription factors ETS1 and PAX3 drive melanoma growth and metastasis by promoting the expression of the MET receptor. Here, we find that there are multiple ETS family members expressed in melanoma and that these factors have redundant functions. The small molecule YK-4-279, initially developed to target the ETS gene-containing translocation product EWS-FLI1, significantly inhibited cellular growth, invasion, and ETS factor function in melanoma cell lines and a clinically relevant transgenic mouse model, BrafCA;Tyr-CreERT2;Ptenf/f. One of the antitumor effects of YK-4-279 in melanoma is achieved via interference of multiple ETS family members with PAX3 and the expression of the PAX3-ETS downstream gene MET. Expression of exogenous MET provided partial rescue of the effects of YK-4-279, further supporting that MET loss is a significant contributor to the antitumor effects of the drug. This is the first study identifying multiple overlapping functions of the ETS family promoting melanoma. In addition, targeting all factors, rather than individual members, demonstrated impactful deleterious consequences in melanoma progression. Given that multiple ETS factors are known to have oncogenic functions in other malignancies, these findings have a high therapeutic impact. SIGNIFICANCE: These findings identify YK-4-279 as a promising therapeutic agent against melanoma by targeting multiple ETS family members and blocking their ability to act as transcription factors.
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/metabolism ; Disease Progression ; Humans ; Indoles/pharmacology ; Melanoma/drug therapy ; Melanoma/metabolism ; Melanoma/pathology ; Mice ; Mice, Transgenic ; Neoplasm Invasiveness ; Oncogene Proteins, Fusion/antagonists & inhibitors ; PAX3 Transcription Factor/antagonists & inhibitors ; PAX3 Transcription Factor/metabolism ; Proto-Oncogene Protein c-ets-1/antagonists & inhibitors ; Proto-Oncogene Protein c-ets-1/metabolism ; Proto-Oncogene Protein c-fli-1/antagonists & inhibitors ; Proto-Oncogene Proteins c-ets/antagonists & inhibitors ; Proto-Oncogene Proteins c-ets/metabolism ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; RNA-Binding Protein EWS/antagonists & inhibitors ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism
    Chemical Substances DNA-Binding Proteins ; ETV4 protein, human ; ETV5 protein, human ; EWS-FLI fusion protein ; Indoles ; Oncogene Proteins, Fusion ; PAX3 Transcription Factor ; PAX3 protein, human ; Proto-Oncogene Protein c-ets-1 ; Proto-Oncogene Protein c-fli-1 ; Proto-Oncogene Proteins c-ets ; RNA-Binding Protein EWS ; Transcription Factors ; YK 4-279 ; MET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-19-1668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.135/5: Show issues Location:
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  4. Article ; Online: Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer.

    Huang, Da / Shen, Jiayu / Zhai, Lingyun / Chen, Huanhuan / Fei, Jing / Zhu, Xiaoqing / Zhou, Jianwei

    Frontiers in immunology

    2022  Volume 12, Page(s) 812713

    Abstract: N-Acylethanolamine Acid Amidase ( ...

    Abstract N-Acylethanolamine Acid Amidase (
    MeSH term(s) Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Biomarkers, Tumor ; Computational Biology/methods ; DNA Copy Number Variations ; DNA Methylation ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunomodulation/genetics ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Microsatellite Instability ; Mutation ; Neoplasms/diagnosis ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/mortality ; Prognosis ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
    Chemical Substances Biomarkers, Tumor ; Amidohydrolases (EC 3.5.-) ; NAAA protein, human (EC 3.5.1.-)
    Language English
    Publishing date 2022-01-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.812713
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  5. Article ; Online: Preparation of ZIF-8/PAN composite nanofiber membrane and its application in acetone gas monitoring.

    Niu, Ben / Zhai, Zhenyu / Wang, Jiaona / Li, Congju

    Nanotechnology

    2023  Volume 34, Issue 24

    Abstract: ... particles with polyacrylonitrile (PAN) nanofibers. ZIF-8/PAN composite nanofiber membrane. The ZIF-8/PAN ...

    Abstract Znic-based metal-organic framework materials (ZIF-8) show great potential and excellent performance in the fields of sensing and catalysis. However, powdered metal-organic framework makes it easy to lose in the process of application. Herein, we use a simple blending electrostatic spinning method to combine ZIF-8 particles with polyacrylonitrile (PAN) nanofibers. ZIF-8/PAN composite nanofiber membrane. The ZIF-8/PAN nanofiber membrane is characterized by scanning electron microscope (SEM), x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and N
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/acc4ca
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  6. Article ; Online: Integrative pan cancer analysis reveals the importance of CFTR in lung adenocarcinoma prognosis.

    Shi, Xiaoshun / Kou, Mengying / Dong, Xiaoying / Zhai, Jianxue / Liu, Xiguang / Lu, Di / Ni, Zhen / Jiang, Jianjun / Cai, Kaican

    Genomics

    2022  Volume 114, Issue 2, Page(s) 110279

    Abstract: Cystic fibrosis (CF) and cystic fibrosis transmembrane conductance regulator (CFTR) mutations have been shown to be associated with the risk of a variety of cancers. However, the clinical significance of aberrant CFTR gene expression in human tumors ... ...

    Abstract Cystic fibrosis (CF) and cystic fibrosis transmembrane conductance regulator (CFTR) mutations have been shown to be associated with the risk of a variety of cancers. However, the clinical significance of aberrant CFTR gene expression in human tumors remains unknown. The expression profiles and prognostic landscapes of CFTR in human cancers were identified from the PubMed, OVID, CNKI, TCGA, ONCOMINE, PrognoScan, and GEPIA databases. Over 11, 000 cancer samples from the literature, GEPIA database, and PrognoScan database were included in this study. In general, CFTR has various expression and prognostic profiles in cancers, but the results from cross-database and meta-analyses revealed that CFTR is a robust biomarker for LUAD prognosis. Collectively, this study suggests that CFTR is an important prognostic biomarker for LUAD survival, implying that it could be used as a prognostic biomarker and therapeutic target for LUAD.
    MeSH term(s) Adenocarcinoma of Lung/metabolism ; Biomarkers ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Lung Neoplasms/pathology ; Mutation ; Prognosis
    Chemical Substances Biomarkers ; CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2022.110279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2367: Show issues Location:
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  7. Article ; Online: Pan-cancer pervasive upregulation of 3' UTR splicing drives tumourigenesis.

    Chan, Jia Jia / Zhang, Bin / Chew, Xiao Hong / Salhi, Adil / Kwok, Zhi Hao / Lim, Chun You / Desi, Ng / Subramaniam, Nagavidya / Siemens, Angela / Kinanti, Tyas / Ong, Shane / Sanchez-Mejias, Avencia / Ly, Phuong Thao / An, Omer / Sundar, Raghav / Fan, Xiaonan / Wang, Shi / Siew, Bei En / Lee, Kuok Chung /
    Chong, Choon Seng / Lieske, Bettina / Cheong, Wai-Kit / Goh, Yufen / Fam, Wee Nih / Ooi, Melissa G / Koh, Bryan T H / Iyer, Shridhar Ganpathi / Ling, Wen Huan / Chen, Jianbin / Yoong, Boon-Koon / Chanwat, Rawisak / Bonney, Glenn Kunnath / Goh, Brian K P / Zhai, Weiwei / Fullwood, Melissa J / Wang, Wilson / Tan, Ker-Kan / Chng, Wee Joo / Dan, Yock Young / Pitt, Jason J / Roca, Xavier / Guccione, Ernesto / Vardy, Leah A / Chen, Leilei / Gao, Xin / Chow, Pierce K H / Yang, Henry / Tay, Yvonne

    Nature cell biology

    2022  Volume 24, Issue 6, Page(s) 928–939

    Abstract: ... studies have traditionally focused on protein-coding alterations. Here we systematically map the pan ...

    Abstract Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3' UTR ends via alternative polyadenylation can activate oncogenes. However, internal 3' UTR splicing remains poorly understood as splicing studies have traditionally focused on protein-coding alterations. Here we systematically map the pan-cancer landscape of 3' UTR splicing and present this in SpUR ( http://www.cbrc.kaust.edu.sa/spur/home/ ). 3' UTR splicing is widespread, upregulated in cancers, correlated with poor prognosis and more prevalent in oncogenes. We show that antisense oligonucleotide-mediated inhibition of 3' UTR splicing efficiently reduces oncogene expression and impedes tumour progression. Notably, CTNNB1 3' UTR splicing is the most consistently dysregulated event across cancers. We validate its upregulation in hepatocellular carcinoma and colon adenocarcinoma, and show that the spliced 3' UTR variant is the predominant contributor to its oncogenic functions. Overall, our study highlights the importance of 3' UTR splicing in cancer and may launch new avenues for RNA-based anti-cancer therapeutics.
    MeSH term(s) 3' Untranslated Regions/genetics ; Adenocarcinoma/genetics ; Alternative Splicing/genetics ; Animals ; Carcinogenesis/genetics ; Colonic Neoplasms/genetics ; Mammals ; Up-Regulation
    Chemical Substances 3' Untranslated Regions
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-022-00913-z
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    Zs.A 5169: Show issues Location:
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  8. Article: Pan-Immune-Inflammatory Value in Patients with Non-Small-Cell Lung Cancer Undergoing Neoadjuvant Immunochemotherapy.

    Zhai, Wen-Yu / Duan, Fang-Fang / Lin, Yao-Bin / Lin, Yong-Bin / Zhao, Ze-Rui / Wang, Jun-Ye / Rao, Bing-Yu / Zheng, Lie / Long, Hao

    Journal of inflammation research

    2023  Volume 16, Page(s) 3329–3339

    Abstract: ... pan-immune-inflammatory value (PIV), in pathological complete response (pCR) of patients ...

    Abstract Background: We aimed to investigate the predictive value of a systematic serum inflammation index, pan-immune-inflammatory value (PIV), in pathological complete response (pCR) of patients treated with neoadjuvant immunotherapy to further promote ideal patients' selection.
    Methods: The clinicopathological and baseline laboratory information of 128 NSCLC patients receiving neoadjuvant immunochemotherapy between October 2019 and April 2022 were retrospectively reviewed. We performed least absolute shrinkage and selection operator (LASSO) algorithm to screen candidate serum biomarkers for predicting pCR, which further entered the multivariate logistic regression model to determine final biomarkers. Accordingly, a diagnostic model for predicting individual pCR was established. Kaplan-Meier method was utilized to estimate curves of disease-free survival (DFS), and the Log rank test was analyzed to compare DFS differences between patients with and without pCR.
    Results: Patients with NSCLC heterogeneously responded to neoadjuvant immunotherapy, and those with pCR had a significant longer DFS than patients without pCR. Through LASSO and the multivariate logistic regression model, PIV was identified as a predictor for predicting pCR of patients. Subsequently, a diagnostic model integrating with PIV, differentiated degree and histological type was constructed to predict pCR, which presented a satisfactory predictive power (AUC, 0.736), significant agreement between actual and our nomogram-predicted pathological response.
    Conclusion: Baseline PIV was an independent predictor of pCR for NSCLC patients receiving neoadjuvant immunochemotherapy. A significantly longer DFS was achieved in patients with pCR rather than those without pCR; thus, the PIV-based diagnostic model might serve as a practical tool to identify ideal patients for neoadjuvant immunotherapeutic guidance.
    Language English
    Publishing date 2023-08-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S418276
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  9. Article: Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome.

    Müller, Philipp / Velazquez Camacho, Oscar / Yazbeck, Ali M / Wölwer, Christina / Zhai, Weiwei / Schumacher, Johannes / Heider, Dominik / Buettner, Reinhard / Quaas, Alexander / Hillmer, Axel M

    Computational and structural biotechnology journal

    2023  Volume 21, Page(s) 1573–1583

    Abstract: Loss of the Y chromosome (LoY) is frequently observed in somatic cells of elderly men. However, LoY is highly increased in tumor tissue and correlates with an overall worse prognosis. The underlying causes and downstream effects of LoY are widely unknown. ...

    Abstract Loss of the Y chromosome (LoY) is frequently observed in somatic cells of elderly men. However, LoY is highly increased in tumor tissue and correlates with an overall worse prognosis. The underlying causes and downstream effects of LoY are widely unknown. Therefore, we analyzed genomic and transcriptomic data of 13 cancer types (2375 patients) and classified tumors of male patients according to loss or retain of the Y chromosome (LoY or RoY, average LoY fraction: 0.46). The frequencies of LoY ranged from almost absence (glioblastoma, glioma, thyroid carcinoma) to 77% (kidney renal papillary cell carcinoma). Genomic instability, aneuploidy, and mutation burden were enriched in LoY tumors. In addition, we found more frequently in LoY tumors the gate keeping tumor suppressor gene
    Language English
    Publishing date 2023-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2023.02.024
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  10. Article ; Online: A pan-cancer analysis of prognostic significance and immunological role of lysosomal-associated membrane protein 3.

    Feng, Xuefei / Gao, Lvye / Shen, Xinyuan / Li, Mingtai / Wang, Xiaohui / Hao, Yanlong / Chen, Jinyan / Zhai, Yuanfang / Zou, Binbin / Yao, Shangman / Guo, Yanlin / Zhang, Ling

    Journal of cellular and molecular medicine

    2023  Volume 28, Issue 3, Page(s) e18088

    Abstract: ... in pan-cancer using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database ...

    Abstract Lysosomal dysfunction can drive carcinogenesis. Lysosomal-associated membrane protein 3 (LAMP3), is a member of the Lysosome Associated Membrane Proteins and is involved in the malignant phenotype such as tumour metastasis and drug resistance, while the mechanisms that regulate the malignant progression of tumour remain vague. Our study aims to provide a more systematic and comprehensive understanding of the role of LAMP3 in the progression of various cancers by various databases.We explored the role of LAMP3 in pan-cancer using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database. Multiple online web platforms and software were used for data analysis, including HPA, TIMER, TISIDB, GEPIA, UALCAN, Kaplan-Meier plotter, DAVID and TIGER. The immunohistochemistry was used to quantify the LAMP3 and PD-L1 expression levels in cancer.High LAMP3 expression was found in most cancers and differentially expressed across molecular and immune subtypes. The expression of LAMP3 was involved in the immune-associated processes of Antigen processing and presentation, Th17 cell differentiation, Th1 and Th2 cell differentiation, and the immune-associated pathways of T cell receptor and B cell receptor signalling pathways in most cancers. It also correlated with genetic markers of immunomodulators in various cancers. LAMP3 and PD-L1 expression in BRCA and HNSC tissues was higher than that in corresponding adjacent normal tissues by immunohistochemistry. There is a significant correlation between the expression of LAMP3 and PD-L1.Our study elucidates that LAMP3 has different expression patterns and genetic alteration patterns in different tumours. It is a potential biomarker for immune-related cancer diagnosis, prognosis and efficacy prediction.
    MeSH term(s) Humans ; B7-H1 Antigen ; Lysosomal-Associated Membrane Protein 3 ; Prognosis ; Lysosomal Membrane Proteins ; Neoplasms
    Chemical Substances B7-H1 Antigen ; Lysosomal-Associated Membrane Protein 3 ; Lysosomal Membrane Proteins
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18088
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