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Article: Maintaining psychological well-being amidst the COVID-19 pandemic: The beneficial effects of health-promoting behaviors and sense of control.

Chung, Edwin Ka Hung / Ho, Alvin Ka Kin / Lam, Alfred Hiu Ki / Yeung, Dannii Yuen-Lan

Current psychology (New Brunswick, N.J.)

2023 , Page(s) 1–15

Abstract: The present research reports the findings of three studies, with objectives to demonstrate the impacts of health-promoting behaviors on psychological well-being as well as the mediating roles of sense of control (SOC) and perceived severity of COVID-19 ... ...

Abstract	The present research reports the findings of three studies, with objectives to demonstrate the impacts of health-promoting behaviors on psychological well-being as well as the mediating roles of sense of control (SOC) and perceived severity of COVID-19 in these relationships. Study 1 was a cross-sectional survey conducted in 473 middle-aged and older Chinese adults before the COVID-19 pandemic to assess their health-promoting behaviors, personal mastery and perceived constraints, life satisfaction, and depressive symptoms. Study 2 was conducted during the second wave of the COVID-19 outbreak in Hong Kong (between March to April 2020), in which 292 participants from Study 1 were successfully contacted to report their emotional responses to the pandemic. Using a different sample, Study 3 was a longitudinal study that measured 495 participants' health-promoting behaviors, personal mastery and perceived constraints at baseline, and their perceived severity and mental health outcomes during the outbreak of omicron cases in Hong Kong (i.e., the fifth wave of the COVID-19 outbreak) in March 2022. All three studies demonstrate that the beneficial effects of health behaviors can be extended to psychological well-being and reveal possible underlying mechanisms through enhancing one's SOC and lowering perceived severity of the COVID-19 outbreak. These results provide important insights to future health promotion programs for improving psychological resources and psychological well-being of middle-aged and older adults in face of disease-related threats.
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021598-8
ISSN	1936-4733 ; 1046-1310
ISSN (online)	1936-4733
ISSN	1046-1310
DOI	10.1007/s12144-023-04514-3
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Article ; Online: USP6-translocated fibroblastic tumour with lipofibromatosis-like morphology.

Yeung, Maximus C F / Yau, Raymond C H / Ho, Kenneth W Y / Lam, Albert Y L / Shek, Tony W H

Pathology

2023 Volume 56, Issue 3, Page(s) 428–431

MeSH term(s)	Humans ; Fibroma/diagnosis ; Fibroma/pathology ; Lipoma/diagnosis ; Lipoma/pathology ; Ubiquitin Thiolesterase
Chemical Substances	Ubiquitin Thiolesterase (EC 3.4.19.12) ; USP6 protein, human (EC 3.4.19.12)
Language	English
Publishing date	2023-09-30
Publishing country	England
Document type	Letter
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2023.07.012
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Zs.A 723: Show issues

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Article ; Online: Active School Commuting in School Children: A Narrative Review of Current Evidence and Future Research Implications.

Lam, Ho Yeung / Jayasinghe, Sisitha / Ahuja, Kiran D K / Hills, Andrew P

International journal of environmental research and public health

2023 Volume 20, Issue 20

Abstract: Active school commuting (ASC) has been proposed as a practical way to inculcate positive physical activity habits in children. This paper reviews the current evidence regarding ASC among children, highlights advances in research techniques and existing ... ...

Abstract	Active school commuting (ASC) has been proposed as a practical way to inculcate positive physical activity habits in children. This paper reviews the current evidence regarding ASC among children, highlights advances in research techniques and existing limitations in the field, and outlines future implications for research and promotion. A comprehensive literature search was conducted to identify English language studies on ASC among children aged 6-12 years, followed by a narrative review. ASC has witnessed a global decline, despite evidence of its contribution to physical activity levels. Context-dependent factors such as commuting distance and parental safety concerns are consistently identified as key determinants of ASC. Several promising interventions have been identified. Despite the limitations in intervention scope and quality, notable advancements in research techniques, such as multilevel regression and agent-based modelling, have been identified. Effective promotion of ASC to tackle childhood physical inactivity requires collaborative efforts among schools, parents, and the government, and should be tailored to address multilevel determinants within the local context. Future research should leverage recent advancements in research techniques to develop effective promotion strategies, while considering the context-dependent nature of ASC behaviours and addressing existing limitations, including the lack of standardised definitions and limited geographical and age coverage.
MeSH term(s)	Humans ; Child ; Transportation/methods ; Exercise ; Schools ; Research Design ; Residence Characteristics ; Walking ; Bicycling
Language	English
Publishing date	2023-10-16
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20206929
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Article ; Online: Aerosol Generating Procedure, Aerosol, and Personal Protective Equipment: The Link Is Still Missing.

Cheung, Jonathan Chun-Hei / Ho, Lap Tin / Yip, Yu-Yeung / Lam, Koon Ngai

Critical care medicine

2022 Volume 49, Issue 10, Page(s) e1054–e1055

MeSH term(s)	Aerosols ; COVID-19 ; Humans ; Personal Protective Equipment
Chemical Substances	Aerosols
Language	English
Publishing date	2022-05-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000005127
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Article ; Online: A single-cell atlas of conventional central chondrosarcoma reveals the role of endoplasmic reticulum stress in malignant transformation.

Su, Zezhuo / Ho, Joshua Wing Kei / Yau, Raymond Ching Hing / Lam, Ying Lee / Shek, Tony Wai Hung / Yeung, Maximus Chun Fai / Chen, Hongtai / Oreffo, Richard O C / Cheah, Kathryn Song Eng / Cheung, Kelvin Sin Chi

Communications biology

2024 Volume 7, Issue 1, Page(s) 124

Abstract: The transformation of benign lesions to malignant tumours is a crucial aspect of understanding chondrosarcomas, which are malignant cartilage tumours that could develop from benign chondroid lesions. However, the process of malignant transformation for ... ...

Abstract	The transformation of benign lesions to malignant tumours is a crucial aspect of understanding chondrosarcomas, which are malignant cartilage tumours that could develop from benign chondroid lesions. However, the process of malignant transformation for chondroid lesions remains poorly understood, and no reliable markers are available to aid clinical decision-making. To address this issue, we conducted a study analysing 11 primary cartilage tumours and controls using single-cell RNA sequencing. By creating a single-cell atlas, we were able to identify the role of endoplasmic reticulum (ER) stress in the malignant transformation of conventional central chondrosarcomas (CCCS). Our research revealed that lower levels of ER stress promote chondrosarcoma growth in a patient-derived xenograft mouse model, while intensive ER stress reduces primary chondrosarcoma cell viability. Furthermore, we discovered that the NF-κB pathway alleviates ER stress-induced apoptosis during chondrosarcoma progression. Our single-cell signatures and large public data support the use of key ER stress regulators, such as DNA Damage Inducible Transcript 3 (DDIT3; also known as CHOP), as malignant markers for overall patient survival. Ultimately, our study highlights the significant role that ER stress plays in the malignant transformation of cartilaginous tumours and provides a valuable resource for future diagnostic markers and therapeutic strategies.
MeSH term(s)	Humans ; Animals ; Mice ; Chondrosarcoma/genetics ; Apoptosis ; Ascomycota ; Cell Survival ; Disease Models, Animal ; Endoplasmic Reticulum Stress
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05790-w
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Article ; Online: Testing a New Protocol of Nature-Based Intervention to Enhance Well-Being: A Randomized Control Trial.

Ho, Po Lam / Li, Tsz Wai / Liu, Huinan / Yeung, Tsun Fung / Hou, Wai Kai

International journal of environmental research and public health

2022 Volume 19, Issue 7

Abstract: This study aims to test the associations of nature contact with multiple dimensions of psychological functioning. A total of 90 university employees were randomly assigned to spend their lunch breaks on (1) a 30-min structured protocol of nature contact ... ...

Abstract	This study aims to test the associations of nature contact with multiple dimensions of psychological functioning. A total of 90 university employees were randomly assigned to spend their lunch breaks on (1) a 30-min structured protocol of nature contact and (2) a control group for 10 consecutive weekdays. Psychological distress, psychological well-being, and work-related psychological outcomes were assessed at baseline (T1), the day after the 10-day intervention (T2), and three months after the intervention (T3). Mixed-design analyses of variance (ANOVA) were conducted. Overall, significant intervention effects were found in the structured protocol of nature contact on psychological distress, well-being outcomes, and work engagement (all p < 0.05), whereas the 3-month post-intervention effects were non-significant. Our study showed that nature-based activities during lunch breaks could enhance office workers’ mental health in general, but the effects could be short-lived, calling for regular nature-based programs in occupational settings.
MeSH term(s)	Humans ; Lunch ; Mental Health ; Occupational Health ; Relaxation Therapy
Language	English
Publishing date	2022-03-25
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19073931
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Article: Comparing the effectiveness of robot-based to human-based intervention in improving joint attention in autistic children.

So, Wing-Chee / Law, Wing-Wun / Cheng, Chun-Ho / Lee, Cassandra / Ng, Ka-Ching / Kwok, Fai-Yeung / Lam, Ho-Wai / Lam, Ka-Yee

Frontiers in psychiatry

2023 Volume 14, Page(s) 1114907

Abstract: Background: Children with autism have impairments in initiation of joint attention (IJA) and response to joint attention (RJA).: Aims: The present study compared the learning effectiveness of robot-based intervention (RBI) with that of content- ... ...

Abstract	Background: Children with autism have impairments in initiation of joint attention (IJA) and response to joint attention (RJA). Aims: The present study compared the learning effectiveness of robot-based intervention (RBI) with that of content-matched human-based intervention (HBI) in improving joint attention (JA). We examined whether RBI would enhance RJA, in comparison to HBI. We also examined whether RBI would increase IJA, in comparison to HBI. Methods and procedures: Thirty-eight Chinese-speaking children with autism aged 6 to 9 years were randomly assigned to RBI and HBI groups. Before intervention, their autism severity, cognitive abilities, and language skills were assessed. Each child received six 30-min training sessions over 3 weeks. During training, he/she watched one or two robot/human dramas twice where two robot/human actors demonstrated eye contact and RJA. Outcomes and results: Children in the RBI (but not HBI) group produced more RJA and IJA behaviors in the delayed post-test than in the pre-test. Parents of the RBI children rated the program more positively than those of the HBI children. Conclusions and implications: RBI may be more effective than HBI in promoting JA in autistic children with high support needs. Our findings shed light on the application of robot dramas in enhancing social communication skills.
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1114907
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Article ; Online: Facile Peptide Macrocyclization and Multifunctionalization via Cyclen Installation.

Cheung, Tsz-Lam / Tam, Leo K B / Tam, Wing-Sze / Zhang, Leilei / Kai, Hei-Yui / Thor, Waygen / Wu, Yue / Lam, Pak-Lun / Yeung, Yik-Hoi / Xie, Chen / Chau, Ho-Fai / Lo, Wai-Sum / Zhang, Tao / Wong, Ka-Leung

Small methods

2024 , Page(s) e2400006

Abstract: Cyclen-peptide bioconjugates are usually prepared in multiple steps that require individual preparation and purification of the cyclic peptide and hydrophilic cyclen derivatives. An efficient strategy is discovered for peptide cyclization and ... ...

Abstract	Cyclen-peptide bioconjugates are usually prepared in multiple steps that require individual preparation and purification of the cyclic peptide and hydrophilic cyclen derivatives. An efficient strategy is discovered for peptide cyclization and functionalization toward lanthanide probe via three components intermolecular crosslinking on solid-phase peptide synthesis with high conversion yield. Multifunctionality can be conferred by introducing different modular parts or/and metal ions on the cyclen-embedded cyclopeptide. As a proof-of-concept, a luminescent Eu
Language	English
Publishing date	2024-04-09
Publishing country	Germany
Document type	Journal Article
ISSN	2366-9608
ISSN (online)	2366-9608
DOI	10.1002/smtd.202400006
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Article ; Online: Actigraphic sleep monitoring in patients with post-traumatic stress disorder (PTSD): A meta-analysis.

Lam, Lam / Ho, Fiona Yan-Yee / Wong, Vincent Wing-Hei / Chan, Ka-Wai / Poon, Chun-Yin / Yeung, Wing-Fai / Chung, Ka-Fai

Journal of affective disorders

2022 Volume 320, Page(s) 450–460

Abstract: Objective: Sleep disruption is a common complaint among patients with post-traumatic stress disorder (PTSD). Modern technology of activity monitoring (actigraphy) enables extended, objective, unobtrusive recording and measuring of daytime and nighttime ... ...

Abstract	Objective: Sleep disruption is a common complaint among patients with post-traumatic stress disorder (PTSD). Modern technology of activity monitoring (actigraphy) enables extended, objective, unobtrusive recording and measuring of daytime and nighttime activity. We conducted a meta-analysis to investigate the actigraphic sleep patterns in PTSD compared with healthy controls. Methods: We searched through seven electronic databases from inception to July 2022. Only case-control studies comparing rest-activity variables measured by actigraphy devices between clinically diagnosed PTSD patients and healthy individuals were included. Results: We identified 12 eligible studies comparing 323 PTSD patients and 416 healthy controls. Using a random-effects model, we showed that PTSD patients have significantly lower sleep efficiency (SMD: -0.26, 95 % CI = -0.51 to -0.004, p < .05, I Limitations: This study included a limited number of studies. Publication bias was not examined on all variables, which could lead to an overestimation of effect size. Four studies involved veterans, which likely differ from civilians regarding traumatic exposure. Conclusion: This meta-analytic review highlighted a pattern of sleep disturbances in PTSD patients compared with non-PTSD individuals. High-quality, large-scale studies are necessary to draw a definitive conclusion regarding the distinctive sleep profile in PTSD. Future research can pay attention to sleep-specific mechanisms underlying PTSD and explore the momentary interactions between sleep-wake variables.
MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/epidemiology ; Actigraphy ; Polysomnography ; Veterans ; Sleep ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology
Language	English
Publishing date	2022-09-26
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.09.045
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Article ; Online: Effects of subjective successful aging on emotional and coping responses to the COVID-19 pandemic.

Yeung, Dannii Y / Chung, Edwin K H / Lam, Alfred H K / Ho, Alvin K K

BMC geriatrics

2021 Volume 21, Issue 1, Page(s) 128

Abstract: Background: Middle-aged and older adults are more vulnerable to hospitalization and mortality if they are infected with the COVID-19 virus. The present study investigates the longitudinal effects of subjective successful aging on middle-aged and older ... ...

Abstract	Background: Middle-aged and older adults are more vulnerable to hospitalization and mortality if they are infected with the COVID-19 virus. The present study investigates the longitudinal effects of subjective successful aging on middle-aged and older adults' emotional and coping responses to the COVID-19 pandemic, and explores an underlying mechanism through perceived time limitation during the pandemic. Methods: A sample of 311 Hong Kong Chinese middle-aged and older adults (M Results: The respondents who perceived themselves as more successful in aging process reported more positive and fewer negative emotions compared with their counterparts with lower levels of subjective successful aging. The mediation analysis showed that perceived time limitation could partially account for the effects of subjective successful aging on emotional and coping responses. Conclusions: Findings of this study unveil the beneficial effects of subjective views of successful aging on emotional and coping responses to the pandemic through alleviating their perception of time limitation.
MeSH term(s)	Adaptation, Psychological ; Aged ; Aged, 80 and over ; Aging ; COVID-19 ; Emotions ; Hong Kong/epidemiology ; Humans ; Middle Aged ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-021-02076-2
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